Li, Wenjun1,4
; Lu, Lina2; Liu, Bin3; Qin, Song1发表期刊BIOMEDICINE & PHARMACOTHERAPY
ISSN0753-3322
2020-12-01
卷号132页码:9
关键词Thorax irradiationPulmonary fibrosisMicrobiotaPhycocyanin
DOI10.1016/j.biopha.2020.110826
通讯作者Liu, Bin(binliu0736@126.com); Qin, Song(sqin@yic.an.cn)
英文摘要Objective: Radiation pneumonia and fibrosis are major clinical complications of radiotherapy for thoracic tumor patients, and may significantly reduce survival and quality of life. At present, no safe and effective radiation protection measures have been approved for clinical use. Phycocyanin, a protein responsible for photosynthesis from Spirulina, has been shown to have a variety of biological activities and to be beneficial for a variety of diseases, including pulmonary fibrosis. However, the preventive and protective effects of phycocyanin on radiation-induced pulmonary fibrosis have not been studied.Design: X-ray single dose irradiation was used on the chest of mice to prepare a mouse model of pulmonary fibrosis, from which the effect of phycocyanin on pulmonary histopathologic change, pulmonary fibrosis, the microbiota in lung and gut, LPS, TNF-alpha, and IL-6 at different time after irradiation were evaluated.Results: Phycocyanin alleviated the radiation-induced lung injury and reduced the level of inflammatory factors. Thorax irradiation led to the disorder in microbiota of the lung and gut. The variation trend of the diversity of the two tissues was opposite, but that of the microbiota composition was similar. The phycocyanin intervention regulated the composition of the lung and gut microbiota, transformed them into normal state, and reduced the level of LPS, which significantly reduced the abundance of inflammation-related bacteria, and increased the abundance of probiotics that produce short-chain fatty acids.Conclusion: Phycocyanin could regulate the radiation-induced disorder in lung and gut microbiota of mice, and reduce the radiation-induced lung inflammation and fibrosis.
资助机构National Natural Science Foundation of China; Key Research and Development Program of Yantai
收录类别SCI
语种英语
关键词[WOS]IRRITABLE-BOWEL-SYNDROME; HELICOBACTER-PYLORI; C-PHYCOCYANIN; INFLAMMATION; EXPRESSION
研究领域[WOS]Research & Experimental Medicine; Pharmacology & Pharmacy
WOS记录号WOS:000593704500002
引用统计被引频次：6[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/28282
专题海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者Liu, Bin; Qin, Song作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China
2.Northwest Minzu Univ, Sch Chem Engn, Lanzhou, Peoples R China
3.Lanzhou Univ, Sch Stomatol, Lanzhou, Gansu, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China
推荐引用方式
GB/T 7714Li, Wenjun,Lu, Lina,Liu, Bin,et al. Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model[J]. BIOMEDICINE & PHARMACOTHERAPY,2020,132:9.
APALi, Wenjun,Lu, Lina,Liu, Bin,&Qin, Song.(2020).Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model.BIOMEDICINE & PHARMACOTHERAPY,132,9.
MLALi, Wenjun,et al."Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model".BIOMEDICINE & PHARMACOTHERAPY 132(2020):9.
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