刘延凯副教授






个人简历：

刘延凯，博士，副教授

中国海洋大学医药学院，药物合成实验室

青岛市鱼山路5号，266003

Phone: **002


E-mail: liuyankai@ouc.edu.cn

教育背景：

2010.04-2013.04 Institut Català d'Investigació Química（ICIQ研究所，西班牙），博士后研究，指导老师：Prof. Dr. P. Melchiorre

2009.09-2009.12 University of Cologne（科隆大学，德国），有机化学学院，交换生，指导老师：Prof. Dr. A. Berkessel

2006.09-2010.07 四川大学，华西药学院，博士研究生，指导老师：陈应春 教授

2004.09-2006.07 四川大学，华西药学院，硕士研究生，指导老师：陈应春 教授

1998.09-2002.07 山东大学，药学院，本科

研究方向：

药物设计与合成，主要研究内容包括：

1. 手性海洋活性天然产物含吲哚类化合物的设计与合成

2. 多取代手性海洋活性天然产物含氮及杂环化合物的设计与合成

3. 多取代手性海洋活性天然产物含羰基化合物及其衍生物的设计与合成

研究经历：

1. 合成并优化了多种有机卡宾催化剂，并将这些催化剂成功应用于以下研究工作：

~Ring-Opening Reactions of Aziridines with Aldehydes Catalyzed by Nucleophilic Carbenes under Aerobic Conditions

2. 合成并优化了多种双功能手性硫脲催化剂，包含硫脲和叔胺两个功能基团，并将这些催化剂成功应用于以下研究工作：

~Organocatalytic Asymmetric One-Pot, Three-Component Reaction of Aldehydes, Diethyl α-Aminomalonate and Nitroalkenes

~Organocatalytic Enantioselective Mannich-Type Reaction of Phosphorus Ylides: Synthesis of Chiral N-Boc-α -Amino-β-methylene Carboxylic Esters

~Organocatalytic Asymmetric 1,3-Dipolar Cycloaddition of Nitrones to Nitroolefins

3. 合成并优化了多种手性仲胺催化剂，并将这些催化剂成功应用于以下研究工作：

~Asymmetric Tandem Michael Addition-Wittig Reaction to Cyclohexenone Annulation

~Asymmetric Michale Additon of Nitrobenzyl Pyridines to Eanals under Iminium Catalysis

~Asymmetric Catalysis of Diels–Alder Reactions with in Situ Generated Heterocyclic ortho-Quinodimethanes

4. 合成并优化了多种手性伯胺催化剂，并将这些催化剂成功应用于以下研究工作：

~Diastereodivergent Asymmetric Sulfa-Michael Additions of alpha-Branched Enones using a Single Chiral Organic Catalyst

~Organocatalytic asymmetric direct Michael addition of aromatic ketones to alkylidenemalononitriles



工作经历：

2002.07-2004.08 横店集团成都分子实验室有限公司，主要负责研发医药化工中间体。

2012.12-2013.09 西南交通大学，生命科学与工程学院，药物合成，副教授

2013.09- 中国海洋大学，医药学院，药物合成，副教授

所得荣誉：

Marie Curie fellowship (欧盟 玛丽·居里奖学金) (Grant FP7-PEOPLE-2010-IIF no.: 273088)

研究项目

? 基于aza-dienamine或aza-trienamine活化历程的不对称催化反应的研究，国家自然科学基金（No. **），25万，2014.01-2016.12

? 不对称催化在合成海洋药物中的应用，中国海洋大学“英才”二层次，20万，2014.01-2016.12

发表论文：

1. David Bastida, Yankai Liu, Xu Tian, Eduardo Escudero-Adán, and Paolo Melchiorre*, “Asymmetric Vinylogous Aldol Reaction via H-Bond-Directing Dienamine Catalysis”, Org. Lett., 2013, 15, 220-223

