姓名：高晓南


职称：
副教授

专业：
化学

博（硕）导：
硕导

最终学历：
博士研究生

联系电话：


电子邮件：
Gaox@sdnu.edu.cn

简历及研究领域 纳米荧光探针

个人简介：
高晓南，2016年5月毕业于美国弗吉尼亚联邦大学获得博士学位，2016年10月至今于山东师范大学工作。主要从事纳米荧光探针在癌症的检测和治疗方面的相关研究工作。目前主持国家自然科学基金青年项目一项，山东省科技厅和教育厅项目各一项，参与国家自然科学基金面上项目以及海外合作研究基金项目等多项。

代表性论文

2020
31. Xiaonan Gao, Congcong Zhao, Keyan Wei, Bo Hu, Yuqin Chen*, Kehua Xu* and Bo Tang. “A differential study on oxidized/reduced ascorbic acid induced tumor cells’ apoptosis under hypoxia.” Analyst, 2020, 145, 6363-6368. (IF = 3.978, SCI 二区)
30. Dongrui Luan, Zengteng Zhao, Dandan Xia, Qiuling Zheng, Xiaonan Gao, Kehua Xu*, Bo Tang. “Hydrogen selenide, a vital metabolite of sodium selenite, uncouples the sulfilimine bond and promotes the reversal of liver fibrosis.” Sci. China Life Sci., 2020, 1-9. (IF = 4.611, SCI 一区)
29. Wenfei Guo, Xiaonan Gao, Renhui Zhan, Zengteng Zhao, Kehua Xu*, Bo Tang. “Tricolor imaging of MMPs to investigate the promoting roles of inflammation on invasion and migration of tumor cells.” Talanta, 2020, 222, 121525. (IF = 5.339, SCI 二区)
28. Renhui Zhan, Wenfei Guo, Xiaonan Gao, Xiaojun Liu, Kehua Xu*, Bo Tang. “Reconstruction of nano-flares based on Au–Se bonds for high-fidelity detection of RNA in living cells.” Chem. Common., 2020, 56, 5178-5181. (IF = 5.996, SCI 一区)
27. Xiaonan Gao, Wenfei Guo, Lulu Jiang, Bo Hu, Xiaojun Liu, Kehua Xu* and Bo Tang*. “Simultaneous bioimaging of MMP-2 and MMP-7 via Au-Se constructed fluorescence nanoprobe” Sci. China Chem., 2020, 63, 135-140. (IF = 6.356, SCI 一区)
26. Xiaonan Gao, Jia Li, Mingming Luan, Yanhua Li, Wei Pan, Na Li*, Bo Tang*. “Real Time in situ Monitoring Cathepsin B and Caspase-3 for Intracellular Apoptosis Pathway Study via Au-Se Constructed Nanoprobe.” Biosens. & Bioelectron., 2020, 147,111755 (IF = 10.257, SCI 一区)
25. Xiaojun Liu, Yingxue Sun, Shushen Xu, Xiaonan Gao, Fanpeng Kong, Kehua Xu* and Bo Tang*. “Homotypic Cell Membrane-Cloaked Biomimetic Nanocarrier for the Targeted Chemotherapy of Hepatocellular Carcinoma.” J. Nanobiotech., 2020, 18, 1-10. (IF = 6.518, SCI 二区)
2019
24. Xiaojun Liu, Yingxue Sun, Shushen Xu, Xiaonan Gao, Fanpeng Kong, Kehua Xu and Bo Tang. “Homotypic cell membrane-cloaked biomimetic nanocarrier for the targeted chemotherapy of hepatocellular carcinoma.” Theranostics, 9, 5828-5838. (IF = 8.537, SCI 一区)
23. Jun Lu, Wei Zhang*, Ping Li, Xiaonan Gao, Wen Zhang, Hui Wang and Bo Tang*. “Photodynamic Therapy for Hypoxic Solid Tumors via Mn-MOF as a Photosensitizer.” Chem. Commun., 2019, 55, 10792-10795. (IF = 6.164, SCI 一区)
22. Fanpeng Kong, Ying Li, Chao Yang, Xiao Li, Junlin Wu, Xiaojun Liu, Xiaonan Gao, Kehua Xu* and Bo Tang*. “A Fluorescent Probe for Simultaneously Sensing NTR and hNQO1 and Distinguishing Cancer Cells.” J. Mater. Chem. B, 2019, 7, 6822-6827. (IF = 5.047, SCI 二区)
