姓名 郭兴启学历博士职称教授
所属部门生物化学与分子生物学系
招生专业生物化学与分子生物学（博士、硕士）
联系方式电话：** E-mail:xqguo@sdau.edu.cn

　
　　
::教师简介::
郭兴启，男，1963年10月生，山东嘉祥人。博士，教授，博士生导师。现任山东农业大学生命科学学院副院长，山东省生物化学与分子生物学学会常务理事。近年来主持承担了国家自然科学基金、国家转基因植物研究专项、中国博士后科学基金、山东省中青年科学家科研奖励基金等多项课题。在棉花和蜜蜂重要抗病抗逆基因的分离与功能分析、植物抗病基因工程等方面，均获得了许多拥有我国自主知识产权的研究成果，获得国家发明专利6项。曾获山东省科技进步二等奖、三等奖各1项；获山东农业大学教学成果一等奖3项、山东省教学成果二等奖、三等奖各1项。在《植物病理学报》、《中国科学》、《Journal of Experimental Botany》、《Plant Molecular Biology》、《FEBS Journal》、《BMC Plant Biology》等国内外著名学术刊物上发表论文60余篇。曾为《Gene》、《Plant Biology》、《Journal of Insect Physiology》、《New Phytologist》等国际学术刊物审稿多篇。

　　
::教学工作::
承担本科生《分子生物学》、《基础生物化学实验》；硕士研究生《分子生物学》、《高级生物化学实验技术》；博士研究生《植物逆境信号转导与基因工程》等课程的教学工作。另外，兼任生物技术国家级特色专业建设项目负责人、生物化学与分子生物学系列课程国家级教学团队建设项目主持工作、生物技术与工程省级实验教学示范中心主任，以及高等教育出版社主办的《高校生物学教学研究》期刊常务编委等。

