Zhu, Minghua1; Wang, Zhongyu1; Chen, Jingwen1; Xie, Huaijun1; Zhao, Hongxia1; Yuan, Xiutang2,3
发表期刊ENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
2020-10-20
卷号54期号:20页码:13175-13185
DOI10.1021/acs.est.0c04421
通讯作者Chen, Jingwen(jwchen@dlut.edu.cn); Yuan, Xiutang(xtyuan@yic.ac.cn)
英文摘要Extensive application of antibiotics leads to their ubiquitous occurrence in coastal aquatic environments. However, it remains largely unknown whether antibiotics can be bioaccumulated and biotransformed in major mariculture organisms such as sea cucumbers and toxicokinetic models for Echinodermata are lacking. In this study, laboratory exposure experiments on juvenile sea cucumber (Apostichopus japonicus) were performed for seven antibiotics (sulfadiazine, sulfamethoxazole, trimethoprim, enrofloxacin, ofloxacin, clarithromycin, and azithromycin). Field sea cucumber and surrounding seawater samples were also analyzed. Results show that the sea cucumbers tend to accumulate high concentrations of the antibiotics with kinetic bioconcentration factors (BCFs) up to 1719.7 L.kg(-1) for ofloxacin. The BCFs determined in the laboratory agree well with those estimated from the field measurements. Seven biotransformation products (BTPs) of the antibiotics were identified, four of which were not reported previously in aquatic organisms. The BTPs were mainly found in the digestive tract, indicating its high capacity in the biotransformation. A multicompartmental toxicokinetic model based on the principles of passive diffusion was developed, which can successfully predict time-course concentrations of the antibiotics in different compartments of the juvenile sea cucumbers. The findings may offer a scientific basis for assessing health risks and guiding healthy mariculture of sea cucumbers.
资助机构National Key R&D Program of China; National Natural Science Foundation of China
收录类别SCI
语种英语
关键词[WOS]CARP CYPRINUS-CARPIO; TISSUE DISTRIBUTION; ORGANIC-CHEMICALS; COASTAL WATER; LAIZHOU BAY; AQUATIC ENVIRONMENT; HYDROXY METABOLITES; DERMAL ABSORPTION; CHINA OCCURRENCE; HUMAN EXPOSURE
研究领域[WOS]Engineering; Environmental Sciences & Ecology
WOS记录号WOS:000584422500039
引用统计被引频次：4[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/28309
专题海岸带生物学与生物资源利用重点实验室
中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者Chen, Jingwen; Yuan, Xiutang作者单位1.Dalian Univ Technol, Sch Environm Sci & Technol, Minist Educ, Key Lab Ind Ecol & Environm Engn, Dalian 116024, Peoples R China
2.Minist Ecol & Environm, Natl Marine Environm Monitoring Ctr, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714Zhu, Minghua,Wang, Zhongyu,Chen, Jingwen,et al. Bioaccumulation, Biotransformation, and Multicompartmental Toxicokinetic Model of Antibiotics in Sea Cucumber (Apostichopus japonicus)[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2020,54(20):13175-13185.
APAZhu, Minghua,Wang, Zhongyu,Chen, Jingwen,Xie, Huaijun,Zhao, Hongxia,&Yuan, Xiutang.(2020).Bioaccumulation, Biotransformation, and Multicompartmental Toxicokinetic Model of Antibiotics in Sea Cucumber (Apostichopus japonicus).ENVIRONMENTAL SCIENCE & TECHNOLOGY,54(20),13175-13185.
MLAZhu, Minghua,et al."Bioaccumulation, Biotransformation, and Multicompartmental Toxicokinetic Model of Antibiotics in Sea Cucumber (Apostichopus japonicus)".ENVIRONMENTAL SCIENCE & TECHNOLOGY 54.20(2020):13175-13185.
PDF全文下载地址:
点我下载PDF
