学 历
博士

职 称
教授

所属部门
生物化学与分子生物学系

招生专业
生物化学与分子生物学（博士、硕士）

联系方式
电话: E-mail: xqguo@sdau.edu.cn

个人简介

郭兴启，男，1963年10月生，山东嘉祥人。博士，教授，博士生导师。2005年5月至2019年3月任生命科学学院教学副院长。山东省优秀教师，山东省教学名师，山东省优秀研究生指导教师，生物化学与分子生物学国家级教学团队负责人，生物技术国家级特色专业主任，生物技术与工程省级实验教学示范中心主任，山东省现代农业产业技术体系蜂产业创新团队岗位专家，山东省生物化学与分子生物学学会副理事长。曾获山东省教学成果特等奖1项（第二位）、二等奖1项（首位）、三等奖1项（首位）。主编出版国家级规划教材2部（中国农业出版社）、教学研究专著1部（高等教育出版社）、科学研究专著1部（科学出版社）。主持国家自然科学基金、国家转基因植物研究专项、农业部现代农业产业技术体系建设专项、山东省现代农业产业技术体系建设专项等多项科研课题。获得国家发明专利6项，以通讯作者在《Plant Biotechnology Journal》、《Free Radical Biology and Medicine》等学术刊物上发表论文多篇。

教学工作

承担本科生《分子生物学》、《基础生物化学实验》；硕士研究生《分子生物学》、《高级生物化学实验技术》；博士研究生《植物逆境信号转导与基因工程》等课程的教学工作。

研究方向

1. 棉花抗病抗逆分子生物学
2. 中华蜜蜂抗病抗逆分子生物学

科研项目

1. 国家自然科学基金《棉花GhMKK6平衡植株免疫反应和生长发育的分子机制》（No. **）
2. 国家自然科学基金《棉花激酶GhMKK6基因的功能分析及其级联信号途经的鉴定》（No. **）
3. 国家自然科学基金《棉花GhMPK7基因广谱抗病功能的分子机理研究》（No. **）
4. 国家自然科学基金《温度对RNA沉默的抑制及其分子机理研究》（No. **）
5. 国家自然科学基金《RNA介导抗性转基因植物的抗病机制及遗传规律》（No. **）
6. 山东省现代农业产业技术体系蜂产业创新团队建设专项（No. SDAIT-24-04）
7. 山东省自然科学基金《DnaJ基因调控中华蜜蜂热激胁迫响应的分子机制》
8. 山东省中青年科学家科研奖励基金《抗病毒转基因植物释放的环境风险性研究》（No. 02BS025）
9. 国家转基因植物研究重大专项《棉花高产性状激素调控基因的克隆和克隆新方法的研究》子课题（No. 2009ZX08009-113B）
10. 农业部现代农业产业技术体系建设专项《现代农业蜂产业技术体系建设》子课题（No. NYCYTX-43）


