姓名：潘伟


职称：
副教授

专业：
分析化学

博(硕)导：
博导

最终学历：
博士

联系电话：


电子邮件：
panwei@sdnu.edu.cn

简历及研究领域

个人简介：
主要研究方向为功能纳米荧光探针的设计、制备及其用于活细胞与活体的检测成像与治疗。在Angew. Chem. Int. Ed., ACS Nano, Adv. Funct. Mater., Chem. Sci., Anal. Chem., Chem. Commun., Chem. Eur. J.等杂志上发表SCI论文50余篇，影响因子大于5.0的40余篇，其中四色纳米荧光探针用于肿瘤细胞中多种肿瘤标志物同时检测与成像的工作发表后，引起了国内外****的广泛关注，美国化学会Chemical & Engineering News以“Four-Color Nanoprobe Could Increase Accuracy Of Cancer Detection”为题对该工作进行了专访和报道，高度评价了此研究工作。主持和完成国家自然科学基金面上项目、国家自然科学基金青年基金、山东省自然科学基金青年基金等国家级和省部级项目。



代表性论文

Selected Publications:
50. Wei Pan*, Xinhao Zhang, Peng Gao, Na Li* and Bo Tang*. An anti-inflammatory nanoagent for tumor-targeted photothermal therapy. Chem. Commun., 2019, 55, 9645-9648.
49. Wei Pan, Shaohua Gong, Jianbo Wang, Longhai Yu, Yuanyuan Chen, Na Li* and Bo Tang*. A nuclear-targeted titanium dioxide radiosensitizer for cell cycle regulation and enhanced radiotherapy. Chem. Commun., 2019, 55, 8182-8185.
48. Peng Gao, Wei Pan, Na Li* and Bo Tang*. Boosting Cancer Therapy with Organelle-Targeted Nanomaterials. ACS Appl. Mater. Interfaces, 2019, 11, 26529-26558.
47. Peng Gao, Wei Pan, Na Li* and Bo Tang*. Fluorescent probes for organelle-targeted bioactive species imaging. Chem. Sci., 2019, 10, 6035-6071.
46. Yuanyuan Chen, Hui Zhong, Jianbo Wang, Xiuyan Wan, Yanhua Li, Wei Pan, Na Li* and Bo Tang*. Catalase-like metal-organic framework nanoparticles to enhance radiotherapy in hypoxic cancer and prevent cancer recurrence. Chem. Sci., 2019, 10, 5773-5778.
45. Mingming Luan, Mingwan Shi, Wei Pan, Na Li* and Bo Tang*. A gold-selenium-bonded nanoprobe for real-time in situ imaging of the upstream and downstream relationship between uPA and MMP-9 in cancer cells. Chem. Commun., 2019, 55, 5817-5820.
44. Xiuyan Wan, Xinhao Zhang, Wei Pan, Bo Liu, Longhai Yu, Honghong Wang, Na Li*, and Bo Tang*. Ratiometric Fluorescent Quantification of the Size-Dependent Cellular Toxicity of Silica Nanoparticles. Anal. Chem., 2019, 91, 6088-6096.
43. Wei Pan, Yegang Ge, Zhengze Yu, Ping Zhou, Bingjie Cui, Na Li* and Bo Tang*. A cancer cell membrane-encapsulated MnO2 nanoreactor for combined photodynamic-starvation therapy. Chem. Commun., 2019, 55, 5115-5118.
42. Limin Yang, Peng Gao, Yuanlei Huang, Xiao Lu, Qian Chang, Wei Pan, Na Li*, Bo Tang. Boosting the photodynamic therapy efficiency with a mitochondria-targeted nanophotosensitizer. Chin. Chem. Lett., 2019, 30, 1293-1296.
41. Yuanyuan Chen, Na Li, Jianbo Wang, Xia Zhang, Wei Pan, Longhai Yu and Bo Tang*. Enhancement of mitochondrial ROS accumulation and radiotherapeutic efficacy using a Gd-doped titania nanosensitizer. Theranostics, 2019, 9, 167-178.
40. Hongyu Wang, Jinjie Chang, Mingwan Shi, Wei Pan, Na Li*, and Bo Tang*. A Dual-Targeted Organic Photothermal Agent for Enhanced Photothermal Therapy. Angew. Chem. Int. Ed., 2019, 131, 1057-1061.
