毛文君教授


个人简介：

毛文君:博士、教授、博士生导师。主要从事以海洋生物资源为主的新糖源发现、糖链结构、构效关系和海洋药物等应用基础及开发研究。曾在美国爱荷华大学药学院Robert J Linhardt教授实验室从事糖胺聚糖及其寡糖的结构与构效关系研究。国家教育部****和创新团队发展计划“海洋创新药物研究与开发(IRT0944)”研究团队成员。先后主持和承担国家自然科学基金、国家科技支撑计划、国家十五重大专项、教育部高等学校博士点基金、山东省科技攻关计划、山东省自然科学基金、青岛市科技计划等多项课题的研究工作。近年来，在Bioresour Technol, Carbohydr Polym, Thromb Haemostasis, Mar Biotechnol, Process Biochem，Int J Biol Macromol 等国际刊物发表SCI收录论文40余篇，参编专著5部，获授权国家发明专利2项，获国家技术发明一等奖、国家教育部高等学校科学技术发明一等奖、山东省科学技术进步二等奖、山东省科学技术进步三等奖、青岛市科学技术进步二等奖等多项奖励。　

　　联系电话：**；E-mail：wenjunm@ouc.edu.cn


研究方向和内容：

　　主要针对心脑血管疾病及肿瘤等严重危害人类健康的重大疾病，应用现代色谱分离、结构测定、活性筛选等技术，获得具有药用价值的海洋糖类新资源。主要包括：海藻、海洋微生物及海洋动物中新糖源探索；结构新颖活性多糖及寡糖的发现；多糖及寡糖的结构修饰和构效关系的研究。




承担和完成主要课题：

1. 礁膜抗凝血活性鼠李聚糖硫酸酯的可控降解与构效关系研究(**), 国家自然科学基金，2011–2013年，课题负责人。

2. 海洋微生物来源的新型多糖PKDN制备技术与开发利用（2010GHY10509），山东省科技攻关计划，2010–2013年，课题负责人。

3. 浒苔多糖资源利用技术研究，青岛国家海洋科学研究中心，2010–2013年，课题负责人。

4. 礁膜多糖的结构及其对凝血酶活性调控机制研究（**015），教育部博士点基金，2010–2012年，课题负责人。

5. 经济海藻精深加工技术集成与产业化示范（2008BAD94B04），国家科技支撑计划，2008–2010年，主要学术骨干。

6. 海洋食品生物活性物质高效制备关键技术研究（2008BAD94B07），国家科技支撑计划，2008–2010年，第2位。

7. 山东省重大新药创制平台建设（2009ZX09301-013）， 国家科技重大专项，2010–2012年，主要学术骨干。

8. 宽礁膜抗凝血多糖结构及作用机理研究（Y2007D03），山东省自然科学基金，2007–2011年，课题负责人。

9. 海洋抗凝血药物鼠李聚糖硫酸酯的研究（2006GG**），山东省科技攻关计划， 2006–2010年，课题负责人。

10. 海藻糖抗凝血药物的研究（06-2-2-4-nsh），青岛市科技攻关计划，2006–2009年，课题负责人。




近期发表主要论文：

1. Yin Chen, Wenjun Mao*, Baofeng Wang, Lina Zhou, Qianqun Gu, Yanli Chen, Chunqi Zhao, Na Li, Chunyan Wang, Jimiao Shan, Mengxia Yan, Cong Lin. Preparation and characterization of an extracellular polysaccharide produced by the deep-sea fungus Penicillium griseofulvum. Bioresour Technol, 2013, 132, 178–181. (SCI, IF 4.750)

2. Yanli Chen, Wenjun Mao*, Junfeng Wang, Weiming Zhu, Chunqi Zhao, Na Li, Chunyan Wang, Mengxia Yan, Tao Guo, Xue Liu. Preparation and structural elucidation of a glucomannogalactan from marine fungus Penicillium commune. Carbohydr Polym, 2013, 97, 293–299. (SCI, IF 3.479)

3. Yin Chen, Wenjun Mao*, Yan Gao, Xiancun Teng, Weiming Zhu, Yanli Chen, Chunqi Zhao, Na Li, Chunyan Wang, Mengxia Yan, Jimiao Shan, Cong Lin, Tao Guo. Structural elucidation of an extracellular polysaccharide produced by the marine fungus Aspergillus versicolor. Carbohydr Polym, 2013, 93, 478–483. (SCI, IF 3.479)

4. Shoudong Guo, Wenjun Mao*, Yuanli Li, Qianqun Gu, Yanli Chen, Chunqi Zhao, Na Li, Chunyan Wang, Tiantian Guo, Xue Liu. Preparation, structural characterization and antioxidant activity of an extracellular polysaccharide produced by the fungus Oidiodendron truncatum GW. Process Biochem, 2013, 48, 539–544. (SCI, IF 2.627)

5. Chunyan Wang, Wenjun Mao*, Zhenqian Chen, Weiming Zhu, Yanli Chen, Chunqi Zhao, Na Li, Mengxia Yan, Xue Liu, Tiantian Guo. Purification, structural characterization and antioxidant property of an extracellular polysaccharide from Aspergillus terreus. Process Biochem, 2013, 48, 1395–1401. (SCI, IF 2.627)

