严沁 讲师，副主任医师
硕士招生类型：专业型
硕士招生专业：妇产科学
博士招生类型：无
博士招生专业：无
所在院系：附属第一妇婴保健院
联系方式：yanqin76@126.com
课题组链接：
研究方向
主要任职
科研业绩

妇科肿瘤学
上海市第一妇婴保健院院长办公室主任，妇科主任医师，医学博士。中华医学会妇科肿瘤学分会青年委员，上海医学会妇科肿瘤学分会委员兼秘书，上海医师协会妇科肿瘤医师分会委员。
发表研究论文20余篇（SCI收录6篇），参编专业著作两部，副主译专业著作1部。获2012年上海市科技进步一等奖（排名第四）。
主持课题：1.基于分子分型的子宫内膜癌后腹膜淋巴结评估新模式研究. 上海市2020年度“科技创新行动计划”医学创新研究专项项目. 12/2020-11/2023
2.预警前移——构建临床“亚危急值”报告管理新模式. 上海申康医院发展中心新兴前沿项目. 11/2018-11/2019
3.自噬与炎症小体促进子宫内膜异位症生长的机制研究. 上海市第一妇婴保健院优青项目. 01/2018-12/2020
发表论文：1.Binya Liu, Guofang Chen, Qizhi He, Minhao Liu, Kun Gao, Bailian Cai, Junjie Qu, Shaojian Lin, Anke Geng, Shuangdi Li, Kai Wang, Zhiyong Mao, Xiaoping Wan*, Qin Yan*. An HMGA2-p62-ERα axis regulates uterine leiomyomas proliferation. FASEB J. 2020; 34(8): 10966-10983.
2.Lei Ye, ShuangDi Li, Wen Lu, QiZhi He, YiRan Li, BiLan Li, XiaoJun Wang, Qin Yan*（共同通讯作者）, XiaoPing Wan*. A Prospective Study of Sentinel Lymph Node Mapping for Endometrial Cancer: Is It Effective in High-Risk Subtypes? Oncologist. 2019 Dec;24(12): e1381-e1387
3.Zhou C, Yan Q, Zou QY, Zhong XQ, Tyler CT, Magness RR, Bird IM, Zheng J. Sexual Dimorphisms of Preeclampsia-Dysregulated Transcriptomic Profiles and Cell Function in Fetal Endothelial Cells. Hypertension. 2019 Jul;74(1):154-163.
4.Zou QY, Zhao YJ, Zhou C, Liu AX, Zhong XQ, Yan Q, Li Y, Yi FX, Bird IM, Zheng J. G Protein α Subunit 14 Mediates Fibroblast Growth Factor 2-Induced Cellular Responses in Human Endothelial Cells. J Cell Physiol. 2019 Jul;234(7):10184-10195.
5.Sun Y, Shao J, Jiang F, Wang Y, Yan Q, Yu N, Zhang J, Zhang J, Li M, He Y. CD33+ CD14+ CD11b+ HLA-DR- monocytic myeloid-derived suppressor cells recruited and activated by CCR9/CCL25 are crucial for the pathogenic progression of endometriosis. Am J Reprod Immunol. 2019 Jan;81(1): e13067.
6.Qingyun Zou, Yingjie Zhao, Hua Li, Xiangzhen Wang, Aixia Liu, Xinqi Zhong, Qin Yan, Yan Li, Chi Zhou, Jing Zheng*. GNA11 differentially mediates fibroblast growth factor 2-and vascular endothelial growth factor A-induced cellular responses in human fetoplacental endothelial cells. J Physiol. 2018; 596(12): 2333-2344.
7.Qin Yan, Fangyuan Wang, Yi Miao, Xiaomei Wu, Mingzhu Bai, Xiaowei Xi, Youji Feng*. Sex-determining region Y-box3 (SOX3) functions as an oncogene in promoting epithelial ovarian cancer by targeting Src Kinase. Tumor Biology. 2016; 37(9): 12263-12271.
8.Miao Y, Yan Q, Li S, Li B, Feng Y. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio are predictive of chemotherapeutic response and prognosis in epithelial ovarian cancer patients treated with platinum-based chemotherapy. Cancer Biomark. 2016; 17(1): 33-40.
9.Jing Zhang, Lei Liu, Yunyan Sun, Jiandong Xiang, Dongmei Zhou, Li Wang, Huali Xu, Xiaoming Yang, Na Du, Meng Zhang, Qin Yan*（共同通讯作者）, Xiaowei Xi*. MicroRNA-520g promotes epithelial ovarian cancer progression and chemoresistance via DAPK2 repression. Oncotarget. 2016; 7(18): 26516-34.