教师信息

1.白念珠菌质膜蛋白 Rch1 对细胞质内钙离子稳态和耐药调控功能的机理研究，国家自然科学基金项目，2014-2017，70 万，参与。

2.白念珠菌 GDT1 基因对胞内钙离子稳态、细胞壁胁迫、菌丝发育和小鼠毒力的调控，国家自然科学基金项目，68 万，2016-2019，参与。

一、论文

1.Huihui Xu, Tianshu Fang , Raha Parvizi Omran , MalcolmWhiteway and Linghuo Jiang. RNA sequencing reveals an additional Crz1-binding motif in promotersof its target genes in the human fungal pathogen Candida albicans. Cell Communication and Signaling. 2020. 18(1):1.doi: 10.1186/s12964-019-0473-9. (IF5.324）

2.Huihui Xu; Tianshu Fang; HongboYan; Linghuo Jiang. The protein kinaseCmk2 negatively regulates the calcium/calcineurin signalling pathway and expression of calcium pump genes PMR1 and PMC1 in budding yeast . Cell Communication and Signaling. 2019, 17(1):7. (IF5.324）

3.Xu H, Whiteway H, Jiang L. The tricarboxylicacid cycle, cell wall integrity pathway, cytokinesis and

intracellular pHhomeostasis are involved in the sensitivity of Candida albicans cells to high levels of extracellular calcium.Genomics,2019, 111(6): 1226-1230. (IF2.910)

4.徐慧慧, 蒋伶活. (2018) CRISPR/Cas9 方法失活白念珠菌 CaMIT1 基因及其突变株表型分析. 中国真菌学杂志, 2018, 13(4): 201-207

5.徐慧慧, 蒋伶活, Malcolm Whiteway.通过 CRISPR/Cas9 基因编辑手段构建白念珠菌 CaHSL1 基因的失活突变体及其表型分析. 中国细胞生物学学报, 2018, 40(4): 542-550。

6.Zhao Y, Yan H, Happeck R, Peiter-Volk T, Xu H,Zhang Y, Peiter E, van Oostende TripletC, Whiteway M, Jiang L. The plasma membrane protein Rch1 is a negative regulator of cytosolic calciumhomeostasis and positively regulated by the calcium/calcineurin signalling pathway in budding yeast. European

Journal of Cell Biology, 2016,95(3-5): 164-174 (IF3.939)

7.Zhao Y, Xu H,Zhang Y, Jiang L. Vcx1-D1 (M383I), the Vcx1 mutant with a calcineurin-independentvacuolar H+/Ca2+ exchanger activity, confers calcineurin- independentMn2+ tolerancein Saccharomyces cerevisiae. CanadianJournal of Microbiology, 2016,62(2): 1-10 (IF1.243)

8.Xiong B, Zhang L, Xu H, Yang Y, Jiang L.Cadmium induces the activation of cell wall integrity pathway in budding yeast. Chemico-Biological Interactions, 2015,240: 316-323 (IF3.296)

9.Jiang L, Cao C, Zhang L, Lin W, XiaJ, XuH, Zhang Y. Cadmium-inducedactivation of high osmolarity

glycerolpathway through its Sln1 branch is dependent on the MAP kinase kinase kinaseSsk2, but not its paralog Ssk22, in budding yeast. FEMS Yeast Research, 2014,14(8):1263-1272 (IF2.609)

10. Zhao Y, Xiong B, Xu H, Jiang L.Expression of NYV1 encoding thenegative regulator of Pmc1 activity is repressed by two transcriptionalrepressors Nrg1 and Mig1. FEBS Letters, 2014,588(17): 3195-3201 (IF3.03)

11.Zhao Y, Du J, Xiong B, Xu H, Jiang L. ESCRTcomponents regulate the expression of the ER/Golgi calcium pump gene PMR1 through the Rim101/Nrg1 pathway in budding yeast. Journal ofMolecular Cell

Biology,2013, 5(5):336-344. (IF5.595)

二、著作（教材） 三、专利