Huang, Y; He, N; Wang, YQ
; Shen, DZ; Kang, Q; Zhao, RF; Chen, LX发表期刊JOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
2019-02-21
卷号7期号:7页码:1149-1159
关键词LUMINESCENT GOLD NANOPARTICLESINDOCYANINE GREENPHOTODYNAMIC THERAPYRENAL CLEARANCEIN-VITROONE-POTNANOMATERIALSDECOMPOSITIONNANOMEDICINETHERANOSTICS
研究领域Materials Science, Biomaterials
DOI10.1039/c8tb03054e
产权排序[Huang, Yan; Shen, Dazhong; Kang, Qi] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes, Minist Educ, Jinan 250014, Shandong, Peoples R China; [Huang, Yan; He, Na; Wang, Yunqing; Zhao, Rongfang; Chen, Lingxin] Chinese Acad Sci, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Chen, Lingxin] Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Peoples R China
作者部门海岸带环境工程技术研究与发展中心
英文摘要Photodynamic therapy (PDT) and photothermal therapy (PTT) are effective cancer treatments, and photosensitizers Way the most important role in the treatment. However, photosensitizers are insufficient for in vivo tumor treatment. Herein, we develop a small molecule fiuorophore Cy-HPT as a novel photosensitizer, which possesses the advantages of near-infrared (NIR) emission, high photothermal conversion efficiency and high singlet oxygen generation efficiency. Moreover, a nanoplatform of HSA@ Cy-HPT was synthesized by self-assembly of Cy-HPT and human serum albumin (HSA) in aqueous solution. Compared to Cy-HPT, HSA@Cy-HPT possesses more stable spectral properties, enhances the effect of PDT/PTT, and exhibits more satisfactory in vivo metabolism. HSA@Cy-HPT demonstrates outstanding tumor targeting in subcutaneous tumor xenograft models owing to its enhanced permeability and retention in tumor tissue. Furthermore, HSA@Cy-HPT was successfully utilized in tumor xenograft models and tumor tissue growth was clearly inhibited without any regrowth, extending survival rate of the models. Also, no distinct damage of the normal tissue of tumor xenograft models was observed using hematoxylin & eosin staining. This study presents a promising therapeutic agent for the synergetic PDT and PTT cancer treatment.
文章类型Article
资助机构National Nature Science Foundation of ChinaNational Natural Science Foundation of China [21575159, 81573393, 21575080]; program of Youth Innovation Promotion Association, CAS [2017256]; Instrument Developing Project of the Chinese Academy of Sciences [YZ201662]
收录类别SCI
语种英语
关键词[WOS]LUMINESCENT GOLD NANOPARTICLES; INDOCYANINE GREEN; PHOTODYNAMIC THERAPY; RENAL CLEARANCE; IN-VITRO; ONE-POT; NANOMATERIALS; DECOMPOSITION; NANOMEDICINE; THERANOSTICS
研究领域[WOS]Materials Science, Biomaterials
WOS记录号WOS:000458659200012
引用统计被引频次：24[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24997
专题中科院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
中科院海岸带环境过程与生态修复重点实验室
作者单位1.Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes, Minist Educ, Jinan 250014, Shandong, Peoples R China;
2.Chinese Acad Sci, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China;
3.Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Peoples R China
推荐引用方式
GB/T 7714Huang, Y,He, N,Wang, YQ,et al. Self-assembly of nanoparticles by human serum albumin and photosensitizer for targeted near-infrared emission fluorescence imaging and effective phototherapy of cancer[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(7):1149-1159.
APAHuang, Y.,He, N.,Wang, YQ.,Shen, DZ.,Kang, Q.,...&Chen, LX.(2019).Self-assembly of nanoparticles by human serum albumin and photosensitizer for targeted near-infrared emission fluorescence imaging and effective phototherapy of cancer.JOURNAL OF MATERIALS CHEMISTRY B,7(7),1149-1159.
MLAHuang, Y,et al."Self-assembly of nanoparticles by human serum albumin and photosensitizer for targeted near-infrared emission fluorescence imaging and effective phototherapy of cancer".JOURNAL OF MATERIALS CHEMISTRY B 7.7(2019):1149-1159.
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