李德海教授
李德海，男，1980年1月生，博士，教授、硕士生导师。中国海洋大学“青年英才工程”（2009）、教育部 “新世纪优秀人才支持计划”（2012）、“山东省自然科学杰出青年基金”（2014）获得者；2013年获“第九届青岛市青年科技奖”；被评为2015年度海洋领域优秀科技青年。

2002年本科毕业于山东大学药学院；2007年在中国海洋大学医药学院硕博连读获药物化学博士学位（导师：顾谦群）；2007年-2009年赴加拿大University of British Columbia化学系Raymond J. Andersen 课题组从事为期两年的海洋药物博士后研究，主要从事海洋天然产物的发现和化学合成；2014年8月-2015年8月于美国加州大学洛杉矶分校（UCLA）Yi Tang课题组从事真菌基因组采掘及天然产物生物合成研究（访问学者）。

目前主要从事海洋天然药物化学研究，聚焦海洋微生物活性次级代谢产物，从中寻找结构新颖的药物先导化合物。近年来承担国家自然科学基金、山东省、教育部等7项课题研究。发表SCI收录论文70余篇，其中以第一或通讯作者在Org. Lett.、J. Org. Chem.、J. Nat. Prod.等国际学术期刊上发表研究SCI收录论文46篇，第一和通讯作者论文被引用366次，其中他引270次。申请国家发明专利8项，授权5项。目前是医药学院院长助理、中国药学会海洋药物专业委员会秘书、中国海洋湖沼学会药学分会副秘书长；Crit. Rev. Microbiol.（IF: 6.087）、RSC Adv.（IF: 3.708）、New J. Chem. （IF: 3.159）、Bioorgan. Med. Chem.（IF: 2.951）、Tetradedron（IF: 2.817）等SCI收录期刊审稿人。



研究方向：

海洋微生物活性次级代谢产物的发现、结构优化及构效关系的研究。利用课题组已有的资源和技术优势，继续对可培养特殊环境海洋微生物进行代谢产物结构和活性多样性的研究，主要包括:（1）采用基因-活性-化学筛选相结合的集成筛选模式发现目标菌株；（2）应用OSMAC策略、表观遗传修饰、基因组采掘等技术进行代谢产物多样性研究并针对多模型、多靶点进行活性多样性研究；（3）对于有潜力的化合物结合作用靶点采用化学合成手段进行结构修饰和优化，以期获得新型药物药物先导化合物，开拓海洋微生物药用新资源。

