张军 副主任医师，讲师
硕士招生类型：学术型
硕士招生专业：临床检验诊断学
博士招生类型：
博士招生专业：
所在院系：附属第一妇婴保健院
联系方式：zhangjun@51mch.com
课题组链接：
研究方向
主要任职
科研业绩

妊娠相关疾病的分子诊断研究
Moleculardiagnosis of pregnancy-associated diseases



上海市遗传学会遗传与分子诊断专业委员会 委员
上海市中医药学会检验医学分会 委员
Genetics and Molecular Diagnosis Branchof Shanghai Association of Genetics, Committee member
Laboratorymedicine branch of Shanghai Association of ChineseMedicine, Committee member




博士及博士后期间主要从事游离核酸在非侵袭性产前诊断、移植排斥和肿瘤诊断方面的研究。近年来主要从事感染性疾病的病毒分子进化与感染免疫方面的研究。已发表SCI论文27篇，主持国家自然基金面上项目1项、上海市科委课题1项、子课题2项和上海市市卫计委课题1项。

代表性论文：
1. LeungTN, Zhang J, Lau TK, Hjelm NM, Lo YM. Maternal plasma fetal DNA as amarker for preterm labour. Lancet 1998;352:1904-5.
2. Zhang J, Tong KL, Li PK, Chan AY, Yeung CK, Pang CC, et al. Presence of donor- and recipient-derivedDNA in cell-free urine samples of renal transplantation recipients: urinary DNAchimerism. Clin Chem 1999;45:1741-6.
3. LoYM, Zhang J, Leung TN, Lau TK, Chang AM, Hjelm NM. Rapid clearance offetal DNA from maternal plasma. Am J Hum Genet 1999;64:218-24.
4. LoYM, Lau TK, Zhang J, Leung TN, Chang AM, Hjelm NM, et al. Increasedfetal DNA concentrations in the plasma of pregnant women carrying fetuses withtrisomy 21. Clin Chem 1999;45:1747-51.
5. LoYM, Wong IH, Zhang J, Tein MS, Ng MH, Hjelm NM. Quantitative analysis ofaberrant p16 methylation using real-time quantitative methylation-specificpolymerase chain reaction. Cancer Res 1999;59:3899-903.
6. Tang NL,Leung TN, Zhang J, Lau TK, Lo YM. Detection of fetal-derived paternallyinherited X-chromosome polymorphisms in maternal plasma. Clin Chem1999;45:2033-5.
7. Zhang J,Fidler C, Murphy MF, Chamberlain PF, Sargent IL, Redman CW, et al.Determination of fetal RhD status by maternal plasma DNA analysis. Ann N YAcad Sci 2000;906:153-5.
8. Leung TN, ZhangJ, Lau TK, Chan LY, Lo YM. Increased maternal plasma fetal DNAconcentrations in women who eventually develop preeclampsia. Clin Chem2001;47:137-9.
9. Chan KC, ZhangJ(并列第一作者), Chan AT, Lei KI, Leung SF, Chan LY, etal. Molecular characterization of circulating EBV DNA in the plasma ofnasopharyngeal carcinoma and lymphoma patients. Cancer Res 2003;63:2028-32.
10. ChanKC, Zhang J(并列第一作者), Hui AB, Wong N, Lau TK, Leung TN, et al.Size distributions of maternal and fetal DNA in maternal plasma. Clin Chem2004;50:88-92.
11.Shen Z, Wang G, Zhang WJ, Qian FX, Li Y, Zhang M, Gu SM, Wang MY, Lin F, Hu YW, Yuan ZH, Zhang J (通讯作者). Rotavirus infection and its genetic characterization in non-hospitalized adults with acutegastroenteritis in Shanghai,China. Archives of Virology, 2013, 158(8):1671-7.
12. Shen Z, Qian FX, Li Y, Hu YW, Yuan ZH, Zhang J (通讯作者). Novel Norovirus GII.4 Variant, Shanghai, China, 2012. EmergingInfectious Diseases, 2013, 19(8):1337-9.
13., Chen ZJ, Li X, Xu L, Guan WC, Cao YS, Hu YW, Zhang J (通讯作者).Host immunological response and factors associated with clinical outcome inpatients with the novel influenza A H7N9 infection. Clinical Microbiology andInfection, 2014, 20(8):O493-500
14.Wang G, Shen Z, Qian FX, Li Y, Yuan ZH,Zhang J (通讯作者). Geneticdiversity of sapovirus in non-hospitalized adults with sporadic cases of acutegastroenteritis in Shanghai, China. Journal of Clinical Virology, 2014, 59(4):250-4.
15.ZhangJ, Shen Z, Zhu ZQ, Zhang WJ, Chen HF, Qian FX, Chen HL, Wang G, Wang MY, HuYW, Yuan ZH. Genotype distribution of norovirus around the emergence of Sydney2012 and the antigenic drift of contemporary GII.4 epidemic strains. Journal of Clinical Virology, 2015, 72:95-101.
课题：
1.国家自然科学基金，诺如病毒GII.4流行株衣壳蛋白分子进化机理的研究。
2.上海市科学技术委员会，噬菌体展示技术在诺如病毒快速检测中的应用研究。
3.上海市卫计委，噬菌体展示技术在诺如病毒快速诊断中的应用。
4.上海市科学技术委员会，乙肝和梅毒等快速诊断试剂的质量对比研究（子课题负责）。
5.上海市科学技术委员会，结核菌抗体诊断试剂盒在肺内外结核的临床再评价（子课题负责）。

The earlierresearch works during the PhD and postdoc were focused on the studies of cell freenucleic acids in non-invasive prenatal diagnosis, graft rejection and tumordiagnosis. In recent years, the research interests concern the moleculardiagnosis of infectious diseases. So far more than 20 papers have beenpublished in SCI. The main research works were supported by several grants including 1 from National Natural Science Foundationof China, 1 Shanghai Scienceand Technology Committee, and 1 Shanghai Municipal Commission of Health andFamily Planning.

