16. 不同碳源条件下冬虫夏草生长的代谢示踪， 泰国农业大学合作横向课题基金， 6 万元，

2017.2-2017.7，主持。

17. 抗癌富丁酸益生菌保健醋的研究， 山东玉兔食品股份有限公司横向课题基金， 10 万元， 2016.11-2018.6，主持。

18.天然药物科技开发，江苏威凌生化科技有限公司-山东理工大学菌种联合研究中心项目，50 万元，

2016-2020，主持。

19.Construction of a ω-3 fatty acid EPA producing cell factory by manipulating the activity and expression of ω-3 desaturase in the fungus Mortierella alpina. Starting Merieux Research grant (法国), 40000 euros, Principle investigator，2013-2014，主持。

20.那西肽生产菌链霉菌分子改造，绿康生化股份有限公司技术开发基金，2012-2014，主持。

21.植物提取物应用于食品防腐剂的研究与开发，郑州绿叶堂本草科技有限公司技术开发基金，

2012-2014，主持。

22.香辛料发酵技术开发. 日本大塚（上海）食品研究所横向合作课题，2012-2013，主持。

23.羊油生物转化制备代可可脂的研究，青海裕泰畜产品有限公司技术开发基金， 2012-2013，主持。

24.高山被孢霉 EPA 细胞工厂构建，江苏省大学生创新课题，指导老师，2012-2013，主持。

25.Characterization of the multiple isoforms of malic enzyme in Mucor circinelloides. Starting grant of Jiangnan University，Principle investigator (2011-2013)，主持。

26.高山被孢霉ω-3 脂肪酸 EPA 合成关键酶的定向分子进化及EPA 细胞工厂的构建. 食品科学与技术国家重点实验室自由探索课题（SKLF-TS-201101）20 万元，2011-2012，主持。

27.微乳化柴油的研制，北京天任瑞创科技发展有限公司科研基金（合同编号: **000065）（100

万元），2008-2011，主持。

28.微生物柴油的生物合成技术，湖南省科技计划（2008SK4057），5 万元，2008-2009，主持。

29.溶血磷脂酸在卵巢癌中的作用，美国国防部基金（W81XWH**）3 万美元， 2006-2007，参与。

30.溶血磷脂在卵巢癌新生血管形成中的作用，美国国家健康研究院（NIH）基金（CA102196-01A1）

75 万美元，2004-2007，参与。

31.脂质代谢平衡的调控因子―氮代谢信号转导蛋白质的结构和功能的关系，美国国家健康研究院

（NIH）基金（GM-59637）50 万美元，2002-2004，参与。

32.植物真菌病的信号转导机理研究，美国国家自然科学基金（ NSF）基金（ IBN-**）、

（IBN-**）20 万美元，2001-2002，参与。

33.油脂生物酶催化水解法制备脂肪酸和甘油，北京矿冶研究总院科研基金,兼该项目工业化生产线建设副总设计师，1993-1997，主持。

34.脂肪酸衍生物―乳化剂的研制、开发、应用，北京矿冶研究总院科研基金，1990-1993，参与。

代表论文、著作、专利

一、论文

1. Tahira Naz, Shaista Nosheen, Shaoqi Li, Yusuf Nazir, Kiren Mustafa, Qing Liu, Victoriano Garre and Yuanda Song*. Comparative Analysis of Carotene Production by Mucor circinelloides Strains CBS 277.49 and WJ11 under Light and Dark Conditions. Metabolites 2020, 10, 38; doi:10.3390/metabo**

2. Meiling Chen . Xiuzhen Gao*. Wu Yang . Caili Sun . Junhuan Yang . Huaiyuan Zhang . Yuanda Song*. Discovery and characterization of a stable lipase with preference toward long-chain fatty acids. Biotechnol Lett (2020) 42:171–180.

3. Ahsan Hameed, Syed Ammar Hussain, Muhammad Umair Ijaz, Samee Ullah, Zafarullah Muhammad, Hafiz Ansar Rasul Suleria, Yuanda Song*. Antioxidant activity of polyphenolic extracts of filamentous fungus Mucor circinelloides (WJ11): Extraction, characterization and storage stability of food emulsions. Food Bioscience, 2020

4. Junhuan Yang, Md. Ahsanul Kabir Khan, Huaiyuan Zhang, Yao Zhang, Milan Certik, Victoriano Garre,

Yuanda Song*. Mitochondrial Citrate Transport System in the Fungus Mucor circinelloides: Identification, Phylogenetic Analysis, and Expression Profiling During Growth and Lipid Accumulation. Current Microbiology 2019. https://doi.org/10.1007/s00284-019-01822-5

5. Samee Ullah, Anees Ahmed Khalil, Faryal Shaukat, Yuanda Song*. (2019). Sources, Extraction and Biomedical Properties of Polysaccharides. Foods, 8(8), 304. doi:10.3390/foods**

