教师信息

1. 山东省科技厅，山东省重点研发计划项目，2018GSF121013，基于一步利用废弃秸秆的卷枝毛霉生产功能性脂质的产业化研究，2018-01 至 2020-12，20 万元，在研，主持

2. 国家自然科学基金委员会，面上项目，**，AMPD、AMPK 对产脂真菌卷枝毛霉脂质积累的协同调控作用及其分子机制，2020-01 至 2023-12,58 万元，在研，第二参加人

3. 淄博市科技局，校城融合项目，2017ZBXC169，果蔬发酵复合益生菌剂的研发及规模化制备技术，

2017-01至 2020-12，25 万元，已结题，主持

4. 中国博士后科学基金会，面上资助，2017M612305，产脂真菌卷枝毛霉脂质积累过程还原力产生途径解析，2017-05 至 2018-09，5 万元，已结题，主持

5. 国家自然科学基金委员会，面上项目，**，柠檬酸转运体系在产脂真菌卷枝毛霉脂质积累中国的作用及机制研究，2017-01 至 2020-12,62 万元，在研，第三参加人

6. 山东省科技厅，山东省泰山产业领军人才项目，LJNY201606，卷枝毛霉细胞工厂高效转化秸秆生产伽马-亚麻酸、十八碳四烯酸技术开发，2017-01 至 2021-12,300 万元，在研，第二参加人

7. 山东省教育厅，山东省高等学校科技计划项目，J16LE20，新型脂肪酶的定向改造及高效分泌研究，

2016-07至 2018-12，5.5 万元，已结题，主持

8. 中国博士后科学基金会，特别资助，2015T80735，多糖对糖尿病大鼠胰岛细胞功能的保护机理研究，2015-07 至 2018-11，15 万元，已结题，主持

9. 中国博士后科学基金会，面上资助，2013M531641，洋葱伯克霍尔德氏菌脂肪酶在大肠杆菌中的分泌表达研究，2013-05 至 2015-06，5 万元，已结题，主持

10. 国家自然科学基金委员会， 青年项目，** ， 基于蛋白质组合代谢组学整合分析的Paraconiothyrium variable GHJ-4 降解木质素的分子机制，2013-01 至 2015-12,23 万元，已结题，第三参加人

一、论文

(1)Lu Wang, Huaiyuan Zhang, Yao Zhang*, Yuanda Song. 13C metabolicflux analysis on roles of malate transporter in lipid accumulation of Mucor circinelloides. Microbial CellFactories, 2019, 18: 154 (*corresponding authors)（IF4.402）

(2)Yao Zhang, XiaoLuan, Huaiyuan Zhang, Victoriano Garre, YuandaSong, Colin Ratledge, Improved gamma-linolenic acid production in Mucor circinelloides by homologousoverexpressing of delta-12 and delta-6 desaturases, Microbial Cell Factories,2017, 16: 113 （IF4.402）

(3)Syed Ammar Hussain, Ahsan Hameed, Md. Ahsanul KabirKhan, YaoZhang, Huaiyuan Zhang, Victoriano Garre, Yuanda Song. Engineering of fatty acid synthases (FASs) to boost the production ofmedium-chain fatty acids (MCFAs) in Mucor circinelloides. InternationalJournal of Molecular Sciences, 2019, 20: 786（IF4.183）

(4)Junhuan Yang, Md. Ahsanul Kabir Khan, HuaiyuanZhang, YaoZhang, Milan Certik, Victoriano Garre, Yuanda Song. Mitochondrial citrate transport system in thefungus Mucor circinelloides:identification, phylogenetic analysis, and expression profiling during growthand lipid accumulation. Current Microbiology,2020, 77(2): 220-231 （IF1.595）

(5)Yao Zhang*, Yuanda Song, Lu Wang, Qing Liu,Improvement on extracellular production of recombinant Burkholderia cepacia Lu10-1 lipase by Escherichia coli, American Journal of Biochemistry andBiotechnology, 2018, 14(2): 76~87

(6)Yao Zhang*, Lu Wang, YuandaSong, Heterologous Expression and Biochemical Characterization of Lipasefrom Burkholderia cepacia Lu10-1,American Journal of Biochemistry and Biotechnology,2017, 13(4): 233~241

(7)Chunjiu Ren#, Yao Zhang#, Weizheng Cui,Guobing Lu, Yanwen Wang, Huiju Gao, Lu Huang, Zhimei Mu*, A polysaccharideextract of mulberry leaf ameliorates hepatic glucose metabolism and insulinsignaling in rats with type 2 diabetes induced by high fat-diet andstreptozotocin, International Journal of Biological Macromolecules, 2015, 72:951-959 (#co-firstauthors) （IF4.784）

(8)Yao Zhang, ChunjiuRen, Guobing Lu, Zhimei Mu, Weizheng Cui,Huiju Gao, Yanwen Wang, Anti-diabeticeffect of mulberry leaf polysaccharide by inhibiting pancreatic islet cellapoptosis and ameliorating insulin secretory capacity in diabetic rats,International Immunopharmacology, 2014, 22: 248-257 （IF3.361）

(9)Yao Zhang, ChunjiuRen, Guobing Lu, Weizheng Cui,Zhimei Mu, Huiju Gao, Yanwen Wang, Purification, characterization andanti-diabetic activity of a polysaccharide from mulberry leaf, RegulatoryToxicology and Pharmacology, 2014, 70(3): 687-695 （IF2.996）

(10)Yao Zhang, Lei Wang, Jian Chen, Jing Wu, Enhanced activity toward PET bysite-directed mutagenesis of Thermobifidafusca cutinase-CBM fusion protein, Carbohydrate Polymers, 2013, 97: 124-129 （IF6.044）

(11)Yao Zhang, ShengChen, Jing Wu, Jian Chen, Enzymaticsurface modification of cellulose acetate fiber by cutinase-CBM(Carbohydrate-Binding Module) fusion proeins, Biocatalysis andBiotransformation, 2012, 30(2): 184-189 （IF1.627）

(12)Yao Zhang, ShengChen, Miao He, Jing Wu, Jian Chen,Qiang Wang, Effects of Thermobifida fusca cutinase-carbohydrate-bindingmodule fusion proteins on cotton bioscouring, Biotechnology and BioprocessEngineering, 2011, 16(4): 645-653 （IF1.438）

(13)Yao Zhang, ShengChen, Meng Xu, Artur Cavaco-Paulo, Jing Wu, JianChen, Characterization of Thermobifida fuscacutinase-carbohydrate-binding module fusion proteins and their potentialapplication in bioscouring, Applied and Environmental Microbiology, 2010, 76(20): 6870-6876 （IF4.077）

二、会议论文

(1)Yao Zhang*. Cloning,expression and characterization of lipase from Mucor circinelloides. The 2ndInternationalConference on Applied Biochemistry and Biotechnology (ABB2019). Best Poster. July 21-24, 2019, Macau, China.

(2)张瑶*，杨红，王璐，王艳霞，宋元达. 卷枝毛霉脂肪酶的基因克隆、表达及定性. 第十二届中国酶工程学术研讨会，2019年8月8-11日，中国长春.