【个人简介】
郝爱友 教授

山东大学化学与化工学院
男，1966年出生，有机化学研究所博士生导师
电 话：
邮 箱：haoay@sdu.edu.cn
地 址：山东大学(中心校区)化学老楼334室



【学习及工作经历】 2003—至今，山东大学，化学与化工学院，教授，有机化学博士生导师；

2001/9—至今，山东大学，化学与化工学院，教授；
1997/9—2001/9，山东大学，化学院，副教授；
1995/9—1997/9，山东大学，化学与环境学院，讲师；
1992/9—1995/8，中国科学院兰州化学物理研究所，有机化学，博士，导师：金道森，童林荟；
1989/9—1992/7，山东大学，有机化学，硕士，导师：黄慧琴；
1985/9—1989/7，山东师范大学，化学，学士；


【主讲课程】 有机化学
生物有机化学
有机合成化学
综合化学实验



【研究领域和兴趣】 超分子化学
功能材料
有机合成
应用化学
环糊精化学
精细化学品化学



【主要论著】 通讯作者论文
2018年
1.Tianxiang Luan, Mingfang Ma, Pengyao Xing, Yajie Wang, Minmin Yang, Yimeng Zhang, Wei An, Qiuhong Cheng and Aiyou Hao*,A Controllable Etching Supramolecular Hydrogel Based on Metal Ion,Soft Matter, 2018, 10, 1753--1758.

2017年

1. Mingfang Ma, Tianxiang Luan, Minmin Yang, Bing Liu, Yajie Wang, Wei An, Bo Wang, Ruipeng Tang and Aiyou Hao*,Self-assemblies of cyclodextrin derivatives modified by ferrocene with multiple stimulus responsiveness?,Soft Matter, 2017, 13, 1534--1538.
2.Li Kong, Feng Zhang, Pengyao Xing, Xiaoxiao Chu,Aiyou Hao*,A binary solvent gel as drug delivery carrier,Colloids and Surfaces A: Physicochem. Eng. Aspects 522 (2017) 577–584.