6. Md. Ahsanul Kabir Khan, Junhuan Yang, Syed Ammar Hussain, Huaiyuan Zhang, Li Liang, Victoriano Garre* and Yuanda Song*. (2019). Construction of DGLA producing cell factory by genetic modification of Mucor circinelloides. Microbial Cell Factories, 18(1). doi:10.1186/s12934-019-1110-4

7. Md. Ahsanul Kabir Khan, Junhuan Yang, Syed Ammar Hussain, Huaiyuan Zhang, Victoriano Garre*, and Yuanda Song*. (2019). Genetic Modification of Mucor circinelloides to Construct Stearidonic Acid Producing Cell Factory. International Journal of Molecular Sciences, 20(7), 1683. doi:10.3390/ijms**

8. Syed Ammar Hussain, Yusuf Nazir, Ahsan Hameed, Wu Yang, Kiren Mustafa and Yuanda Song*. (2019). Optimization of Diverse Carbon Sources and Cultivation Conditions for Enhanced Growth and Lipid and Medium-Chain Fatty Acid (MCFA) Production by Mucor circinelloides. Fermentation, 5(2), 35. doi:10.3390/fermentation**

9. Syed Ammar Hussain, Ahsan Hameed, Md. Ahsanul Kabir Khan, Yao Zhang, Huaiyuan Zhang, Victoriano Garre and Yuanda Song*. (2019)Engineering of Fatty Acid Synthases (FASs) to Boost the Production of Medium-Chain Fatty Acids (MCFAs) in Mucor circinelloides. International Journal of Molecular Sciences. 2019, 20, 786. Published: 12 February 2019. doi:10.3390/ijms**

10. Junhuan Yang, Shaoqi Li, Md. Ahsanul Kabir Khan, Victoriano Garre, Wanwipa Vongsangnak*, Yuanda Song*. (2019). Increased lipid accumulation in Mucor Circinelloides by overexpression of mitochondrial citrate transporter genes. Industrial & Engineering Chemistry Research. doi:10.1021/acs.iecr.8b05564

11. Huaiyuan Zhang, Xinxin Kang, Na Xiao, Meng Gao, Yanlei Zhao, Baixi Zhang, Yuanda Song*. (2019). Intracellular Expression of Vitreoscilla Hemoglobin Improves Lipid Production in Yarrowia lipolytica. Letters in Applied Microbiology. doi:10.1111/lam.13111

12. Wanwipa Vongsangnak*, Amornthep Kingkaw, Junhuan Yang, Yuanda Song, Kobkul Laoteng*. (2018). Dissecting metabolic behavior of lipid over-producing strain of Mucor circinelloides through genome-scale metabolic network and multi-level data integration. Gene, 2018, 670: 87–97. doi:10.1016/j.gene.2018.05.085. Epub 2018 May 23.

13. Yusuf Nazir, Syed Ammar Hussain, Aidil Abdul Hamid*, and YuandaSong*. (2018). Probiotics and Their Potential Preventive and Therapeutic Role for Cancer, High Serum Cholesterol, and Allergic and HIV Diseases. BioMed Research International, 2018, 1–17. doi:10.1155/2018/**

14. Yusuf Nazir, Shuwahida Shuib, Mohd Sahaid Kalil, Yuanda Song*, and Aidil Abdul Hamid*. (2018). Optimization of Culture Conditions for Enhanced Growth, Lipid and Docosahexaenoic Acid (DHA) Production of Aurantiochytrium SW1 by Response Surface Methodology. Scientific Reports, 8(1). doi:10.1038/s41598-018-27309-0

15. Syed Ammar Hussain, Ahsan Hameed, Yusuf Nazir, Tahira Naz, Yang Wu, Hafiz Ansar Rasul Suleria* and Yuanda Song*. (2018). Microencapsulation and the Characterization of Polyherbal Formulation (PHF) Rich in Natural Polyphenolic Compounds. Nutrients, 10(7), 843. doi:10.3390/nu**

16. Xinyi Zan, Xin Tanga, Linfang Chua, Yuanda Song*. (2018). Characteristics of cell growth and lipid accumulation of high and low lipid-producing strains of Mucor circinelloides grown on different glucose-oil mixed media. Process Biochemistry, 72, 31–40. doi:10.1016/j.procbio.2018.06.012

17. Xinyi Zan, Xin Tang, Linfang Chu, and Yuanda Song*. (2018). Dual Functions of Lip6 and Its Regulation of Lipid Metabolism in the Oleaginous Fungus Mucor circinelloides. Journal of Agricultural and Food Chemistry, 66(11), 2796–2804. doi:10.1021/acs.jafc.7b06024

18. Luning Zhang, Huaiyuan Zhang, and Yuanda Song*. (2018). Identification and Characterization of

Diacylglycerol Acyltransferase from Oleaginous Fungus Mucor circinelloides. Journal of Agricultural and Food Chemistry, 66(3), 674–681. doi:10.1021/acs.jafc.7b04295

