Zhu X; Li MY; Chen XQ; Wang JY; Li LZ
; Tu C; Luo YM; Li HB; Ma LQ发表期刊Environment International
ISSN0160-4120
2019
卷号130页码:104875
关键词Heavy metalsMouse modelBioavailabilityIn vitro assayBioaccessibility
研究领域Environmental Sciences
DOI10.1016/j.envint.2019.05.069
产权排序[Zhu, Xia; Li, Lian-Zhen; Tu, Chen; Luo, Yong-Ming] Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Zhu, Xia; Luo, Yong-Ming] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Li, Meng-Ya; Chen, Xiao-Qiang; Wang, Jue-Yang; Li, Hong-Bo; Ma, Lena Q.] Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Jiangsu, Peoples R China; [Luo, Yong-Ming] Chinese Acad Sci, Inst Soil Sci, Key Lab Soil Environm & Pollut Remediat, Nanjing 210008, Jiangsu, Peoples R China; [Ma, Lena Q.] Univ Florida, Soil & Water Sci Dept, Gainesville, FL 32611 USA
通讯作者Luo, Yong-Ming(ymluo@yic.ac.cn); Li, Hong-Bo(hongboli@nju.edu.cn)
作者部门海岸带环境过程实验室
英文摘要The robustness of in vitro bioaccessibility assays to predict oral relative bioavailability (RBA) of multiple metals in contaminated soils requires validation using additional soil samples. In this study, 11 contaminated soils from mining/smelting areas were analyzed for As-, Cd-, and Pb-RBA using a mouse bioassay and metal bioaccessibility via the UBM gastric phase assay. Metal-RBA varied considerably among soils, with As-RBA (2.5-23%, mean 12%) being generally lower than Cd-and Pb-RBA (3.4-88 and 3.3-59%, mean 42 and 28%), due to higher proportions of As in the residual fractions. Metal-RBA generally decreased with increasing metal concentrations probably due to reduced labile metal fractions. In addition, strong negative correlations were observed between total Fe with As-, Cd-, and Pb-RBA (R-2 = 0.46-0.77), suggesting the role of Fe in controlling metal-RBA in soils. Like RBA, metal bioaccessibility by the UBM assay also varied among samples. However, strong in vivo-in vitro correlations (IVIVCs) were observed between metal-RBA and bioaccessibility (R-2 = 0.52-0.81). Further, there were little differences when As-, Cd-, and Pb-IVIVCs established using soils from this study and soils pooled from literature were compared, suggesting the robustness of the UBM assay to predict metal-RBA in contaminated soils.
文章类型Article
资助机构National Key Research and Development Plan Projects; National Natural Science Foundation of China
收录类别SCI
语种英语
关键词[WOS]IN-VITRO ASSAYS; UNIFIED BARGE METHOD; ARSENIC BIOAVAILABILITY; PREDICTIVE CAPABILITIES; BIOACCESSIBILITY; LEAD; VIVO; CADMIUM; VALIDATION; SPECIATION
研究领域[WOS]Environmental Sciences
WOS记录号WOS:000477934800014
引用统计被引频次：11[WOS][WOS记录][WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cnhttp://ir.yic.ac.cn/handle/133337/24141
专题中科院海岸带环境过程与生态修复重点实验室
中科院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
通讯作者Luo YM; Li HB推荐引用方式
GB/T 7714Zhu X,Li MY,Chen XQ,et al. As, Cd, and Pb relative bioavailability in contaminated soils: Coupling mouse bioassay with UBM assay[J]. Environment International,2019,130:104875.
APAZhu X.,Li MY.,Chen XQ.,Wang JY.,Li LZ.,...&Ma LQ.(2019).As, Cd, and Pb relative bioavailability in contaminated soils: Coupling mouse bioassay with UBM assay.Environment International,130,104875.
MLAZhu X,et al."As, Cd, and Pb relative bioavailability in contaminated soils: Coupling mouse bioassay with UBM assay".Environment International 130(2019):104875.
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