39. Zhengze Yu, Ping Zhou, Wei Pan, Na Li* and Bo Tang*. A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis. Nat. Commun., 2018, 9, 5044.
38. Wei Pan, Mingwan Shi, Yanhua Li, Yuanyuan Chen, Na Li* and Bo Tang. A GSH-responsive nanophotosensitizer for efficient photodynamic therapy. RSC Adv., 2018, 8, 42374-42379.
37. Wei Pan, Shaohua Gong, Yanhua Li, Huiwen Zhang, Na Li* and Bo Tang*. A DR4 capturer with AKT siRNA for synergetic enhancement of death receptor-mediated apoptosis. Chem. Commun., 2018, 54, 13439-13442.
36. Mingming Luan, Jinjie Chang, Wei Pan, Yuanyuan Chen, Na Li*, and Bo Tang*. Simultaneous Fluorescence Visualization of EMT and Apoptosis Processes in Tumor Cells for Evaluating the Impact of EMT on Drug Efficacy. Anal. Chem., 2018, 90, 10951-10957.
35. Wei Pan, Bo Liu, Xiaonan Gao, Zhengze Yu, Xiaohan Liu, Na Li* and Bo Tang*. A graphene-based fluorescence nanoprobe for simultaneous monitoring of miRNA and mRNA in living cells. Nanoscale, 2018, 10, 14264-14271.
34. Na Li, Qiaoqiao Sun, Zhengze Yu, Xiaonan Gao, Wei Pan, Xiuyan Wan, and Bo Tang*. Nuclear-Targeted Photothermal Therapy Prevents Cancer Recurrence with Near-Infrared Triggered Copper Sulfide Nanoparticles. ACS Nano, 2018, 12, 5197-5206.
33. Yanli Li, Xiaonan Gao, Zhengze Yu, Bo Liu, Wei Pan, Na Li*, and Bo Tang*. Reversing Multidrug Resistance by Multiplexed Gene Silencing for Enhanced Breast Cancer Chemotherapy. ACS Appl. Mater. Interfaces, 2018, 10, 15461-15466.
32. Limin Yang, Jia Li, Wei Pan, Hongyu Wang, Na Li* and Bo Tang*. Fluorescence and photoacoustic dual-mode imaging of tumor-related mRNA with a covalent linkage-based DNA nanoprobe. Chem. Commun., 2018, 54, 3656-3659.
31. Zhengze Yu, Bo Liu, Wei Pan, Tingting Zhang, Lili Tong, Na Li* and Bo Tang*. A simple approach for glutathione functionalized persistent luminescence nanoparticles as versatile platforms for multiple in vivo applications. Chem. Commun., 2018, 2018, 54, 3504-3507.
30. Zhengze Yu, Yegang Ge, Qiaoqiao Sun, Wei Pan, Xiuyan Wan, Na Li* and Bo Tang*. A pre-protective strategy for precise tumor targeting and efficient photodynamic therapy with a switchable DNA/upconversion nanocomposite. Chem. Sci., 2018, 2018, 9, 3563-3569.
29. Na Li, Longhai Yu, Jianbo Wang, Xiaonan Gao, Yuanyuan Chen, Wei Pan and Bo Tang*. A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy. Chem. Sci., 2018, 2018, 9, 3159-3164.
28. Limin Yang, Bo Liu, Meimei Wang, Jia Li, Wei Pan, Xiaonan Gao, Na Li*, and Bo Tang*. A Highly Sensitive Strategy for Fluorescence Imaging of MicroRNA in Living Cells and in Vivo Based on Graphene Oxide-Enhanced Signal Molecules Quenching of Molecular Beacon. ACS Appl. Mater. Interfaces, 2018, 10, 6982-6990.
27. Yanhua Li, Yuanyuan Chen, Wei Pan, Zhengze Yu, Limin Yang, Hongyu Wang, Na Li* and Bo Tang*. Nanocarriers with multi-locked DNA valves targeting to intracellular tumor-related mRNAs for controlled drug release. Nanoscale, 2017, 9, 17318-17324.
