Xie, YY; Li, WJ
; Zhu, LM; Zhai, SX; Qin, S; Du, ZN发表期刊MICROBIOLOGYOPEN
ISSN2045-8827
2019-09
卷号8期号:9页码:e825
关键词16S rRNA high-throughput sequencingintestinal barrierintestinal microbiotaphycocyanin
研究领域Microbiology
DOI10.1002/mbo3.825
产权排序[Xie, Yuanyuan; Du, Zhenning] Yantai Univ, Yantai, Peoples R China; [Xie, Yuanyuan; Li, Wenjun; Zhu, Limeng; Zhai, Shixiang; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China; [Zhu, Limeng] Chinese Acad Sci, Inst Proc Engn, Beijing, Peoples R China
通讯作者Qin, Song(sqin@yic.ac.cn); Du, Zhenning(zhenning.du@163.com)
作者部门海岸带生物学与生物资源保护实验室
英文摘要The health-promoting effects of phycocyanin (PC) have become widely accepted over the last two decades. In this study, we investigated the effects of different doses of PC in modulating the intestinal microbiota and the intestinal barrier in mice. Six-week-old male C57BL/6 mice were treated with PC for 28 days. Fecal samples were collected before and after PC intervention, and the microbiota were analyzed by 16S rRNA high-throughput sequencing. Bacterial abundance and diversity increased after PC intervention. Saccharolytic bacteria of the families Lachnospiraceae and Ruminococcaceae, which can produce butyric acid, increased after PC treatment. The family Rikenellaceae, which contains hydrogen-producing bacteria, also increased after PC intervention. The PC treatment reduced intestinal permeability and increased the intestinal barrier function, as demonstrated by hematoxylin-eosin staining and reduced serum lipopolysaccharide levels. The modulating effects on the intestinal microbiota were more favorable in the low-dose PC group.
文章类型Article
收录类别SCI
语种英语
关键词[WOS]OXIDATIVE STRESS; DIET; LACHNOSPIRACEAE; SPECIALIZATION; INFLAMMATION; ANTIOXIDANT; DIVERSITY; BUTYRATE; ECOLOGY
研究领域[WOS]Microbiology
WOS记录号WOS:000485975100004
引用统计被引频次：14[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24866
专题海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位1.Yantai Univ, Yantai, Peoples R China;
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China;
3.Chinese Acad Sci, Inst Proc Engn, Beijing, Peoples R China
推荐引用方式
GB/T 7714Xie, YY,Li, WJ,Zhu, LM,et al. Effects of phycocyanin in modulating the intestinal microbiota of mice[J]. MICROBIOLOGYOPEN,2019,8(9):e825.
APAXie, YY,Li, WJ,Zhu, LM,Zhai, SX,Qin, S,&Du, ZN.(2019).Effects of phycocyanin in modulating the intestinal microbiota of mice.MICROBIOLOGYOPEN,8(9),e825.
MLAXie, YY,et al."Effects of phycocyanin in modulating the intestinal microbiota of mice".MICROBIOLOGYOPEN 8.9(2019):e825.
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