21. Xiaonan Gao*, Ai-Yun Fu*, Bo Liu, Jun-cheng Jin, Long-Tao Dou, Li-Xia Chen. “Unique Topology Analysis by ToposPro for a Metal-Organic Framework with Multiple Coordination Centers” Inorg. Chem., 2019, 58, 3099-3106. (IF = 4.700, SCI 一区)
20. Xiaonan Gao, Keyan Wei, Bo Hu, Kehua Xu*, Bo Tang*. “Ascorbic acid induced HepG2 cells’ apoptosis via intracellular reductive stress” Theranostics, 2019, 9, 4233-4240. (IF = 8.537, SCI 一区)
19. Yuehui Zhao, Keyan Wei, Fanpeng Kong, Xiaonan Gao, Kehua Xu*, Bo Tang*. “Dicyanoisophorone-Based Near-Infrared Fluorescent Probe for Detecting NAD(P)H in Living Cells and in Vivo” Anal. Chem., 2019, 91, 1368-1374 (IF = 6.042, SCI 一区)
18. Yu Ma*; Aijie Li; Xiaonan Gao; Fang Huang; Xuan Kuang; Peng Yang; Jieyu Yue; Bo Tang* “Effective Separation of Enantiomers Based on Novel chiral Hierarchical Porous Metal-organic Gels” Macromol. Rapid Comm., 2019, **. (IF = 4.441，SCI 二区)
2018
17. Wei Zhang,* Jiheng Xu, Ping Li, Xiaonan Gao, Wen Zhang, Hui Wang, Bo Tang*. “Treatment of hyperphosphatemia based on specific interaction between phosphorus and active center Zr(IV) of nano-MOFs” Chem. Sci., 2018, 9, 7483-7487 (IF = 8.668, SCI 一区)
16. Wei Pan, Bo Liu, Xiaonan Gao, Zhengze Yu, Xiaohan Liu, Na Li* and Bo Tang*. “A graphene-based fluorescence nanoprobe for simultaneous monitoring of miRNA and mRNA in living cells.” Nanoscale, 2018, 10, 14264-14271 (IF = 7.233, SCI一区)
15. Dongrui Luan, Xiaonan Gao, Xiaoxiao Song, Kehua Xu, Bo Tang*. “Cyclic Regulation of Sulfilimine Bond in Peptides and NC1 Hexamers via HOBr/H?Se Conjugated System” Anal. Chem., 2018, 90, 9523-9528. (共同一作，IF = 6.042, SCI 一区)
14. Xiaonan Gao, Lulu Jiang, Bo Hu, Fanpeng Kong, Xiaojun Liu, Kehua Xu, Bo Tang*. “Au-Se Bond Based Nanoprobe for Imaging MMP-2 in Tumor Cells under High Thiols Environment” Anal. Chem., 2018, 54, 3656-3659. (共同一作，IF = 6.042, SCI 一区)
13. Xiaonan Gao, Wenfei Guo, Lihong Ge, Xiaohong Pan, Fanpeng Kong, Xiaojun Liu, Kehua Xu, Bo Tang*. “Double-ratiometric fluorescence imaging of H₂Se and O₂^˙? under hypoxia for exploring Na₂SeO₃-induced HepG2 cells' apoptosis” RSC Adv., 2018, 8, 40984-40988 (IF = 2.936, SCI 三区， 2018.11.16)
12. Wei Zhang, Jun Lu, Xiaonan Gao, Ping Li, Wen Zhang, Yu Ma, Hui Wang, Bo Tang*. “Enhanced Photodynamic Therapy by Reduced Intracellular Glutathione Levels Employing Nano-MOF with Cu (II) as Active Center” Angew. Chem., Int. Ed., 2018, 57, 4891-4896. (IF = 12.102, SCI 一区)
