Meng, XJ; Li, F
; Wang, XQ; Liu, JL; Ji, CL; Wu, HF发表期刊JOURNAL OF HAZARDOUS MATERIALS
ISSN0304-3894
2019-10-15
卷号378页码:UNSP 120778
关键词Joint effectsGrapheneTriphenyl phosphate (TPP)ToxicityMussel
研究领域Engineering, Environmental; Environmental Sciences
DOI10.1016/j.jhazmat.2019.120778
产权排序[Meng, Xiangjing; Li, Fei; Wang, Xiaoqing; Liu, Jialin; Ji, Chenglong; Wu, Huifeng] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China; [Ji, Chenglong; Wu, Huifeng] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China; [Meng, Xiangjing; Wang, Xiaoqing] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
通讯作者Li, Fei(fli@yic.ac.cn); Wu, Huifeng(hfwu@yic.ac.cn)
作者部门海岸带环境过程实验室
英文摘要Owing to its unique surface properties, graphene can absorb environmental pollutants, thereby affecting their environmental behavior. Triphenyl phosphate (TPP) is a highly produced flame retardant. However, the toxicities of graphene and its combinations with contaminants remain largely unexplored. In this work, we investigated the toxicological effects of graphene and TPP to mussel Mytilus galloprovincialis. Results indicated that graphene could damage the digestive gland tissues, but no significant changes were found in the graphene + TPP co-exposure group. There was a significant decrease in the content of GSH and the activities of GST and CAT in the co-exposure group compared to that in graphene-exposed group. It seemed that the adsorption of TPP on graphene could inhibit the surface activity of graphene and thus reduced its tissue damage and oxidative stress in mussels. Expression levels of stress response (MyD88a), cytoskeleton (MHC1, PMyo and TMyo) and reproductive (CP450 and HSD) genes were up-regulated in the graphene-exposed group, but significantly down-regulated after combined exposure of graphene and TPP. Furthermore, PPI analysis proved that the interactions of HSP90AA1 with UNC45B and FKBP4/5/6/L contributed to the toxicity caused by the combined exposure. Because of the potential toxicity of graphene and TPP, government administrators should consider its risks prior to the widespread environmental exposure.
文章类型Article
资助机构National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41530642, 21677173]; Youth Innovation Promotion Association CAS [2017255, 2015169]
收录类别SCI
语种英语
关键词[WOS]ORGANOPHOSPHATE FLAME RETARDANTS; MESSENGER-RNA EXPRESSION; DEVELOPMENTAL TOXICITY; OXIDATIVE STRESS; OXIDE; MECHANISMS; NETWORK; PLASTICIZERS; CYTOTOXICITY; ECOTOXICITY
研究领域[WOS]Engineering, Environmental; Environmental Sciences
WOS记录号WOS:000489188300067
引用统计被引频次：9[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24833
专题中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
支撑部门
中科院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China;
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China;
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714Meng, XJ,Li, F,Wang, XQ,et al. Combinatorial immune and stress response, cytoskeleton and signal transduction effects of graphene and triphenyl phosphate (TPP) in mussel Mytilus galloprovincialis[J]. JOURNAL OF HAZARDOUS MATERIALS,2019,378:UNSP 120778.
APAMeng, XJ,Li, F,Wang, XQ,Liu, JL,Ji, CL,&Wu, HF.(2019).Combinatorial immune and stress response, cytoskeleton and signal transduction effects of graphene and triphenyl phosphate (TPP) in mussel Mytilus galloprovincialis.JOURNAL OF HAZARDOUS MATERIALS,378,UNSP 120778.
MLAMeng, XJ,et al."Combinatorial immune and stress response, cytoskeleton and signal transduction effects of graphene and triphenyl phosphate (TPP) in mussel Mytilus galloprovincialis".JOURNAL OF HAZARDOUS MATERIALS 378(2019):UNSP 120778.
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