山东大学基础医学院副教授
教育经历（按时间倒排序）：
2003/9 - 2007/1, 清华大学, 生物学, 博士 获优秀博士生三等奖学金
2000/9 - 2003/6, 山东大学, 分子生物学, 硕士 获优秀研究生奖学金
1992/9 - 1996/6, 山东大学, 微生物学, 学士 校级优秀毕业论文
工作经历（科研与学术工作经历, 按时间倒序排序）：
2010/6 - 至今, 山东大学基础医学院, 副教授
2009/8 - 2010/5, 生物芯片北京国家工程研究中心, 研究科学家
2007/4 – 2009/7, 美国华盛顿大学（西雅图）, 博士后（Research Associate）
1996/7 - 2000/8, 山东省农业科学院, 资源与环境研究所, 研实员
研究方向：
人体微生物组；肿瘤发生机理
讲授课程：
医学微生物学（本科、留学生）；医学微生物实验（本科、留学生）；现代医学微生物学（研究生，讲授内容为人体微生物组、肿瘤免疫和CRISPR基因编辑技术）
学术兼职：
中华医学会微生物与免疫学分会青年委员；济南市实验室装备与技术学会青年委员会副主任委员；山东省微生物学会科普委员会委员；《微生物学杂志》、《Oncology Letters》编委
主要论著：1. 刘世利, 吴凤娟, 人体微生物组. 化学工业出版社, 362000字, 2014. 书/著作
2. 刘世利, 韩明勇, 肿瘤细胞免疫. 化学工业出版社, 305000字, 2016. 书/著作
3. 刘世利, 李海涛, 王艳丽, CRISPR基因编辑技术. 化学工业出版社, 311000字, 2020. 书/著作
4. 李明远主编,《微生物学与免疫学》（第6版教材）2018,（刘世利编撰第11章微生物分布与医学微生态学）
5. 吉爱国主编,《营养药物概论》, 2018,（刘世利编撰第9章 肠道菌群与营养药物）
6. 刘世利, 韩明勇, 迟洪波, 戴建建, 宋宁, 一种检测胃癌的生物标志物及其应用, 发明专利, 授权公告号: CN 10****6988 B, 申请号: ZL 2017 1 **.3.
7. Feng Qiang (#), Lan Xiang (#), Ji Xiaoli (#), Li Meihui (#), Liu Shili (#), Jianghui Xiong, Yanbo Yu, Zhipeng Liu, Zi Xu, Li He, Ying Chen, Haisheng Dong, Pu Chen, Bin Chen, Kunlun He, Yinghui Li, Time series analysis of microbiome and metabolome at multiple body sites in steady long-term isolation confinement, Gut, 2020, 0: 1-3. doi:10.1136/gutjnl-2020-320666. (并列第一作者) (影响因子19.819)
8. Ying Yang (#), Liu Shili(#), Yihua Wang (#), Zhibin Wang, Wenyu Ding, Xiaoyuan Sun, Kunlun He, Qiang Feng(*), Xiandang Zhang(*), Changes in salivary microbiota in the onset and after the treatment of diabetes. Aging, 2020, 12(13): 13090-13114. (并列第一作者) (影响因子4.831)
9. Liu Shili (#), Wang Yihua (#), Zhao Le, Feng Qiang(*), Microbiome succession with the increase of age in three oral sites, Aging, 2020, 12 (9); 7874-7907. (第一作者) (影响因子4.831).
10. Wang Peixia(#), Liu Shili(#), Hu Mingxiang, Zhang Hongwei, Duan Demin, He Jiuyang, Hong Juanji, Lv Ruitao, Choi Hak Soo, Yan Xiyun(*), Minmin Liang(*), Peroxidase-like nanozymes induce a novel form of cell death and inhibit tumor growth in vivo, Advanced functional materials, 2020, ****0647. (并列第一作者) (影响因子16.836)。
11. Song Ning, Liu Xia, Feng Qiang, Xu Mengchen, Lan Xiang, Li Meihui, Liu Rutao, Li Caixia, Dong Tianyi, Wang Deqiang (*), Liu Shili (*), Whole body vibration triggers a change in the mutual shaping state of intestinal microbiota and body's immunity, Frontiers in Bioengineering and Biotechnology, 2019, 7: article 377. (通讯作者) (影响因子5.122).
