ToStudy the Effect of Akt Phosphorylation in the RAW264.7 Activation Induced byAstragalus Polysaccharide，2017/04-2018/04, 5 万港币

代表性论文：

1. Li Z#, Chu S#, He W, Zhang Z, Liu J, Cui L, Yan X, Li D*, Chen N*. Zinc-finger proteinA20 as a novel target for the anti-neuroinflammatory effect of chrysin viainhibition of NF-κB signaling pathway. Brain,Behavior, and Immunity, doi.org/10.1016/j.bbi.2019.02.005.

2. Li Z#, Liao J#, Yang Z#, Choi E, Lapidus R, XuefengLiu X, Cullen K, Dan H*. Co- targeting of EGFR and IKKβ/NF-κB signalingpathways in head and neck squamous cell carcinoma: a potential novel therapyfor head and neck squamous cell cancer. Britishjournal of cancer 2019, 120: 306-316.

3. Yang Z, Guan Y, Li J, LiL*, Li Z*. Chrysin attenuatescarrageenan-induced lung injury via activation of SIRT1/NRF2 pathway in rats.European journal of pharmacology. 2018, 836,83-88.

4. Li Z, Liu H, Zhang Q, Li L, Bao W, Ma D, Leung C, Bian Z, Lu A*, Han Q*. Interference of quercetin onAstragalus polysaccharide-induced macrophage activation. Molecules 2018, 23, 1563.

5. Li Z, Li L, Zhang Q, Wei W, Liu H, Bao W,Ma D, Leung C, Bian Z, Lu A*, Han Q*. Akt downstream of NFκB, MAPKs and IRF3pathway involved in RAW264.7 macrophages activation induced by Astragaluspolysaccharide RAP. Journal of Functional Foods. Journal of Functional Foods2017, 39: 152-159.

6. Li Z, Li L, Zhang Q, Wei W, Li L, Ma D, LeungC, Lu A, Bian Z*, Han Q*. Luteolin

exerted less inhibitory effect on macrophageactivation induced by Astragalus polysaccharide than by lipopolysaccharide. Journal of Functional Foods 2017, 37: 618-623.

7. Li Z, Yang Z, Passaniti A, Lapidus R, Liu X, Cullen K, Dan H*. A positivefeedback

loop involving EGFR/Akt/mTORC1 and IKK/NF-κB regulates headand neck

squamous cell carcinoma proliferation. Oncotarget 2016. 7:31892-31906.

8. Li Z#, YangZ#, Lapidus R, Liu X, Cullen K, Dan H*. IKKphosphorylation of NF-

κB at serine 536contributes to acquired cisplatin resistance in head and neck squamous cellcancer. American Journal of Cancer Research. 2015,5:3098-3110.

9.Li Z#, Shangguan Z#, Liu Y, Wang J, Li X, Yang S*, Liu S*. Puerarin protects

pancreatic βcell survival via PI3K/Akt signaling pathway. Journal of MolecularEndocrinology. 2014, 53: 71-79.

10. Li Z, Ji H, Song X, Hu J, Han N, ChenN*. Osthole attenuates the development of carrageenan-induced lung inflammationin rats. International Immunopharmacology. 2014, 20: 33-36.

11. Li Z, Hu J, Sun M, Song X, Li G, Liu Y,Li G, Ji H, Liu G, Chen N*. In vitro and in vivo anti-inflammatory effects of IMMLG5521, a coumarin derivative. International Immunopharmacology. 2013, 17: 400-403.

12. Li Z, Hu J, Sun M, Ji H, Chu S, Liu G,Chen N*. Anti-inflammatory effect of IMMLG5521, a coumarin derivative, onSephadex-induced lung inflammation in rats. International Immunopharmacology.2012, 14: 145-149.

13. Li Z, Hu J, Sun M, Ji H, Zhao M, Wu D, Li G, Liu G, Chen N* Effect of compoundIMMLG5521, a novel coumarin derivative, on carrageenan-induced pleurisy inrats. European Journal of Pharmacology. 2011, 661: 118-123.

社会兼职：

1. 中国药理学会补益药药理专业委员会委员