Selectedpublications:
1. LeungTN, Zhang J, Lau TK, Hjelm NM, Lo YM. Maternal plasma fetal DNA as amarker for preterm labour. Lancet 1998;352:1904-5.
2. Zhang J, Tong KL, Li PK, Chan AY, Yeung CK, Pang CC, et al. Presence of donor- and recipient-derivedDNA in cell-free urine samples of renal transplantation recipients: urinary DNAchimerism. Clin Chem 1999;45:1741-6.
3. LoYM, Zhang J, Leung TN, Lau TK, Chang AM, Hjelm NM. Rapid clearance offetal DNA from maternal plasma. Am J Hum Genet 1999;64:218-24.
4. LoYM, Lau TK, Zhang J, Leung TN, Chang AM, Hjelm NM, et al. Increasedfetal DNA concentrations in the plasma of pregnant women carrying fetuses withtrisomy 21. Clin Chem 1999;45:1747-51.
5. LoYM, Wong IH, Zhang J, Tein MS, Ng MH, Hjelm NM. Quantitative analysis ofaberrant p16 methylation using real-time quantitative methylation-specificpolymerase chain reaction. Cancer Res 1999;59:3899-903.
6. Tang NL,Leung TN, Zhang J, Lau TK, Lo YM. Detection of fetal-derived paternallyinherited X-chromosome polymorphisms in maternal plasma. Clin Chem1999;45:2033-5.
7. Zhang J,Fidler C, Murphy MF, Chamberlain PF, Sargent IL, Redman CW, et al.Determination of fetal RhD status by maternal plasma DNA analysis. Ann N YAcad Sci 2000;906:153-5.
8. Leung TN, ZhangJ, Lau TK, Chan LY, Lo YM. Increased maternal plasma fetal DNAconcentrations in women who eventually develop preeclampsia. Clin Chem2001;47:137-9.
9. Chan KC, ZhangJ(并列第一作者), Chan AT, Lei KI, Leung SF, Chan LY, etal. Molecular characterization of circulating EBV DNA in the plasma ofnasopharyngeal carcinoma and lymphoma patients. Cancer Res 2003;63:2028-32.
10. ChanKC, Zhang J(并列第一作者), Hui AB, Wong N, Lau TK, Leung TN, et al.Size distributions of maternal and fetal DNA in maternal plasma. Clin Chem2004;50:88-92.
11.Shen Z, Wang G, Zhang WJ, Qian FX, Li Y, Zhang M, Gu SM, Wang MY, Lin F, Hu YW, Yuan ZH, Zhang J (通讯作者). Rotavirus infection and its genetic characterization in non-hospitalized adults with acutegastroenteritis in Shanghai,China. Archives of Virology, 2013, 158(8):1671-7.
12. Shen Z, Qian FX, Li Y, Hu YW, Yuan ZH, Zhang J (通讯作者). Novel Norovirus GII.4 Variant, Shanghai, China, 2012. EmergingInfectious Diseases, 2013, 19(8):1337-9.
13., Chen ZJ, Li X, Xu L, Guan WC, Cao YS, Hu YW, Zhang J (通讯作者).Host immunological response and factors associated with clinical outcome inpatients with the novel influenza A H7N9 infection. Clinical Microbiology andInfection, 2014, 20(8):O493-500
14.Wang G, Shen Z, Qian FX, Li Y, Yuan ZH,Zhang J (通讯作者). Geneticdiversity of sapovirus in non-hospitalized adults with sporadic cases of acutegastroenteritis in Shanghai, China. Journal of Clinical Virology, 2014, 59(4):250-4.
15.ZhangJ, Shen Z, Zhu ZQ, Zhang WJ, Chen HF, Qian FX, Chen HL, Wang G, Wang MY, HuYW, Yuan ZH. Genotype distribution of norovirus around the emergence of Sydney2012 and the antigenic drift of contemporary GII.4 epidemic strains. Journal of Clinical Virology, 2015, 72:95-101.

Research projects:
1. National Natural Science Foundation of China，Molecular evolution of viral capsid protein innorovirus GII.4 strains.
2. Shanghai Science and Technology Committee，The study of phage display techniquesused in the diagnosis of norovirus.
3. Shanghai Municipal Commission of Healthand Family Planning，Rapid detection of norovirus by the use of phage display techniques.
4. Shanghai Science and TechnologyCommittee，Comparativestudy on quality of rapid diagnostic kits for hepatitis B virus and syphilis (sub-project).
5.Shanghai Science and Technology Committee，Clinical evaluation of TBantibody diagnostic kit in internal and external pulmonary tuberculosis (sub-project).