发表论文

1. Chen Wang, Hongbin Guo, Xiaowen He, Shuxin Zhang, Jiayu Wang, Lijun Wang, Dezheng Guo, Xingqi Guo*. Scaffold protein GhMORG1 enhances the resistance of cotton to Fusarium oxysporum by facilitating the MKK6-MPK4 cascade, Plant Biotechnol J., 2019, Doi: 10.1111/pbi.13307.
2. Guilin Li, Hang Zhao, Zhenguo Liu, Hongfang Wang, Baohua Xu*, Xingqi Guo*. The wisdom of honeybee defenses against environmental stresses, Frontiers in Microbiology, 2018, 9: 722.
3. Guilin Li, Hang Zhao, Lijun Wang, Ying Wang, Xingqi Guo*, Baohua Xu*. The animal nuclear factor Y: an enigmatic and important heterotrimeric transcription factor, American Journal of Cancer Research, 2018; 8(7): 1106-1125.
4. Guilin Li, Hang Zhao, Xuemei Zhang, Yanming Zhang, Huayu Zhao, Xinxin Yang, Xingqi Guo*, Baohua Xu*. Environmental Stress Responses of DnaJA1, DnaJB12 and DnaJC8 in Apis cerana cerana, Frontiers in Genetics, 2018, 9: 445.
5. Chen Wang, Xiaowen He, Yuzhen Li, Lijun Wang, Xulei Guo, Xingqi Guo*. The cotton MAPK kinase GhMPK20 negatively regulates resistance to Fusarium oxysporum by mediating the MKK4-MPK20-WRKY40 cascade, Molecular Plant Pathology, 2018, 19(7): 1624-1638.
6. Chen Wang, Xiaowen He, Xinxin Wang, Shuxin Zhang, Xingqi Guo*. ghr-miR5272a-mediated regulation of GhMKK6 gene transcription contributes to the immune response in cotton, Journal of Experimental Botany, 2017, 68(21-22): 5895-5906.
7. Chen Wang, Wenjing Lu, Xiaowen He, Fang Wang, Yuli Zhou, Xulei Guo, Xingqi Guo*. The cotton Mitogen-Activated Protein Kinase Kinase 3 functions in drought tolerance by regulating stomatal responses and root growth. Plant and Cell Physiology, 2016, 57(8): 1629-1642.
8. Fang Wang, Chen Wang, Yan Yan, Haihong Jia, Xingqi Guo*. Overexpression of cotton GhMPK11 decreases disease resistance through the gibberellin signaling pathway in transgenic Nicotiana benthamiana. Frontiers in Plant Science, 2016, 7: 689.
9. Haihong Jia, Lili Hao, Xulei Guo, Shuchang Liu, Yan Yan, Xingqi Guo*. A Raf-like MAPKKK Gene, GhRaf19, negatively regulates tolerance to drought and salt and positively regulates resistance to cold stress by modulating Reactive Oxygen Species in cotton. Plant Science, 2016, 252: 267-281.
10. Yan Yan, Haihong Jia, Fang Wang, Chen Wang, Shuchang Liu, Xingqi Guo*. Overexpression of GhWRKY27a reduces tolerance to drought stress and resistance to Rhizoctonia solani infection in transgenic Nicotiana benthamiana. Frontiers in Physiology, 2015, 6: 265.
11. Xiaobo Chen, Ji Wang, Ming Zhu, Hailong An, Dongdong Liu, Lili Hao, Xingqi Guo*. A cotton Raf-like MAP3K gene, GhMAP3K40, mediates reduced tolerance to biotic and abiotic stress in Nicotiana benthamiana by negatively regulating growth and development. Plant Science, 2015, 240: 10-24.
12. Yifeng Huaxia, Fang Wang, Yan Yan, Feng Liu, Hongfang Wang, Xingqi Guo*, Baohua Xu*. A novel 1-Cys thioredoxin peroxidase gene in Apis cerana cerana: characterization of AccTpx4 and its role in oxidative stresses. Cell Stress & Chaperones, 2015, 20(4): 663-672.
13. Xiaobo Chen, Pengbo Yao, Xiaoqian Chu, Lili Hao, Xingqi Guo*, Baohua Xu*. Isolation of arginine kinase from Apis cerana cerana and its possible involvement in response to adverse stress. Cell Stress & Chaperones, 2015, 20(1): 169-183.
14. Yuzhen Li, Liang Zhang, Wenjing Lu, Xiuling Wang, Changai Wu, Xingqi Guo*. Overexpression of cotton GhMKK4 enhances disease susceptibility and affects abscisic acid, gibberellin and hydrogen peroxide signalling in transgenic Nicotiana benthamiana. Molecular Plant Pathology, 2014, 15(1): 94-108.
