学历
博士

职称
教授

所属部门
生物化学与分子生物学系

招生专业
生物化学与分子生物学（硕士、博士）

联系方式
电话: E-mail: cawu@sdau.edu.cn

个人简介

吴长艾，女，山东巨野人。2004年获得山东农业大学理学博士学位，至今在山东农业大学生命科学学院工作。生物化学与分子生物学国家级教学团队成员。承担本科生《生物化学A》、《基础生物化学B》和《基因工程》；研究生《基因工程原理和技术》等课程的教学工作。“泰山****”特聘岗位学术骨干。主要从事重要经济作物棉花及模式植物拟南芥耐盐、抗旱等重要基因的克隆、鉴定，探讨其调控机制及在作物遗传改良上的应用价值。近年来，承担了转基因生物新品种培育科技重大专项、国家自然科学基金和山东省自然基金等课题6项，参加2项。获国家发明专利4项。在《Plant and cell Physiology》、《RNA》、《FEBS Journal》、《Plant Science》和《作物学报》等国内外著名学术刊物上发表研究论文30余篇。

教学工作

承担本科生《基础生物化学》，《基础生物化学实验》；研究生《基因工程原理与技术》、《基因表达调控》等课程的教学工作。

研究方向

1. 棉花和拟南芥盐碱、干旱等非生物逆境响应基因的分离、鉴定及分子调控
2. 棉花和拟南芥盐碱、干旱等非生物逆境响应的脱落酸、茉莉酸等激素调控

科研项目

1. 转基因生物新品种培育科技重大专项《棉花抗旱、耐盐和低温重要新基因的克隆和功能验证》2009-2012，主持
2. 国家自然科学基金《棉花盐诱导的4个海藻糖6-磷酸合酶和6个LEA基因的生理功能及其应用研究》2011-2013，主持
3. 国家自然科学基金《五个拟南芥盐和干旱诱导的miRNAs的功能鉴定及调控途径研究》2010-2012，主持
4. 国家自然科学基金《水稻干旱、盐胁迫相关microRNAs的分离和表达调控分析》2006-2008，主持
5. 教育部“****创新团队发展计划”《作物高产优质的生理与分子基础》2007-2009，子课题主持
6. 山东省自然科学基金《“棉花新型转录调节因子GhPLATZ1的功能和作用机理研究》，2015-2017，主持
7. 山东农业大学博士基金《棉花Na+/H+逆向运转体基因的耐盐机理及其转基因耐盐棉花新种质的创造》2005-2007，主持
8. 国家自然科学基金《棉花GhSAG基因的功能分析和分子机理研究》，2015-2018，第二位
9. 973前期《玉米高温干旱抗性关键microRNA基因的分离及功能鉴定》，2014-2016，第二位

个人荣誉

1. 2012年获得山东农业大学“青年岗位能手”荣誉称号
2. 2011年获得山东农业大学“巾帼建功先进个人”荣誉称号
3. 2009年获得山东农业大学优秀学士学位论文（指导教师）
4. 2004年获得山东省优秀博士毕业生花金属硫蛋白基因

研究专利

1. 棉花Na+/H+反向转运蛋白基因及其应用，专利号：ZL**.1
2. 棉花金属硫蛋白基因GhMT1序列及其克隆与应用，专利号：ZL1.X
3. 一种棉花促分裂原蛋白激酶基因GhMAPK6及其应用，专利号：ZL3.X
4. 一种可提高转基因作物细菌抗性的基因GhMKK5及其应用，ZL3.X




