Zhai, Shixiang; Zhu, Limeng; Qin, Song
; Li, Lili发表期刊MICROBIOLOGYOPEN
ISSN2045-8827
2018-12
卷号7期号:6页码:e612
关键词16S rRNA high-throughput sequencinggut microbiotaprebioticprobioticsshort chain fatty acids
研究领域Microbiology
DOI10.1002/mbo3.612
产权排序[Zhai, Shixiang; Zhu, Limeng; Qin, Song; Li, Lili] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Shandong, Peoples R China; [Zhai, Shixiang; Zhu, Limeng] Univ Chinese Acad Sci, Beijing, Peoples R China; [Zhu, Limeng] Chinese Acad Sci, Inst Proc Engn, Beijing, Peoples R China
作者部门海岸带生物学与生物资源保护实验室
英文摘要Gut microbiota have strong connections with health. Lactulose has been shown to regulate gut microbiota and benefit host health. In this study, the effect of short-term (3 week) intervention of lactulose on gut microbiota was investigated. Gut microbiota were detected from mouse feces by 16S rRNA high-throughput sequencing, and short chain fatty acids (SCFAs) were detected by gas chromatography-mass spectrometry (GC-MS). Lactulose intervention enhanced the alpha-diversity of the gut microbiota; increased the abundance of hydrogen-producing bacteria Prevotellaceae and Rikenellaceae, probiotics Bifidobacteriaceae and Lactobacillaceae, and mucin-degrading bacteria Akkermansia and Helicobacter; decreased the abundance of harmful bacteria Desulfovibrionaceae and branched-chain SCFAs (BCFAs). These results suggest that lactulose intervention effectively increased the diversity and improved the structure of the intestinal microbiota, which may be beneficial for host health.
文章类型Article
资助机构National Key Research and Development plan [2017YFC0506200]; National Natural Science Foundation of China [21306221]; Science and Technology Major Project of Shandong Province [2015ZDJS03002]
收录类别SCI
语种英语
关键词[WOS]RELATIVE ORGAN WEIGHT; GROWTH-PERFORMANCE; FECAL MICROBIOTA; DIET; SUPPLEMENTATION; FERMENTATION; METABOLISM; HEALTH; LACTOBACILLUS; ALCOHOL
研究领域[WOS]Microbiology
WOS记录号WOS:000453616500014
引用统计被引频次：31[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24594
专题海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Shandong, Peoples R China;
2.Univ Chinese Acad Sci, Beijing, Peoples R China;
3.Chinese Acad Sci, Inst Proc Engn, Beijing, Peoples R China
推荐引用方式
GB/T 7714Zhai, Shixiang,Zhu, Limeng,Qin, Song,et al. Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57BL/6J mice[J]. MICROBIOLOGYOPEN,2018,7(6):e612.
APAZhai, Shixiang,Zhu, Limeng,Qin, Song,&Li, Lili.(2018).Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57BL/6J mice.MICROBIOLOGYOPEN,7(6),e612.
MLAZhai, Shixiang,et al."Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57BL/6J mice".MICROBIOLOGYOPEN 7.6(2018):e612.
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