李国云 副教授


个人简介

李国云，女，1987年生，博士，副教授。2009年6月毕业于中国海洋大学食品科学与工程专业，获学士学位；2015年6月于中国海洋大学获得水产品加工及贮藏工程专业博士学位。2012年9月至2014年9月在美国伦斯勒理工学院Robert J. Linhardt教授实验室开展糖化学方面研究。2015年7月以中国海洋大学“青年英才工程”身份加入医药学院糖化学与糖药物研究团队（于广利教授课题组）。近五年来在Anal. Chem., ACS Chem. Biol., J. Biol. Chem.等国际学术期刊发表SCI论文33篇，授权国家发明专利4项。



联系方式

Tel：+86 ** E-mail: liguoyun@ouc.edu.cn

研究方向及内容

1．重大疾病相关的内源性糖链精细结构分析及其高灵敏分析方法学研究；

2. 海洋糖类化合物的提取分离、结构鉴定及其构效关系研究；

3. 糖类药物分析、质量控制新方法研究。

研究生招生与培养

招收研究生专业：药物化学、制药工程

主要代表性论文

1. G. Li, C. Cai, L. Li, L. Fu, T. Toida, C. Xue, R.J. Linhardt. Method to detect contaminants in heparin using radical depolymerization and liquid chromatography-mass spectrometry, Anal Chem, 2014, 86 (1): 326-330 (IF: 5.825)

2. G. Li, J. Steppich, Z. Wang, Y. Sun, C. Xue, R.J. Linhardt, L. Li. Bottom-up low molecular weight heparin analysis using LC-FTMS for extensive characterization. Anal Chem. 2014, 86 (13):6626-6632 （IF: 5.825)

3. G. Li, L. Li, F. Tian, L. Zhang, C. Xue, R. J. Linhardt. Glycosaminoglycanomics of cultured cells using a rapid and sensitive LC-MS/MS approach. ACS Chem Biol, 2015, 10(5):1303-1310 (IF: 5.356)

4. G. Li, L. Li, C. Xue, D. Middleton, R. J. Linhardt, F. V. Avci. Profiling pneumococcal type 3-derived oligosaccharides by high resolution liquid chromatography-tandem mass spectrometry. J Chromatogr A, 2015,1397:43-51 (IF: 4.258)

5. G. Li, B. Yang, L. Li, F. Zhang, C. Xue, R. J. Linhardt. Analysis of 3-O-sulfo group containing tetrasaccharides in heparin by liquid chromatography-mass spectrometry. Anal Biochem, 2014, 455: 3-9. (IF: 2.305)

6. G. Li, S. Masuko, D. E. Green, Y. Xu, L. Li, F. Zhang, R. J. Linhardt. N-sulfotestosteronan, a novel substrate for heparan sulfate 6-O-sulfotransferases and its analysis by oxidative degradation. Biopolymers, 2013, 99(10):675-685 (IF: 2.228)

7. G. Li, S. Chen, C. Xue. A novel glycosaminoglycan-like polysaccharide from abalone Haliotis discus hannai Ino: Purification, structure identification and anticoagulant activity. Int J Biol Macromol, 2011, 49(5): 1160-1166 (IF: 3.096)

8. P. Datta, G. Li, B. Yang, X. Zhao, J. Baik, R.J. Linhardt. Bioengineered Chinese hamster ovary cells with Golgi-targeted 3-O-sulfotransferase-1 biosynthesize heparan sulfate with an antithrombin binding site. J Biol Chem, 2013, 288(52): 37308-37318. (IF: 4.600)

9. E.P. Schmidt, G. Li, L. Li, L. Fu, Y. Yang, K.H. Overdier, I. S. Douglas, R. J. Linhardt: The circulating glycosaminoglycan signature of respiratory failure in critically Ill adults. J Biol Chem, 2014, 289(12):8194-202 (IF: 4.600)

10. W. He, L. Fu, G. Li, J. A. Jones, R. J. Linhardt, M. Koffas. Production of chondroitin in metabolically engineered E. coli., Metab Eng, 2015, 27: 92-100 (IF: 8.258)

11. E. Sterner, S. Masuko, G. Li, L. Li, D. E. Green, N. J. Otto, Y. Xu, P. L. DeAngelis, J. Liu, J. S. Dordick, R. J. Linhardt. Fibroblast growth factor-based signaling through synthetic heparan sulfate block copolymers studied using high-cell density 3D cell printing, J Biol Chem 2014, 289(14): 9754-9765. (IF: 4.600)

12. S. Chen, G. Li, N. Liao, C. Xue. Sulfation pattern of the fucose branch is important for the anticoagulant and antithrombotic activities of fucosylated chondroitin sulfates, BBA-Gen Subjects, 2013, 1830 (4):3054-3066 (IF: 3.892)

13. L. Fu, G. Li, B. Yang, A. Onishi, L. Li, P. Sun, , R. J. Linhardt. Structural characterization of pharmaceutical heparins prepared from different animal tissues. J Pharm Sci-US, 2013, 102: 1447-1457 (IF: 3.007)

14. U. Bhaskar, G. Li, L. Fu, A. Onishi, M. Suflita, R. J. Linhardt. Combinatorial one-pot chemoenzymatic synthesis of heparin, Carbohyd Polym, 2015, 122:399-407. (IF: 3.916)