姓名
钟明
性别
女
出生
年月
1968.04
导师聘任时间
2003年

职务
无
职称
主任医师
学历
博士研究生
学位
博士

指导研究生类型
?学术学位研究生 ?专业学位研究生

工作单位名称（全称）：
山东大学齐鲁医院

研究方向
及领域
1. 动脉粥样硬化、心衰及高血压相关疾病的基础与临床研究
2. 糖尿病心血管并发症的基础与临床研究
3. 心理干预对心血管疾病的影响

科研项目
1. 脂肪细胞来源Microparticles介导新生血管生成在2型糖尿病易损斑块形成中的作用，国家自然科学基金
2. PGF2α-FP受体信号通路在调控糖尿病性心肌病心肌间质纤维化中的作用，国家自然科学基金
3. STAMP2/Akt信号传导通路在2型糖尿病ApoE-/-LDLr-/-小鼠易损斑块形成中的作用，国家自然科学基金
4. 糖/TSP-1/TGFβ1/Smads信号传导通路在糖尿病心肌病发病中的作用，国家自然科学基金
5. 血管衰老及相关疾病的生物学基础，973计划项目子课题
6. 代谢性因素在心力衰竭发病中的作用机制研究，973计划项目子课题
7. Microvesicles介导血小板活化在非瓣膜性房颤脑卒中的研究，山东省重点研发计划
8. 糖尿病动脉粥样硬化发生机制和干预的研究，山东省自然科学基金
9. AngII/TSP-1/TGFβ1/Smads信号传导途径在糖尿病血管病变中作用，山东省科技攻关项目

