【个人简介】姓名：马晨，教授/博士生导师
性别：男；籍贯：济南
工作单位：山东大学化学与化工学院，有机化学研究所
社会兼职：民革山东大学委员会东区支部主委；山东大学化学与化工学院学术、学位委员会委员；山东省药物化学专业委员会委员。
联系方式：Tel: **; E-mail: chenma@sdu.edu.cn


【学习及工作经历】学士：山东大学
硕士：山东大学
博士：韩国国立昌原大学
博士后：香港科技大学
访问教授：德国海德堡大学

【主讲课程】有机化学（本科双语）
药物合成（本科限选）
药物化学（硕研）

【研究领域和兴趣】
1. 高效及环境友好的有机合成方法学研究；
2. 药物活性化合物的组合合成、小分子库构建及筛选；



【主要论著】
1). Caixia Xie, Zhen Dai, Yadi Niu,and Chen Ma* “Cascade One-Pot Method To SynthesizeIsoquinolin-1(2H)?ones with α?Bromo Ketones and Benzamides via Pd-catalyzed C?H Activation”
J. Org.Chem., 83, 2317-2323, 2018.
2). Xianglong Chu, Ziqiang Tang, Jiangshan Ma,Libowen He, Lei Feng, Chen Ma* Synthesis of furo[3,2-c]coumarins via I2/TBHP-mediatedreaction of 4-hydroxycoumarins with terminal alkynes
Tetrahedron, 74, 970–974, 2018.
3). Zeyuan Zhang,Yiwen Zheng,Zuobang Sun,Zhen Dai,ZiqiangTang,Jiangshan Ma,Chen Ma*“Direct Olefination of FluorinatedQuinoxalinesviaCross-DehydrogenativeCoupling Reactions: A New NIR Probe for Mitochondria”
Advanced Synthesis &Catalysis., 359, 2259-2268, 2017.
4). Caixia Xie,Zeyuan Zhang,DanyangLi, Jian Gong, Xushuang Han, Xuan Liu, and Chen Ma*“Dimethyl Sulfoxide Participated One-potSynthesis of Quinoxaline Derivatives”
J. Org.Chem., 82, 3491-3499, 2017.
5). Caixia Xie,Xushuang Han,Jian Gong,Danyang Li and Chen Ma* “A new strategy of copper-catalyzed one–pot synthesis of 1,2-disubstitutedbenzimidazoles”
Org.Biomol. Chem., 15, 5811-5819, 2017.
6). Huanhuan Liu,Feiyu Zhou,Wen Luo,Yuxin Chen,ChenyangZhang andChen Ma* “Application of unprotected α-amino acids for the transition-metal-freesynthesis of pyrrolo[1,2-a]quinoxalinesin aqueous solution”
Org.Biomol. Chem., 15, 7157-7164, 2017.
7). Xianglong Chu,TiantianDuan, Xuan Liu, Lei Feng, Jiong Jiaand Chen Ma* “N-iodosuccinimideinvolved One-Pot Metal-free Synthesis of 2-Heteroaromatic BenzothiazoleCompounds”
Org.Biomol. Chem., 15, 1606-1611, 2017.
8). Xianglong Chu, Zeyuan Zhang,Congcong Wang, Xuan Chen, Bin Wang, Chen Ma*“CH₃CO₂H-promptedthree components tandem reaction: an efficient and practical approach totrisubstituted pyrrolo[1,2-a]pyrazines”
Tetrahedron, 73, 7185–7189, 2017.
9). Zeyuan Zhang, Zhen Dai,XinkunMa, YihanLiu, Xiaojun Ma, Wanli Li, Chen Ma* “Cu-Catalyzed One-pot Synthesis of Fused Oxazepinone Derivativesvia sp² C-H and O-H Cross-Dehydrogenative Coupling”
Org. Chem. Front., 3, 799-803, 2016.
10). Huanhuan Liu, Tianran Zhai,Shiteng Ding, Yalei Hou,Xiangyu Zhang, LeiFeng, and Chen Ma* “Direct and Metal-freeOxidative Amination of sp³ C-H Bonds for the Construction of2-Hetarylquinazolin-4(3H)-ones”
Org. Chem. Front., 3, 1096-1099, 2016.
11). Tiantian Duan, TianranZhai, Huanhuan Liu,Zilong Yan, Yue Zhao, Lei Feng, Chen Ma*“One-pot three-component synthesis ofquinazolines via a copper-catalysedoxidative amination reaction”
Org.Biomol. Chem., 14, 6561-6567, 2016.
12). Caixia Xie, LeiFeng, Wanli Li, Xiaojun Ma,Xinkun Ma, Yihan Liu,andChen Ma*“EfficientSynthesis of Pyrrolo[1,2-a]quinoxalines Catalyzed by Br?nstedAcid throughCleavage of C-C Bond”
Org.Biomol. Chem., 14, 8529-8535, 2016.
13). Fangdong Hu, Huanhuan Liu, Jiong Jia, Chen Ma* “Transition-Metal-Free Synthesis of Indole-FusedDibenzo[b,f][1,4]oxazepines viaSmiles Rearrangement”