6. Hongyan Li, Wenjun Mao* , Yujiao Hou, Xiaohui Qi, Chunqi Zhao, Yin Chen, Yanli Chen, Na Li, Chunyan Wang. Preparation, structure and anticoagulant activity of a low molecular weight fraction produced by mild acid hydrolysis of sulfated rhamnan from Monostroma latissimum. Bioresour Technol, 2012, 114, 414–418. (SCI, IF 4.980)

7. Yin Chen, Wenjun Mao*, Yupin Yang, Xiancun Teng, Weiming Zhu, Xiaohui Qi, Yanli Chen, Chunqi Zhao, Yujiao Hou, Chunyan Wang, Na Li. Structure and antioxidant activity of an extracellular polysaccharide from coral-associated fungus, Aspergillus versicolor LCJ-5-4. Carbohydr Polym, 2012, 87, 218–226. (SCI, IF 3.628)

8. Hongyan Li, Wenjun Mao*, Yin Chen, Sumei Ren, Xiaohui Qi, Yanli Chen, Chunqi Zhao, Na Li, Chunyan Wang, Cong Lin, Mengxia Yan, Jimiao Shan. Sequence analysis of the sulfated rhamno-oligosaccharides derived from a sulfated rhamnan. Carbohydr Polym, 2012, 90, 1299–1304. (SCI, IF 3.628)

9. Xiaohui Qi, Wenjun Mao*, Yan Gao, Yin Chen, Yanli Chen, Chunqi Zhao, Na Li, Chunyan Wang. Mengxia Yan, Cong Lin, Jimiao Shan. Chemical characteristic of an anticoagulant-active sulfated polysaccharide from Enteromorpha clathrata. Carbohydr Polym, 2012, 90, 1804–1810. (SCI, IF 3.628)

10. Yin Chen, Wenjun Mao*, Hongwen Tao, Weiming Zhu, Xiaohui Qi, Yanli Chen, Hongyan Li, Chunqi Zhao, Yupin Yang, Yujiao Hou, Chunyan Wang, Na Li. Structural characterization and antioxidant properties of an exopolysaccharide produced by the mangrove endophytic fungus Aspergillus sp.Y16. Bioresour Technol, 2011, 102, 8179–8184. (SCI, IF 4.980)

11. Hongyan Li, Wenjun Mao*, Xiuli Zhang, Xiaohui Qi, Yin Chen, Yanli Chen, Jian Xu, Chunqi Zhao, Yujiao Hou, Yupin Yang, Na Li, Chunyan Wang. Structural characterization of an anticoagulant–active sulfated polysaccharide isolated from green alga Monostroma latissimum. Carbohydr Polym, 2011, 85, 394–400. (SCI, IF 3.628)

12. Haihong Sun, Wenjun Mao*, Jieying Jiao, Jiachao Xu, Hongyan Li, Yin Chen, Xiaohui Qi, Yanli Chen, Jian Xu, Chunqi Zhao, Yujiao Hou, Yupin Yang. Structural characterization of the extracellular polysaccharides produced by the marine fungus Epicoccum nigrum JJY-40 and their antioxidant activities. Mar Biotechnol, 2011, 13, 1048–1055. (SCI, IF 3.430)

13．Shoudong Guo, Wenjun Mao*, Yin Han, Xiaohua Zhang, Chunli Yang, Yin Chen, Yanli Chen, Jian Xu, Hongyan Li, Xiaohui Qi, Jiachao Xu. Structural characteristics and antioxidant activities of the extracellular polysaccharides produced by marine bacterium Edwardsiella tarda. Bioresour Technol, 2010, 101, 4729–4732. (SCI, IF 4.365)

14. Wenjun Mao*, Hongyan Li, Yi Li, Huijuan Zhang, Xiaohui Qi, Haihong Sun, Yin Chen. Chemical characteristic and anticoagulant activity of the sulfated polysaccharide isolated from Monostroma latissimum (Chlorophyta). Int J Biol Macromol, 2009, 44, 70–74. (SCI, IF 2.366)

15. Haihong Sun, Wenjun Mao*, Yin Chen, Shoudong Guo, Hongyan Li, Xiaohui Qi, Yanli Chen, Jian Xu. Isolation, chemical characteristics and antioxidant properties of the polysaccharides from marine fungus Penicillium sp. F23-2. Carbohydr Polym, 2009, 78, 117–124. (SCI, IF 3.167)

16. Wenjun Mao*, Fang Fang, Hongyan Li, Xiaohui Qi, Haihong Sun, Yin Chen, Shoudong Guo. Heparinoid-active two sulfated polysaccharides isolated from marine green algae Monostroma nitidum. Carbohydr Polym, 2008, 74, 834–839. (SCI, IF 2.644)

17. Huijuan Zhang, Wenjun Mao*, Fang Fang, Hongyan Li, Haihong Sun, Yin Chen, Xiaohui Qi. Chemical characteristics and anticoagulant activities of a sulfated polysaccharide and its fragments from Monostroma latissimum. Carbohydr Polym, 2008, 71, 428–434. (SCI, IF 2.644)