花晓琳 主任医师/副教授
硕士招生类型：学术型；专业型
硕士招生专业：妇产科学
博士招生类型：学术型；专业型
博士招生专业：妇产科学
所在院系：附属第一妇婴保健院
联系方式：huaxiaolin_sh@163.com
课题组链接：
研究方向
主要任职
科研业绩

胎盘源性疾病、宫内感染、盆腔脏器损伤修复的组织工程
Placental diseases; Intrauterine infection; Tissue engineering for the repair of pelvic organ damage
行政职务：同济大学附属第一妇婴保健院东院产科主任（妊娠高血压疾病）
学术任职：中华围产学会重症学组委员；中华医学会上海妇产科分会青年委员会委员兼秘书；中国妇幼保健协会妇幼健康服务产业委员会委员；上海市性教育协会理事；全国卫生产业企业管理协会抗衰老分会常务理事
Administrative position: Director of Obstetrics Department of the East Branch of Shanghai First Maternity and Infant Hospital (focused on Pregnancy-Induced Hypertension) Affiliated to Shanghai Tongji University
Academic position: Member of the Intensive Care Group of Chinese Perinatal Society；Member and Secretary of the Youth Committee of the Shanghai Obstetrics and Gynecology Branch of the Chinese Medical Association；Member of the Maternal and Child Health Service Industry Committee of Chinese Maternal and Child Health Association；Director of Shanghai Sex Education Association；Executive Director of Anti-Aging Branch of National Health Industry Enterprise Management Association
1.长期从事应用组织工程治疗盆底疾病的研究，致力于应用骨髓间充质干细胞（BMSCs）治疗早期盆底脱垂和盆腔脏器的损伤修复等相关机制和临床研究；聚焦高危妊娠对母儿结局的影响的研究，针对子痫前期这一妊娠期严重并发症，进行深入的机制研究，为子痫前期新的潜在治疗靶点提供理论依据。
Professor Hua has been long engaged in explorations in the tissue engineering for pelvic floor dysfunctions. She has been working on the application and the mechanism of bone marrow mesenchymal stem cells (BMSCs) in the treatment of early pelvic floor prolapse and pelvic organ damage, and achieved a more effective treatment than traditional methods. She has also focused on the impact of high-risk pregnancy on maternal and neonatal outcomes. Her in-depth mechanistic and clinical researches have made many contributions to the pathogenesis and treatment of preeclampsia, one of the serious pregnancy complications, and provided a theoretical basis for potential therapeutic targets for preeclampsia.
2.主持多项科研基金，包括3项国家自然科学基金，上海市卫健委卫生行业临床研究专项基金，上海市卫计委课题，上海交通大学“医工交叉”面上项目等。
Host a number of scientific research projects, including 3 National Natural Science Foundation of China, the Shanghai Municipal Health Commission’s Special Fund for Clinical Research in the Health Industry, the Shanghai Municipal Commission of Health and Family Planning, and the Medical-Engineering Cross Fund of Shanghai Jiaotong University.
近5年来主持的科研项目：
1.LncRNA-DIO3OS编码的新型小分子功能肽调控JAM2治疗盆底功能障碍性疾病的作用和机制研究，国家自然科学基金（**），经费52万，2021.1～2024.12，在研，主持；
2.人工智能眼底识别技术在妊娠期高血压疾病的开发与应用研究，上海市卫健委卫生行业临床研究专项基金（），经费10万，2021.1～2023.12，在研，主持；
3.雌激素作用下BMSCs结合改性PRP水凝胶支架的设计及其在子宫内膜损伤修复障碍中的应用，国家自然科学基金（**），经费57万，2019.1～2022.12，在研，主持；
4.质子泵抑制剂抑制胎盘滋养细胞外泌体分泌调控血管内皮功能治疗子痫前期的实验研究，浦东卫健委联合攻关课题（PW2019D-13），经费30万，2019.11～2022.10，在研，主持；
5.评价“超高龄”妊娠对母儿结局的影响及不同产前诊断技术在诊断和干预出生缺陷中的作用，上海市卫计委课题（），经费10万元，2017.1～2019.12，主持（已结题）；
6.微囊化VEGF缓释系统转染BMSCs治疗子宫内膜损伤的实验研究，上海交通大学“医工交叉”面上项目（YG2016MS71），经费21万元，2017.1～2019.12，主持（已结题）；