Org.Biomol. Chem., 14, 11076-11079, 2016.
14). Liu, H.; Duan, T.; Zhang, Z.;Xie, C.; Ma, C.*“One-Pot Synthesisof Pyrrolo[1,2-a]quinoxaline Derivativesvia a Copper-Catalyzed Aerobic Oxidative Domino Reaction”
Org.Lett., 17, 2932-2935, 2015.
15). Zhang, Z.;Xie, C.;Tan, X.; Song, G.; Wen, L.; Gao, H.; Ma, C.*“I₂-CatalyzedOne-pot Synthesis of Pyrrolo[1,2-a]quinoxalineand Imidazo[1,5-a]quinoxaline Derivatives via sp³ and sp² C-HCross-DehydrogenativeCoupling”
Org. Chem. Front., 2, 942-946 , 2015.
16). Tan, X.; Du, Y.; Yang, B.; Ma, C.*“Novel type of AIE materialas highly selective fluorenscent sensor for the detection of cysteine and glutathione”
RSCAdvances, 5, 55165-55169, 2015.
17). Wang, W.; Peng, X.; Qin, X.;Zhao, X.; Ma,C.*; Tung, C.; Xu, Z.*“Synthesis of Quinolinones withPalladium-Catalyzed Oxidative Annulation between Acrylamides and Arynes”
J. Org. Chem., 80, 2835-2841,2015.
18). Hu, F.; Xia, Y.; Ma, C.; Zhang, Y.; Wang, J.* “C–H bond functionalization based on metal carbenemigratory insertion”
Chem. Comm,51, 7986-7995, 2015.
19). Xie, C.; Zhang, Z.; Yang, B.;Song, G.; Gao, H.; Wen, L.; Ma, C.* “Anefficient iodine–DMSO catalyzed synthesis of quinoxaline derivatives”
Tetrahedron, 71, 1831–1837, 2015.
20). Yang, B.; Tan, X.; Guo, R.;Chen, S.; Zhang, Z.; Chu, X.; Xie, C.; Zhang, D.*;Ma,C.* “A Transition Metal-FreeOne-Pot Synthesis of Fused 1,4-Thiazepin-5(4H)-ones and Theoretical Study on S-N Type SmilesRearrangement Process”
J. Org. Chem., 79, 8040-8048,2014.
21). Fang, S.; Niu, X.; Zhang, Z.;Sun, Y.; Si, X.; Shan, S.; Wei, L.; Xu,A.; Feng, L.;Ma, C.* “A one-pot synthetic strategy for construction of the dibenzodiazepineskeletonviaa transition metal-free process”
Org. Biomol. Chem., 12, 6895-6900,2014.
22). Hu, F.; Xia, Y.; Ma, C.*; Zhang, Y.; Wang, J.* “Cu(I)-CatalyzedCross Coupling of Conjugated Ene-Yne-Ketones and Terminal Alkynes: Synthesis ofFuran-Substituted Allenes”
Org.Lett., 16, 4082-4085, 2014.
23). Hu, F.; Xia, Y.; Liu, Z.; Ma, C.*; Zhang, Y.; Wang, J.* “Palladium-catalyzedthree-component reaction of N-tosylhydrazone, norbornene and aryl halide”
Org. Biomol. Chem., 12, 3590–3593, 2014.
24). Fang, S.; Niu, X.; Yang, B.; Li,Y.; Si, X.; Feng, L.;Ma, C.* “One-PotSynthesis of Benzo[4,5]imidazo[1,2-a]quinazoline Derivatives via FacileTransition-Metal-Free Tandem Process”
ACS Combinatorial Science, 16, 328–332, 2014.
25). Niu, X.; Yang, B.; Fang, S.; Li, Y.; Zhang, Z.; Jia, J.; Ma, C.* “An efficientone-pot synthesis of 1,2,4-triazoloquinoxalines”
Tetrahedron, 70, 4657–4660, 2014.
26). Huang, A.; Chen, Y.; Zhou, Y.; Guo, W.; Wu,X.; Ma, C.* “An Efficient One-Pot Synthesis of Benzo[4,5]imidazo[1,2-a]quinoxalines viaCopper-CatalyzedProcess”
Org.Lett., 15, 5480–5483, 2013.
27). Li, Y.; Yang, B.; Sun, Y.; Wang, H.; Li, H.; Fang, S.;Niu, X.;Ma,C.* “Metal-Free Tandem CycloadditionStrategy for the Synthesis of Indolizines from Pyridine Derivatives andγ-Bromo-crotonates under Mild Conditions”
RSC Advances, 3, 21418–21423, 2013.3.708
28). Yang, B.; Huang, Z.; Guan, H.; Niu, X.; Liu, Y.; Fang, S.;Ma, C.* “Newroutes forthe synthesis of fused pyrrole scaffolds through transitionmetal-free tandem reactions”
TetrahedronLett., 54, 5994–5997, 2013.2.391