26. Yuanyuan Chen, Tingting Zhang, Xiaonan Gao, Wei Pan, Na Li*, Bo Tang. A highly selective and instantaneous upconversion fluorescent nanoprobe for ascorbic acid detection in biological samples. Chin. Chem. Lett., 2017, 28, 1983-1986.
25. Mingming Luan, Longhai Yu, Yanhua Li, Wei Pan, Xiaonan Gao, Xiuyan Wan, Na Li*, and Bo Tang*. Visualizing Breast Cancer Cell Proliferation and Invasion for Assessing Drug Efficacy with a Fluorescent Nanoprobe. Anal. Chem., 2017, 89, 10601-10607.
24. Limin Yang, Yuanyuan Chen, Zhengze Yu, Wei Pan, Hongyu Wang, Na Li*, and Bo Tang*. A Dual-Ratiometric Fluorescent Nanoprobe for Visualizing the Dynamic Process of pH and Superoxide Anion Changes in Autophagy and Apoptosis. ACS Appl. Mater. Interfaces, 2017, 9, 27512-27521.
23. Na Li, Meimei Wang, Xiaonan Gao, Zhengze Yu, Wei Pan, Hongyu Wang, and Bo Tang*. A DNA Tetrahedron Nanoprobe with Controlled Distance of Dyes for Multiple Detection in Living Cells and In Vivo. Anal. Chem., 2017, 89, 6670-6677.
22. Limin Yang, Yuanyuan Chen, Wei Pan, Hongyu Wang, Na Li*, and Bo Tang*. Visualizing the Conversion Process of Alcohol-Induced Fatty Liver to Steatohepatitis in Vivo with a Fluorescent Nanoprobe. Anal. Chem., 2017, 89, 6196-6201.
21. Zhengze Yu, Meimei Wang, Wei Pan, Na Li*, Hongyu Wang and Bo Tang*. Tumor microenvironment-triggered fabrication of gold nanomachines for tumor-specific photoacoustic imaging and photothermal therapy. Chem. Sci., 2017, 8, 4896-4903.
20. Na Li, Yanli Li, Xiaonan Gao, Zhengze Yu, Wei Pan and Bo Tang*. Multiplexed gene silencing in living cells and in vivo using a DNAzymes-CoOOH nanocomposite. Chem. Commun., 2017, 53, 4962-4965.
19. Na Li, Huijun Yang, Zhengze Yu, Yanli Li, Wei Pan, Hongyu Wang and Bo Tang*. Nuclear-targeted siRNA delivery for long-term gene silencing. Chem. Sci., 2017, 8, 2816-2822.
18. Yanhua Li, Na Li, Wei Pan, Zhengze Yu, Limin Yang, and Bo Tang*. Hollow Mesoporous Silica Nanoparticles with Tunable Structures for Controlled Drug Delivery. ACS Appl. Mater. Interfaces, 2017, 9, 2123-2129.
17. Mingming Luan, Na Li, Wei Pan, LiminYang, Zhengze Yu and Bo Tang*. Simultaneous detection of multiple targets involved in PI3K/AKT pathway for investigating cellular migration and invasion with a multicolor fluorescence nanoprobe. Chem. Commun., 2017, 53, 356-359.
16. Limin Yang, Yanfei Ren, Wei Pan, ZhengzeYu, Lili Tong, Na Li*, and Bo Tang*. Fluorescent Nanocomposite for Visualizing Cross-Talk between MicroRNA-21 and Hydrogen Peroxide in Ischemia-Reperfusion Injury in Live Cells and In Vivo. Anal. Chem., 2016, 88, 11886-11891.
15. Wei Pan, Honghong Wang, Limin Yang, Zhengze Yu, Na Li*, and Bo Tang*. Ratiometric Fluorescence Nanoprobes for Subcellular pH Imaging with a Single-Wavelength Excitation in LivingCells. Anal. Chem., 2016, 88, 6743-6748.
14. Zhengze Yu,Wei Pan, Na Li* and Bo Tang*. A nuclear targeted dual-photosensitizer for drug-resistant cancer therapy with NIR activated multiple ROS. Chem. Sci., 2016, 7, 4237-4244.