12. Liu Fengyan, Fan Ziyan, Song Ning, Han Mingyong, Yan Ming (*), Guo Liang-Hong, Jia Jihui, Liu Shili (*), XRCC4, which is inhibited by PFDA, regulates DNA damage repair and cell chemosensitivity, J Cell Biochem, 2019, 120(8): 12665-12676. (通讯作者) (影响因子4.237).
13. Zhang Zhun, Fan Bingbing, Liu Fengyan, Song Ning, Peng Yanping, Ma Wenzheng, Ma Rongtao, Dong Tianyi, Liu Shili (*), HOX transcript antisense RNA is elevated in gastric carcinogenesis and regulated by the NF-κB pathway, J Cell Biochem, 2019, 120(6): 10548-10555 (通讯作者) (影响因子4.237).
14. Zhang Zhun, Song Ning, Peng Yanping, Fan Ziyan, Han Mingyong, Zhao Min, Dong Tianyi, Liu Shili (*),Evironmental pollutant per?uorodecanoic acid upregulates cIAP2 to suppress gastric cell senescence, Oncology Reports, 2019, 41(2): 981-988. (通讯作者) (影响因子3.417).
15. Zhang Zhun, Dong Tianyi, Fu Ying, Zhou Wenhong, Tian Xingsong (*), Chen Gengyu, Liu Shili (*), MMP‐11 promotes papillary thyroid cell proliferation and invasion via the NF‐κB pathway, J Cell Biochem, 2019, 120(2): 1860-1868. (通讯作者) (影响因子4.237).
16. Fan Ziyan, Li Zhonghao, Liu Shanshan, Yang Fei, Bian Zhaoyang, Wang Ying, Tang Gangling, Zhao Qinxiao, Deng Huimin (*), Liu Shili (*), Rapid fluorescence immunoassay of benzo[a] pyrene in mainstream cigarette smoke based on a dual-functional antibody-DNA conjugate, RSC Adv., 2018, 8: 29562. (通讯作者) (影响因子3.049).
17. Dong Tianyi, Zhang Zhun, Zhou Wenhong, Zhou Xiangyu, Geng Chong, Chang Lap Kam, Tian xingsong (*), Liu Shili (*), WNT10A/β?catenin pathway in tumorigenesis of papillary thyroid carcinoma, Oncology Reports, 2017, 38: 1287-1294 (通讯作者) (影响因子2.976).
18. Dong Tianyi, Peng Yanping, Zhong Ning, Liu Fengyan, Zhang Hanyu, Xu Mengchen, Liu Rutao, Han Mingyong, Tian Xingsong, Jia Jihui, Chang Lap Kam, Guo Liang-Hong (*), Liu Shili (*), Per?uorodecanoic acid (PFDA) promotes gastric cell proliferation via sPLA2-IIA, Oncotarget, 2017, 8: 50911-50920 (通讯作者) (影响因子5.168).
19. Zhou Xiangyu, Dong Tianyi, Fan Ziyan, Peng Yanping, Zhou Rongbin, Wang Xiaqiong, Song Ning, Han Mingyong, Fan Bingbing, Jia Jihui, Shili Liu (*), Per?uorodecanoic acid stimulates NLRP3 in?ammasome assembly in gastric cells, Scitific Reports. 2017, 7: 45468. (通讯作者) (影响因子4.259).
20. Tianyi Dong, Qiang Feng, Fengyan Liu, Lap Kam Chang, Xiangyu Zhou, Mingyong Han, Xingsong Tian, Ning Zhong (*), Shili Liu (*), Alteration of stomach microbiota compositions in the progression of gastritis induces nitric oxide in gastric cell, Experimental and therapeutic medicine, 2017, 13: 2793-2800 (通讯作者) (影响因子1.261).