19. Syed Ammar Hussain*, Ahsan Hameed*, Jingjing Fu, Haifang Xiao, Qing Liu, Yuanda Song. (2018). Comparative in vitro analysis of anti-diabetic activity of indo-pak black cardamom (Amomum subulatum Roxb.) and chinese black cardamom (Amomum tsao-ko Crevost et Lemaire).Progress in Nutrition 2018; 20(3):403-414. DOI: 10.23751/pn.v20i3.6196

20. Ahsan Hameed, Syed Ammar Hussain, Junhuan Yang, Muhammad Umair Ijaz, Qing Liu, Hafiz Ansar Rasul Suleria, and Yuanda Song*. (2017). Antioxidants Potential of the Filamentous Fungi (Mucor circinelloides). Nutrients, 9(10), 1101. doi:10.3390/nu**

21. Jingjing Fu, Haifang Xiao, Shaoxuan Yu, Han Wu, Aydin Berenjian and Yuanda Song*. (2017). Response Surface Optimized Ultrasonic Assisted Extraction of Total Flavonoids from Walnut Leaves and In Vitro Antibacterial Activities. American Journal of Biochemistry and Biotechnology, 13(4), 176–188. doi:10.3844/ajbbsp.2017.176.188

22. Qi Fan, Lei Wang, Yuanda Song, Zheng Fang, Muriel Subirade, Li Liang*. (2017). Partition and stability of resveratrol in whey protein isolate oil-in-water emulsion: Impact of protein and calcium concentrations. International Dairy Journal, 73, 128–135. doi:10.1016/j.idairyj.2017.06.002

23. Xin Tang, Haiqin Chen*, Zhennan Gu, Hao Zhang, Yong Q. Chen, Yuanda Song*, and Wei Chen. (2017). Comparative Proteome Analysis between High Lipid-Producing Strain Mucor circinelloides WJ11 and Low Lipid-Producing Strain CBS 277.49. Journal of Agricultural and Food Chemistry, 65(24), 5074–5082. doi:10.1021/acs.jafc.7b00935

24. Yao Zhang, Xiao Luan, Huaiyuan Zhang, Victoriano Garre, Yuanda Song*, and Colin Ratledge. (2017). Improved γ-linolenic acid production in Mucor circinelloides by homologous overexpressing of delta-12 and delta-6 desaturases. Microbial Cell Factories, 16(1):113. doi:10.1186/s12934-017-0723-8

25. Waseem Safdar, Muhammad Shamoon, Xinyi Zan, Junaid Haider, Hafiz Rizwan Sharif, Muhammad Shoaib and Yuanda Song*. (2017). Growth kinetics, fatty acid composition and metabolic activity changes of Crypthecodinium cohnii under different nitrogen source and concentration. AMB Express, 7(1):85. doi:10.1186/s13568-017-0384-3

26. Waseem Safdar, Xinyi Zan, Muhammad Shamoon, Hafiz Rizwan Sharif, Omar Mukama, Xin Tang, Yuanda Song*. (2017). Effects of twenty standard amino acids on biochemical constituents, docosahexaenoic acid production and metabolic activity changes of Crypthecodinium cohnii. Bioresource Technology, 238, 738–743. doi:10.1016/j.biortech.2017.04.024

27. Waseem Safdar, Xinyi Zan, Yuanda Song*.(2017). Synergistic Effects of pH, Temperature and Agitation on Growth Kinetics and Docosahexaenoic Acid Production of C. cohnii Cultured on Different Carbon Sources.International Journal of Research in Agricultural Sciences, 4(2): 94–101.ISSN (Online) 2348-3997

28. Waseem Safdar, Xinyi Zan, Yuanda Song*.(2017). Synergistic Effect of Phosphorus and Nitrogen on Growth, Lipid Accumulation and Docosahexaenoic Acid Production in Crypthecodinium Cohnii. International Journal of Agriculture Innovations and Research. 5(5):768-775. ISSN (Online) 2319-1473

29. Waseem Safdar, Junaid Haider, Hafiz Rizwan Sharif, Yuanda Song.(2017). Metabolic switching: synergistic induction of lipogenesis in C. cohnii under the influence of phosphorus, pH and salinity, 2017. Journal of Food and Nutrition Research (In press).

