报 告 人：Prof. David B. Berkowitz
报告人单位：University of Nebraska Lincoln
报告时间：2016年12月22日（星期四）上午9:30–10:30
报告地点：能源楼216会议室
主持人：王庆刚研究员
报告摘要：
This talk will trace the evolution of a technique that has been dubbed In Situ Enzymatic Screening (ISES) wherein enzymes act as analytical tools/realtime sensors to assist synthetic chemists in the discovery of new catalytic reaction manifolds of interest and in the identification of useful chiral ligand families. For reactions for which this screening strategy is well suited, one obtains real time information on relative rates and/or enantioselectivity for an array of catalysts being screened in parallel, without the need to draw aliquots or quench the reactions. The nature of the signal readout and information content, as well as colorimetric and miniaturized versions of such bio-analytical screens will be discussed.
The application of ISES to the discovery of (i) the first examples of asymmetric allylic amination mediated by Ni(0)-catalysts; the identification of new (ii) bromorhodiation-carbocyclization and (iii) thiocyanopalladationcarbocyclization transformations, as well as (iv) the identification of useful new chiral salen ligands will be presented. Then, the tables will be turned; reporting enzymes will shed their analytical chemistry role and take on asymmetric catalytic roles in promising hybrid chemo/biocatalytic synthetic schemes.
报告人简介：
Education:
| 1990-1991 | Postdoctoral Research, Yale University (Samuel J. Danishefsky, Mentor) |
| 1990 | Ph.D., Harvard University (Steven A. Benner, Thesis Advisor) |
| 1986-1990 | Traveling Scholar, Eidgen?ssische Technische Hochschule (ETH), Zürich, Switzerland |
| 1982 | B.S., University of Chicago |
| 2015 | Division Director, Division of Chemistry, National Science Foundation |
| 2011-2013 | National Science Foundation-CHE Chemistry of Life Processes (CLP) Program Lead |
| 2010-2013 | National Science Foundation-CHE Chemical Synthesis (SYN) Program Officer |
| 2012 | NSF Representative/Administrator - NSF/NASA Joint Workshop – “Alternative Chemistries of Life: Empirical Approaches.” – April 1-4 Washington DC [NASA Administrators-Michael New; Mary Voytek; Workshop Organizers: David Lynn (Emory), Cynthia Burrows (Utah), E. Virginia Armbrust (U. Washington)] 2 |
| 2011-2012 | NSF MPS Directorate Distinguished Lectureship Committee – CHE Representative [organized visits of Emily Carter (Princeton), Carolyn Bertozzi (UCB)] |
| 2004-2008 | American Heart Association, Inaugural Bioengineering and Biotechnology Study Section, Co-Chair (Spring 2007, 2008) |
