刘明 副教授



刘明，男，博士，副教授，丹麦外交部“DANIDA”计划资助获得者、中国海洋大学“青年英才工程” 计划资助获得者。

2003-2008年在中国海洋大学和丹麦Roskilde大学学习，获医学博士学位。2008年7月起，在中国科学院海洋研究所工作，方向为海洋活性物质的发现及作用机制的研究。2013年11月起，经中国海洋大学“青年英才工程”人才引进在中国海洋大学医药学院工作，研究方向为抗肿瘤药物的发现和作用机制研究。

近年来，针对肿瘤、代谢性疾病等疾病中重要的分子靶点或调控网络，以海洋天然产物为研究对象，开展了先导化合物的发现与功能研究；阐明这些活性物质的作用机制，探索新的药物靶点及调控网络，为新药研究提供物质基础和理论支持。在Oncotarget、Toxicol Lett、BBA、J Biochem等杂志发表SCI论文30余篇，核心期刊论文10余篇，申请专利14项、授权2项，参与编写英文专著2部。

联系方式：

电话：**；邮箱：lmouc@hotmail.com

主持科研项目：

1. 国家自然科学基金青年基金：文蛤抗肿瘤多肽MML抑制微管聚合的分子机制（**），2011.1-2013.12，项目负责人

2. 国家科技部“重大新药创制”科技专项：抗肿瘤药物MML的临床前研究（2009ZX09102-240），2009.1-2012.12，子课题项目负责人

3. 国家科技部“863”计划项目：抗肿瘤新药海鞘多肽CS5931的研制与开发（2014AA093503），2014.1-2016.12，子课题项目负责人

4. 山东省自然科学基金面上项目：海洋来源新骨架化合物抑制Hsp90的分子机制（ZR2015HM010），2015.7-2017.12，项目负责人

5. 中国海洋大学青年英才工程基金：肿瘤血管破坏剂CA-1HP的抗肿瘤作用及其作用机制（**），2014.1-2016.12，项目负责人

研究方向及内容：

1. 抗肿瘤化合物作用机制的研究

2. 海洋活性化合物的筛选及活性评价

代表性SCI论文（*通讯作者）：

Liu M, Zhang W, Tang W, Wang Y, Zhao X, Wang, X, Qi, X, Li J*. Isocyclopamine, a novel synthetic derivative of cyclopamine, reverts doxorubicin resistance in MCF-7/ADR cells by increasing intracellular doxorubicin accumulation and downregulating breast cancer stem-like cells. Tumor Biol. 2015, 1-13.Song X, Zhao Z, Qi X, Tang S, Wang Q, Zhu T, Gu Q, Liu M*, Li J*. Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90. Oncotarget, 2015, 5. Liu M, Yin H, Liu G, Dong J, Qian Z, Miao J*. Xanthohumol, a prenylated chalcone from beer hops, act as an α-glucosidase inhibitor in vitro. J. Agric. Food Chem., 2014, 62 (24), 5548–5554. Liu M, Zhao X, Xiao lin, Liu Ge, Liu H, Wang X, Feng X, Lin X*. Cytotoxicity of the compounds isolated from Pulsatilla chinensis (Bunge) Regel saponins and apoptosis induced by 23-hydroxybetulinic acid. Pharm Biol, 2014, Jul 15:1-9.Liu M, Wang G, Xiao L, Xu X, Liu X, Xu P, Lin X. Bis(2,3-dibromo-4,5-dihydroxybenzyl) Ether, a marine algae derived bromophenol, inhibits the growth of botrytis cinerea and interacts with DNA molecules. Mar Drugs. 2014 Jun 27;12(7):3838-51. Liu G, Liu M*, Wei J, Huang H, Zhang Y, Zhao J, Xiao L, Wu N, Zheng L, Lin X*. CS5931, a novel polypeptide in Ciona savignyi, represses angiogenesis via inhibiting VEGF and MMPs. Mar Drugs, 2014, 12(3):1530-44. Zhao J, Wei J, Liu M*, Xiao L, Wu N, Liu G, Huang H, Zhang Y, Zheng L, Lin X*. Cloning, characterization and expression of a cDNA encoding a granulin-like polypeptide in Ciona savignyi. Biochimie. 2013, 95(8):1611-9. Qiu L, Liu M* and Pan K *. A Triple Staining Method for Accurate Cell Cycle Analysis Using Multiparameter Flow Cytometry. Molecules. 2013, 18(12), 15412-15421. Liu M, Yin H, Dong J, Xiao L, Liu G, Qian Z, Miao J. Inhibition and Interaction with Hyaluronidase by Compounds from Hop (Humulus lupulus L) Flowers. Asian J Chem 2013, 25(18), 10262-10266.Liu M, Zhao X, Zhao J, Xiao L, Liu H, Wang C, Cheng L, Wu N, Lin X. Induction of apoptosis, G0/G1 phase arrest, and microtubule disassembly in K562 leukemia cells by Mere15, a novel polypeptide from Meretrix meretrix Linnaeus. Mar Drugs, 2012, 10(11), 2596-2607.Liu M, Zhang W, Wei J, Lin X. Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, induces mitochondrial apoptosis in K562 cells and inhibits topoisomerase I in vitro. Toxicol Lett, 2012, 211(2):126-134. Liu M, Wei J, Wang H, Ding L, Zhang Y, Lin X. Extract of Meretrix meretrix Linnaeus induces angiogenesis in vitro and activates endothelial nitric oxide synthase. Chin. J. Oceanol. Limnol. 2012, 30(5):724-730.Lin X, Liu M*. Bromophenols from Marine Algae with Potential Anti-diabetic Activities. J. Ocean Univ. China. 2012, 11(4):533-538.Liu M*, Hansen PE, Wang G, Qiu L, Dong J, Yin H, Qian Z, Yang M, Miao J*. Pharmacological profile of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus). Molecules. 2015 Jan 7;20(1):754-79.Qi X, Liu G, Qiu L, Lin X, Liu M*, Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems, Biomedicine & Pharmacotherapy, 2015, 75, Pages 58-66.Liu M, Hansen PE, Lin X. Bromophenols in marine algae and their bioactivities. Mar Drugs. 2011,9(7):1273-92. Liu M, Zhang W, Qiu L, Lin X. Synthesis of butyl-isobutyl-phthalate and its interacition with α–glucosidase in vitro, J Biochem. 2011, 149(1):27-33. Liu M, Zhang W, Wei J, Lin X. Synthesis and α-glucosidase inhibitory mechanisms of bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, a potential marine bromophenol α-glucosidase inhibitor. Mar Drugs 2011, 9(9), 1554-1565.参编英文专著：

1. Liu M, Lin X and Zheng LH. Handbook of Anticancer Drugs from Marine Origin (Chapter 25: Targeting Cellular Proapoptotic Agents from Marine Sources). Springer International Publishing Switzerland. 2014.

2. Zhang W, Liu M and Hansen PE. Marine Biomaterials: Isolation, Characterization and Application. (Chapter: Structure elucidation and biological effects of carrageenans from red algae). CRC-Taylor & Francis. 2013.