韩凌斐 副主任医师，副教授
硕士招生类型：学术型、专业型
硕士招生专业：妇产科学
博士招生类型：专业型
博士招生专业：妇产科学
所在院系：附属第一妇婴保健院
联系方式：lingfeihan@126.com
课题组链接：
研究方向
主要任职
科研业绩

科研方向：妇科肿瘤/肿瘤免疫；MDSC在肿瘤免疫中的免疫调节机理研究；共刺激分子在宫颈恶性肿瘤微环境中的免疫调控作用研究
临床专业领域：宫颈癌、卵巢癌、内膜癌、卵巢囊肿、子宫肌瘤、子宫内膜异位症、不孕不育等妇科良恶性疾病的宫腹腔镜微创治疗、单孔腹腔镜手术治疗
中国研究型医院学会妇科肿瘤专业委员会青年委员；
上海市医学会妇科肿瘤分会卵巢癌学组副组长；
上海市医学会子宫内膜异位症分会会员；
中国医师协会妇产科医师分会终身会员；
美国腹腔镜医师协会会员
师从妇科肿瘤马丁院士，长期致力于宫颈癌发病分子机制及免疫防治策略研究，主持3项国家自然科学基金、1项上海市青年科技启明星（A类）、1项上海市自然科学基金等多项国家级和省部级课题研究。在Cancer Letters(影响因子7.36)等国外知名肿瘤学期刊发表SCI论著10余篇。
主要第一及通讯作者论著：
1.Xiaofeng Li , Jiapo Wang, Weimin Wu, Hao Gao, Na Liu, Guangxi Zhan, Li Li, Lingfei Han*, Xiaoqing Guo*, Myeloid-derived suppressor cells promote epithelial ovarian cancer cell stemness by inducing the CSF2/p-STAT3 signalling pathway. The FEBS Journal, 2020 Apr 2；
2.Junwei Zhao, Qin zhan, Junhan Guo, Min Liu, Yetian Ruan, Tailin Zhu, Lingfei Han*, Fang Li*,Phylogeny and polymorphism in the E6 and E7 of human papillomavirus: alpha-9 (HPV16, 31, 33, 52, 58), alpha-5 (HPV51), alpha-6 (HPV53, 66), alpha-7 (HPV18, 39, 59, 68) and alpha-10 (HPV6, 44) in women from Shanghai. Infectious Agents and Cancer, 2019, 14:38；
3.Shu Li*, Xiaofeng Li*, Jianyi Ding, Lingfei Han*, Xiaoqing Guo*. Anti-tumor efficacy of folate modified PLGA-based nanoparticles for the co-delivery of drugs in ovarian cancer. Drug Design Development and Therapy. 2019 Apr 18;13:1271-1280；
4.Xiaojing Chen#, Lingfei Han#, Xiangguang Wu#, Wenfei Wei, Lanfang Wu, Hongyan Yi, Ruiming Yan, Xiangyang Bai, Mei Zhong, Yanhong Yu, Li Liang*, Wei Wang*. Clinical Significance of CD163+ and CD68+ Tumor-associated Macrophages in High-risk HPV-related Cervical Cancer. Journal of Cancer. 2017 Oct 17;8(18):3868-3875；
5.Wenfei Wei#, Lingfei Han#, Dan Liu#, Lanfang Wu, Xiaojing Chen, Hongyan Yi, Xiangguang Wu, Mei Zhong, Yanhong Yu, Li Liang*, Wei Wang*. Orthotopic Xenograft Mouse Model of Cervical Cancer for Studying the Role of MicroRNA-21 in Promoting Lymph Node Metastasis. International Journal of Gynecological Cancer. 2017 Oct;27(8):1587-1595；
6.Lanfang Wu#, Lingfei Han#, Chenfei Zhou#, Wenfei Wei, Xiaojing Chen, Hongyan Yi, Xiangguang Wu, Xiangyang Bai, Suiqun Guo, Yanhong Yu, Li Liang*, Wei Wang*.TGF-β1-induced CK17 enhances cancer stem cell-like properties rather than EMT in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway. FEBS Journal. 2017 Sep;284(18):3000-3017；
7.Yunyun Yu#, Lingfei Han#, Wen Yu, Yankang Duan, Zhewei Wang, Huiyan Hu, Junwei Zhao, Suman Singh, Fanfei Kong, Lin Jin, Jing Sun, Fang Li*. High risk factors associated with HPV persistence after loop electrosurgical excision procedure in patients with intraepithelial neoplasia. International Journal of Gynecological Pathology 2017;10(2):1817-1824；
8.Junwei Zhao#, Lu Wang#, Hui Lin, Wen Yu, Xianghong Xu, Huiyan Hu, Laifang Zhu, Lingfei Han*, Fang Li*. Association of HLA-DRB1/DQB1 polymorphism with high-risk HPV infection and cervical intraepithelial neoplasia women from Shanghai. Int J Clin Exp Pathol 2017;10(11)；
9.Lingfei Han#*, Wei Wang#, Jiahong Lu#, Fanfei Kong, Ge Ma, Yiping Zhu, Dong Zhao, Jianlong Zhu, Wen Shuai, Qian Zhou, Ping Chen, Lei Ye, Jie Tao, Sarfraz Ahmad, Fang Li*, Jing Sun*. AAV-sBTLA facilitates HSP70 vaccine-triggered prophylactic antitumor immunity against a murine melanoma pulmonary metastasis model in vivo. Cancer Lett. 2014 Nov 28;354(2):398-406；
10.Fang Li#*, Yi Guo, Lingfei Han#, Yankang Duan, Fang Fang, Sumei Niu, Qiujie Ba, Huaishi Zhu, Fanfei Kong, Chao Lin, Xuejun Wen. In vitro and in vivo growth inhibition of drug-resistant ovarian carcinoma cells using a combination of cisplatin and a TRAIL-encoding retrovirus. Oncol Lett. 2012 Dec;4(6):1254-1258；
11.Mingfu Wu#, Lingfei Han#, Yanyan Shi, Gang Xu, Juncheng Wei, Luanyin You, Yin Chen, Tao Zhu, Qiong Li, Shuang Li, Li Meng, Yunpin Lu, Jianfeng Zhou, Shixuan Wang*, Ding Ma*. Development and characterization of a novel method for the analysis of gene expression patterns in lymphatic endothelial cells derived from primary breast tissues. J Cancer Res Clin Oncol. 2010 Jun;136(6):863-72；
12.Lingfei Han#, Wei Wang#, Yong Fang, Zuohua Feng, Shujie Liao, Wei Li, Yan Li, Chunxiao Li, Mayinuer Maitituoheti, Hong Dong, Zhiwen Lai, Qinglei Gao, Ling Xi, Mingfu Wu, Daowen Wang, Jianfeng Zhou, Li Meng, Shixuan Wang*, Ding Ma*. Soluble B and T lymphocyte attenuator possesses antitumor effects and facilitates heat shock protein 70 vaccine-triggered antitumor immunity against a murine TC-1 cervical cancer model in vivo. J Immunol. 2009 Dec 15;183(12):7842-50.