科研论文
及著作
1. Shang GK, Han L, Wang ZH, Liu YP, Yan SB, Sai WW, Wang D, Li YH, Zhang W, Zhong M.Sarcopenia is attenuated by?TRB3?knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles.J Cachexia Sarcopenia Muscle. 2020 Feb 25. doi: 10.1002/jcsm.12560. [Epub ahead of print]2. Li Y, Zhou H, Li Y, Han L, Song M, Chen F, Shang G, Wang D, Wang Z, Zhang W, Zhong M*. PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy. J Cell Mol Med. 2019 Jun;23(6):4179-4195.3. Yang LW, Song M, Li YL, Liu YP, Liu C, Han L, Wang ZH, Zhang W, Xing YQ*, Zhong M*. L-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway. Biogerontology. 2019 Apr;20(2):203-211.4. Chen FF, Song FQ, Chen YQ, Wang ZH, Li YH, Liu MH, Li Y, Song M, Zhang W, Zhao J*, Zhong M* Exogenous testosterone alleviates cardiac fibrosis and apoptosis via Gas6/Axl pathway in the senescent mice. Exp Gerontol. 2019 May;119:128-137.5. Wang F, Chen FF, Shang YY, Li Y, Wang ZH, Han L, Li YH, Zhang L, Ti Y, Zhang W, Zhong M*. Insulin resistance adipocyte-derived exosomes aggravate atherosclerosis by increasing vasa vasorum angiogenesis in diabetic ApoE-/- mice. Int J Cardiol. 2018 Aug 15;265:181-187.6. Li Y, Zhou H, Wang F, Han L, Liu M, Li Y, Wang Z, Tang M, Zhang W, Zhong M*. Overexpression of PTPN2 in Visceral Adipose Tissue Ameliorated Atherosclerosis via T Cells Polarization Shift in Diabetic Apoe-/- Mice. Cell Physiol Biochem. 2018;46(1):118-132.7. Shang G, Yang X, Song D, Ti Y, Shang Y, Wang Z, Tang M, Zhang Y, Zhang W, Zhong M*. Effects of Levosimendan on Patients with Heart Failure Complicating Acute Coronary Syndrome: A Meta-Analysis of Randomized Controlled Trials. Am J Cardiovasc Drugs. 2017 Dec;17(6):453-463.8. Liu MH, Li Y, Han L, Zhang YY, Wang D, Wang ZH, Zhou HM, Song M, Li YH, Tang MX, Zhang W, Zhong M*. Adipose-derived stem cells were impaired in restricting CD4+T cell proliferation and polarization in type 2 diabetic ApoE-/- mouse. Mol Immunol. 2017 Jul;87:152-160.9. Li Y, Han L, Ding WY, Ti Y, Li YH, Tang MX, Wang ZH, Zhang Y, Zhang W, Zhong M*. Prostaglandin F2α receptor silencing attenuates vascular remodeling in rats with type 2 diabetes. Exp. Mol. Pathol. 2015 99(3); 517-523.10. Gong HP, Zhang W, Li L, Tan HW, Ma ZY, Zhong XZ, Wang ZH, Song T, Zhang Y, Zhong M*. Possible beneficial effect of olmesartan medoxomil on left atrial function in patients with hypertension : noninvasive assessment by acoustic quantification. Clin Drug Investig. 2008;28(4):241-9.11. Chen YQ, Zhao J, Jin CW, Li YH, Tang MX, Wang ZH, Zhang W, Zhang Y, Li L*,Zhong M*. Testosterone delays vascular smooth muscle cell senescence and inhibits collagen synthesis via the Gas6/Axl signaling pathway. Age (Dordr). 2016 Jun;38(3):60. 12. Zhao J, Yan HM, Li Y, Wang J, Han L, Wang ZH, Tang MX, Zhang W, Zhang Y, Zhong M*. Pitavastatin calcium improves endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia. J Zhejiang Univ Sci B. 2015 May;16(5):380-7. 13. Zhang XJ, Wei CY, Li WB, Zhang LL, Zhou Y, Wang ZH, Tang MX, Zhang W, Zhang Y, Zhong M*. Association between single nucleotide polymorphisms in thrombospondins genes and coronary artery disease: A meta-analysis. Thromb Res. 2015 Jul;136(1):45-51. 14. Sun H, Zhao Y, Bi X, Li S, Su G, Miao Y, Ma X, Zhang Y, Zhang W, Zhong M*. Valsartan blocks thrombospondin/transforming growth factor/Smads to inhibit aortic remodeling in diabetic rats. Diagn Pathol. 2015 Apr 2;10:18.15. Jin CW, Wang H, Chen YQ, Tang MX, Fan GQ, Wang ZH, Li L, Zhang Y, Zhang W, Zhong M*. Gas6 delays senescence in vascular smooth muscle cells through the PI3K/ Akt/FoxO signaling pathway. Cell Physiol Biochem. 