2016年

1. Yajie Wang,? Pengyao Xing,? Shangyang Li,? Mingfang Ma,? Minmin Yang,? Yimeng Zhang,? Bo Wang,? and Aiyou Hao*,?, Facile Stimuli-Responsive Transformation of Vesicle to Nanofiber to Supramolecular Gel via ω-Amino Acid-Based Dynamic Covalent Chemistry, Langmuir 2016, 32, 10705?10711.
2. Xing Pengyao, Chen Hongzhong, Bai Linyi,Hao Aiyou*, Zhao Yanli*, Superstructure Formation and Topological Evolution Achieved by Self-Organization of a Highly Adaptive Dynamer, ACS Nano, 2016, 10(2): 2716-2727.
3. Xing Pengyao, Zhao Zhuo, Hao Aiyou*, Zhao Yanli*, Tailoring luminescence color conversion via affinitive co-assembly of glutamates appended with pyrene and naphthalene dicarboximide units, Chem Commun (Camb), 2016, 52(6): 1246-1249.
4. Xing Pengyao, Chen Hongzhong, Ma Mingfang, Xu Xingdong, Hao Aiyou*, Zhao Yanli, Light and cucurbit uril complexation dual-responsiveness of a cyanostilbene-based self-assembled system, Nanoscale, 2016, 8(4): 1892-1896.
5. Minmin Yang, Pengyao Xing, Mingfang Ma, Yimeng Zhang, Yajie Wang and Aiyou Hao*, Controlled self-organization of cyanostilbene: emission tuning and photo-responsiveness, Soft Matter, 2016, 12, 6038?6042.
6. Yimeng Zhang, Shangyang Li, Mingfang Ma, Minmin Yang, Yajie Wang, Aiyou Hao* and Pengyao Xing, Tuning of gel morphology with supramolecular chirality amplification using a solvent strategy based on an Fmoc-amino acid building block, New J. Chem., 2016, 40, 5568?5576.
7. Yimeng Zhang, Pengyao Xing, Minmin Yang, Yajie Wang, Bo Wang, Aiyou Hao* and Mingfang Ma, Solvent-polarity-tuned nanostructures assembled from modified octadecylcarbamate with an anthracen moiety, RSC Adv., 2016, 6, 71963?71969.
8. Pengyao Xing,ab Zhuo Zhao,c Aiyou Hao*b and Yanli Zhao*ad, Tailoring luminescence color conversion via affinitive co-assembly of glutamates appended with pyrene and naphthalene dicarboximide units, Chem. Commun., 2016, 52, 1246?1249.
2015年
1. Chu Xiaoxiao, Xing Pengyao, Li Shangyang, Ma Mingfang, Hao Jingcheng, Hao Aiyou*, Dual-tuning multidimensional superstructures based on a T-shaped molecule: vesicle, helix, membraneand nanofiber-constructed gel?, RSC Advances, 2015, (5): 1969-1978.
2. Ma Mingfang, Gu Jinge, Yang Minmin, Li Zhaolou, Lu Zhuoqun, Zhang Yimeng, Xing Pengyao, Li Shangyang, Chu Xiaoxiao, Wang Yajie, Li Qi, Lin Minyan, Hao Aiyou*, Controllable self-assemblies of sodium benzoate in different solventenvironments?, RSC Advances, 2015, (5): 70178-70185.
3. Zhang Hanqiang, Huang Yihong, Huang Qitong, Wei Chan, Zhang Wuxiang, Yang Weize, Dong Peihui, Hao Aiyou*, Hu Shirong*, Self-assembly of graphitic carbon nitride nanosheets–carbon nanotube compositefor
electrochemical simultaneous determination of catechol and hydroquinone, Electrochimica Acta, 2015, 176: 28-35.
4. Li Shangyang, Zhang Lin, Wang Bo, Ma Mingfang, Xing Pengyao, Chu Xiaoxiao, Zhang Yimeng, Hao Aiyou*, An easy approach for constructing vesicles by using aromatic molecules with beta-cyclodextrin, Soft Matter, 2015, 11(9): 1767-1777.
5. Shirong Hu, Wuxiang Zhang, Jianzhong Zheng, Jiangu Shi, Zhongqiu Lin, Ling Zhong，Guixiang Cai, Chan Wei, Hanqiang Zhang, Aiyou Hao*, One step synthesis cadmium sulphide/reduced graphene oxide sandwiched film modified electrode for simultaneous electrochemical determination of hydroquinone, catechol and resorcinol, RSC Advances, 2015，-(5): 18615-18621.
6. Ma Mingfang, Shang Wenqing, Xing Pengyao, Li Shangyang, Chu Xiaoxiao, Hao Aiyou*, Liu Guangcun, Zhang Yimeng, A supramolecular vesicle of camptothecin for its water dispersion and controllable releasing, Carbohydrate Research, 2015, 402: 208-214.