30. Ahsan Hameed, Syed Ammar Hussain, Muhammed Asim Shabbir, Imran Pasha*, and Yuanda* Song. (2017). Nutritional and Fatty Acids Profile Analyses of Commonly Consumed Fresh Water Fish Species in Pakistan. American Journal of Biochemistry and Biotechnology 2017, 13(1): 15.26 DOI: 10.3844/ajbbsp.2017.15.26

31. Zhen Wang, Huaiyuan Zhang, Lina Zhao and Yuanda Song*. (2016). Identification and Characterization

of Diacylglycerol Acyltransferase in Oleaginous Yeast Rhodosporidium toruloides. American Journal of

Biochemistry and Biotechnology, 12(4), 230–240. doi:10.3844/ajbbsp.2016.230.240

32. Huaiyuan Zhang, Chao Wu, Qingyu Wu, Junbiao Dai*, Yuanda Song*. (2016). Metabolic Flux Analysis of Lipid Biosynthesis in the Yeast Yarrowia lipolytica Using 13C-Labled Glucose and Gas Chromatography-Mass Spectrometry. PLOS ONE, 11(7), e**. doi:10.1371/journal.pone.**

33. Aihua Xu, Md. Ahsanul Kabir Khan, Fangzhi Chen, Zhaohui Zhong, Han-chun Chen*, Yuanda Song*. (2016). Overexpression of autotaxin is associated with human renal cell carcinoma and bladder carcinoma and their progression. Medical Oncology, 33(11):131. doi:10.1007/s12032-016-0836-7

34. Haifang Xiao*, Quancai Sun, Xuebo Liu and Yuanda Song*. (2016). Binding Interaction between Bovine Serum Albumin and Chicoric Acid, a Food Functional Component. American Journal of Biochemistry and Biotechnology, 12(3), 149–158. doi:10.3844/ajbbsp.2016.149.158

35. Xinyi Zan, Xin Tang, Lina Zhao, Linfang Chu, Haiqin Chen, Wei Chen, Yong Q. Chen, Yuanda Song*. (2016). Bioinformatical analysis and preliminary study of the role of lipase in lipid metabolism in Mucor circinelloides. RSC Advances, 6(65), 60673–60682. doi:10.1039/c6ra08285h

36. Xinyi Zan, Xin Tang, Linfang Chu, Lina Zhao, Haiqin Chen, Yong Q. Chen, Wei Chen, Yuanda Song*. (2016). Lipase genes in Mucor circinelloides: identification, sub-cellular location, phylogenetic analysis and expression profiling during growth and lipid accumulation. Journal of Industrial Microbiology & Biotechnology, 43(10):1467–1480. doi:10.1007/s10295-016-1820-0

37. Linfang Chu, Xinyi Zan, Xin Tang, Lina Zhao, Haiqin Chen, Yong Q. Chen, Wei Chen, Yuanda Song*. (2016). The role of a xylose isomerase pathway in the conversion of xylose to lipid in Mucor circinelloides. RSC Advances, 6(81), 77944–77952. doi:10.1039/c6ra12379a

38. Qiuyan Mo, Huaiyuan Zhang, Qing Liu, Xin Tang, Lina Zhao, Xinyi Zan, Yuanda Song*. (2016). Enhancing nosiheptide production in Streptomyces actuosusby heterologous expression of haemoprotein from Sinorhizobium meliloti. Letters in Applied Microbiology, 62(6):480–487. doi:10.1111/lam.12575

39. Luxuan Huang, Lina Zhao, Xinyi Zan, Yuanda Song*, Colin Ratledge. (2016). Boosting fatty acid synthesis in Rhodococcus opacus PD630 by overexpression of autologous thioesterases. Biotechnology Letters, 38(6):999–1008. doi:10.1007/s10529-016-2072-9

40. Xin Tang, Xinyi Zan, Lina Zhao, Haiqin Chen, Yong Q. Chen, Wei Chen, Yuanda Song* and Colin Ratledge. (2016). Proteomics analysis of high lipid-producing strain Mucor circinelloides WJ11: an explanation for the mechanism of lipid accumulation at the proteomic level. Microbial Cell Factories, 15(1):35. doi:10.1186/s12934-016-0428-4

41. Gbago Onivogui, Rebaone Letsididi, Mohamed Diaby, Liping Wang, Yuanda Song*. (2016). Influence of extraction solvents on antioxidant and antimicrobial activities of the pulp and seed of Anisophyllea laurina R. Br. ex Sabine fruits. Asian Pacific Journal of Tropical Biomedicine, 6(1):20–25. doi:10.1016/j.apjtb.2015.09.023

42. Lina Zhao, José T. Cánovas -Márquez, Xin Tang, Haiqin Chen, Yong Q. Chen, Wei Chen, Victoriano Garre*, Yuanda Song*, Colin Ratledge. (2016). Role of malate transporter in lipid accumulation of oleaginous fungus Mucor circinelloides. Applied Microbiology and Biotechnology, 100(3), 1297–1305. doi:10.1007/s00253-015-7079-y

43. Lei Wang, Yahui Gao, Juan Li, Muriel Subirade, Yuanda Song*, Li Liang*. (2016). Effect of resveratrol or ascorbic acid on the stability of α-tocopherol in O/W emulsions stabilized by whey protein isolate: Simultaneous encapsulation of the vitamin and the protective antioxidant. Food Chemistry, 196, 466-474. doi:10.1016/j.foodchem.2015.09.071

