王 成副教授




王成，博士, 副教授。主要从事生物医用纳米载体材料的构建靶向给药系统的研究，主讲《药剂学》。作为第三负责人参与国家科技重大专项—重大新药创制2项，作为第一负责人主持国家自然科学基金青年科学基金、中国博士后科学基金、中国博士后科学基金特别资助、山东省博后创新项目各1项，中国海洋大学青年教师专项1项；此外，承接制药企业委托新药研究开发项目3项。并于2015年9月借调国家新药审评中心（CDE）挂职工作一年。现已在Nat Med, J Biomed Nanotechnol, Oncotarget, Nanoscale, Curr Drug Metab, Int J Pharm等国际纳米载体及传输领域期刊上发表SCI论文15篇；申报中国发明专利9项，其中已获得授权4项。应邀为J Biomed Nanotechnol, Int J Pharm, Colloid and Surface B, J Nanosci Nanotechnol等国际杂志审稿十余篇次。

联系方式：**， wangcheng@ouc.edu.cn

研究方向：

（1） 靶向给药系统的研究

（2） 生物医用纳米载体材料的构建

（3） 应用药物制剂的研究与开发

代表性论文

1. Cheng Wang¹*, Biao Liu²⁺, Xuelian Xu¹, Bo Zhuang¹, Hongxia Li¹, Jiaqi Yin¹, Mengyi Cong¹, Wei Xu^3,4* and Aiping Lu²* Toward Targeted Therapy in Chemotherapy-resistant Pancreatic Cancer with A Smart Triptolide Nanomedicine Oncotarget 2016

2. Bo Zhuang, Liang Du, Hongxia Xu, Xuelian Xu, Cheng Wang*, Yingfang Fan, Mengyi Cong, Jiaqi Yin, Hongxia Li and Huashi Guan*.Micelle Loading Cabazitaxel for therapy of Lung Cancer. Int J Pharm. 499:146-155.2016.

3. Yingfang Fan, Bo Zhuanga, Cheng Wang*, Xuelian Xu, Wei Xu, Zhihua Lv*. Pimecrolimus micelle exhibits excellent therapeutic effect forKeratoconjunctivitis Sicca. Colloid and Surface B. 140 1-10. 2016.

4. Cheng Wang, Ying Shan, Jiuli Yang, Xuelian Xu, Bo Zhuang, Yingfang Fan and Wei Xu*. Inhibition of Cancer Angiogenesis Using Triptolide Nanoparticles . J Biomed Nanotechnol. 10:1-11. 805-815 2015.

5.Chao Liang^#, Baosheng Guo^#, Heng Wu^#, Ningsheng Shao, Defang Li, Jin Liu, Lei Dang, Cheng Wang, Hui Li, Shaohua Li, etc. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy. Nat Med. 21(3):288-94, 2015.

6. Cheng Wang*, Biao Liu, Jun Lu, Ge Zhang and Aiping Lu*. Strategies for Combination of Aptamer and Targeted drug delivery. J Nanosci Nanotechnol. 14(1): 501-512,2014

7. Cheng Wang, Chaofeng Long, Chengshi Xie, Xiaoxin Chen, Lan Zhang, Bingyang Chu, Yujun Wang, Feng Luo, and Zhiyong Qian* Two Novel Nanoscale Preparations of Micelle and Thermosensitive Hydrogel for Docetaxel to Treat Malignant Tumor. J Biomed Nanotechnol. 9(3): 357-366,2013

8. Cheng Wang, Jian Liang+, Xin Deng, Chaofeng Long, Chengshi Xie, Xiaoxin Chen, Lan Zhang, Qingfa Guo, Yingjing Wang, Yujun Wang, Feng Luo and Zhiyong Qian*. Systhesis, Characterization, and Application of Amino-Terminated Poly(ethylene glycol)-block-Poly(ε-caprolactone) Copolymer for Paclitaxel. J Nanosci Nanotechnol. 13(1): 68-76, 2013

9. Cheng Wang, Jing Wang+, Tiezhu Chen, zhiqiang Luo, Xuemei Yang, Xiongfei Pan, Yunfeng Lin, zhiyong Qian* and Xiaoxiao Cai*. Absorption, Pharmacokinetics and Disposition of Biodegradable Nanoscale Preparations. Curr Drug Metab. 13(4): 429-439, 2012

10.Cheng Wang, YingJing Wang, YuJun Wang, Min Fan, Feng Luo, ZhiYong Qian*.Characterization, pharmaco kinetics and disposition of novel nanoscale preparations of paclitaxel. Int J Pharm. 414(1-2): 251-259, 2011