2. Xu Tian, Yan-kai Liu, Paolo Melchiorre*, “Aminocatalytic Enantioselective 1,6-Additions of Alkyl Thiols to Cyclic Dienones: Vinylogous Iminium Ion Activation”, Angew. Chem. Int. Ed. 2012, 51, 6439-6422

3. Yan-Kai Liu, Manuel Nappi, Eduardo C. Escudero-Adán, and Paolo Melchiorre*, “Multicatalytic Asymmetric Synthesis of Complex Tetrahydrocarbazoles via a Diels–Alder/Benzoin Reaction Sequence”, Org. Lett., 2012, 14, 1310-1313

4. Yan-Kai Liu, Manuel Nappi, Elena Arceo, Silvia Vera, and Paolo Melchiorre*, “Asymmetric Catalysis of Diels–Alder Reactions with in Situ Generated Heterocyclic ortho-Quinodimethanes”. J. Am. Chem. Soc., 2011, 133, 15212-15218

5. Xu Tian, Carlo Cassani, Yan-kai Liu, Antonio Moran, Atsushi Urakawa, Patrizia Galzerano, Elena Arceo, Paolo Melchiorre*, “Diastereodivergent Asymmetric Sulfa-Michael Additions of alpha-Branched Enones using a Single Chiral Organic Catalyst” J. Am. Chem. Soc., 2011, 133, 17934-17941

6. Silvia Vera, Yan-kai Liu, Mauro Marigo, Eduardo C. Escudero-Adán, Paolo Melchiorre “Asymmetric Michael Additon of Nitrobenzyl Pyridines to Eanals under Iminium Catalysis”. Synlett., 2011, 489-494

7. Hailei Cui, Kun Jiang, Yan-Kai Liu, Wei Du, Yingchun Chen,* “Enantioselective direct aldol-type reaction of 4-hydroxycoumarin with ethyl trifluoropyruvate catalyzed by modified cinchona alkaloids”, Chin. Sci. Bull. 2010, 55, 1732

8. Yan-Kai Liu, Chao Ma, Kun Jiang, Tian-Yu Liu, and Ying-Chun Chen*, “Asymmetric Tandem Michael Addition-Wittig Reaction to Cyclohexenone Annulation”. Org. Lett., 2009, 11, 2848-2851

9. Yan-Kai Liu, Hao Liu, Wei Du, Lei Yue, and Ying-Chun Chen*, “Reaction Control in the Organocatalytic Asymmetric One-Pot, Three-Component Reaction of Aldehydes, Diethyl a-Aminomalonate and Nitroalkenes: Toward Diversity-Oriented Synthesis”, Chem. Eur. J. 2008, 14, 9873-9877

10. Yan Zhang, Yan-Kai Liu, Tai-Ran Kang, Ze-Kai Hu, and Ying-Chun Chen*, “Organocatalytic Enantioselective Mannich-Type Reaction of Phosphorus Ylides: Synthesis of Chiral N-Boc-α -Amino-β-methylene Carboxylic Esters”. J. Am. Chem. Soc., 2008, 130, 2456-2457

11. Lei Yue, Wei Du, Yan-Kai Liu, Ying-Chun Chen*, “Organocatalytic asymmetric direct Michael addition of aromatic ketones to alkylidenemalononitriles”. Tetrahedron Lett., 2008, 49, 3881-3884

12. Wei Du, Yan-Kai Liu, Lei Yue, Chen, Ying-Chun*, “Organocatalytic Asymmetric 1,3-Dipolar Cycloaddition of Nitrones to Nitroolefins”. Synlett., 2008, 19, 2997-3000

13. Yan-Kai Liu, Rui Li, Lei Yue, Bang-Jing Li, Ying-Chun Chen,* Yong Wu, and Li-Sheng Ding, “Unexpected Ring-Opening Reactions of Aziridines with Aldehydes Catalyzed by Nucleophilic Carbenes under Aerobic Conditions”, Org. Lett., 2006, 8, 1521-1524