宛宝山 讲师，主管技师
硕士招生类型：学术型；专业型
硕士招生专业：临床检验诊断学
博士招生类型：
博士招生专业：
所在院系：附属肺科医院
联系方式：bswan@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

病原微生物的致病机制
（Pathogenesisof pathogenic microorganisms）

同济大学附属上海市肺科医院，检验科，主管技师
（Supervising Technician,Medical laboratory, Shanghai pulmonary hospital affiliated to Tongji university）
上海市医学会结核病学专科分会委员
（Memberof Shanghai medical association, Tuberculosis Branch）

专注于常见病原菌致病机制的基础研究，尤其是肠道病原菌。在肠出血型大肠埃希菌（EHEC）VI型分泌系统（T6SS）的研究中，取得了重要的原创成果，提出了T6SS有助于增强EHEC在宿主巨噬细胞内的生存水平，从而表现出对宿主的毒力作用。标志性成果发表在《PLOS Pathogens》上。他的发现在中华医学会第十二次全国临床微生物学术年会上被评为大会论文一等奖。目前以一作或合作发表论文共10篇，其中SCI 收录5篇。
（Focus on the basicresearch of pathogenesis of pathogenic bacteria, especially intestinalpathogens. In the study about type VI secretory system (T6SS) in EHEC,important and original achievements have been obtained, suggesting that T6SS ishelpful to up regulate the survival level of EHEC in host macrophages, thusshowing virulence to the host. The iconic work was published on “PLOS Pathogens”.His discovery was awarded the first prize in the 12th national annual meetingof clinical microbiology by the Chinese medical association. At present, he haspublished a total of 10 papers with one work or cooperation, 5 of which areincluded in SCI.）
主持项目：
国家自然科学基金青年项目
同济大学优秀青年人才行动计划
上海市肺科医院“梦想导师”—优秀青年人才计划
代表性论文：
(1) Wan B^#, Zhang Q^#, NiJ, Li S, Wen D, Li J, Xiao H, He P, Ou HY, Tao J, Teng Q, Lu J, Wu W^*,Yao YF^*, Type VI secretion system contributes to EnterohemorrhagicEscherichia coli virulence by secreting catalase against host reactiveoxygen species (ROS). PLOS Pathogens, 2017, 13(3): p. e**
(2) Wan B, Zhang Q, Tao J, Zhou A, Yao YF^*, Ni J^*,Global transcriptional regulation by H-NS and its biological influence on the virulenceof Enterohemorrhagic Escherichia coli. Gene, 2016, 588(2): 115-123
(3) Chen WW#, Wan B#, Zhang R, Cao W, Liang L, Zhao YL, ChenJ*, Yue J*, Genetic Polymorphisms of miR-149 Associated with Susceptibility toBoth Pulmonary and Extrapulmonary Tuberculosis. Genet Test Mol Biomarkers. 2019Jul;23(7):442-447. doi: 10.1089/gtmb.2019.0003. Epub 2019 Jun 20
(4) Zhang Q, Wan B, Zhou A, Ni J, Xu Z, Li S, Tao J, Yao Y^*, Whole genome analysis of an MDRBeijing/W strain of Mycobacterium tuberculosis with large genomic deletionsassociated with resistance to isoniazid, Gene, 2016, 582(2): 128-136
(5) Zhang Q, Zhou A, Li S, Ni J, Tao J, Lu J, Wan B, Li S,Zhang J, Zhao S, Zhao GP, Shao F, Yao YF^*, Reversible lysine acetylation is involved in DNA replicationinitiation by regulating activities of initiator DnaA in Escherichia coli,Sci Rep, 2016 Aug 3, 6: 30837