21. Peng Yanping, Zhao Qian, Zhang Hanyu, Han Bo, Liu Suxia, Han Mingyong, Liu Shili (*), TIPE2, a negative regulator of TLR signaling, regulates p27 through IRF4-induced signaling, Oncology Reports, 2016, 35: 2480-2486 (通讯作者) (影响因子2.662).
22. Zhao Qian, Zhao Min, Dong Tianyi, Zhou Chengjun, Peng Yanping, Zhou Xiangyu, Fan Bingbing, Ma Wenzheng, Han Mingyong, Liu Shili(*), Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2) upregulates p27 to decrease gastic cancer cell proliferation, Journal of Cellular Biochemistry, 2015, 116: 1121–1129 (通讯作者) (影响因子3.446).
23. Liu Shili, Jiang Man, Zhao Qiang, Li Shancheng, Peng Yanping, Zhang Pengfei, Han Mingyong(*), Vascular endothelial growth factor plays a critical role in the formation of the pre-metastatic niche via prostaglandin E2, Oncology Reports, 2014, 32: 2477-2484. (第一作者) (影响因子2.486).
24. Liu Shi-Li, Chen Shou-Zhen, Zhao Qian, Xu Zheng-Hu, Li Yu, Jia Ji-Hui, Guo Liang-Hong(*), Photoelectroch emical Competitive Detection of Biotin, Chinese Journal of Analytical Chemistry, 2013, 41 (10): 1477-1481 (第一作者) (影响因子0.554).
25. 陈守臻，杨鹏，宋静，赵敏，赵倩，徐政虎，刘世利(*)，大肠埃希菌脂多糖诱导树突状细胞杀灭幽门螺杆菌作用的研究，中国预防医学杂志，2013，14 (7)：481-484.（通讯作者）
26. Liu Shili, Tran Kenny K., Pan Steven, Shen Hong(*), Detecting and differentiating microbes by dendritic cells for the development of cell-based biosensors, Biosens Bioelectron, 2009, 24(8): 2598-603 (第一作者) (1区SCI期刊)
27. Liu Shili, Li Chao, Cheng Jing, Zhou Yuxiang(*), Selective photoelectrochemical detection of DNA with high-affinity metallointercalator and tin oxide nanoparticle electrode,. Anal Chem., 2006, 78(13): 4722-6 (第一作者) (1区SCI期刊).
28. 刘世利, 汪天虹(*), 秦楠, 侯运华, 刘谨, 产适冷木聚糖酶的海洋青霉的筛选和诱变, 菌物学报, 2003, 22 (2): 272-276. (第一作者) (核心期刊).
29. Ma Lin, Zeng Jiping, Guo Qing, Liang Xiuming, Shen Li, Li Shuyan, Sun Yundong, Li Wenjuan, Liu Shili, Yu Han, Chen Chunyan, Jia Jihui, Mutual amplification of HNF4α and IL-1R1 composes an inflammatory circuit in Helicobacter pylori associated gastric carcinogenesis, Oncotarget, 2016, 7:11349-11363.
30. Liang Xiuming, Zeng Jiping, Wang Lixiang, Shen Li, Ma Xueping, Li Shuyan, Wu Yujiao, Ma Lin, Ci Xinyu, Guo Qing, Jia Mutian, Shen Haiyu, Sun Yundong, Liu Zhifang, Liu Shili, Li Wenjuan, Yu Han, Chen Chunyan and Jia Jihui, Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF-β1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit, Oncotarget, 2015, 6:17661-17674.
31. Yu Han, Zeng Jiping, Liang Xiuming, Wang Wenfu, Zhou Yabin, Sun Yundong, Liu Shili, Li Wenjuan, Chen Chunyan, Jia Jihui(*), Helicobacter pylori Promotes Epithelial-Mesenchymal Transition in Gastric Cancer by Downregulating Programmed Cell Death Protein 4 (PDCD4), Plos One, 2014, 9 (8): e105306.
32. Wei Fang, Wang Xianghua, Peng Shasha, Jia Qiuhui, Jiang Chao, Liu Shili, Xu Zhenghu(*), Direct Gold-Catalyzed Regioselective Tetrafunctionalization of Nonactivated Alkynes, Synthesis, 2014, 46 (16): 2168-2174.