11. Bo Hu, Fanpeng Kong, Xiaonan Gao, Lulu Jiang, Xiaofeng Li, Wen Gao, Kehua Xu, Bo Tang*. “Avoiding Thiol Compound Interference: A High-Fidelity Au-Se Bonding Nanoplatform and Its Biological Applications” Angew. Chem., Int. Ed., 2018, 57, 5306-5309 (IF = 12.102, SCI 一区)
10. Limin Yang, Bo Liu, Meimei Wang, Jia Li, Wei Pan, Xiaonan Gao, Na Li*, Bo Tang*. “A Highly Sensitive Strategy for Fluorescence Imaging of MicroRNA in Living Cells and in Vivo Based on Graphene Oxide-Enhanced Signal Molecules Quenching of Molecular Beacon” ACS. Appl. Mater. Inter., 2018, 10, 6982-6990. (IF = 7.504, SCI 一区， 2018.02.06)
9. Bo Hu, Ranran Cheng, Xiaonan Gao, Xiaohong Pan, Fanpeng Kong, Xiaojun Liu, Kehua Xu, Bo Tang*. “Targetable Mesoporous Silica Nanoplatforms to Monitor the Subcellular Distribution of H₂Se in HepG2 Cells Induced by Na₂SeO₃” ACS. Appl. Mater. Inter., 2018, 10, 17345-17351. (IF = 8.097, SCI 一区)
8. Na Li, Longhai Yu, Jianbo Wang, Xiaonan Gao, Yuanyuan Chen, Wei Pan and Bo Tang*. “A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy” Chem. Sci., 2018, 9, 3159-3164 (IF = 8.668, SCI 一区)
7. Na Li, Qiaoqiao Sun, Zhengze Yu, Xiaonan Gao, Wei Pan, Xiuyan Wan and Bo Tang*. “Nuclear-Targeted Photothermal Therapy Prevents Cancer Recurrence with Near-Infrared Triggered Copper Sulfide Nanoparticles” ACS Nano, 2018, 12, 5197-5206 (IF = 13.942, SCI 一区)
6. Yanli Li,^? Xiaonan Gao,^? Zhengze Yu, Bo Liu, Wei Pan, Na Li* and Bo Tang*. “Reversing multidrug resistance by multiple gene silencing for enhanced breast cancer chemotherapy” ACS. Appl. Mater. Inter., 2018, 10, 15461-15466 (共同一作，IF = 8.097, SCI 一区，2018.04.17)
2017
5. Yuanyuan Chen, Tingting Zhang, Xiaonan Gao, Wei Pan, Na Li, Bo Tang*. “A highly selective and instantaneous upconversion fluorescent nanoprobe for ascorbic acid detection in biological samples” Chin. Chem. Lett., 2017, 28, 1983-1986 (IF = 1.571, SCI 四区)
4. Luan, Mingming; Yu, Longhai; Li, Yanhua; Pan, Wei; Gao, Xiaonan; Wan, Xiuyan; Li, Na; Tang, Bo*. “Visualizing Breast Cancer Cell Proliferation and Invasion for Assessing Drug Efficacy with a Fluorescent Nanoprobe” Anal. Chem., 2017, 89, 10601-10607 (IF = 6.042, SCI 一区)
3. Hongyu Wang, Kaiye Wang, Yunquan Man, Xiaonan Gao, Limin Yang, Yanfei Ren, Na Li*, Bo Tang*, Gang Zhao. “Asymmetric Intermolecular Rauhut-Currier Reactions for the Construction of 3,3-Disubstituted Oxindoles with Quaternary Stereogenic Centres.” Adv. Synth. Catal., 2017, 359, 3934-3939 (IF = 6.453, SCI 一区)
2. Na Li, Meimei Wang, Xiaonan Gao, Zhengze Yu, Wei Pan, Hongyu Wang, and Bo Tang*. “A DNA Tetrahedron Nanoprobe with Controlled Distance of Dyes for Multiple Detection in Living Cells and In Vivo.” Anal. Chem., 2017, 89, 6670-6677. (IF = 6.042, SCI 一区)