招生专业：药物化学，制药工程

联系方式：电话 **， email：dehaili@ouc.edu.cn

代表论文（2011-至今）：

Qian Che, Tong Li, Xiaofang Liu, Tingting Yao, Jing Li, Qianqun Gu, Dehai Li*, Wenli Li*, and Tianjiao Zhu*.Genome Scanning Inspired Isolation of Reedsmycins A-F, Polyene-polyol Macrolides from Streptomyces sp. CHQ-64. RSC Adv. 2015,5(29): 22777-22782. (IF = 3.708)Wenqiang Guo, Dan Li, Jixing Peng, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Penicitols A-C and Penixanacid A from the Mangrove Derived Penicillium chrysogenum HDN11-24. J. Nat. Prod. 2015,78(2): 306?310. (IF = 3.947)Jixing Peng,Huquan Gao, Xiaomin Zhang, Shuai Wang, Chongming Wu,Qianqun Gu, Peng Guo,Tianjiao Zhu,*and Dehai Li*. Psychrophilins E–H and Versicotide C, Cyclic Peptides from the Marine-Derived Fungus Aspergillus versicolor ZLN-60. J. Nat. Prod. 2014, 77(10): 2218-2223. (IF = 3.947)Jixing Peng, Huquan Gao, Jing Li, Jing Ai, Meiyu Geng, Guojian Zhang, Tianjiao Zhu, Qianqun Gu, Dehai Li*. Prenylated Indole Diketopiperazines from the Marine–Derived Fungus Aspergillus versicolor. J. Org. Chem., 2014, 79 (17): 7895–7904. (IF = 4.638)Yepeng Luan,Hongjuan Wei,Zhenpei Zhang,Qian Che,Yankai Liu,Tianjiao Zhu, Attila Mándi, Tibor Kurtán,Qianqun Gu, and Dehai Li*. Eleganketal A, a Highly Oxygenated Dibenzospiroketal from the Marine-Derived Fungus Spicaria elegans KLA03.J. Nat. Prod. 2014,77(7):1718-1723. (IF = 3.947)Jixing Peng, Xiaomin Zhang, Lin Du, Wei Wang, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Sorbicatechols A and B, Antiviral Sorbicillinoids from the Marine-Derived Fungus Penicillium chrysogenum PJX-17. J. Nat. Prod. 2014,77(2):424-428 (IF = 3.947)Guangwei Wu, Xinhua Sun, Guihong Yu, Wei Wang, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Cladosins A?E, Hybrid Polyketides from a Deep-Sea-Derived Fungus, Cladosporium sphaerospermum. J. Nat. Prod. 2014,77 (2): 270–275 (IF = 3.947)Xinhua Ma, Letao Li, Tianjiao Zhu, Mingyu Ba, Guoqiang Li, Qianqun Gu, Ying Guo^* and Dehai Li^*. Phenylspirodrimanes with Anti-HIV Activity from the Sponge-derived Fungus Stachybotrys chartarum MXH-X73. J. Nat. Prod. 2013, 76(12): 2298–2306. (IF = 3.947)Wenqiang Guo, Jixing Peng, Tianjiao Zhu, Qianqun Gu, Robert A. Keyzers,and Dehai Li*. Sorbicillamines A-E, Nitrogen Containing Sorbicillinoids from the Deep-sea Derived Fungus Penicillium sp. F23-2.J. Nat. Prod.2013, 76(11):2106-2112. (IF = 3.947)Guojian Zhang, Guangwei Wu, Tianjiao Zhu, Tibor Kurtán, Attila Mándi, Jieying Jiao, Jing Li, Xin Qi, Qianqun Gu and Dehai Li*. Meroterpenoids with Diverse Ring Systems from the Sponge-Associated Fungus Alternaria sp. JJY-32.J. Nat. Prod. 2013, 76, 1946–1957. (IF = 3.947)Jixing Peng, Tao Lin, Wei Wang, Zhihong Xin,* Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Antiviral Alkaloids Produced by the Mangrove-Derived Fungus Cladosporium sp. PJX-41. J. Nat. Prod. 2013, 76(6): 1133-1140. (IF = 3.947)Guangwei Wu, Aiqun Lin, Qianqun Gu, Tianjiao Zhu* and Dehai Li*. Four new chloro-eremophilane sesquiterpenes from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Mar. Drugs, 2013, 11:1399-1408 (IF = 3.512)Shengxin Cai, Yepeng Luan, Xianglan Kong, Tianjiao Zhu, Qianqun Gu,and Dehai Li*. Isolation and photoinduced conversion of 6-epi-Stephacidins from Aspergillus taichungensis.Org. Lett. 2013, 15(9): 2168-2171 (IF = 6.324)Qian Che, Tianjiao Zhu, Robert A. Keyzers, Xiaofang Liu, Jing Li, Qianqun Gu, and Dehai Li*.Polycyclichybrid isoprenoids from a reed rhizosphere-soil derived Streptomyces sp. CHQ-64.J. Nat. Prod. 2013, 76(4): 759-763 (IF = 3.947)Huquan Gao, Weizhong Liu,Tianjiao Zhu, Xiaomei Mo, Attila Mándi,Tibor Kurtán,* Jing Li,* Jing Ai, Qianqun Gu, andDehai Li*.Diketopiperazine Alkaloids from a Mangrove Rhizosphere SoilDerived Fungus Aspergillus effuses H1-1.Org. Biomol. Chem., 2012, 10(47):9501-9506. (IF = 3.487)Qian Che, Tianjiao Zhu, Xin Qi, Attila Mándi, Tibor Kurtán, Xiaomei Mo, Jing Li,Qianqun Gu, and Dehai Li*. Hybrid Isoprenoids from a Reeds Rhizosphere Soil Derived Actinomycete Streptomyces sp. CHQ-64. Org. Lett. 2012, 14(13): 3438-3441. (IF = 6.324)GuojianZhang, Shiwei Sun, Tianjiao Zhu, Zhenjian Lin, Jingyan Gu, Dehai Li* and Qianqun Gu*. Antiviral isoindolone derivatives from an endophytic fungus Emericella sp.associated with mangroveAegiceras corniculatum. Phytochemistry. 2011, 72,1436-1442. (IF = 3.350)Dehai Li, Gavin Carr, Yonghong Zhang, David E. Williams, Ashraf Amlani, Helen Bottriell, Alice L.-F. Mui, and Raymond J. Andersen*. Turnagainolides A and B, Cyclic Depsipeptides Produced in Culture by a Bacillus sp. Isolation, Structure Elucidation, and Synthesis.J. Nat. Prod. 2011, 74(5): 1093-1099. (IF = 3.947)Shengxin Cai, Shiwei Sun, Huinan Zhou, Xianglan Kong, Tianjiao Zhu, Dehai Li*, and Qianqun Gu*. Prenylated polyhydroxy-p-terphenyls from Aspergillus taichungensis ZHN-7-07. J. Nat. Prod., 2011, 74(5): 1106-1110. (IF = 3.947)