7. Ma Mingfang, Xu Shengguang, Xing Pengyao, Li Shangyang, Chu Xiaoxiao, Hao Aiyou*, A multistimuli-responsive supramolecular vesicle constructed by cyclodextrins andtyrosine，Colloid and Polymer Science, 2015, 293: 891-900.
8. Zhang Hanqiang, Huang Yihong, Huang Qitong, Wei Chan, Zhang Wuxiang, Kang Lianping, Huang Zhouyi, Hu Shirong*, Hao Aiyou*, Fluorescent probes for “off–on” sensitive and selective detection ofmercury ions and
L-cysteine based on graphitic carbon nitrid nanosheets?, Journal of Materials Chemistry C, 2015, (3): 2093-2100.
2014年
1. Hou Yuehui, Li Shangyang, Sun Tao, Yang Jingshu, Xing Pengyao, Liu Wenqi, Hao Aiyou*, Organogels based on beta-cyclodextrin system with molecular recognition property, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2014, 80(3-4): 217-224.
2. Xing Pengyao, Chu Xiaoxiao, Ma Mingfang, Li Shangyang, Hao Aiyou*, Melamine as an effective supramolecular modifier and stabilizer in a nanotube-constituted supergel, Chem Asian J, 2014, 9(12): 3440-3450.
3. Chu Xiaoxiao, Xing Pengyao, Li Shangyang, Ma Mingfang, Hao Aiyou*, Inorganic salt-tuned multiple self-assemblies of supramolecular beta-cyclodextrin gel, Colloids and Surfaces A: Physicochemical and Engineering
Aspects, 2014, 461: 11-17.
4. Ma Mingfang, Sun Tao, Xing Pengyao, Li Zhaolou, Li Shangyang, Su Jie, Chu Xiaoxiao, Hao Aiyou*, A supramolecular curcumin vesicle and its application in controlling curcumin release，Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014, 459: 157-165.
5. Ma Mingfang, Su Jie, Sheng Xiang, Su Fan, Li Shangyang, Xing Pengyao, Hao Aiyou*, Rapid regio- and enantioselectivities and kinetic resolution of DL-lysine by an effective supramolecular system in water, Journal of Molecular Liquids, 2014, 198: 1-4.
6.Xing Pengyao, Chu Xiaoxiao, Du Guangyan, Ma Mingfang, Li Shangyang, Hao Aiyou*, Utilizing dual responsive supramolecular gel to stabilize grapheme oxidein apolar solvents, Colloid and Polymer Science, 2014, 242: 3223-3231.
7. 马明放，邢鹏遥，李尚洋，初晓晓，王波，郝爱友*，主客体超分子囊泡及其药物载运性能研究，化学进展，2014，（08）：1317-1328。
8. Xing Pengyao, Chu Xiaoxiao, Li Shangyang, Ma Mingfang, Hao Aiyou*, Hybrid Gels Assembled from Fmoc-Amino Acid and Graphene Oxide with Controllable Properties, ChemPhysChem, 2014, 15(11): 2377-2385.
9. Li Zhaolou, Hao Aiyou*, Li Xiang, beta-Cyclodextrin supramolecular organogels induced by different carboxylic acids that exhibit diverse morphologies, Journal of Molecular Liquids, 2014, 196: 52-60.
10. Ma Mingfang, Guan Yun, Zhang Cai, Hao Jingcheng, Xing Pengyao, Su Jie, Li Shangyang, Chu Xiaoxiao, Hao Aiyou*, Stimulus-responsive supramolecular vesicles with effective anticancer activity prepared by cyclodextrin and ftorafur, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014, 454: 38-45.
11. Li Zhaolou, Liu Wenqi, Hao Aiyou*, Gel-sol-gel evolution triggered by formic acid, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014, 451: 25-32.
12. Hu Shirong, Huang Qitong, Lin Yi, Wei Chan, Zhang Hanqiang, Zhang Wuxiang, Guo Zhenbo, Bao Xiuxiu, Shi Jiangu, Hao Aiyou*, Reduced graphene oxide-carbon dots composite as an enhanced material for electrochemical determination of dopamine, Electrochimica Acta, 2014, 130: 805-809.
13. HouYuehui, Sun Tao, Xin Feifei, Xing Pengyao, Li Shangyang, Hao Aiyou*, Transformation from a heat-set organogel to a room-temperature organogel induced by alcohols, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2014, 79(1-2): 133-140.
14. Su Jie, Su Fan, Ma MingFang, Li Shangyang, Xing Pengyao, Hao Aiyou*, Selection of Amino Acids and the Biomimetic Synthesis of Amido Bond in the Presence of beta-CD, Synthetic Communications, 2014, 44(8): 1111-1121.