44. Lina Zhao, Xin Tang, Xiao Luan, Haiqin Chen, Yong Q. Chen, Wei Chen, Yuanda Song*, Colin Ratledge. (2015). Role of pentose phosphate pathway in lipid accumulation of oleaginous fungus Mucor circinelloides. RSC Advances, 5(118):97658–97664. doi:10.1039/c5ra20364c

45. Xin Tang, Haiqin Chen, Yong Q. Chen, Wei Chen, Victoriano Garre, Yuanda Song*, ColinRatledge

(2015). Comparison of Biochemical Activities between High and Low Lipid-Producing Strains of Mucor circinelloides: An Explanation for the High Oleaginicity of Strain WJ11. PLOS ONE, 10(6), e**. doi:10.1371/journal.pone.**

46. Gbago Onivogui, Mohamed Diaby, Xiaotian Chen, Huaiyuan Zhang, M’balu Regina Kargbo, Yuanda Song*. (2015). Antibacterial and antifungal activities of various solvent extracts from the leaves and stem bark of Anisophyllea laurina R. Br ex Sabine used as traditional medicine in Guinea. Journal of Ethnopharmacology, 168:287–290. doi:10.1016/j.jep.2015.03.055

47. M’balu Regina Kargbo, Gbago Onivogui, Yuanda Song*. (2015). In vitro anti-diabetic activity and phenolic compound profile of ethanol extracts of Anisophyllea laurina R. Br. ex Sabine leaves and stem bark. European Academic Research, 2(12):16089-16106. ISSN 2286-4822

48. Xin Tang, Lina Zhao, Haiqin Chen, Yong Q. Chen, Wei Chen, Yuanda Song*, Colin Ratledge. (2015). Complete Genome Sequence of a High Lipid-Producing Strain of Mucor circinelloides WJ11 and Comparative Genome Analysis with a Low Lipid-Producing Strain CBS 277.49. PLOS ONE, 10(9):e**. doi:10.1371/journal.pone.**

49. Lina Zhao, Huaiyuan Zhang, Liping Wang, Haiqin Chen, Yong Q. Chen, Wei Chen, Yuanda Song*. (2015). 13 C-metabolic flux analysis of lipid accumulation in the oleaginous fungus Mucor circinelloides. Bioresource Technology, 197:23–29. doi:10.1016/j.biortech.2015.08.035

50. Hamideh Vaghari, Maryam Eskandari, Vahideh Sobhani, Aydin Berenjian*, Yuanda Song and Hoda Jafarizadeh-Malmiri. (2015). Process Intensification for Production and Recovery of Biological Products. American Journal of Biochemistry and Biotechnology, 11(1):37–43. doi:10.3844/ajbbsp.2015.37.43

51. Dan Xiong, Huaiyuan Zhang, Yifang Xie, Nianchu Tang, Aydin Berenjian and Yuanda Song*. (2015). Conversion of Mutton Fat to Cocoa Butter Equivalent by Increasing the Unsaturated Fatty Acids at the Sn-2 Position of Triacylglycerol Through Fermentation by Yarrowia Lipolytica. American Journal of Biochemistry and Biotechnology, 11(2):57–65. doi:10.3844/ajbbsp.2015.57.65

52. Xiaotian Chen, Changyin Wang, Jianxin Chen, Gbago Onivogui and Yuanda Song*. (2015). Antibacterial Activity of Lotus Leaves (Nelumbo Nucifera) Against Food-Borne Pathogens. American Journal of Biochemistry and Biotechnology, 11(1):11–16. doi:10.3844/ajbbsp.2015.11.16

53. Huaiyuan Zhang, Luning Zhang, Haiqin Chen, Yong Q. Chen, Wei Chen, Yuanda Song*, Colin Ratledge. (2014). Enhanced lipid accumulation in the yeast Yarrowia lipolytica by over-expression of ATP:citrate lyase from Mus musculus. Journal of Biotechnology, 192:78–84. doi:10.1016/j.jbiotec.2014.10.004

54. Mingxuan Wang, Jianxin Chen, Huaiyuan Zhang, Yuanda Song*. (2014). Molecular switch that controls the flux of linoleic acid into n-6 or n-3 polyunsaturated fatty acids in microorganisms. American Journal of Biochemistry and Biotechnology, 10(2): 105-115. DOI:10.3844/ajbbsp.2014.105.115

55. Gbago Onivogui, Huaiyuan Zhang, Erasto Mlyuka, Mohamed Diaby, Yuanda Song*. (2014). Chemical Composition, Nutritional Properties and Antioxidant Activity of Monkey Apple (Anisophyllea laurina R. Br. ex Sabine). Scandinavian Journal of Food & Nutrition, 2(2):281-287. DOI：10.12691/jfnr-2-6-3

56. Xin Tang, Huaiyuan Zhang, Haiqin Chen, Yong Q. Chen, Wei Chen, Yuanda Song*. (2014). Effects of 20 Standard Amino Acids on the Growth, Total Fatty Acids Production, and γ-Linolenic Acid Yield in Mucor circinelloides. Current Microbiology, 69(6):899–908. doi:10.1007/s00284-014-0671-z