发表论文

1. Caili Wang, Shicai Zhang, Shengdong Qi, Chengchao Zheng, Changai Wu* (2015) Delayed germination of Arabidopsis seeds under chilling stress by overexpressing an abiotic stress inducible GhTPS11. GENE, doi: 10.1016/j.gene.2015.08.056.
2. Rui Xu, Yuhan Wang, Hao Zheng, Wei Lu, Changai Wu, Jinguang Huang, Kang Yan, Guodong Yang and Chengchao Zheng. (2015) Salt-induced transcription factor MYB74 is regulated by the RNA-directed DNA methylation pathway in Arabidopsis. Journal of Experimental Botany, 66(19): 5997-6008.
3. Fengjuan Jia, Chunyan Wang, Jinguang Huang, Guodong Yang, Changai Wu and Chengchao Zheng. (2015) SCF E3 ligase PP2-B11 plays a positive role in response to salt stress in Arabidopsis. Journal of Experimental Botany, 66(15): 4683–4697.
4. Changtian Chen, Changai Wu1, Jiaming Miao, Yunxue Lei, Dongxiao Zhao, Dan Sun, Guodong Yang, Jinguang Huang and Chengchao Zheng. (2014) Arabidopsis SAG protein containing the MDN1 domain participates in seed germination and seedling development by negatively regulating ABI3 and ABI5. Journal of Experimental Botany, 65(1): 35-45.
5. Nana Ma, Hailong Feng, Xia Meng, Dong Li, Dongyue Yang, Changai Wu*, Qingwei Meng*. (2014) Overexpression of tomato SlNAC1 transcription factor alters fruit pigmentation and softening. BMC Plant Biology, 14:351.
6. Yunxue Lei, Yaru Fu, Changtian Chen, Jinguang Huang, Changai Wu*. (2014) Overexpression of Arabidopsis wali7 domain-containing protein ASR produces auxin-mediated short-root phenotype. Journal of Plant Growth Regulation, 33:355-363.
7. Yanjie Li, Yi Fang, Yaru Fu, Jinguang Huang, Changai Wu*, Chengchao Zheng*. (2013) NFYA1 is involved in regulation of postgermination growth arrest under salt stress in Arabidopsis. PLoS One, 8(4): e61289.
8. Peng Liu, Kang Yan, YunXue Lei, Rui Xu, YueMin Zhang, Guodong Yang, Jinguang Huang, Changai Wu*, Chengchao Zheng*. (2013) Transcript profiling of microRNAs during the early development of the maize brace root via Solexa sequencing. Genomics, 101: 149-156.
9. Kang Yan, Peng Liu, Chang-Ai Wu, Guo-Dong Yang, Rui Xu, Qian-Huan Guo, Jin-Guang Huang, and Cheng-Chao Zheng. (2012) Stress-Induced Alternative Splicing Provides a Mechanism for the Regulation of MicroRNA Processing in Arabidopsis thaliana. Molecular Cell, 48: 521-531.
10. Wei Lu, Xiaoli Tang, Yanqing Huo, Rui Xu, Shengdong Qi, Jingguang Huang, Chengchao Zheng, Changai Wu*. (2012) Identi?cation and characterization of fructose 1,6-bisphosphate aldolase genes in Arabidopsis reveals a gene family with diverse responses to abiotic stresses. Gene, 503: 65-74.
11. Gang Wang, Qingguo Zhu, Qingwei Meng, Changai Wu*. (2012) Transcript pro?ling during salt stress of young cotton (Gossypium hirsutum) seedlings via Solexa sequencing. Acta Physiologiae Plantarum, 34:107-115.
12. Yanjie Li, Yaru Fu, Jingguang Huang, Changai Wu*, Chengchao Zheng*. (2011) Transcript profiling during the early development of the maize brace root via Solexa sequencing. The FEBS Journal, 278: 156-166.
13. Ruirui Xu, Shengdong Qi, Longtao Lu, Changtian Chen, Changai Wu*, Chengchao Zheng*. (2011) A DExD/H box RNA helicase is important for potassium deprivation responses and tolerance in Arabidopsis thaliana. The FEBS Journal, 278(13): 2293-2306.
14. Jing Shi, Liang Zhang, Hailong An, Changai Wu*, Xingqing Guo*. (2011) GhMPK16, a novel stress-responsive group D MAPK gene from cotton, is involved in disease resistance and drought sensitivity. BMC Molecular Biology, 12:22.
15. Yanjie Li, Yaru Fu, Lusha Ji, Changai Wu*, Chengchao Zheng*. (2010). Characterization and expression analysis of the Arabidopsis mir169 family. Plant Science, 178: 271-280.
16. Pei Liu, Guodong Yang, Hong Li, Changai Wu*. (2010) Overexpression of NHX1s in transgenic Arabidopsis enhances photoprotection capacity in high salinity and drought conditions. Acta Physiologiae Plantarum, 32: 81-90.
17. Hanhua Liu, Xin Tian, Yanjie Li, Changai Wu*, Chengchao Zheng*. (2008) Microarray-based Analysis of Stress-regulated microRNAs in Arabidopsis thaliana. RNA, 14: 836-843.
18. Changai Wu, Guodong Yang, Qingwei Meng, Chengchao Zheng. (2004) The cotton GhNHX1 gene encoding a novel putative tonoplast Na+/H+ antiporter plays an important role in salt stress. Plant & Cell Physiology, 45: 600-607.