基本信息

刘士凯，1984年 4 月出生，博士，教授、博士生导师

主要研究领域：水产动物基因组学、生物信息学、分子遗传育种。联系方式：liushk@ouc.edu.cn /(0532)**

学习/工作经历

2002-2006烟台大学本科

2006-2008 中国海洋大学硕士

2008-2014 美国奥本大学博士

2014-2017美国奥本大学博士后、研究员

2017.5-中国海洋大学青年英才工程一层次教授

科研/教学情况

长期从事水产动物基因组学、生物信息学、分子遗传育种等领域的研究。在水产动物基因组、转录组测序分析、分子标记开发、高密度芯片构建、重要经济性状精细遗传解析和基因组选择育种等领域系统开展工作。目前，已在国际知名学术刊物发表 SCI 论文 80 余篇。参编学术专著 4 部。

主持科研项目

主持国家自然基金应急管理项目、海洋国家实验室功能实验室开放课题、中国海洋大学青年英才工程科研启动项目等，共计经费110 万。

学术成果

主要学术论文（^*共同第一作者）：

Geng X, Liu S, Yuan Z, Jiang Y, Zhi D, Liu Z. A Genome-Wide Association Study Reveals That Genes with Functions for Bone Development Are Associatedwith Body Conformation in Catfish.Marine Biotechnology, 2017, 19:570-578.Nunes J*, Liu S*, Pértille F, PerazzaC, Val V, Hilsdorf A, Liu Z, Coutinho L.Large-scale SNP discovery and construction of a high-density genetic map ofColossoma macropomum though genotyping-by-sequencing. Scientific

Reports.2017, 7:46112.

Zhou T, Liu S,Geng X, Jin Y, Jiang C, Bao L, Yao J, Zhang Y, Zhang J, Sun L, Wang X, LiN, Tan S, Liu Z. GWAS analysis of QTL for entericsepticemia of catfish and their involved genes suggest evolutionaryconservation of a molecular mechanism of disease resistance. Molecular Genetics and Genomics,2017, 292(1):231-242.

Wang X, Liu S, Jiang C, Geng X, Zhou T,Li N, Bao L, Li Y,Yao J, Yang Y,Jin Y, Dunham R, Liu Z. Multipleacross-strain and within-strain QTLs suggest

highly complex genetic architecture for hypoxia tolerance in channelcatfish. Molecular Genetics and Genomics, 2017, 292:63-76.

Gao S*, Liu S*, Yao J, Zhou T, Li N, Li Q, DunhamR, Liu Z. Taste Receptors andGustatory Associated G proteins in Channel Catfish. CBP - Part D: Genomics and Proteomics 2017, 21:1-9.

Gao S*, Liu S*, Yao J, LiN, Yuan Z, Zhou T, Li Q,Liu Z. Genomic Organization and Evolution of Olfactory Receptors and Trace Amine-Associated Receptors in Channel Catfish. BBA -General Subjects, 2017, 1861:644-651.

Yuan Z*, Liu S*, Yao J. Zeng Q, Tan S, Liu Z. Expression of Bcl-2 genesin channel catfish afterbacterial infection and hypoxia stress. Developmental Comparative Immunology, 2016, 69:79-90.

Liu Z*, Liu S*, Yao J*, Bao L*,Zhang J*, Li Y*, Jiang C, Sun L, Zhang Y, ZhouT, Zeng Q, Fu Q, Gao S, Li N, Wang R, Koren S, Jiang Y, Zimin A, Xu P, Phillippy A, Geng X, Song L, Sun F, Li C, Wang X, ChenA, Jin Y, Yuan Z, Yang Y, Tan S,Peatman E, Lu J, Qin Z, Dunham R, Li Z, Sonstegard T, Feng J, Danzmann R, Schroeder S, Scheffler B, Duke M, BallardL, Kucuktas H, Kaltenboeck L, Liu H, Armbruster J, Xie Y, Kirby M, Tian Y, FlanaganM, Mu W, Waldbieser G. Thechannel catfish genome sequence provides insights into evolution of scale formation in teleosts. Naturecommunications, 2016, 7:11757.

Liu S*, Li Y*, Qin Z, Geng X, Bao L, Kaltenboeck L, Kucuktas H, Dunham R, Liu

Z. High-density interspecific genetic linkage mapping providesinsights into genomic incompatibility between channel catfish and blue catfish.Animal Genetics, 2016, 47:81-90.

Liu S, Zhang J, Yao J, Liu Z.The complete mitochondrial genome of the armored catfish, Hypostomus plecostomus (Siluriformes: Loricariidae). MitochondrialDNA, 2016, 27(3):1908-9.