7.elastin基因修饰的BMSCs在bFGF纳米缓释系统诱导下注射治疗盆底功能障碍性疾病的实验研究，国家自然科学基金（**），经费23万元，2015.1～2017.12，主持（已结题）；
8.组织工程纳米可吸收补片重建盆底功能的研究，上海市卫生局青年科研项目（20114y079），经费4万元，2012.1～2014.12，主持（已结题）;
9.可吸收纳米生物补片重建盆底功能的实验研究，上海交通大学医工交叉青年研究基金（YG2011MS33），经费10万元， 2012.1～2013.12，主持（已结题）
Projects that Hua host in recent 5 years are listed as follow：
National Natural Science Foundation of China (**),2021.01-2024.12,52,0000
Shanghai Municipal Health Commission’s Special Fund for Clinical Research in the Health Industry (),2021.01-2023.12,10,0000
Pudong Health Commission Joint Project (PW2019D-13),2019.11-2022.10,30,0000
National Natural Science Foundation of China (**),2019.01-2022.12,57,0000
Shanghai Municipal Commission of Health and Family Planning (),2017.01-2019.12,10,0000
Surface Project of Medical-Engineering Cross Fund of Shanghai Jiaotong University (YG2016MS71),2017.01-2019.12,21,0000
National Natural Science Foundation of China (**),2015.01-2017.12,23,0000
Youth Project of Shanghai Health Bureau (20114y079),2012.01-2014.12,4,0000
Youth Project of Medical-Engineering Cross Fund of Shanghai Jiaotong University (YG2011MS33) ,2012.01-2013.12,10,0000
近五年以第一/通讯作者发表学术论文21篇，其中SCI论文17篇，累积IF超过50分。
近5年来以第一/通讯作者发表的论文：
1.Wu Y#, Wan S#, Gu S, Mou Z, Dong L, Luo Z, Zhang J*, Hua X (花晓琳，通讯作者)*. Gestational weight gain and adverse pregnancy outcomes: a prospective cohort study. BMJ Open. 2020 Sep 2;10(9):e038187.(IF 2.50) ；
2.Zhou Y#, Shen H#, Wu Y, Zhao X, Pei J, Mou Z, Dong J*, Hua X (花晓琳，通讯作者)*. Platelet-Rich Plasma Therapy Enhances the Beneficial Effect of Bone Marrow Stem Cell Transplant on Endometrial Regeneration. Front Cell Dev Biol. 2020 Feb 21;8:52. doi: 10.3389/fcell.2020.00052. eCollection 2020.(IF 5.20)；
3.Yang MN#, Zhang GH#, Du K, Wang WJ, Dong Y, He H, Chiu HC, Guo YN, Ouyang F, Zhang J, Hua X (花晓琳，共同通讯作者)*, Luo ZC*. Retinol-binding protein 4, fetal overgrowth and fetal growth factors. Pediatr Res. 2020 Apr;87(5):946-951.(IF 2.86)；
4.Gu S#, Shen H#, Zhou Y, Ni J, Zheng T, Mou Z, Hua X (花晓琳,通讯作者)*. Tetramethylpyrazine reduces the consequences of nitric oxide inhibition in pregnant rats. J Cell Physiol. 2019 Nov;234(11):19799-19806 （IF 5.55）；
5.Shen H#, Jin M#, Gu S, Wu Y, Yang M, Hua X (花晓琳,通讯作者)*. CD97 Is Decreased in Preeclamptic Placentas and Promotes Human Trophoblast Invasion Through PI3K/Akt/mTOR Signaling Pathway. Reprod Sci. 2019 Feb 21:**28067. [Epub ahead of print]（IF 2.62）；
6.Wu Y, Chen Y, Shen M, Guo Y, Wen SW, Lanes A, White RR, Adanlawo A, Walker M*, Hua X (花晓琳，通讯作者)*. Adverse maternal and neonatal outcomes among singleton pregnancies in women of very advanced maternal age: a retrospective cohort study. BMC Pregnancy Childbirth. 2019 Jan 3;19(1):3.（IF 2.24）；
7.Stealey S, Guo X, Ren L, Bryant E, Kaltchev M, Chen J, Kumpaty S, Hua X (花晓琳,共同通讯作者)*, Zhang W*. Stability improvement and characterization of bioprinted pectin-based scaffold. J Appl Biomater Funct Mater. 2019 Jan-Mar;17(1):07108. doi: 10.1177/07108 （IF 2.0）；