2015;35(3):1151-66. 16. Shang YY, Fang NN, Wang F, Wang H, Wang ZH, Tang MX, Peng J, Zhang Y, Zhang W, Zhong M*. MicroRNA-21, induced by high glucose, modulates macrophage apoptosis via programmed cell death 4. Mol Med Rep. 2015 Jul;12(1):463-9. 17. Han L, Fu KL, Zhao J, Wang ZH, Tang MX, Wang J, Wang H, Zhang Y, Zhang W, Zhong M*. Visceral adiposity index score indicated the severity of coronary heart disease in Chinese adults. Diabetol Metab Syndr. 2014 Dec 22;6(1):143. 18. Ding WY, Liu L, Wang ZH, Tang MX, Ti Y, Han L, Zhang L, Zhang Y, Zhong M*, Zhang W*. FP-receptor gene silencing ameliorates myocardial fibrosis and protects from diabetic cardiomyopathy. J Mol Med (Berl). 2014 Jun;92(6):629-40.19. Wang J, Han L, Wang ZH, Ding WY, Shang YY, Tang MX, Li WB, Zhang Y, Zhang W*, Zhong M*. Overexpression of STAMP2 suppresses atherosclerosis and stabilizes plaques in diabetic mice. J Cell Mol Med. 2014 Apr;18(4):735-48.20. Ding WY, Li WB, Ti Y, Bi XP, Sun H, Wang ZH, Zhang Y, Zhang W*, Zhong M*. Protection from renal fibrosis, putative role of TRIB3 gene silencing. Exp Mol Pathol. 2014 Feb;96(1):80-4.21. Zheng T, Zhao J, Wang Y, Liu W, Wang Z, Shang Y, Zhang W, Zhang Y, Zhong M*. The limited effect of omega-3 polyunsaturated fatty acids on cardiovascular risk in patients with impaired glucose metabolism: a meta-analysis. Clin Biochem. 2014 Apr;47(6):369-77.22. Han L, Tang MX, Ti Y, Wang ZH, Wang J, Ding WY, Wang H, Zhang Y, Zhang W, Zhong M*. Overexpressing STAMP2 improves insulin resistance in diabetic ApoE?/?/LDLR?/? mice via macrophage polarization shift in adipose tissues. PLoS One. 2013 Nov 13;8(11):e78903.23. Ding WY, Ti Y, Wang J, Wang ZH, Xie GL, Shang YY, Tang MX, Zhang Y, Zhang W*, Zhong M*. Prostaglandin F2α facilitates collagen synthesis in cardiac fibroblasts via an F-prostanoid receptor/protein kinase C/Rho kinase pathway independent of transforming growth factor β1. Int J Biochem Cell Biol. 2012 Jun;44(6):1031-9.24. Wang ZH, Gong HP, Shang YY, Tang MX, Fang NN, Jiang GH, Zhang Y, Zhong M*, Zhang W*. An integrative view on the carotid artery alterations in metabolic syndrome. Eur J Clin Invest. 2012 May;42(5):496-502.25. Ti Y, Xie GL, Wang ZH, Bi XL, Ding WY, Wang J, Jiang GH, Bu PL, Zhang Y, Zhong M*, Zhang W*. TRB3 gene silencing alleviates diabetic cardiomyopathy in a type 2 diabetic rat model. Diabetes. 2011 Nov;60(11):2963-74.26. Yan HM, Zhao J, Ma DZ, Wang H, Wang J, Wang ZH, Li L, Zhang Y, Zhang W, Zhong M*. The effect of pitavastatin calcium on endothelial dysfunction induced by hypercholesterolemia. Expert Opin Pharmacother. 2011 Jul;12(10):1463-71.27. Wang ZH, Zhang W, Gong HP, Guo ZX, Zhao J, Shang YY, Feng JB, Zhang Y, Zhong M*. Expression of STAMP2 in monocytes associates with cardiovascular alterations. Eur J Clin Invest. 2010 Jun;40(6):490-6.28. Gong HP, Wang ZH, Jiang H, Fang NN, Li JS, Shang YY, Zhang Y, Zhong M*, Zhang W*. TRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis. Diabetes Care. 2009 Jul;32(7):1311-3.
学术奖励、荣誉称号
1. 张薇，钟明，张运，王志浩，唐梦熊，巩会平，尚嫄嫄，毕秀萍，李少华，谭红伟代谢综合征及相关疾病防治的转化医学，山东省人民政府，山东省科技进步奖，一等奖，20122. 张薇，张运，钟明，朱慧，杨贵荣，李建平，皮延生，马骁，张学义，张供，马长生持续性心房颤动心房重构机制和栓塞并发症防治的研究，山东省人民政府，山东省科技进步奖，一等奖，20073. 张薇，钟明，张运，郑兆通，赵静，安丰双，白晨，张学义，葛志明，季晓平，冠状循环检测方法和临床意义的研究，教育部，教育部科技进步奖，二等奖，20044. 钟明，张运，张薇，卜培莉，钟敬泉，赵静，安丰双，季晓平，张梅舒张性心力衰竭发病机制、诊断和治疗的研究，山东省人民政府，山东省科技进步奖，二等奖，20035. 张薇，钟明，张运，安丰双，白晨，张学义，葛志明，季晓平，赵静冠状循环血流动力学的临床研究，山东省人民政府，山东省科技进步奖，二等奖，20026. 张运，张薇，张梅，姚桂华，钟明，多平面经食管超声心动图的临床研究，国务院，国家科技进步奖，三等奖，1997
备注
通讯地址
山东省济南市文化西路107号
邮政编码
250012

办公电话

E-mail
zhongming2@medmail.com.cn