15. Li Shangyang, Xing Pengyao, Zhang Lin, Xin Feifei, Nie Jinhui, Wang Hailu, Ma Mingfang, Wu Yurong, Hao Aiyou*, Controllable self-assembly of an amphiphilic drug with beta-cyclodextrin and alpha-amylase, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014, 445: 67-74.
16. Li Zhaolou, Hao Aiyou*, Hao Jingcheng, Formation of heat-triggered supramolecular organogel in which beta-cyclodextrin as sole gelator, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014, 441: 8-15.
17. Xing Pengyao, Chu Xiaoxiao, Ma Mingfang, Li Shangyang, Zhang Yimeng, Hao Aiyou*, Self- assembly of folic acid/melamine complexes with hierarchy levels: from membranes to porous spherulites and networks, RSC
Advances, 2014, 4(69): 36633-36639.
18. Xing Pengyao, Chu Xiaoxiao, Ma Mingfang, Li Shangyang, Hao Aiyou*, Supramolecular gel from folic acid with multiple responsiveness, rapid self-recovery and orthogonal self-assemblies, Physical Chemistry Chemical
Physics, 2014, 16(18): 8346-8359.
19. Ma Mingfang, Xing Pengyao, Xu Shengguang, Li Shangyang, Chu Xiaoxiao, Hao Aiyou*, Reversible pH-responsive helical nanoribbons formed using camptothecin, RSC Advances, 2014, 4(80): 42372-42375.
20.杨旭，郝爱友*，冯维春，叠氮化钠的水相合成方法及其废液处理，应用化工，2014，（06）：1156-1158+1164。
2013年
1. Li Shangyang, Xing Pengyao, Hou Yuehui, Yang Jingshu, Yang Xuezhi, Wang Bo, Hao Aiyou*, Formation of a sheet-like hydrogel from vesicles via precipitates based on an ionic liquid-based surfactant and beta-cyclodextrin, Journal of Molecular Liquids, 2013, 188: 74-80.
2. Li Shangyang, Sun Tao, Yang Xuezhi, Wang Bo, Xing Pengyao, Hou Yuehui, Su Jie, Hao Aiyou*, Light-responsive drug carrier vesicles assembled by cinnamic acid-based peptide, Colloid and Polymer Science, 2013, 291(11): 2639-2646.
3. Li Liuzhong, Wu Yuxiang, Dong Qi, Hao Aiyou*, Cheng Ruihua, Zhong Lei, Liu Boping, Effect of Al-alkyl cocatalyst on ethylene polymerization behavior using silyl chromate (SC)/SiO2 catalyst, Asia-Pacific Journal of Chemical Engineering, 2013, 8(4): 539-546.
4. Tao Sun, Mingfang Ma, Hui Yan, Jian Shen, Jie Su,Aiyou Hao*, Vesicular particles directly assembled from the cyclodextrin/UR-144 supramolecular amphiphiles, Colloids and Surfaces A: Physicochemical and Engineering
Aspects, 2013, 424: 105-112.
5. Sun Tao, Yan Hui, Xing Pengyao, Su Jie, Li Shangyang, Hao Aiyou*, Cu(II)-triggered release of paclitaxel from a supramolecular complex，SUPRAMOLECULAR CHEMISTRY, 2013, 25(5): 302-309.
6. Pengyao Xing, Tao Sun, Shangyang Li, Aiyou Hao*, Jie Su, Yuehui Hou, An instant-formative heat-set organogel induced by small organic molecules at a high temperature, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2013, 421: 44-50.
7. Xing Pengyao, Li Shangyang, Xin Feifei, Hou Yuehui, Hao Aiyou*, Sun Tao, Su Jie, Multi-responsive supramolecular organogel with a crystalline-like structure, Carbohydr Res, 2013, 367: 18-24.
8. Xin Feifei, Xing Pengyao, Li Shangyang, Hou Yuehui, Hao Aiyou*, A facile method to construct dual-responsive organogels with color changes, RSC Advances, 2013, 3(44): 21959-21963.
9. Xing Pengyao, Chu Xiaoxiao, Li Shangyang, Xin Feifei, Ma Mingfang, Hao Aiyou*, Switchable and orthogonal self-assemblies of anisotropic fibers, New Journal of Chemistry, 2013, 37(12): 3949-3955.
10. Xing Pengyao, Chu Xiaoxiao, Li Shangyang, Hou Yuehui, Ma Mingfang, Yang Jingshu, Hao Aiyou*, Self-recovering beta-cyclodextrin gel controlled by good/poor solvent environments, RSC Advances, 2013, 3(44): 22087-22094.
11. Xing Pengyao, Sun Tao, Hao Aiyou*, Vesicles from supramolecular amphiphiles, RSC Advances, 2013, 3(47): 24776-24793.
12. Xing Pengyao, Chu Xiaoxiao, Du Guangyan, Li Mingzhi, Su Jie, Hao Aiyou*, Hou Yuehui, Li Shangyang, Ma Mingfang, Wu Le, Yu Qiubing, Controllable self-growth of a hydrogel with multiple membranes, RSC ADVANCES, 2013, 3(35): 15237-15244.