57. Jiayu Yang, Xinjie Hu, Huaiyuan Zhang, Haiqin Chen, M’balu.R.Kargbo, Jianxin Zhao,Yuanda Song*, Yong Q. Chen, Hao Zhang, Wei Chen*. (2014). Expression, Purification, and Characterization of NADP+-Dependent Malic Enzyme from the Oleaginous Fungus Mortierella Alpina. Applied Biochemistry and Biotechnology, 173(7):1849–1857. doi:10.1007/s12010-014-0971-6

58. Guangfei Hao, Haiqing Chen,Lei Wang, Zhennan Gu, Yuanda Song, Hao Zhang, Wei Chen*, Yong Q. Chen*. (2014). Role of Malic Enzyme during Fatty Acid Synthesis in the Oleaginous Fungus Mortierella

alpina. Applied and Environmental Microbiology, 80(9):2672–2678. doi:10.1128/aem.00140-14

59. Guangfei Hao, Haiqin Chen*, Kai Du, Xiaoyun Huang, Yuanda Song, Zhennan Gu, Lei Wang, Hao Zhang, Wei Chen, Yong Q. Chen. (2014). Increased fatty acid unsaturation and production of arachidonic acid by homologous over-expression of the mitochondrial malic enzyme in Mortierella alpina. Biotechnology Letters, 36(9):1827–1834. doi:10.1007/s10529-014-1546-x

60. Guangqiang Wang, Yu Xia, Jing Cui, Zhennan Gu, Yuanda Song, Yong Q. Chen, Haiqin Chen*, Hao Zhang and Wei Chen*. The Roles of Moonlighting Proteins in Bacteria. Current Issues in Molecular Biology, 2014, 16(2):15-22.https://doi.org/10.21775/cimb.016.015

61. Guangqiang Wang, Haiqin Chen, Yu Xia, Jing Cui, Zhennan Gu, Yuanda Song, Yong Q. Chen, Hao Zhang*, Wei Chen*. (2013). How are the Non-classically Secreted Bacterial Proteins Released into the Extracellular Milieu? Current Microbiology, 67(6):688–695. doi:10.1007/s00284-013-0422-6

62. Huaiyuan Zhang, Luning Zhang, Haiqin Chen, Yongquan Chen, Colin Ratledge, Yuanda Song*, Wei Chen. (2013). Regulatory properties of malic enzyme in the oleaginous yeast, Yarrowia lipolytica, and its non-involvement in lipid accumulation. Biotechnology Letters, 35(12):2091–2098. doi:10.1007/s10529-013-1302-7

63. Baixi Zhang, Haiqin Chen, Min Li, Zhennan Gu, Yuanda Song, Colin Ratledge, Yong Q Chen, Hao Zhang*, Wei Chen*. (2013). Genetic engineering of Yarrowia lipolytica for enhanced production of trans-10, cis-12 conjugated linoleic acid. Microbial Cell Factories, 12(1):70. doi:10.1186/1475-2859-12-70

64. Wanwipa Vongsangnak*, Rawisara Ruenwai, Xin Tang, Xinjie Hu , Hao Zhang, Bairong Shen, Yuanda Song , Kobkul Laoteng*. (2013). Genome-scale analysis of the metabolic networks of oleaginous Zygomycete fungi. Gene, 521(1)：180–190. doi:10.1016/j.gene.2013.03.012

65. Yi-Ning Dong, Ling Wang, Qiong Gu, Haiqin Chen*, Xiaoming Liu, Yuanda Song, Wei Chen, Arnold T. Hagler, Hao Zhang, Jun Xu*. (2013). Optimizing lactose hydrolysis by computer-guided modification of the catalytic site of a wild-type enzyme. Molecular Diversity, 17(2):371–382. doi:10.1007/s11030-013-9437-y

66. Hongchao Wang, Haiqin Chen*, Guangfei Hao, Bo Yang, Yun Feng, Yu Wang, Lu Feng, Jianxin Zhao, Yuanda Song, Hao Zhang, Yong Q. Chen, Lei Wang, Wei Chen*. (2013). Role of the Phenylalanine-Hydroxylating System in Aromatic Substance Degradation and Lipid Metabolism in the Oleaginous Fungus Mortierella alpina. Applied and Environmental Microbiology, 79(10): 3225–3233. doi:10.1128/aem.00238-13

67. Guangqiang Wang, Haiqin Chen, Hao Zhang, Yuanda Song*, Wei Chen*. (2013). The Secretion of an Intrinsically Disordered Protein with Different Secretion Signals in Bacillus subtilis. Current Microbiology, 66(6):566–572. doi:10.1007/s00284-013-0315-8