29). Yang, B.; Niu, X.; Huang, Z.; Zhao, C.; Liu, Y.;Ma, C.* “A novel kind of dimmer (excimer)-induced-AIE compound 2-phenylisothiazolo[5,4-b]pyridin-3(2H)-one as high selectivebisulfite anion probe”
Tetrahedron, 69, 8250–8254,2013.
30). Huang, A.; Liu, H.; Ma, C.* “One-pot synthesis of 6H-benzo[b]benzo[4,5]imidazo[1,2-d][1,4]oxazines via copper-catalyzedprocess”
RSC Advances, 3, 13976–13982, 2013.
31). Niu, X.; Yang, B.; Li, Y.; Fang, S.; Huang, Z.;Xie, C.; Ma,C.* “A transition metal-free tandem process topyridazinopyrido[3,2-f][1,4]thiazepine-dionesvia Smiles rearrangement”
Org. Biomol. Chem., 11, 4102–4108, 2013.
32).Zhao, Y.; Bai, Y.; Zhang,Q.; Chen, Z.; Dai, Q.; Ma, C.* “A Facile Method for the Synthesis of Pyridazino[4,5-b][1,4]thiazine-diones via Smiles Rearrangement”
Tetrahedron Lett., 54, 3253–3255, 2013.
33). Hu, F.;Zhao,X.; Li, Y.; Feng, L.; Ma, C.* “RegioselectiveSynthesis of Phenoxathiine Derivatives underTransition Metal-Free Conditions”
Synthesis, 45, 966–970,2013.2.443
34). Huang, A.; Ma,C.* “RecentProgress in Biological Activities and Synthetic Methodologies of Pyrroloquinoxalines”
Mini-Reviews in MedicinalChemistry,13 (4), 607–616, 2013.
35). Zhao, Y.; Dai, Q.; Chen, Z.; Zhang, Q.; Bai, Y.; Ma, C.* “One pot regioselectivesynthesis of a small library of dibenzo[b,f][1,4]thiazepin-11(10H)-ones via SmilesRearrangement”
ACS Combinatorial Science, 15, 130–134, 2013.
36). Li, Y.; Zhan, C.; Yang, B.; Cao, X.; Ma, C.* “A one-pot transitionmetal-free tandem process to 1,4-benzodiazepine scaffolds”
Synthesis,45,111–117, 2013.
37). Huang, A.; Feng, L.; Qiao, Z.; Yu, W.; Zheng, Q.; Ma, C.* “Synthesis ofpyrrolobenzoxazepinones by CuI/L-proline-catalyzedintramolecular couplingreactions”
Tetrahedron, 69, 642–646, 2013.
38). Liu, Y.; Zhang, X.; Ma, Y.; Ma,C.* “An Efficient C-C Bond Formation Reaction for the Synthesisof α-Arylated Ketones under Mild Conditions”
TetrahedronLett., 54, 402–405, 2013.
39). Zhao, Y.; Wu, Y.; Jia, J.; Zhang, D.*; Ma, C.* “A One-Pot Synthesis ofBenzo[1,4]thiazin-3(4H)-ones and Theoretical Study on S-N Type SmilesRearrangement Mechanism”
J. Org. Chem., 77,8501–8506, 2012.
40). Zhang, X.; Jia, J.; Ma,C.* “A one-pot regioselective synthesis ofbenzo[d]imidazo[2,1-b]thiazoles”
Org. Biomol. Chem., 10,7944–7948, 2012.
41). Zhan, C.; Jia, J.; Yang, B.; Huang, A.; Liu, Y.; Ma, C.* “A Tandem Coupling/SmilesRearrangement/Cyclization Approach to 1,4-Benzooxazinones or1,4-Pyridooxazinones under Mild Conditions”
RSC Advances, 2 (19), 7506–7512, 2012.
42). Liu, Y.; Ma, Y.; Zhan, C.; Huang, A.; Ma, C.* “One-Pot Synthesis of Fused Pyridazino[4,5-b][1,4]Oxazepiones via Smiles Rearrangement”
Synlett, 23, 255–258, 2012.2.463
43). Huang, A.; Qiao, Z.; Zhang, X.; Yu, W.; Zheng, Q.; Ma,Y.; Ma, C.* “A Transition metal-free Tandem Process toPyrrolopyrazino[2,3-d]pyridazine-diones”
Tetrahedron, 68,906–912, 2012.
44). Huang, A.; Liu, F.; Zhan, C.; Liu Y.; Ma, C.* “One-pot synthesis ofpyrrolo[1,2-a]quinoxalines”
Org. Biomol.Chem., 9, 7351–7357, 2011.
45). Liu, Y.; Chu, C.; Huang, A.; Zhan, C.; Ma,Y.; Ma, C.* “Regioselective Synthesis of Fused Oxazepinone Scaffoldsthrough One-Pot Smiles Rearrangement Tandem Reaction”
ACS Combinatorial Science, 13,547–553, 2011.