　　
::研究方向::
1. 棉花抗病抗逆分子生物学

2. 中华蜜蜂抗病抗逆分子生物学

　　
::科研项目::
1. 国家自然科学基金《棉花激酶GhMKK6基因的功能分析及其级联信号途经的鉴定》（No. **）

2. 国家自然科学基金《棉花GhMPK7基因广谱抗病功能的分子机理研究》（No. **）

3. 国家自然科学基金《温度对RNA沉默的抑制及其分子机理研究》（No. **）

4. 国家自然科学基金《RNA介导抗性转基因植物的抗病机制及遗传规律》（No. **）

5. 中国博士后科学基金《转基因植物中RNA介导抗性的遗传学》（No. **）

6. 山东省中青年科学家科研奖励基金《抗病毒转基因植物释放的环境风险性研究》（No. 02BS025）

7. 国家转基因植物研究重大专项《棉花高产性状激素调控基因的克隆和克隆新方法的研究》子课题（No. 2009ZX08009-113B）

8. 农业部现代农业产业技术体系建设专项《现代农业蜂产业技术体系建设》子课题（No. NYCYTX-43）

　　
::学术论文::
Huiru Yan, Haihong Jia, Xiaobo Chen, Lili Hao, Hailong An, Xingqi Guo^*. The cotton WRKY transcription factor GhWRKY17 functions in drought and salt stress in transgenic Nicotiana benthamiana through ABA signaling and the modulation of reactive oxygen species production. Plant & Cell Physiology, 2014, online, doi: 10.1093/pcp/pcu133.Yan Yan, Yuanying Zhang, Yifeng Huaxia, XiulingWang, Pengbo Yao, Xingqi Guo^*, Baohua Xu. Identification and characterisation of a novel 1-Cys thioredoxin peroxidase gene (AccTpx5) from Apis cerana cerana. Comparative Biochemistry and Physiology, Part B, 2014, 172-173: 39-48.Weina Shi, Lili Hao, Jing Li, Dongdong Liu, Xingqi Guo^*, Han Li. The Gossypium hirsutum WRKY gene GhWRKY39-1 promotes pathogen infection defense responses and mediates salt stress tolerance in transgenic Nicotiana benthamiana. Plant Cell Report, 2014, 33(3): 483-498.Xiuling Wang, Yan Yan, Yuzhen Li, Xiaoqian Chu, Changai Wu, Xingqi Guo^*. GhWRKY40, a multiple stress-responsive cotton WRKY gene, plays an important role in the wounding response and enhances susceptibility to ralstonia solanacearum infection in transgenic Nicotiana benthamiana. PLoS ONE, 2014, 9(4): e93577.Yuzhen Li, Liang Zhang, Wenjing Lu, Xiuling Wang, Changai Wu,Xingqi Guo^*. Overexpression of Cotton GhMKK4 enhances disease susceptibility and affects abscisic acid, gibberellin and hydrogen peroxide signalling in transgenic Nicotiana benthamiana. Molecular Plant Pathology, 2014, 15(1): 94-108.Pengbo Yao, Xiaobo Chen, Yan Yan, Feng Liu, Yuanying Zhang, Xingqi Guo^*, Baohua Xu. Glutaredoxin, glutaredoxin 2, thioredoxin 1 and thioredoxin peroxidase 3 play important roles in antioxidant defense in Apis cerana cerana. Free Radical Biology and Medicine, 2014, 68: 335-346. Yuzhen Li, Liang Zhang, Xiuling Wang, Wei Zhang, Lili Hao, Xiaoqian Chu, Xingqi Guo^*. Cotton GhMPK6a negatively regulates osmotic tolerance and bacterial infection in transgenic Nicotiana benthamiana, and plays a pivotal role in development. The FEBS Journal, 2013, 280: 5128-5144.Wenjing Lu, Xiaoqian Chu, Yuzhen Li, Chen Wang, Xingqi Guo^*. Cotton GhMKK1 induces the tolerance of salt and drought stress, and mediates defence responses to pathogen infection in transgenic Nicotiana benthamiana. PLoS ONE, 2013, 8(7): e68503.Pengbo Yao, Lili Hao, Fang Wang, Xiaobo Chen, Yan Yan, Xingqi Guo^*, Baohua Xu. Molecular cloning, expression and antioxidant characterisation of a typical thioredoxin gene (AccTrx2) in Apis cerana cerana. Gene, 2013, 527(1): 33-41. Pengbo Yao, Wenjing Lu, Fei Meng, Xiuling Wang, Baohua Xu, Xingqi Guo^*. Molecular cloning, expression and oxidative stress response of a mitochondrial thioredoxin peroxidase gene (AccTpx-3) from Apis cerana cerana. Journal of Insect Physiology, 2013, 59(3): 273-282.Huiru Yan, Haihong Jia, Xiuling Wang, Hongru Gao, Xingqi Guo^*, Baohua Xu. Identification and characterization of an Apisceranacerana Delta class glutathione S-transferase gene (AccGSTD) in response to thermal stress. Naturwissenschaften, 2013, 100(2): 153-163. Yuanying Zhang, Huiru Yan, Wenjing Lu, Yuzhen Li, Xingqi Guo^*, Baohua Xu. A