68. Bo Yang, Haiqin Chen, Yuanda Song*, Yong Q. Chen, Hao Zhang, Wei Chen*. (2013). Myosin-cross-reactive antigens from four different lactic acid bacteria are fatty acid hydratases. Biotechnology Letters, 35(1):75–81. doi:10.1007/s10529-012-1044-y

69. Baixi Zhang, Chunchi Rong, Haiqin Chen, Yuanda Song*, Hao Zhang*and Wei Chen. (2012). De novo synthesis of trans-10, cis-12 conjugated linoleic acid in oleaginous yeast Yarrowia Lipolytica. Microbial Cell Factories, 11(1):51. doi:10.1186/1475-2859-11-51

70. Wanwipa Vongsangnak,•Yingtong Zhang, Wei Chen, Colin Ratledge, Yuanda Song*. (2012). Annotation and analysis of malic enzyme genes encoding for multiple isoforms in the fungus Mucor circinelloides CBS 277.49. Biotechnology Letters, 34(5):941–947. doi:10.1007/s10529-012-0859-x

71. Haiqin Chen , Xie Yan, Fengwei Tian, Yuanda Song, Yong Q. Chen, Hao Zhang, Wei Chen*. (2012). Cloning, expression, and identification of a novel class IIa bacteriocin in the Escherichia coli cell-free protein expression system. Biotechnology Letters, 34(2):359–364. doi:10.1007/s10529-011-0779-1

72. Guangqiang Wang, Yining Dong, Haiqin Chen, Heping Zhang, Yuanda Song, Hao Zhang and Wei Chen*. (2011). High Incidence of Disorder-Promoting Amino Acids in the Amino Terminus of Mature Proteins in

Bacillus subtilis. American Journal of Biochemistry and Biotechnology, 7(4), 172-178.

doi:10.3844/ajbbsp.2011.172.178

73. Lei Wang, Wei Chen, Yun Feng, Yan Ren, Zhennan Gu, Haiqin Chen, Hongchao Wang, Michael J. Thomas, Baixi Zhang, Isabelle M. Berquin, Yang Li, Jiansheng Wu, Huanxin Zhang, Yuanda Song, Xiang Liu, James S. Norris, Suriguga Wang, Peng Du, Junguo Shen, Na Wang, Yanlin Yang, Wei Wang, Lu Feng, Colin Ratledge, Hao Zhang*, Yong Q. Chen*. (2011). Genome Characterization of the Oleaginous Fungus Mortierella alpina. PLoS ONE, 6(12), e28319. doi:10.1371/journal.pone.**

74. Mousumi Tania, Md. Asaduzzaman Khan, Huaiyuan Zhang, Jinhua Li, Yuanda Song*. (2010). Autotaxin: A protein with two faces. Biochemical and Biophysical Research Communications, 401(4):493–497. doi:10.1016/j.bbrc.2010.09.114

75. Yuanda Song, Emily Dilger, Jessica Bell, William A Barton and Xianjun Fang*. (2010). Large scale purification and characterization of recombinant human autotaxin/lysophospholipase D from mammalian cells. BMB Reports 43(8): 541-546. doi:10.5483/BMBRep.2010.43.8.541

76. Mousumi Tania, Md. Asaduzzaman Khan and Yuanda Song*. (2010). Association of lipid metabolism with ovarian cancer. Current Oncology, 17(5):6-11. doi:10.3747/co.v17i5.668

77. Yuanda Song, Jinhua Wu, Regina A. Oyesanya, Zendra Lee, Abir Mukherjee, and Xianjun Fang*. (2009). Sp-1 and c-Myc Mediate Lysophosphatidic Acid-Induced Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Cells via a Hypoxia-Inducible Factor-1-Independent Mechanism. Clinical Cancer Research, 15(2), 492–501. doi:10.1158/1078-0432.ccr-08-1945

78. Regina A. Oyesanya, Zendra P. Lee, Jinhua Wu, Jing Chen, Yuanda Song, Abir Mukherjee, Paul Dent, Tomasz Kordula, Huiping Zhou, and Xianjun Fang*. (2008). Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells. The FASEB Journal, 22(8):2639–2651. doi:10.1096/fj.07-101428

79. Yuanda Song, Palmer Wilkins, Wenhui Hu, Karnam S. Murthy, Jing Chen, Zendra Lee, Regina Oyesanya, Jinhua Wu, Suzanne E. Barbour, Xianjun Fang*. (2007). Inhibition of calcium-independent phospholipase A2suppresses proliferation and tumorigenicity of ovarian carcinoma cells. Biochemical Journal, 406(3), 427–436. doi:10.1042/bj**

80. Zhennai Yang, Linda M. Rogers, Yuanda Song, Wenjin Guo, P. E. Kolattukudy*. (2005). Homoserine and asparagine are host signals that trigger in planta expression of a pathogenesis gene in Nectria haematococca. Proceedings of the National Academy of Sciences, 102(11), 4197–4202. doi:10.1073/pnas.**02

81. Yuanda Song, Daniel Peisach, Augen A. Pioszak, Zhaohui Xu, Alexander J. Ninfa*. (2004). Crystal Structure of the C-terminal Domain of the Two-Component System Transmitter Protein Nitrogen Regulator II (NRII; NtrB), Regulator of Nitrogen Assimilation in Escherichia coli. Biochemistry, 43(21), 6670–6678. doi:10.1021/bi049474r

82. Yuanda Song, Augen A. Pioszak, Alexander J. Ninfa, Zhaohui Xu. (2003). Structure of NRII histidine kinase domain. The FASEB Journal, 17 (5), A1309.