第一作者论文
1. 郝爱友，黄惠琴，林吉茂，马晨，利用氯化锌/微孔球状硅胶色谱柱制备α-叔丁基醛酮，有机化学，1999，(04)：435-437。
2. 郝爱友，亲核重排反应中氢的迁移能力，化学通报(网络版)，1999，-(c00037)：1-3。
3. AI-YOU HAO, JI-MAO LIN, LIN-HUI TONG, Selective arylation of β-CD with an ethylenediamino group and characteristics of arylated β-CD dervatives in host-guest complexation, Journal of Inclusion Phenomena and
Macrocyclic Chemistry, 1999, 34(-): 445-454.
4. Ai You Hao, Lin Hui TONG, Min ZHOU, Selective Modification of -CD on the Secondary Side 4: preparation of arylation of β-CD with a Flexible Chain, Chinese Chemical Letters, 1998, 9(1): 13-16.
5. Ai You HAO, Lin Hui TONG, Tian Lin YANG, Ji Mao LIN, Characteristic Studies of Arylated -Cyclodextrrins in Host-Guest Complexation with Small Molecules, Chinese Chemical Letters, 1998, 9(3): 265-268.
6. 郝爱友，童林荟，环糊精在环境保护中的功能应用，化学试剂，1997，(05)：302-303。
7. 郝爱友，童林荟，张复升，光谱活性化环糊精主体与过量客体复合作用性能的简易数学表达式，化学物理学报，1996，(05)：450-452。
8. 郝爱友，童林荟，张复升，β－环糊精为TLC流动相添加剂分离对映体，化学通报，1996，(04)：16-18。
9. Ai-You HAO, Lin-Hui TONG, Yao-HONG FU, Xia-FEI LAO, Hou-Ming WU, Dimerization constant determination of 6-O-benzoyl-β-CD in aqueous solution, Chinese Chemical Letters, 1996, 7(9): 853-854.
10. Ai You Hao, Lin Hui Tong, Fu Sheng Zhang, Xing Ming Gao, Convenient preparation of monoacylated β-cyclodextrin (cyclomaltoheptaose) on the secondary hydroxyl side, Carbohydrate Research, 1995, 277(2): 333-337.
11. 郝爱友，童林荟，金道森，环糊精的第二面选择性修饰方法新进展，合成化学，1995，-(03)：208-214。
12. 郝爱友，童林荟，金道森，2─氧─(2─羟基丙基)─β─环糊精的简便合成及纯化，化学试剂，1995，(03)：161-162。
13. 郝爱友，童林荟，张复升，金道森，亲脂类分子增溶剂单2－氧一(2一羟基丙基)一β一环糊精(单2一HP一β一CD)的制备及其NMR表征，合成化学，1995，(04)：369-371。
14. 郝爱友，童林荟，高兴明，张复升，β-萘甲酰化β-环糊精的分子识别性能研究，Acta Physico - Chimica Sinica，1995，(03)：202-205。
15. Ai-You Hao, Lin-Hui Tong, Fu-Sheng Zhang, Xing-Ming Gao, and Yoshihisa Inoue, Direct TLC sepration of selected six enantiomersof amino-acids using 2-o-[(R) -2-hydroxypropyl]-β-CD as a mobile phase additive, Analytical Letters, 1995, 28(11): 2041-2048.
16. Ai You HAO, Lin Hui TONG, Fu Sheng ZHANG, Dao Sen JIN, A Convenient synthesis of β-cyclodextrion 2- and 3-O-monobenzoate, Chinese Chemical Letters, 1994, 5(8): 645-645.
17. 郝爱友，张立新，张海光，化学滴定法测定羟乙基β-环糊精的平均取代度，应用化学，2002，(03)：301-303。
18. 郝爱友，王金山，用环糊精合成楔筒状主体分子新模型，Acta Chimica Sinica，2002，60(8)：1536-1538。
19. 郝爱友，王金山，辛志荣，水溶性显色型分子识别器--甲基红基乙二胺基羟丙基-β-环糊精，Acta Chimica Sinica，2002，60(8)：1531-1535。
20. Ai You HAO, Jin Shan WANG, The Preparation of 2-O-Acetonyl-β-cyclodextrin as One Key Intermediate for Water Soluble β-Cyclodextrin Derivatives, 中国化学快报(英文版), 2002, 13(9): 832-835.