novel Omega-class glutathione S-transferase gene in Apis cerana cerana: molecular characterisation of GSTO2 and its protective effects in oxidative stress. Cell Stress and Chaperones, 2013, 18(4): 503-516. Huiru Yan, Haihong Jia, Hongru Gao, Xingqi Guo^*, Baohua Xu. Identification, genomic organization, and oxidative stress response of a sigma class glutathione S-transferase gene (AccGSTS1) in the honey bee, Apis cerana cerana. Cell Stress and Chaperones, 2013, 18(4): 415-426. Liang Zhang, Yuzhen Li , Wenjing Lu, Fei Meng, Changai Wu, Xingqi Guo^*. Cotton GhMKK5 affects disease resistance, induces HR-like cell death, and reduces the tolerance to salt and drought stress in transgenic Nicotiana benthamiana. Journal of Experimental Botany, 2012, 63(10): 3935-3952.Feifei Yu, Yifeng Huaxia, Wenjing Lu, Changai Wu, Xuecheng Cao, Xingqi Guo^*. GhWRKY15, a member of the WRKY transcription factor family identified from cotton (Gossypium hirsutum L.), is involved in disease resistance and plant development. BMC Plant Biology, 2012, 12(1): 144.Wang Mian, Li Shanwei, Yang Haifang, Gao Zheng, Wu Changai, Xingqi Guo^*. Characterization and functional analysis of GhRDR6, a novel RDR6 gene from cotton (Gossypium hirsutum L.). Bioscience Reports, 2012, 22: 139-151.Huiru Yan, Fei Meng, Haihong Jia, Xingqi Guo^*, Baohua Xu. The identification and oxidative stress response of a zeta class glutathione S-transferase (GSTZ1) gene from Apis cerana cerana. Journal of Insect Physilology, 2012, 58(6): 782-791.Fei Meng, Wenjing Lu, Feifei Yu, Minjiang Kang, Xingqi Guo^*, Baohua Xu. Ribosomal protein L11 is related to brain maturation during the adult phase in Apis cerana cerana (Hymenoptera, Apidae). Naturwissenschaften, 2012, 99(2): 343-352. Xiaoli Yu, Wenjing Lu, Rujiang Sun, Xingqi Guo^*, Baohua Xu. Identification and characterization of a novel calcyclin binding protein (CacyBP) gene from Apis cerana cerana. Molecular Biology Reports, 2012, 39(8): 8053-8063. Liang Zhang, Dongmei Xi, Shanwei Li, Zheng Gao, SL Zhao, Jing Shi, Changai Wu, Xingqi Guo^*. A cotton group C MAP kinase gene, GhMPK2, positively regulates salt and drought tolerance in tobacco. Plant Molecular Biology, 2011, 77: 17-31.Jing Shi, Liang Zhang, Hailong An, Changai Wu, Xingqi Guo^*. GhMPK16, a novel stress-responsive group D MAPK gene from cotton, is involved in disease resistance and drought sensitivity. BMC Molecular Biology, 2011, 12: 22Liang Zhang, Dongmei Xi, Lu Luo, Fei Meng, Yuzhen Li, Changai Wu, Xingqi Guo^*. Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress. The FEBS Journal, 2011, 278(8): 1367-1378. Xiaoli Yu, Mian Wang, Minjiang Kang, Li Liu, Xingqi Guo^*, Baohua Xu. Molecular cloning and characterization of two nicotinic acetylcholine receptor β subunit genes from Apis cerana cerana. Archives of Insect Biochemistry and Physiology, 2011, 77(4): 163-178.Feifei Yu, Mingjiang Kang, Fei Meng, Xingqi Guo^*, Baohua Xu. Molecular cloning and characterization of a thioredoxin peroxidase gene from Apis cerana cerana. Insect Molecular Biology, 2011, 20(3): 367-378.Fei Meng, Mingjiang Kang, Li Liu, Lu Luo, Baohua Xu, Xingqi Guo^*. Characterization of the TAK1 gene in Apis cerana cerana (AccTAK1) and its involvement in the regulation of tissue-specific development. BMB reports, 2011, 44(3): 187-192. Haifang Yang, Mian Wang, Zheng Gao, Changxiang Zhu, Xingqi Guo^*. Isolation of a novel RNA-dependent RNA polymerase 6 from Nicotiana glutinosa, NgRDR6, and analysis of its response to biotic and abiotic stresses. Molecular Biology Reports, 2011, 38: 929-937. Ruoyu Guo, Feifei Yu, Zheng