33. Liang Xiuming, Zeng Jiping, Wang Lixiang, Shen Li, Li Shuyan, Ma Lin, Ci Xinyu, Yu Jingya, Jia Mutian, Sun Yundong, Liu Zhifang, Liu Shili, Li Wenjuan, Yu Han, Chen Chunyan, Jia Jihui, Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells, Oncotarget. 2014, 5:5798-5807.
34. Tan Xiaojuan, Liu Lin, Liu Shili, Yang Dongting, Liu Yikun, Yang Shuang, Jia Aiqun(*), Qin Nan, Genome of Staphylococcus xylosus and Comparison with S. aureus and S. epidermidis, Journal of Genetics and Genomics, 2014, 41 (7): 413-416.
35. Liang Xiuming, Zeng Jiping, Wang Lixiang, Fang Ming, Wang Qing, Zhao Min, Xu Xia, Liu Zhifang, Li Wenjuan, Liu Shili, Yu, Han, Jia Jihui, Chen Chunyan(*), Histone Demethylase Retinoblastoma Binding Protein 2 is Overexpressed in Hepatocellular Carcinoma and Negatively Regulated by hsa-miR-212, PLos One, 2013, 8 (7): e69784.
36. Zeng Jiping, Fang Ming, Wang, Lixiang, Liang, Xiuming, Shan Yuqun, Yu, Han, Sun Yundong, Liu Zhifang, Liu Shili, Chen Chunyan, Jia Jihui, MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2, Journal of Cellular Biochemistry, 2013, 114(12):2666-2672.
37. Feng Yimin, Wang Lixiang, Zeng Jiping, Shen Li, Liang Xiuming, Yu Han, Liu Shili, Liu Zhifang, Sun Yundong, Li Wenjuan, Chen Chunyan, Jia Jihui(*), FoxM1 is Overexpressed in Helicobacter pylori-Induced Gastric Carcinogenesis and Is Negatively Regulated by miR-370, Molecular Cancer Research, 2013, 11 (8): 834-844.
38. Sun Yundong, Li Xinpeng, Li Wen, Zhao Min, Wang Lixiang, Liu Shili, Zeng Jiping, Liu Zhifang(*), Jia Jihui, Proteomic analysis of the function of spot in Helicobacter pylori anti-oxidative stress in vitro and colonization in vivo, Journal of Cellular Biochemistry, 2012, 113 (11): 3393-3402.
39. Wang Hongyan, Sun Yundong, Liu Shili, Yu Han, Li Wenjuan, Zeng Jiping, Chen Chunyan, Jia Jihui(*), Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration, FEMS Immunology and Medical Microbiology, 2011, 63 (1): 82-92.
40. Liang Minmin, Liu Shili, Wei Mingyuan, Guo Liang-Hong(*), Photoelectrochemical oxidation of DNA by ruthenium tris(bipyridine) on a tin oxide nanoparticle electrode, Anal Chem., 2006, 78(2): 621-3.
41. Li Chao, Liu Shili, Guo Liang-Hong(*), Chen Depu, A new chemically amplified electrochemical system for DNA detection in solution, Electrochem. Commun., 2005, 7(1): 23-28.
42. Wang Tian-Hong, Liu Ti, Wu Zhi-Hong, Liu Shi-Li, Lu Yi, Qu Yin-Bo, Novel Cellulase Profile of Trichoderma Reesei Strains Constructed by cbh1 Gene Replacement With eg3 Gene Expression Cassette, Acta Biochim Biophys Sin, 2004, 36 (10): 667-72
43. Wang Tian-Hong , Wu Zhi-Hong , Liu Shi-Li, Huang Wei , Cloning and Sequence Analysis of a Mitochondrial Gene Cluster Encoding Cytochrome C Oxidase Subunit III From Trichoderma Pseudokoningii, DNA Seq, 2002, 13 (5): 271-5.


以上论著全文下载：https://www.researchgate.net/profile/Shili_Liu2