【科研项目】 1.山东省科学技术厅，低碳烯烃控制聚合与超支液体石蜡生产新技术，2016/1-01-2018/12，主持；

2. 山东省科学技术厅，高性能聚甘油脂肪酸酯制备新方法，2012/01-2013/12，已结题，主持；
3. 山东省科学技术厅，强力医药控缓释新材料：含低聚乳酸基团的环糊精衍生物的制备，2003/01-2004/12，已结题，主持；
4. 山东省教育厅，智能提取剂：硅胶载改性环糊精衍生物，2002/01-2003/12，4万元，主持；
5. 国家自然科学基金青年基金，**，构筑具有楔形筒状空腔的主体分子新模型，2000/01-2002/12，已结题，主持；
6. 山东省科学技术厅，合成功能性大环分子构筑高性能药用模型，1999/01-2003/12，已结题，主持；


【科研成果】 已发表论文200余篇及十余项专利
专著：郝爱友，孙昌俊，曲荣军，徐胜广，刘希光，张文志，精编有机化学教程，山东大学出版社，845000字，2009。


【所获专利】 1. 鲁卓群，郝爱友，李啟，谷锦阁，一种3位取代的苯甲酰基-β-环糊精的制备方法，2017.06.06，山东，ZL 2015 1 **.X。
2. 初晓晓，郝爱友，邢鹏遥，一种多重响应的自修复叶酸凝胶及其制备方法，2015.10.28，山东，ZL 2013 1 **.6。
3. 邢鹏遥，郝爱友，刘文奇，一种无毒稳定小分子有机凝胶及其制备方法，2013.11.6，山东，ZL 2012 1 082269.X。
4. 李尚洋，苏杰，郝爱友，一种赖氨酸α-氨基的苄氧羰基高效选择性保护方法及其产品，2013.7.3，山东，ZL 2011 1 **.4。
5. 邢鹏遥，孙涛，郝爱友，一种负载紫杉醇的囊泡的制备方法，2013.7.3，山东，ZL 2012 1 **.2。
6. 郝爱友，孙涛，赵文静，一种二氮喹喔啉类化合物的制备方法，2010.6.9-2029.12.3，山东，ZL 2009 1 **.8。
7. 孙涛，郝爱友，一种对1-硝基蒽醌废渣综合利用的方法，2009.3.25-2028.10.15，山东，ZL 2008 1 **.4。
8.郝爱友，申健，低聚乳酸基环糊精衍生物及其制备方法，2005.9.7-2025.2.21，山东，ZL 2005 1 **.1。




【联合培养情况】

【拟招收研究生情况】 每年计划招收2名硕士研究生，1名博士研究生。