Liu, Qi1; Li, Wenjun1,2
; Qin, Song1,2发表期刊BIOMEDICINE & PHARMACOTHERAPY
ISSN0753-3322
2020-10-01
卷号130页码:7
关键词phycocyaninRadiationOxidative stressLiver damageNrf2/ HO-1 signaling pathwayDNA damage
DOI10.1016/j.biopha.2020.110553
通讯作者Li, Wenjun(wjli@yic.ac.cn); Qin, Song(sqin@yic.an.cn)
英文摘要1) Background: Phycocyanin (PC) is a type of natural protein in algae with antioxidant and anti-inflammatory properties. However, the protective effect of PC on hepatic damage induced by X-ray remains unknown.2) Methods: Male C57BL/6 mice were gavaged with 200mg/kg PC for consecutive 7 days before or after radiation. The blood samples and tissues were collected on days 1 and 7 after radiation exposure.3) Results: Pretreatment or treatment with PC decreased significantly the levels of alanine aminotransferase (ALT), aspartate aminotransferase(AST) in the plasma. Histological evaluation further confirmed the protection of PC against radiation-induced hepatotoxicity. PC-treatment also increased the relative mRNA expression of superoxide dismutase (SOD) and glutathione (GSH-PX), and descended the ROS in the liver. Moreover, the expression of H2AX, an indicator of DNA damage in mice, of the PC-intervention group was much smaller than that of the radiation group. In vivo, PC-treatment markedly up-regulated NF-E2-related factor 2(Nrf2) expression and downstream gene such as hemeoxygenase-1 (HO-1), NQO1. 4) Conclusion: PC could attenuate the radiation-induced oxidative stress damage by activating Nrf2/ HO-1 signaling pathway, and reduce the radiation-induced DNA damage. Therefore, PC is a protective agent against radiation-induced liver damage.
资助机构National Key Research and Development Program of China; Marine Economy Innovation Development Demonstration Project; KeyResearch and Development Program of Yantai
收录类别SCI
语种英语
关键词[WOS]SPIRULINA-PLATENSIS; RADIATION; INJURY; NRF2; ANTIOXIDANT; MICE; ACTIVATION; MODEL
研究领域[WOS]Research & Experimental Medicine; Pharmacology & Pharmacy
WOS记录号WOS:000582697900058
引用统计被引频次：3[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/28306
专题海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者Li, Wenjun; Qin, Song作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Shandong, Peoples R China
推荐引用方式
GB/T 7714Liu, Qi,Li, Wenjun,Qin, Song. Therapeutic effect of phycocyanin on acute liver oxidative damage caused by X-ray[J]. BIOMEDICINE & PHARMACOTHERAPY,2020,130:7.
APALiu, Qi,Li, Wenjun,&Qin, Song.(2020).Therapeutic effect of phycocyanin on acute liver oxidative damage caused by X-ray.BIOMEDICINE & PHARMACOTHERAPY,130,7.
MLALiu, Qi,et al."Therapeutic effect of phycocyanin on acute liver oxidative damage caused by X-ray".BIOMEDICINE & PHARMACOTHERAPY 130(2020):7.
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