15. Pengbo Yao, Xiaobo Chen, Yan Yan, Feng Liu, Yuanying Zhang, Xingqi Guo*, Baohua Xu*. Glutaredoxin, glutaredoxin 2, thioredoxin 1 and thioredoxin peroxidase 3 play important roles in antioxidant defense in Apis cerana cerana. Free Radical Biology and Medicine, 2014, 68: 335-346.
16. Huiru Yan, Haihong Jia, Xiaobo Chen, Lili Hao, Hailong An, Xingqi Guo*. The cotton WRKY transcription factor GhWRKY17 functions in drought and salt stress in transgenic Nicotiana benthamiana through ABA signaling and the modulation of reactive oxygen species production. Plant and Cell Physiology, 2014, 55(12): 2060-2076.
17. Yuzhen Li, Liang Zhang, Xiuling Wang, Wei Zhang, Lili Hao, Xiaoqian Chu, Xingqi Guo*. Cotton GhMPK6a negatively regulates osmotic tolerance and bacterial infection in transgenic Nicotiana benthamiana, and plays a pivotal role in development. FEBS Journal, 2013, 280: 5128-5144.
18. Yuanying Zhang, Huiru Yan, Wenjing Lu, Yuzhen Li, Xingqi Guo*, Baohua Xu*. A novel Omega-class glutathione S-transferase gene in Apis cerana cerana: molecular characterisation of GSTO2 and its protective effects in oxidative stress. Cell Stress & Chaperones, 2013, 18(4): 503-516.
19. Huiru Yan, Haihong Jia, Hongru Gao, Xingqi Guo*, Baohua Xu*. Identification, genomic organization, and oxidative stress response of a sigma class glutathione S-transferase gene (AccGSTS1) in the honey bee, Apis cerana cerana. Cell Stress & Chaperones, 2013, 18(4): 415-426.
20. Pengbo Yao, Wenjing Lu, Fei Meng, Xiuling Wang, Baohua Xu*, Xingqi Guo*. Molecular cloning, expression and oxidative stress response of a mitochondrial thioredoxin peroxidase gene (AccTpx-3) from Apis cerana cerana. Journal of Insect Physiology, 2013, 59(3): 273-282.
21. Liang Zhang, Yuzhen Li, Wenjing Lu, Fei Meng, Changai Wu, Xingqi Guo*. Cotton GhMKK5 affects disease resistance, induces HR-like cell death, and reduces the tolerance to salt and drought stress in transgenic Nicotiana benthamiana. Journal of Experimental Botany, 2012, 63(10): 3935-3952.
22. Feifei Yu, Yifeng Huaxia, Wenjing Lu, Changai Wu, Xuecheng Cao, Xingqi Guo*. GhWRKY15, a member of the WRKY transcription factor family identified from cotton (Gossypium hirsutum L.), is involved in disease resistance and plant development. BMC Plant Biology, 2012, 12(1): 144.
23. Huiru Yan, Fei Meng, Haihong Jia, Xingqi Guo*, Baohua Xu*. The identification and oxidative stress response of a zeta class glutathione S-transferase (GSTZ1) gene from Apis cerana cerana. Journal of Insect Physilology, 2012, 58(6): 782-791.
24. Liang Zhang, Dongmei Xi, Lu Luo, Fei Meng, Yuzhen Li, Changai Wu, Xingqi Guo*. Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress. FEBS Journal, 2011, 278(8): 1367-1378.
25. Liang Zhang, Dongmei Xi, Shanwei Li, Zheng Gao, Shuoli Zhao, Jing Shi, Changai Wu, Xingqi Guo*. A cotton group C MAP kinase gene, GhMPK2, positively regulates salt and drought tolerance in tobacco. Plant Molecular Biology, 2011, 77: 17-31.
26. Feifei Yu, Mingjiang Kang, Fei Meng, Xingqi Guo*, Baohua Xu*. Molecular cloning and characterization of a thioredoxin peroxidase gene from Apis cerana cerana. Insect Molecular Biology, 2011, 20(3): 367-378.
27. Jing Shi, Hailong An, Liang Zhang, Zheng Gao, Xingqi Guo*. GhMPK7, a novel multiple stress-responsive cotton group C MAPK gene, has a role in broad spectrum disease resistance and plant development. Plant Molecular Biology, 2010, 74: 1-17.