8.Yusen Ding, Yan Wang, Yanjie Su, Zhi Yang, Jiaqiang Liu*, Xiaolin Hua (花晓琳，共同通讯作者)*,Hao Wei*.A novel channel-wall engineering strategy for two-dimensional cationic covalent organic frameworks: Microwave-assisted anion exchange and enhanced carbon dioxide capture. Chinese Chemical Letters, In press, corrected proof, Available online 7 May 2019. (IF 4.63) ；
9.Hua X (花晓琳，第一作者)#, Shen M#, Reddy UM, Buck Louis G, Souza JP, Gülmezoglu AM, Zhang J*，Comparison of the INTERGROWTH-21st, National Institute of Child Health and Human Development, and WHO fetal growth standards. Int J Gynaecol Obstet,2018: 10.1002/ijgo.12637. [Epub ahead of print]（IF 2.22）；
10.Wang L#, Yang M#, Jin M, Wu Y, Zheng T, Gu S, Hua X (花晓琳，通讯作者)*. Transplant of insulin-like growth factor-1 expressing bone marrow stem cells improves functional regeneration of injured rat uterus by NF-κB pathway. J Cell Mol Med.2018,22(5):2815-2825. (IF：4.49)；
11.Jin M#, Wu Y#, Wang J, Ye W, Wang L, Yin P, Liu W, Pan C, Hua X (花晓琳，通讯作者)*. MicroRNA-29 facilitates transplantation of bone marrow-derived mesenchymal stem cells to alleviate pelvic floor dysfunction by repressing elastin. Stem Cell Res Ther. 2016,17;7(1):167.( IF 5.12)；
12.Jin M#, Chen Y#, Zhou Y, Mei Y, Liu W, Pan C, Hua X (花晓琳，通讯作者)*. Transplantation of bone marrow-derived mesenchymal stem cells expressing elastin alleviates pelvic floor dysfunction. Stem Cell Res Ther. 2016 , 5;7(1):51.(IF 5.12)；
13.Hua X (花晓琳, 第一作者)#, Zhang J#, Guo Y, Shen M, Gaudet L, Janoudi G, Walker M*, Wen SW*. Effect of folic acid supplementation during pregnancy on gestational hypertension/preeclampsia: A systematic review and meta-analysis. Hypertens Pregnancy. 2016，35(4):447-460.（IF 2.10）；
14.Jin M, Yang Z, Ye W, Yu X, Hua X (花晓琳，通讯作者)*. Prognosis significance of Histone methyltransferase enhancer of zeste homolog 2 in patients with cervical squamous cell carcinoma. Oncol Lett. 2015, 10(2):857-862. (IF 2.31)；
15.Jin M, Yang Z, Ye W, Xu H, Hua X (花晓琳，通讯作者)*. MicroRNA-150 predicts a favorable prognosis in patients with epithelial ovarian cancer, and inhibits cell invasion and metastasis. PLoS One. 2014, 4;9(8):e103965. (IF 2.776)；
16.Hua X (花晓琳，第一作者), Zeng Y, Zhang R, Wang H, Diao J, Zhang P*. Using platelet-rich plasma for the treatment of symptomatic cervical ectopy. Int J Gynecol Obstet. 2012, 119(1):26-9. (IF 1.671)；
17.Wu T#, Hua X (花晓琳, 共同第一作者)#, He Z, Wang X, Yu X, Ren W The bactericidal and biocompatible characteristics of reinforced calcium phosphate cements. Biomed Mater. 2012, 7(4):045003. (IF 3.44)；
18.曾嫣，伍岳琳，沈华祥，杨梦楠，顾盛奕，牟正骞，花晓琳（通讯作者）*. 多学科管理下鸟氨酸氨甲酰基转移酶缺乏症妇女连续三次妊娠分娩健康儿一例. 中华围产医学杂志，2020，23（2）：111-113；
19.顾盛奕,金敏菲,花晓琳（通讯作者）*.胎盘植入相关因子的研究进展.国际妇产科学杂志,2018,45(04):365-369；
20.杨梦楠，顾盛奕，王俊，花晓琳（通讯作者）*.产前辅助检查对诊断先天性膈疝及其预后评价的研究进展.中华围产医学杂志，2018，21（08）：895-898；
21.梅艳，张萍，金敏菲，伍岳琳，花晓琳（通讯作者）*.妊娠相关B族链球菌感染的研究进展.中华围产医学杂志,2017,20(12):365-369.