Yu, Q; Wang, YQ
; Mei, RC; Yin, YC; You, JM; Chen, LX发表期刊ANALYTICAL CHEMISTRY
ISSN0003-2700
2019-04-16
卷号91期号:8页码:5270-5277
关键词ENHANCED RAMAN-SCATTERINGLABEL-FREE DETECTIONPHOTOTHERMAL ABLATIONSHELL NANOPARTICLESGOLD NANOPARTICLESNANOPROBESPLATFORMSNANORODS
研究领域Chemistry, Analytical
DOI10.1021/acs.analchem.9b00038
产权排序[Yu, Qian; You, Jinmao; Chen, Lingxin] Qufu Normal Univ, Dept Chem & Chem Engn, Qufu 273165, Peoples R China; [Yu, Qian; Wang, Yunqing; Mei, Rongchao; Yin, Yingchao; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Wang, Yunqing; Yin, Yingchao] Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China; [Chen, Lingxin] Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China
通讯作者Wang, Yunqing(yqwang@yic.ac.cn); Chen, Lingxin(lxchen@yic.ac.cn)
作者部门海岸带环境工程技术研究与发展中心
英文摘要Surface coating determined the sensitivity and stability of surface enhanced Raman scattering (SERS) tags in bioanalysis. The reported various coatings suffered from the drawbacks of a lack of rigidity, stability, or synthesis versatility. Herein, we demonstrated robust polystyrene (PS) coated SERS tags that could be prepared by an easy and universal approach. Taking advantages of biocompatible, transparent, compact properties of PS shell, the coated tags showed satisfactory sensitivity, biocompatibility, and superior structural stability in cell and in vivo imaging applications. More importantly, the PS coating strategy allowed for the encapsulation of SERS tags encoded with not only thiolated but also nonthiolated Raman reporters without loss of sensitivity, as exemplified in the synthesis of 9 different resonant dye-encoded tags. Moreover, the coating of SERS tags with various kinds of substrates was achieved via the same standard protocol. Comparing with widespread silica coated tags, the PS coated ones were more stable in harsh conditions and had an easily expanded ultrasensitive (resonant) tags library with much lower cost (no need of expensive sulfhydryl/isothiocyano reporters with limited types), illustrating great promise as standard analytical tools of commercialized value for bioanalysis, medical diagnostics, and environmental science studies.
文章类型Article
资助机构National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81573393, 21575159]; Youth Innovation Promotion Association CAS [2017256]; Instrument Developing Project of the Chinese Academy of Sciences [YZ201662]
收录类别SCI
语种英语
关键词[WOS]ENHANCED RAMAN-SCATTERING; LABEL-FREE DETECTION; PHOTOTHERMAL ABLATION; SHELL NANOPARTICLES; GOLD NANOPARTICLES; NANOPROBES; PLATFORMS; NANORODS
研究领域[WOS]Chemistry, Analytical
WOS记录号WOS:000465189600047
引用统计被引频次：24[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24956
专题中科院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
中科院海岸带环境过程与生态修复重点实验室
作者单位1.Qufu Normal Univ, Dept Chem & Chem Engn, Qufu 273165, Peoples R China;
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China;
3.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China;
4.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China
推荐引用方式
GB/T 7714Yu, Q,Wang, YQ,Mei, RC,et al. Polystyrene Encapsulated SERS Tags as Promising Standard Tools: Simple and Universal in Synthesis; Highly Sensitive and Ultrastable for Bioimaging[J]. ANALYTICAL CHEMISTRY,2019,91(8):5270-5277.
APAYu, Q,Wang, YQ,Mei, RC,Yin, YC,You, JM,&Chen, LX.(2019).Polystyrene Encapsulated SERS Tags as Promising Standard Tools: Simple and Universal in Synthesis; Highly Sensitive and Ultrastable for Bioimaging.ANALYTICAL CHEMISTRY,91(8),5270-5277.
MLAYu, Q,et al."Polystyrene Encapsulated SERS Tags as Promising Standard Tools: Simple and Universal in Synthesis; Highly Sensitive and Ultrastable for Bioimaging".ANALYTICAL CHEMISTRY 91.8(2019):5270-5277.
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