Liu S, Yao J, Zhang J, Liu Z. Next generation sequencing yields thecomplete mitochondrial genome of the striped raphael catfish, Platydoras armatulus (Siluriformes:Doradidae). Mitochondrial DNA, 2016, 27(3):1963-4.

Zeng Q*, Liu S*, Yao J*, ZhangY, Yuan Z, Jiang C, Chen A, Fu Q, Sun B, DunhamR, Liu Z. Transcriptome Display during Testicular Differentiation of ChannelCatfish (Ictalurus punctatus) asRevealed by RNA-Seq Analysis. Biology of Reproduction, 2016, 95:19, 1-17.

Li Y*, Liu S*, Qin Z, Waldbieser G, Wang R, Sun L, Bao L, Danzmann R, DunhamR, Liu Z. Construction of high-density SNP-based genetic map and itsintegration with BAC-based physical map in channel catfish. DNA Research, 2015,22 (1): 39-52.

Li Y*, Liu S*,Qin Z, Yao J, Jiang C, Song L, Dunham R, Liu Z. The serpin superfamily inchannel catfish: Identification, phylogenetic analysis and expression profilingin mucosal tissues after bacterial infection. Developmental and ComparativeImmunology, 2015, 49(2), 267-277.

Liu S*, Wang X*, Sun F, Zhang J, Feng J,Liu H, Rajendran KV, Sun L, Zhang Y,Jiang Y, Peatman E,Kaltenboeck L, Kucuktas H and Liu Z. RNA-Seq reveals

expression signatures of genes involvedin oxygen transport, protein synthesis,folding and degradation in response to heat stress in catfish. PhysiologicalGenomics, 2013, 45 (12):462-476.

Liu S, Li Q, Liu Z. Genome-wideidentification and evolutionary analysis of the ATP-binding cassette (ABC)transporter superfamily in catfish. PLoS ONE, 2013, 8(5): e63895.

Liu S, Zhang Y, Zhou Z, WaldbieserG, Sun F, Lu J, Zhang J, Jiang Y, Zhang H, Wang X, Rajendran KV, Kucuktas H,Peatman E, Liu Z. Efficient assembly and annotation of the transcriptome ofcatfish by RNA-Seq analysis of a doubled haploid homozygote. BMC Genomics.2012, 13:595.

Liu S, Zhou Z, Lu J, Sun F, WangS, Liu H, Jiang Y, Kucuktas H,Kaltenboeck L, Peatman E, Liu Z. Generation of genome-scale gene-associatedSNPs in catfish for the construction of a high-density SNP array.BMC Genomics. 2011, 12:53.

主要学术专著章节：

Liu S, Zhang Y, Sun F, Jiang Y, WangR, Li C, Zhang J, Liu Z. 2012. Functional genomics research in aquaculture:principles and general approaches. In: Functional Genomics in Aquaculture,Wiley and Blackwell Publishing, Ames, IA (Eds. Saroglia M and Liu Z). Ch1:1-40.

Liu S andLiu Z. 2017. Introduction to Linux and command line tools for bioinformatics.In: Bioinformatics in Aquaculture: Principles and Methods, Wiley and BlackwellPublishing, Ames, IA (Ed. Liu Z). Ch1: 3-29.

Liu S andLiu Z. 2017. Analysis of microRNAs and their target genes. In: Bioinformaticsin Aquaculture: Principles and Methods, Wiley and Blackwell Publishing, Ames,IA (Ed. Liu Z). Ch13: 200-227.

Liu S, Zeng Q, Wang X and Liu Z. 2017. SNP array development, genotyping, data analysis,and applications. In: Bioinformatics in Aquaculture: Principles and Methods,Wiley and Blackwell Publishing, Ames, IA (Ed. Liu Z). Ch18: 308- 337.

Liu S, Zeng P and Liu Z. 2017. Geneset analysis of SNP data from genome-wide association studies. In: Bioinformatics in Aquaculture: Principles and Methods, Wileyand Blackwell Publishing, Ames, IA (Ed. Liu Z). Ch24: 434-459.

Li Y, Liu S, Wang R, Qin Z and Liu Z. 2017.Bioinformatic considerations and approaches for high-density Linkage Mapping inAquaculture. In: Bioinformatics in Aquaculture: Principles and Methods, Wileyand Blackwell Publishing, Ames, IA (Ed. Liu Z). Ch20: 356-379.

Jin Y, Liu S, Yuan Z, Yang Y, Tan S, Liu Z. 2015. Catfish genomicstudies: Progress andperspectives. In: Genomics in Aquaculture, Elsevier (Eds. MacKenzie S andJentoft S). Ch 4: 73-104.