83. Yuanda Song, James P. Wynn*, Yonghua Li, David Grantham, Colin Ratledge. (2001). A pre-genetic study of the isoforms of malic enzyme associated with lipid accumulation in Mucor circinelloides. Microbiology, 147 (6): 1507-1515.（SCI IF=2.828）

84. 肖海芳, 杨淑青, 王旭光, 王静, 宋元达*. 菊苣酸对蛋白质氧化损伤的作用[J]. 食品科

学,2018,39(07):119-124.

85. 肖海芳,付晶晶,王友玲,李凡玥,宋元达*.菊苣酸对活性氧诱导脂质和 DNA 氧化损伤的影响[J].食品科学,2018,39(13):235-240.

二、著作（教材）

1.Kiren Mustafa, Yuanda Song. Chapter 1. Functional Foods and Cancer: Bioactive Compounds and Cancer. Functional Food Center INC., 2017.

2. Aydin Berenjian, Hoda J. Malmiri, Yuanda Song. High Value Processing Technologies. Nova Science Publishers, Inc. 2016.

3. Fang Hu, Yingtong Zhang and Yuanda Song. Chapter 9. Lipid Metabolism, Metabolic Syndrome, and Cancer. Chapter 9 in “Lipid Metabolism”edited by Bodrigo Valenzuela Baez, published by InTech. 脂 质代谢（第 9 章 脂质代谢、代谢综合征以及癌症），Bodrigo Valenzuela Baez 主编，InTech 出版。2013. 4.Yuanda Song. Chapter 18. Oncogenes, Tumor Suppressor Genes and Growth Factors. Biochemistry：A Textbook for Medical Students，生物化学英文版教材 (第 18 章 癌基因、抑癌基因与生长因子)，赵宝昌主编，北京科学出版社，ISBN：978-7-03-024721-6. 2009.

三、专利

1. 发明专利，一种油脂用天然抗氧化芝麻提取物的制备方法申请号：**2275.9

2. 发明专利，一种提高男性性功能的复方草药制剂，申请号：**7678.0

3. 发明专利，一种提高卷枝毛霉产油量的制备方法，申请号：**4454.3

4. 发明专利，一种玉米低聚肽粉发酵乳解酒饮料的制备办法，申请号：**9748.8

5. 发明专利，一种抗Ⅱ型糠尿病及并发症的黑豆蔻和小豆蔻提取物及其应用，申请号： **1365.4

6. 发明专利，一种抗Ⅱ型糠尿病及并发症的猴果树叶与树皮乙醇提取物制备及其应用，申请号：

**1391.7

7. 发明专利，一种以羊油为原料制备类可可脂的生物转化法, 专利申请号：**2017.9

8. 发明专利，一株能够高产脂的卷枝毛霉及应用, 专利申请号：**2019.8

9. 发明专利， 一种分子改造提高耶氏解脂酵母油脂含量的方法及其重组菌株. 专利申请号：

**7626.9

10. 发明专利，一种水提絮凝法制备松针天然防腐剂的方法.申请号：**0914.6，

11.实用新型，一种微生物发酵消泡装置，申请号：**2256.7，授权公告日 2015 年 1 月 28 日

12. 发明专利，栗壳提取物在苹果汁防腐中的应用，申请号：**4832.3

13. 发明专利，一种用于食品饮料的天然复合防腐剂，申请号：**4276.8

14. 发明专利，一种用于提高卷枝毛霉产 γ-亚麻酸的发酵培养基及其用途，申请号：**4941.2

授权公告日 2016 年 3 月 9 日

15. 发明专利，一种用于多不饱和脂肪酸生物合成的脱饱和酶-ω3 Des，申请号：**9215.2，授权公告日 2014 年 7 月 30 日

16. 发明专利，一种用于多不饱和脂肪酸生物合成的脱饱和酶-△9 Des，申请号：**0769.4

17. 发明专利，生产共轭亚油酸的重组酵母菌株及其用途，申请号：**2130.9，授权公告日 2013

年 6 月 5 日

18. 发明专利，利用鞭毛蛋白 Hag 的前 50 个氨基酸作为融合标签提高外源蛋白质在枯草芽孢杆菌中的表达量，申请号：**6792.0

19. 发明专利，利用一类转运信号来实现外源蛋白质的分泌表达，申请号：**6794.X，授权公告

日 2014 年 7 月 9 日

获奖及荣誉