13. Wei Pan, Yanli Li, Meimei Wang, Huijun Yang, Na Li and Bo Tang*. FRET-based nanoprobes for simultaneous monitoring of multiple mRNAs in living cells using single wavelength excitation. Chem. Commun., 2016, 52, 4569-4572.
12. Zhengze Yu, Qiaoqiao Sun, Wei Pan, Na Li*, and Bo Tang*. A Near-Infrared Triggered Nanophotosensitizer Inducing Domino Effect on Mitochondrial Reactive Oxygen Species Burst for Cancer Therapy. ACS Nano, 2015, 9, 11064-11704.
11. Limin Yang, Na Li, Wei Pan, Zhengze Yu, and Bo Tang*. Real-Time Imaging of Mitochondrial Hydrogen Peroxide and pH Fluctuations in Living Cells Using a Fluorescent Nanosensor. Anal. Chem., 2015, 87, 3678-3684.
10. Wei Pan, HuijunYang, Na Li, Limin Yang, and Bo Tang*. Simultaneous Visualization of Multiple mRNAs and Matrix Metalloproteinases in Living Cells Using a Fluorescence Nanoprobe. Chem. Eur. J., 2015, 21, 6070-6073.
Highlighted: ChemistryViews
9. Na Li, Wei Diao,Yaoyao Han, Wei Pan, Tingting Zhang, and Bo Tang*. MnO2-Modified Persistent Luminescence Nanoparticles for Detection and Imaging of Glutathione in Living Cells and In Vivo. Chem. Eur. J., 2014, 20, 16488-16491.
8. Na Li, Huijun Yang, Wei Pan, Wei Diao and Bo Tang*. A tumour mRNA-triggered nanocarrier for multimodal cancer cell imaging and therapy. Chem. Commun., 2014, 50, 7473-7476.
7. Na Li, Yanhua Li, Yaoyao Han, Wei Pan, Tingting Zhang, and Bo Tang*. A Highly Selective and Instantaneous Nanoprobe for Detection and Imaging of Ascorbic Acid in Living Cells and in Vivo. Anal. Chem., 2014, 86, 3924-3930.
6. Zhengze Yu, Na Li, Peipei Zheng, Wei Pan and Bo Tang*. Temperature-responsive DNA-gated nanocarriers for intracellular controlled release. Chem. Commun., 2014, 50, 3494-3497.
5. Na Li, Zhengze Yu, Wei Pan, Yaoyao Han, Tingting Zhang, and Bo Tang*. A Near-Infrared Light-Triggered Nanocarrier with Reversible DNA Valves for Intracellular Controlled Release. Adv. Funct. Mater., 2013, 23, 2255-2262.
4. Wei Pan, Tingting Zhang, Huijun Yang, Wei Diao, Na Li*, and Bo Tang*. Multiplexed Detection and Imaging of Intracellular mRNAs Using a Four-Color Nanoprobe. Anal. Chem., 2013, 85, 10581-10588.
Highlighted: Chemical& Engineering News [link]
3. Wei Pan, Huijun Yang, Tingting Zhang, Yanhua Li, Na Li*, and Bo Tang*. Dual-Targeted Nanocarrier Based on Cell Surface Receptor and Intracellular mRNA: An Effective Strategy for Cancer Cell Imaging and Therapy. Anal. Chem., 2013, 85, 6930-6935.
2. Na Li, Chenyang Chang, Wei Pan, and Bo Tang*. A Multicolor Nanoprobe for Detection and Imaging of Tumor-Related mRNAs in Living Cells. Angew. Chem. Int. Ed., 2012, 51, 7426-7430.
1. Shiguo Wang, Na Li, Wei Pan, Bo Tang*. Advances in functional fluorescent and luminescent probes for imaging intracellular small-molecule reactive species. TrAC-Trend Anal. Chem., 2012, 39, 3-37.