Wang, Yue; Wang, Xiaoyan; Zhang, Li; Huang, Yan; Bi, Liyan; Lv, Changjun; Chen, Lingxin
发表期刊JOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
2020-02-07
卷号8期号:5页码:1017-1025
关键词CISPLATIN-INDUCED NEPHROTOXICITYREACTIVE OXYGENVITAMIN-CCELL-PROLIFERATIONLIPID-PEROXIDATIONOXIDATIVE STRESSCURCUMINMECHANISMSMITOCHONDRIAINHIBITION
研究领域Materials Science, Biomaterials
DOI10.1039/c9tb02453k
产权排序[Wang, Yue; Wang, Xiaoyan; Zhang, Li; Huang, Yan; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Wang, Yue; Zhang, Li] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Wang, Xiaoyan; Huang, Yan; Bi, Liyan; Lv, Changjun; Chen, Lingxin] Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China; [Chen, Lingxin] Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China; [Chen, Lingxin] Qufu Normal Univ, Dept Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China
通讯作者Chen, Lingxin(lxchen@yic.ac.cn)
作者部门海岸带环境工程技术研究与发展中心
英文摘要Tumor resistance and drug-induced nephrotoxicity pose great challenges to the clinical treatment of tumors, and they also limit the clinical application of oncology drugs. Finding an effective adjuvant, which can sensitize tumor treatment, is an effective method for tumor treatment. Here, we developed a ratiometric fluorescent probe, TP-Tfs, for superoxide anion (O-2 & x2d9;(-)) detection in living cells and in vivo during the process of tumor treatment for the first time. TP-Tfs with simple synthesis steps and high yields can detect O-2 & x2d9;(-) sensitively and selectively, and the detection limit was determined to be 37 nM. Using TP-Tfs, we found that cis-diaminodichloroplatinum(ii) (DDP) was effective in treating tumors by inducing O-2 & x2d9;(-) burst. Curcumin (cum) can sensitize tumor treatment effectively by inducing more severe O-2 & x2d9;(-) burst. These results indicated that the probe TP-Tfs was a promising candidate for drug screening and tumor treatment evaluation.
文章类型Article
资助机构National Nature Science Foundation of ChinaNational Natural Science Foundation of China [21976209, 21575159, 21778026]; Taishan Scholar Project Special Funding [ts20190962]
收录类别SCI
语种英语
关键词[WOS]CISPLATIN-INDUCED NEPHROTOXICITY; REACTIVE OXYGEN; VITAMIN-C; CELL-PROLIFERATION; LIPID-PEROXIDATION; OXIDATIVE STRESS; CURCUMIN; MECHANISMS; MITOCHONDRIA; INHIBITION
研究领域[WOS]Materials Science
WOS记录号WOS:000528811300014
引用统计被引频次：7[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/25089
专题中科院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
中科院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China;
4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China;
5.Qufu Normal Univ, Dept Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China
推荐引用方式
GB/T 7714Wang, Yue,Wang, Xiaoyan,Zhang, Li,et al. A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(5):1017-1025.
APAWang, Yue.,Wang, Xiaoyan.,Zhang, Li.,Huang, Yan.,Bi, Liyan.,...&Chen, Lingxin.(2020).A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment.JOURNAL OF MATERIALS CHEMISTRY B,8(5),1017-1025.
MLAWang, Yue,et al."A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment".JOURNAL OF MATERIALS CHEMISTRY B 8.5(2020):1017-1025.
PDF全文下载地址:
点我下载PDF
