Zhao, Ye; Liu, Hui
; Wang, Qing; Li, Bingjun发表期刊FISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
2019-01
卷号84页码:434-440
关键词AntibioticsApostichopus japonicasImmune responseDigestive enzyme activityAquaculture
研究领域Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences
DOI10.1016/j.fsi.2018.10.022
产权排序[Zhao, Ye; Li, Bingjun] Yantai Univ, Ocean Sch, Yantai 264005, Peoples R China; [Liu, Hui; Wang, Qing] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai, Peoples R China
作者部门海岸带生物资源高效利用研究与发展中心
英文摘要The global abuse and misuse of antibiotics in the treatment and prevention of bacterial infections has resulted in the ubiquitous existence of these drugs in aquatic environments, which causes frequent antimicrobial resistance and pollution in ecosystems. However, the chronic effects of antimicrobial agents on aquatic animal growth and health have not been fully evaluated. In the present study, three typical antibiotics (tetracycline, erythromycin, and norfloxacin) were administered orally to juvenile sea cucumbers Apostichopus japonicus for 45 days, to mimic the long-term use of antibiotics. As a result, tetracycline and erythromycin promoted the growth and digestive activity of lipase, pepsin, and trypsin, but norfloxacin did not show significant prompting effect on digestive activity and even retarded the weight gain of the sea cucumbers. The mortality was higher in antibiotic treated groups between the 2nd and 4th days after challenge with Vibrio splendidus. At the same time, lower immune related parameters were found in antibiotic feeding juveniles, suggesting that the use of antibiotics might weaken the immune defense system of sea cucumbers. This study revealed that antibiotic administration could facilitate the growth of sea cucumbers to varying degrees yet coupled with high risks of impaired immune function and compromised disease resistance.
文章类型Article
资助机构Shandong Provincial Natural Science Foundation, China [ZR2017BD026]; Yantai University Doctoral Start-up Fund [HX15B14]; Demonstration Project on Innovative Development of Marine Economy Fund [YHCX-SW- P201701]; Key Research Program of the Chinese Academy of Sciences [KFZD-SW-106]
收录类别SCI
语种英语
关键词[WOS]WASTE-WATER TREATMENT; VETERINARY ANTIBIOTICS; OXIDATIVE STRESS; CYPRINID FISH; OXOLINIC ACID; IN-VIVO; OXYTETRACYCLINE; FATE; FLORFENICOL; EXPOSURE
研究领域[WOS]Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences
WOS记录号WOS:000457666800049
引用统计被引频次：11[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24616
专题海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
作者单位1.Yantai Univ, Ocean Sch, Yantai 264005, Peoples R China;
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai, Peoples R China
推荐引用方式
GB/T 7714Zhao, Ye,Liu, Hui,Wang, Qing,et al. The influence of three antibiotics on the growth, intestinal enzyme activities, and immune response of the juvenile sea cucumber Apostichopus japonicus selenka[J]. FISH & SHELLFISH IMMUNOLOGY,2019,84:434-440.
APAZhao, Ye,Liu, Hui,Wang, Qing,&Li, Bingjun.(2019).The influence of three antibiotics on the growth, intestinal enzyme activities, and immune response of the juvenile sea cucumber Apostichopus japonicus selenka.FISH & SHELLFISH IMMUNOLOGY,84,434-440.
MLAZhao, Ye,et al."The influence of three antibiotics on the growth, intestinal enzyme activities, and immune response of the juvenile sea cucumber Apostichopus japonicus selenka".FISH & SHELLFISH IMMUNOLOGY 84(2019):434-440.
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