蔡超 副教授
蔡超，博士，副教授。中国海洋大学“青年英才工程”计划资助获得者。

2007年毕业于山东大学，并先后获得学士、硕士学位；2011年毕业于中国科学院生态环境研究中心，获博士学位；2011至2014年在美国伦斯勒理工学院（RPI）化学生物学系Robert J. Linhardt教授课题组从事博士后研究工作；2014年底经中国海洋大学“青年英才工程”计划引进在医药学院工作。主要从事活性寡糖及天然小分子的合成研究工作，完成十二糖分子MMP及天然小分子(-)-Cleistenolide的全合成工作；应用化学酶法合成系列超低分子量肝素寡糖化合物；针对过硫酸化的糖胺聚糖进行结构解析等研究。在Chem. Rev.，Nat. Chem. Biol.，Org. Lett.，Anal. Chem.，J. Org. Chem.等国际学术期刊发表论文20余篇。

联系方式：Tel: **; E-mail:caic@ouc.edu.cn

研究方向及内容：

1. 糖胺聚糖（如肝素、硫酸软骨素等）寡糖分子的化学及酶法合成工作；

2. 糖胺聚糖的结构修饰、模拟物及簇合物的构建及活性评价工作；

3. 海洋来源多糖及寡糖的化学修饰及结构鉴定工作；

4. 海洋来源天然小分子的化学合成（辅以糖分子为手性模板）工作。

代表性论文和专利：

1. Dimitrievska S., Cai C., Weyers A., et al. Click-coated, heparinized, decellularized vascular grafts. Acta Biomaterialia2015, 13, 177–187.

2. Farrán A., Cai C., Sandoval M., et al.Green solvents in carbohydrate chemistry: from raw materials to fine chemicals. Chem. Rev.2015, 115, 6811–6853.

3. Cai C., Dickinson D. M., Li L., et al. Fluorous-assisted chemoenzymatic synthesis of heparan sulfate oligosaccharides. Org. Lett.2014, 16, 2240–2243.

4. Xu Y., Cai C., Chandarajoti K., et al.Homogeneous low molecular weight heparins with reversible anti-coagulant activity. Nat. Chem. Biol. 2014, 10, 248–250.

5. Li G., Cai C., Li L., et al.A new method to detect contaminants in heparin using radical depolymerization and liquid chromatography-mass spectrometry. Anal. Chem. 2014,86, 326–330.

6. Ucakturk E., Cai C., Li L., et al. Capillary electrophoresis for total glycosaminoglycan analysis. Anal. Bioanal. Chem.2014, 406, 4617–4626.

7. Cai C., Li L., Harvey C., Liu J., Linhardt R. J.^* Towards the chemoenzymatic synthesis of heparan sulfate oligosaccharides: Oxidative cleavage of p-nitrophenyl group with ceric ammonium salts. Tetrahedron Lett. 2013, 54, 4471-4474.

8. Cai C., Edgar K., Liu J., Linhardt R. J.^* Preparation and application of a “clickable” acceptor for enzymatic synthesis of heparin oligosaccharides. Carbohydr. Res.2013,372, 30-34.

9. Chang Y., Cai C., Li L., et al. Ultrasensitive detection and quantification of acidic disaccharides using capillary electrophoresis and quantum dot-based fluorescence resonance energy transfer. Anal. Chem. 2013, 85, 9356–9362.

10. Cai C., Solakyildirim K., Yang B., Beaudet J. M., Weyers A., Linhardt R. J., Zhang F.^* Semi-synthesis of Chondroitin Sulfate-E from Chondroitin Sulfate-A. Carbohydr. Polym.2011, 87, 822-829.

11. Cai C.,Liu J., Du Y.^* and Linhardt R. J.^*Stereoselective Total Synthesis of (?)-Cleistenolide. J. Org. Chem. 2010, 75, 5754-5756.

12. Wei G., Cai C., Du Y.^* Highly Efficient and Versatile Synthesis of Some Important Precursors from 1,6-Anhydrous-β-D-glucopyranose as a Green Starting Material. Chin. J. Chem, 2009, 27, 1589-1592.

13. Wei G., Zhang L., Cai C., Cheng S., Du Y.^* Selective Cleavage of Sugar Anomeric O-acyl Groups Using

FeCl₃·6H₂O. Tetrahedron Lett.2008, 49, 5488-5491.