龙红岸山东省汶上县人，教授，博士生导师

进化基因组学实验室 Laboratory of Evolutionary Genomics 负责人

1982 年 8 月出生

HonganLong, Professor, Ph.D. E-mail: longhongan@ouc.edu.cn Tel: +86 532 8203 1723

研究方向

以微生物为主要研究对象，利用组学、分子遗传学和细胞生物学方法，结合种群遗传学与微生物学理论，聚焦微生物的基因组突变以及行为的进化生物学研究，具体研究方向如下：

A.原生动物的表型可塑性与适应性演化；

B.海洋微生物的基因组进化以及稳定性机制；

C.微生物环境胁迫下的突变形成；

D.医疗及环境水体中病源微生物的抗药性演化；

E.原生动物生殖方式的调控与演化。

Research

We are interested inmicrobial evolution, with a focuson mutation rate andbehavior evol ution. Theresearch models are quite broad, includingcilaites, bacteria, yeast, etc. Ourrese arch strategy combines population genetics theory, experimental evolution, -omics sequencin g, genetic techniques, andbioinformatic tools. The lab deems the training of indepedent re searchers asour first task and research asthe second. Graduate students would geta com plete training ofscientific research and multiple undergrad assistants are provided for theirresearch. We are now exploring the followingtopics:

A. Phenotypicplasticity of ciliates, and its role in evolution;

B.Genome instability and evolution ofmarine microbial organisms;

C.Ecological dependence of mutation rate;

D.Antibiotic resistance evolution ofpathogens in medical and natural environments;

E. Geneticregulation and evolution of reproduction inciliates.

招聘/招生

招聘：协助拟加入人员申请中国海洋大学“青年英才工程”（http://rsc.ouc.edu.cn/04/50/c1485 a66640/page.htm）等各层次人才计划；定期招收实验室管理、技术等科研助理岗位。

招生：常年招收优秀本科生兼职助理、硕士生、博士生和博士后。具体信息请邮件咨询（longhongan@ouc.edu.cn）

承担课题

第 15 批国家“青千”（2019-2022）

山东省“泰山学者”青年项目（2019.1-2024.1）

国家自然科学基金面上项目（**; 2019.1-2022.12）

中央高校基本科研业务费（2018.1-2021.1）

中国海洋大学“筑峰人才计划”启动经费（2018.9-2021.8）

RunningProjects

'TaishanScholar' grant for young scientists, Shandong Province (2019.1-2024.1)

NSFC grant (No.**; 2019.1-2022.12; Phenotypicplasticity and itsevolution in theciliate Glaucone ma trihymene)

Research grant from the Central Government of China(2018.1-2021.1) Startup grant from Ocean University of China (2018.9-2021.8)

近期代表性论文(*,correspondingauthor; #, co-first-author) Recent publications

Full texts of publications can be downloaded from researchgate

Long*, H.; Miller, S.F.; Williams, E.; Lynch, M. 2018. Specificity of the DNA mismatch repair system (MMR) and mutagenesis bias inbacteria. MolecularBiology and Evolution 35(10):2414–2421.

Long,H.; Sung#, W.;Kucukyildirim#,S.; Williams,E.; Miller, S.;Guo, W.;Patterson, C.; Gregory, C.;Str auss, C.; Stone, C.;Berne, C.; Kysela, D.;Shoemaker, W.; Muscarella, M.;Luo, H.; Lennon, J.;Brun, Y.; Lynch*, M. 2018.Evolutionary determinants ofgenome-wide nucleotide composition. NatureEcology and Evolution 2: 237-240.

Strauss, C.; Long*,H.; Patterson, C.;Te,R.; Lynch, M.2017. Genome-wide mutation rate response top H change in the coral reef pathogen Vibrio shilonii AK1. mBio 8 (4): e01021-17

Long, H.; Miller, Samuel F;Strauss, Chloe; Zhao, Chaoxian; Cheng, Lei; Ye,Zhiqiang; Griffin, Katherin e; Te, Ronald; Lee, Heewook;Chen, Chi-Chun; Lynch*, Michael. 2016.Antibiotic treatment enhances the genome-wide mutation rate of target cells. Proceedingsof the National Academy ofSciences U.S.A. 113(18): E2498-E2505

Long*, H.; Kucukyildirim#,Sibel; Sung, Way; Williams, Emily; Lee, Heewook; Ackerman, Matthew; Doa k, Thomas G; Tang, Haixu; Lynch, Michael. 2015. Background mutational features ofthe radiation-resista ntbacterium Deinococcus radiodurans. MolecularBiology and Evolution 32(9): 2383-2392