1. Na Li, Yanli Li, Xiaonan Gao, Zhengze Yu, Wei Pan andBo Tang*. “Multiplexed gene silencing in living cells and in vivo using a DNAzymes-CoOOH nanocomposite.” Chem. Commun., 2017, 53, 4962-4965. (IF = 6.567, SCI 一区)
2009-2016
1. Gao, X.; Esteves, R. J.; Luong, T. T. H.; Jaini, R.; Arachchige I. U. “Oxidation-Induced Self-Assembly of Ag Nanoshells into Transparent and Opaque Ag Hydrogels and Aerogels”J. Am. Chem. Soc.,2014,136, 7993–8002. (IF = 13.038, SCI一区)
2. Gao, X.; Esteves, R. J.; Nahar, L.; Nowaczyk, J.; Arachchige, I. U. “Direct Cross-Linking of Au/Ag Alloy Nanoparticles into Monolithic Aerogels for Application in Surface Enhanced Raman Scattering” ACS appl. Mater. Interfaces, 2016, 8, 13076-13085. (IF = 7.145, SCI一区)
3. Gao, X.; Fu, A. Y.; Wang Y.-Y. “Shape-Asymmetry Supramolecular Isomerism in Asymmetrical Ligand PCPs and the Expression Method of Three-Level Isomerism” Inorg. Chem. 2016, 55, 4330-4334 (IF = 4.820, SCI 一区)
4. Ranmohotti, K. G. S.; Gao, X.; Arachchige I. U. “Salt-Mediated Self-Assembly of Metal Nanoshells into Monolithic Aerogel Frameworks”Chem. Mater.2013,25, 3528–3534. (IF = 9.407, SCI 一区)
5. Jiang, Y. L.; Gao X.; Zhou G., Patel A.; Javer A. “Selective Recognition of Uracil and Its Derivatives Using a DNA Repair Enzyme Structural Mimic” J. Org. Chem. 2010, 75, 324–333. (IF = 4.785, SCI 二区)
6. Fu, A. Y.; Jiang Y. L.; Wang Y. Y.; Gao X.; Yang G. P.; Hou L.; Shi Q. Z. “DMF/H₂O Volume Ratio Controls the Syntheses and Transformations of a Series of Cobalt Complexes Constructed Using a Rigid Angular Multitopic Ligand”, Inorg. Chem. 2010, 49, 5495–5502. (IF = 4.820, SCI 一区)
7. White, L. S.; Echard, D. R.; Bertino, M. F.; Gao, X.; Donthula, S.; Leventis, N.; Shukla, N.; Ko?ny, J.; Saeed, S.; Saoud K. “Fabrication of Native Silica, Cross-Linked, and Hybrid Aerogel Monoliths with Customized Geometries” Trans. Mater. Res. 2016, 3, 015002 (1-11) (IF = 0.689, SCI 四区)
8. White, L. S.; Migenda, J.; Gao, X.; Clifford, D. M.; Bertino, M. F.; Saoud, K. M. “Synthesis of Silicon Dioxide, Silicon, and Silicon Carbide Mesoporous Spheres from Polystyrene Sphere Templates”J. Sol-Gel Sci. and Techno.2015,02 (IF = 1.517, SCI 三区)
9. Gao, X. Bis (μ-N-acetyl-N-phenylglycinato-κ2O:O′)bis[dinitrato-κ4O,O′-bis (1,10-phenan- throline-κ2N,N′) lanthanum(III)]. Acta Cryst. Section E, 2009, 65(1), 59


研究课题

国家自然科学基金青年项目
定量指示活细胞内不同细胞器pH的比率纳米荧光探针的设计与合成

山东省科技厅博士基金项目
癌症诊疗一体化纳米荧光探针的设计合成及应用

山东省高等学校科研计划项目
精确检测活细胞内不同细胞器pH的比率纳米荧光探针的设计合成

青年科研培育基金
设计合成比率纳米荧光探针用于活细胞内不同细胞器pH的精准检测

全英文课程建设项目
基础化学

校级教学改革立项面上项目
普通化学全英文授课在国际联合培养创新性人才的改革与实践

教育部产学合作协同育人项目
VR技术在基础化学实验中的应用

荣誉称号

2018
山师化学院优秀班主任

2019
山师化学院优秀班主任

2019
山师化学院青年教学能手

2020
山师化学院优秀班主任

2020
山师化学院青年教学能手