【科研项目】
1.“惰性键活化的新型Smiles重排串联反应在杂环合成中的应用” (2016-2019)，国家自然科学基金。
2.“基于Smiles重排串联反应的并三环杂环体系的构建” (2012-2015)，国家自然科学基金。
3.“叶醇合成新工艺的开发” (2014-2015)，山东新和成药业有限公司 (横向)。
4.“几种异喹啉类天然产物及其类似物的合成及生物活性研究” (2010-2012)， 山东省自然科学基金重点项目。
5．“几种多药耐药逆转活性中药单体及其类似物的全合成及活性研究”（2009-2011），国家自然科学基金。
6．“抗寄生虫药吡喹酮的合成方法研究” (2008-2010)，山东省科技发展计划。
7.“噁嗪并异喹啉杂环有机分子的合成及生物活性研究” (2007-2009)，山东省自然科学基金重点项目。
8.“含异喹啉杂环化合物的设计, 合成及生物活性研究” (2006-2008)，山东省优秀中青年科学家科研奖励基金。
9.“哒嗪-1,4-噁嗪并异喹啉衍生物的设计, 合成及生物活性评价” (2005-2007), 教育部留学回国人员启动基金。

【科研成果】【课题组】


硕士研究生：戴朕，牛亚迪，李世琛，王新凤，孙哲。
博士研究生：刘欢欢，谢彩霞，储向龙。
已毕业学生：辛亮，万年星，罗丽，张宏志，张伟，周利，张群，丁锴，李靖，展春景，刘艳丽，赵永梅，张鑫海，黄爱萍，李艳秋，牛晓毅，房帅，杨冰川，段田田，胡芳东，于小颖，范金皓，张泽远。



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【所获专利】

【联合培养情况】本课题组与北京大学化学与分子工程学院有机所王剑波教授课题组联合培养博士研究生。

【拟招收研究生情况】每年招收硕士、博士研究生各1-2名（包括工程硕士）。培养的研究生适合在高校、科研院所、企业等从事有机合成、药物合成方面的教学、科研及技术开发等工作。