Zhang, Jian-Long; Zhou, Feng-Feng; Li, You-Zhi; Feng, Tao; Jiang, Lin-Lin; Jiang, Ren-Wang; Zhang, Xing-Xiao; Li, Xiao-Dong
发表期刊FITOTERAPIA
ISSN0367-326X
2020-03
卷号141页码:104470
关键词ANGULATAWITHANOLIDES
研究领域Chemistry, Medicinal; Pharmacology & Pharmacy
DOI10.1016/j.fitote.2020.104470
产权排序[Zhang, Jian-Long; Jiang, Lin-Lin; Zhang, Xing-Xiao; Li, Xiao-Dong] Ludong Univ, Sch Life Sci, Yantai 264025, Peoples R China; [Zhang, Jian-Long; Li, You-Zhi; Feng, Tao; Jiang, Lin-Lin] Shandong Prov Key Lab Qual Safty Monitoring & Ris, Jinan 250022, Peoples R China; [Li, Xiao-Dong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Zhou, Feng-Feng] Linyi City People Hosp, Dept Infect Dis, Linyi 276000, Shandong, Peoples R China; [Zhang, Jian-Long; Jiang, Ren-Wang] Jinan Univ, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Peoples R China
通讯作者Zhang, Xing-Xiao(zhangxingxiao@ldu.edu.cn); Li, Xiao-Dong(imnli@163.com)
作者部门中科院烟台海岸带研究所知识产出
英文摘要Phytochemical investigations on Physalis. alkekengi L. var. franchetii, a widespread traditional Chinese medicine, led to the isolation and identification of three new sesquiterpenoids physalisitins A-C (1-3). Their structures were elucidated by NMR and HRESIMS analysis, and their absolute configurations were determined by quantum chemical NMR and ECD calculations, as well as by comparing their optical rotation values with those known analogues. All of the isolated compounds were evaluated for their cyclooxygenase-2 (COX-2) inhibitory activity. Compounds 1-3 dose-dependently inhibited the COX-2 enzyme with IC50 values of 3.22 +/- 0.25, 6.35 +/- 0.84, and 11.13 +/- 1.47 mu M, respectively.
文章类型Article
资助机构National Key Research and Development Program of China [2016YFD0501010, 2017YFD-0500806, 2018YFD0501402]; Key Research and Development Program of Shandong Province [2017NC210009, 2019GSF107091]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81600672]; Major Agricultural Applied Technological Innovation Projects of Shandong Province; Key Research and Development Plan of Yantai [2018XSCC045]; Innovation Team Project for Modem Agricultural Industrious Technology System of Shandong Province [SDAIT-11-10]
收录类别SCI
语种英语
关键词[WOS]ANGULATA; WITHANOLIDES
研究领域[WOS]Pharmacology & Pharmacy
WOS记录号WOS:000518703900013
引用统计被引频次：2[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/25082
专题中科院烟台海岸带研究所知识产出
作者单位1.Ludong Univ, Sch Life Sci, Yantai 264025, Peoples R China;
2.Shandong Prov Key Lab Qual Safty Monitoring & Ris, Jinan 250022, Peoples R China;
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China;
4.Linyi City People Hosp, Dept Infect Dis, Linyi 276000, Shandong, Peoples R China;
5.Jinan Univ, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Peoples R China
推荐引用方式
GB/T 7714Zhang, Jian-Long,Zhou, Feng-Feng,Li, You-Zhi,et al. New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii[J]. FITOTERAPIA,2020,141:104470.
APAZhang, Jian-Long.,Zhou, Feng-Feng.,Li, You-Zhi.,Feng, Tao.,Jiang, Lin-Lin.,...&Li, Xiao-Dong.(2020).New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii.FITOTERAPIA,141,104470.
MLAZhang, Jian-Long,et al."New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii".FITOTERAPIA 141(2020):104470.
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