陈恬
chentian@sdu.edu.cn

教育与工作经历
? 助理研究员（2019.11至今）
山东大学基础医学院病原生物学系
? 博士（2013.8-2019.7），
美国田纳西大学，微生物系
导师：Prof. Todd Reynolds
? 教学助理（2015.8-2019.5）
美国田纳西大学微生物系
? 硕士（2009.8-2012.6），病原微生物方向
西南大学，生命科学学院
导师：谢建平教授
? 学士（2005.9-2009.6），生物技术
重庆师范大学，生命科学学院

科研经历
现主要研究宿主抗病原真菌白色念珠菌的天然免疫过程。博士期间从事白色念珠菌致病的分子机理研究。重点研究细胞壁内层组分葡聚糖的免疫原性，以及如何促进Dectin-1受体对病原真菌的识别。

发表论文
1. Tian Chen, Andrew Wagner, Robert Tams, James Eyer, Sarah Kauffman, Eric Gann, Elias Fernandez, Todd Reynolds*. Lrg1 regulates β (1,3)-glucan masking in Candida albicans through the Cek1 MAP kinase pathway. mBio. 2019;10(5). doi: 10.1128/mBio.01767-19. PubMed PMID: **; PubMed Central PMCID: PMCPMC**.
2. Tian Chen, Joseph Jackson, Robert Tams, Sarah Davis, Timothy Sparer, Todd Reynolds*. Unmasking of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathway. Plos Genetics, 2019;15(1):e**. doi: 10.1371/journal.pgen.**. PMID: **.
3. Tian Chen, Quanju Zhao, Wu Li, Jianping Xie*. Mycobacterium tuberculosis PE_PGRS17 promotes the death of host cell and cytokines secretion via Erk kinase accompanying with enhanced survival of recombinant M. smegmatis. Journal of Interferon and Cytokine Research. 2013, 33, 452-458.
4. Tian Chen, Liming He, Wanyan Deng, Jianping Xie*. The Mycobacterium DosR regulon structure and diversity revealed by comparative genomic analysis. Journal of Cellular Biochemistry 2013, 114, 1-6.
5. Tian Chen, Jian-Ping Xie*: Roles of PE_PGRS family in Mycobacterium tuberculosis pathogenesis and novel measures against tuberculosis. Microb Pathog 2010, 49, 311-314.
6. Sarah Davis, Robert Tams, Norma Solis, Andy Wagner, Tian Chen, Joseph Jackson, Sahar Hasim, Anthony Montedonico, Justin Dinsmore, Timpothy Sparer, Scott Filler, Todd
Reynolds*. Candida albicans cannot acquire sufficient ethanolamine from the host to support virulence in the absence of de novo phosphatidylethanolamine synthesis. Infection and Immunity 2018, 86, e00815-17.
7. Steven Wilhelm*, Jordan Bird, Kyle Bonifer, Benjamin Calfee, Tian Chen, Samantha Coy, Jackson Gainer. Eric Gann, Huston Heatherly, Jasper Lee, Xiaolong Liang, Jiang Liu, April Armes, Mohammad Moniruzzaman, Hunter Rice, Joshua Stough, Robert Tams, Evan Williams, Gary LeCleir. A Student's Guide to Giant Viruses Infecting Small Eukaryotes: From Acanthamoeba to Zooxanthellae. Viruses 2017, 9, 46.

学术活动
1. 口头报告,“白色念珠菌Lrg1 蛋白通过Cek1 信号通路调控葡聚糖暴露”，第十一届全国微生物青年****学术讨论会。2019.9, 重庆
2. 口头报告, “Unmasking of Candida albicans β (1,3)-glucan is Promoted by Activation of the Cek1 Pathway” , Cellular Biology of Eukaryotic Pathogens Symposium, Clemson University, South Carolina, USA. 2018.10.
3. 口头报告, “Unmasking of Candida albicans β (1,3)-glucan is Impacted by the Activation States of Small GTPases”, 14th American Society of Microbiology on Candida and Candidiasis annual conference. Rhoda Island, USA . 2018.4.
4. 口头报告, “Regulation of β(1,3)-glucan Unmasking by Cell Wall Signaling Proteins”. Fungal Pathogens Group Research Conference, Oxford, Mississippi, USA . 2017.7.
5. 口头报告, “Phosphatidylserine Synthase (Cho1p) Affects the Cell Wall MAPKs in Candida albicans”. Women Symposium at University of Tennessee, Knoxville, Tennessee, USA . 2017.3.
6. 墙报: Phosphatidylserine Synthase (Cho1p) Affects Cell Wall MAPKs in Candida albicans. American Society of Microbiology Annual conference, New Orleans, Louisiana, USA . 2017.6.
7. 口头报告, “Phosphatidylserine Synthase Affects the Cell Wall MAPKs in C. albicans”. South Central Medical Micology Conference, Memphis, Tennessee, USA . 2016.11.
8. 墙报, “Role of Phosphatidylserine Synthase in β (1,3)-Glucan Exposure in the Cell Wall of Candida albicans”. Cell Biology of Eukaryotic Pathogens Symposium, Clemson University, South Carolina, USA . 2014.10.