江涛教授

个人简介：

江涛，女， 博士，教授，博士生导师；教育部优秀青年奖励计划的获得者，《精细化工》杂志编委，E. J. Med. Chem, Bioorg. Med. Chem., Tetrahedron等杂志审稿人。

1988-1993中国科学院长春应用化学研究所 博士学位，1993-1995香港浸会大学博士后研究，1996年英国University of Essex 访问学者。1997年至今 中国海洋大学医药学院和海洋药物与食品研究所工作，其中2004年11-12月在加拿大McGill 大学进行合作研究。1997年12月晋升教授，2001年聘为博士生导师。

近年来设计合成了一些列核酸插入试剂和剪切试剂；完成了多种海洋天然产物海洋生物碱杂多环的合成及其结构优化与构效关系研究；进行了基于糖结构的药物设计与合成及生物活性研究；多个化合物进入候选药物或系统临床前研究阶段。共主持、承担23项科研项目，项目转让4项；目前在研课题科技部国际合作项目1项、国家自然科学基金项目2项及其他项目,到位总经费356万元。在Chem. Comm., J. Med. Chem, E. J. Med. Chem., Bioorg. Med. Chem等发表研究论文70余篇；申请国家发明专利12余项，授权4项。

联系方式： Tel: **； Fax: **；Email: jiangtao@ouc.edu.cn

通讯地址：山东省青岛市鱼山路5号 中国海洋大学医药学院 海洋药物教育部重点实验室 266003

研究生招生与培养：

招收研究生专业：药物化学、制药工程。

实验室已毕业博士15人，硕士22人，目前在读博士生6人，硕士 10人。毕业研究生主要从事药物研发、教学工作，有三位已进入高级管理层。

主要研究方向：药物设计与合成

1.海洋天然产物如海洋生物碱杂多环的合成及其结构优化与构效关系研究；

2.活性分子的糖基化、磷酸酯化等化学修饰和基于糖结构的药物设计与合成。

近期承担的学术课题：

1.国家科技部国际合作重点项目(2013DFG32160)；

2.国家自然科学基金（课题编号：**）；

3.国家自然科学基金（课题编号：**）。

近期发表文章：

1. Exploring pyrimidine-substituted curcumin analogues: Design, synthesis and effects on EGFR signaling, Peiju Qiu , Lingling Xu , Lei Gao, Meng Zhang, Shixi Wang, Sheng Tong, Yue Sun, Lijuan Zhang*, Tao Jiang*, Bioorganic & Medicinal Chemistry 21 (2013) 5012–5020.

2. Different cytotoxicities and cellular localizations of novel quindoline derivatives with or without boronic acid modifications in cancer cells, Ruijuan Yin, Meng Zhang, Cui Hao, Wei Wang, Peiju Qiu, Shengbiao Wan, Lijuan Zhang* and Tao Jiang*, ChemComm, (2013), Cite this: DOI: 10.1039/c3cc45203d

3. Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid, Jiuyang Zhao, Wei Li, Rui Ma, Shaopeng Che, Sumei Ren and Tao Jiang *, Int. J. Mol. Sci. 2013, 14, 16851-16865; doi:10.3390/ijms**

4. Total Synthesis and Biological Activity of Marine Alkaloid Eudistomins Y1–Y7 and Their Analogues, Huijuan Jin, Puyong Zhang, Krikor Bijian, Sumei Ren, Shengbiao Wan, Moulay A. Alaoui-Jamali,* and Tao Jiang,* Mar. Drugs 2013, 11, 1427-1439; doi:10.3390/md**

5. Synthesis and biological activity of novel organoselenium derivatives targeting multiple kinases and capable of inhibiting cancer progression to metastases， Krikor Bijian, Zhongwei Zhang, Bin Xu, Su Jie, Bo Chen, Shengbiao Wan, JianHui Wu b, Tao Jiang*, Moulay A. Alaoui-Jamali* Eur. J. Med. Chem., 48 (2012) 143-152

6. Synthesis, Saccharide–Binding, and Anti-cancer Cell Proliferation Properties of Arylboronic Acid Derivatives of Indoquinolines, Jun-xiuMeng, Shao-qing Yu, Sheng-biao Wan, Su-mei Ren, Tao Jiang* Chem. Biol. Drug Des., 2011,78:816-825（SCI IF=2.52）

7. Design and Synthesis of a Series of Novel Bisquinazoline Glycosides as Epidermal Growth Factor Receptor Inhibitors, Shaopeng Chen, Xiaowei Zhang, Junlei Wang, Shengbiao Wan, Meiyu Geng,* and Tao Jiang* Chem Biol Drug Des, 2011,78:1006-1013.

Dr. Jiang Tao, professor with the Marine Drug and Food Institute of Ocean University of China, was graduated in 1993 for her doctoral degree from Changchun Institute of applied Chemistry, Chinese Academic of Sciences. After that She studied in Hong Kong Baptist University for her post-doctoral training from Nov. 1993 to Nov. 1995， and then she worked with the department of Chemistry and Biological Sciences, University of Essex in UK for visiting scientist for one year. She joined Ocean University of China in 1997 and became a professor in medicinal chemistry in the Marine Drug and Food Institute of the University. Her research interests focus on the Chemical Modification of Bioactive Compounds by Saccharide and Anti-tumor Activities of the Modified Compounds, Synthesis and Molecular Structure of transition-metal-saccharide Complexes and their Bioactivities. She has published about 70 refereed research papers and leaded several research projects from Chinese government.