万敏：1978 年 8 月出生，教授/博士生导师

教育及工作经历

1996.09-2000.06 中国海洋大学，水产养殖专业，本科

2000.09-2003.07 中国海洋大学，水产养殖专业，硕士

2003.08-2004.12 瑞典卡洛琳斯卡医学院，分子生物学，硕士

2005.01-2010.02 瑞典卡洛琳斯卡医学院，生物医药学，博士

2010.02-2012.02 瑞典卡洛琳斯卡医学院，博士后

2012.02-2017.06 瑞典卡洛琳斯卡医学院，助理教授

2017.06-至今 中国海洋大学水产学院，筑峰三岗教授

目前的研究方向

水生动物营养免疫学和营养微生态学，主要研究水产动物的营养代谢、先天免疫、肠道菌群和病原菌之间的交互影响作用。

已发表论文

到目前为止在 SCI 收录期刊和出版书籍中共发表论文 24 篇，通讯作者 6 篇，第一作者 8 篇。

1.Wan M*, Tang X,Rekha RS, Muvva SSVJR, Brighenti S, Agerberth B, Haeggström JZ. Prostaglandin E2 suppresses hCAP18/LL-37expression in human macrophages via EP2/EP4: implications for treatment ofMycobacterium tuberculosis infection. FASEBJ. 2018 Jan 17; doi: 10.1096/fj.**8.[Epub ahead of print] *通讯作者

2.Wan M, Tang X, Stsiapanava A and Haeggström JZ. Biosynthesis of

LeukotrieneB4. Semin Immunol. 2017 Oct; 33:3-15.

3.Xu X, Bi D, Wan M*. Characterization andimmunological evaluation of low molecular weight alginate derivatives. Curr TopMed Chem. 2016;16(8):874-

87. *通讯作者

4.Wan M*, Tang X, Haeggstrom JZ. Host Defense Peptides and Their Potentialas Therapeutic Agents (Edited by Richard M. Epand). Chapter 6: Host Defense Peptidesand the Eicosanoid Cascade. 2016. *通讯作者

5.TangX, Basavarajappa D, Haeggström JZ, Wan M*.P2X7 receptor regulates

internalization of antimicrobial peptideLL-37 by human macrophages that promotes intracellular pathogen clearance. J Immunol. 2015 Aug

1;195(3):1191-201. *通讯作者

6.Xu X, Bi D, Wu X,Wang Q, Wei G, Chi L, JiangZ, Oda T, Wan M*. Unsaturatedguluronate oligosaccharide enhances the antibacterial activities ofmacrophages. FASEB J. 2014 Jun;28(6):2645-2654. *通讯作者

7.Wan M,Soehnlein O, Tang X, van der Does AM,Smedler E, Uhlén P,

Lindbom L, Agerberth B, and Haeggström JZ.Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by humanmacrophages and triggers eicosanoid generation in vivo. FASEB J. 2014 Aug;28(8):3456-67.

8.Wan M, Van Der Does AM, Tang X, Lindbom L, Agerberth B, Haeggström JZ. Antimicrobialpeptide LL-37 promotes bacterial phagocytosis by human macrophages. J Leukoc Biol. 2014 Jun;95(6):971-81.

9.Basavarajappaa D, WanM, Lukica A, Steinhilber D, Samuelssona B, and Rådmarka O. Coactosin -like protein (CLP) and 5-lipoxygenaseactivating protein (FLAP): roles in cellular leukotriene biosynthesis. ProcNatl Acad Sci U S A. 2014 Aug 5;111(31):11371-6.

10.Wan M, Godson C,Guiry PJ, Agerberth B, Haeggström JZ. Leukotriene B4/LL-37 proinflammatorycircuits are mediated by BLT1 andFPRL-1, and are counter-regulated by lipoxin A4 and resolvin E1. FASEB J.2011, 25(5):1697-705.

联系方式

中国海洋大学水产学院，山东省青岛市鱼山路5 号，266003E-mail: wanmin@ouc.edu.cn