Wang, Mingchao; Li, Jie
; Li, Wenjun; Du, Zhenning; Qin, Song发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
2018-10-15
卷号118期号:A页码:41-48
关键词CollagenPoly (vinyl alcohol)Double-networkHydrogelSelf-crosslink
研究领域Biochemistry & Molecular Biology; Chemistry; Polymer Science
DOI10.1016/j.ijbiomac.2018.05.200
产权排序[Wang, Mingchao; Du, Zhenning] Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Minist Educ, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China; [Li, Jie; Li, Wenjun; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
作者部门海岸带生物学与生物资源保护实验室
英文摘要Hydrogels prepared by conventional methods show poor performance in many aspects. Many double network (DN) hydrogels prepared by crosslinking agents have disadvantages such as toxicity. In this work, we prepared novel DN hydrogels with fish-originated collagen (Col) and poly (vinyl alcohol) (PVA), in which self-assembly of collagen and self-crosslinking of PVA were achieved. Infrared spectra indicated the existence of double network with chemical interactions between Col and PVA. X-ray diffraction (XRD) patterns showed that characteristic peak of freeze-thaw PVA in DN hydrogel was retained. Scanning electron microscope (SEM) images before and after degradation and swelling property tests indicated that the morphology of the hydrogel was a compact meshwork, which is consistent with the high water-retention rate. The degradation rate of the DN hydrogels was controlled by the ratio of Col and PVA. Compared with a pure collagen hydrogels, the stress of DN hydrogels was greatly enhanced from 6 to 33 kPa at a strain of 40%. This study indicates that DN hydrogels prepared by Col and PVA are an ideal biomaterial for tissue engineering. (C) 2018 Published by Elsevier B.V.
文章类型Article
资助机构Yantai Innovative Marine Medical Materials Industry Incubation Aggregation Innovation and Demonstration Project [YHCX-SW-Y-201701]; National Key Research and Development Program China [2016YFF0202304]; [KFZD-SW-218]
收录类别SCI
语种英语
关键词[WOS]MECHANICAL-PROPERTIES; COLLAGEN HYDROGELS; BONE REGENERATION; ALCOHOL HYDROGEL; HYBRID HYDROGELS; SKIN COLLAGEN; FISH COLLAGEN; I COLLAGEN; GELLAN GUM; CHITOSAN
研究领域[WOS]Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WOS记录号WOS:000445170200006
引用统计被引频次：20[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24549
专题海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位1.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Minist Educ, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China;
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714Wang, Mingchao,Li, Jie,Li, Wenjun,et al. Preparation and characterization of novel poly (vinyl alcohol)/collagen double-network hydrogels[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,118(A):41-48.
APAWang, Mingchao,Li, Jie,Li, Wenjun,Du, Zhenning,&Qin, Song.(2018).Preparation and characterization of novel poly (vinyl alcohol)/collagen double-network hydrogels.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,118(A),41-48.
MLAWang, Mingchao,et al."Preparation and characterization of novel poly (vinyl alcohol)/collagen double-network hydrogels".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 118.A(2018):41-48.
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