Gao, Hailong An, Xuecheng Cao, Xingqi Guo^*. GhWRKY3, a novel cotton (Gossypium hirsutum L.) WRKY gene, is involved in diverse stress responses. Molecular Biology Reports, 2011, 38: 49-58. Taobo Ai, Liang Zhang, Zheng Gao, Changxiang Zhu, Xingqi Guo^*. Highly efficient virus resistance mediated by artificial microRNAs that target the suppressor of PVX and PVY in plants. Plant Biology, 2011, 13: 304-316. Jing Shi, Hailong An, Liang Zhang, Zheng Gao, Xingqi Guo^*. GhMPK7, a novel multiple stress-responsive cotton group C MAPK gene, has a role in broad spectrum disease resistance and plant development. Plant Molecular Biology, 2010, 74: 1-17.Fei Meng, Liang Zhang, Mingjiang Kang, Xingqi Guo^*, Baohua Xu. Molecular characterization immunohistochemical localization and expression of a ribosomal protein L17 gene from Apis cerana cerana. Archives of Insect Biochemistry and Physiology, 2010, 75(2): 121-138. Wang Mian, Kang Mingjiang, Xingqi Guo^*, Baohua Xu. Identification and characterization of two phospholipid hydroperoxide glutathione peroxidase gene from Apis cerana cerana. Comparative Biochemistry and Physiology, Part C, 2010, 152: 75-83. Ying Zhang, Jing Shi, Yan Liu, Yi Zhang, Jiedao Zhang, Xingqi Guo^*. Identification of a novel NPR1-like gene from Nicotiana glutinosa and its role in resistance to fungal, bacterial and viral pathogens. Plant Biology, 2010, 12: 23-34. Yan Liu, Qiouqiang Gao, B Wu, Taobo Ai, Xingqi Guo^*. NgRDR1, an RNA-dependent RNA polymerase isolated from Nicotiana glutinosa, was involved in biotic and abiotic stresses. Plant Physiology and Biochemistry, 2009, 47(5): 359-368. Yi Zhang, Dongmei Xi, Jian Wang, D Zhu, Xingqi Guo^*. Functional analysis reveals effects of tobacco alternative oxidase gene (NtAOX1a) on regulation of defence responses against abiotic and biotic stress. Bioscience Reports, 2009, 29(6): 375-383. Qiouqiang Gao, Yan Liu, Meimei Wang, Jiedao Zhang, Yingqi Gai, Changxiang Zhu, Xingqi Guo^*. Molecular cloning and characterization of an inducible RNA- dependent RNA polymerase gene, GhRdRP, from cotton (Gossypium hirsutum L.). Molecular Biology Reports, 2009, 36(1): 47-56. Fang Li, Yi Zhang, Meimei Wang, Ying Zhang, Xiaoliang Wu, Xingqi Guo^*. Molecular cloning and expression characteristics of alternative oxidase gene of cotton (Gossypium hirsutum). Molecular Biology Reports, 2008, 35: 97-105. Xiaoliang Wu, Wencui Hou, Meimei Wang, Fang Li, Jiedao Zhang, Xingqi Guo^*. RNA silencing-mediated resistance is related to biotic/abiotic stresses and cellular RdRP expression in transgenic tobacco plants. BMB Reports, 2008, 41(5): 376-381. Jian Wang, Xia Wang, Cheng Liu, Jiedao Zhang, Changxiang Zhu, Xingqi Guo^*. The NgAOX1a gene cloned from Nicotiana glutinosa is implicated in response to abiotic and biotic stresses. Bioscience Reports, 2008, 28(5): 259-266. Ying Zhang, Xia Wang, Cheng Cheng, Qiuqiang Gao, Jingyun Liu, Xingqi Guo^*. Molecular cloning and characterization of GhNPR1, a gene implicated in pathogen responses from cotton (Gossypium hirsutum L.). Bioscience Reports, 2008, 28(1): 7-14. Meimei Wang, Yi Zhang, Jian Wang, Xiaoliang Wu, Xingqi Guo^*. A novel cotton (Gossypium hirsutum L.) MAP kinase gene, GhMAPK1, involved in encountering diverse environmental stresses. Journal of Biochemistry and Molecular Biology, 2007, 3: 325-332. Xia Wang, Yi Zhang, Jiedao Zhang, Cheng Cheng, Xingqi Guo^*. Molecular characterization of a transient expression gene encoding 1-aminocyclopropane -1-carboxylate synthase in cotton (Gossypium hirsutum L.). Journal of Biochemistry and Molecular Biology, 2007, 5: 791-800.