金莉萍 教授
硕士招生类型：学术型
硕士招生专业：妇产科学
博士招生类型：学术型
博士招生专业：妇产科学
所在院系：附属第一妇婴保健院
联系方式：jinlp01@163.com
课题组链接：
研究方向
主要任职
科研业绩


生殖免疫学，生殖内分泌学
Reproductiveimmunology; Reproductive endocrinology


中文:
中国免疫学会，理事
中国免疫学会生殖免疫分会,副主任委员
华夏医学科技奖，理事
中国中西医结合学会生殖医学会，常务委员
中国整形美容协会干细胞研究与应用分会, 常务理事
上海市医学会妇科内分泌学组,副组长
上海市免疫学会生殖免疫分会，委员
American Journal of Clinical andExperimental Immunology，编委
Journal of Vaccines and Immunology，编委
国际生殖健康|计划生育杂志，编委
发育医学电子杂志， 编委
英文:
Chinese Society for Immunology (CSI) ,Committee member
The reproductive immunity branch of theChinese society of Immunology Vice chairperson
Huaxia Medical Scienceand Technology Award, Committee member
China Society of Integrated TraditionalChinese and Western Medicine，Standing committee member
Branch of stem cell research andApplication chapter of China Orthopedics and Beauty Association Standingcommittee member
The gynecological endocrine group of ShanghaiMedical Association, Vice-group leader:
Reproductive Immunology Branch of ShanghaiSociety for Immunology, Committee member
American Journal of Clinical andExperimental Immunology, Editorial board member
Journal of Vaccines and Immunology, Editorialboard member
Journal of International ReproductiveHealth/Family Planning, Editorial board member
Journal Developmental Medicine Editorial board member

获奖及荣誉
2015年上海市领军人才
2015年上海市优秀学术带头人。
2013年上海市卫生系统优秀学科带头人（新百人）
2013年上海市优秀硕士学位论文，指导导师
2013年复旦大学优秀硕士学位论文，指导导师
2012年复旦大学研究生教学成果二等奖“临床免疫学”
2012年复旦大学附属妇产科医院优秀科研人员奖
作为第三完成人获：
2014年度中华医学科技二等奖
2014年度上海市医学科技二等奖
2007年度教育部科学技术进步二等奖
2006年度中华医学科技三等奖
2006年度上海市科技进步二等奖
2005年度上海市医学科技二等奖
2004年度上海市医学科技三等奖

承担科研项目（近五年）
1. 国家自然科学基金重点项目**：内分泌-免疫调节失常诱发蜕膜化障碍与母-胎免疫紊乱致妊娠失败的机制研究，286万，2018.01-2022.12，项目负责人。
2. 国家重点研发计划专项2017YFC**：人类胚胎着床调控及相关重大妊娠疾病发生机制，345万，2017.07-2020.12，课题负责人。
3. 国家自然科学基金面上项目**：琥珀酸通过IL-1β通路调节滋养细胞侵袭的功能及机制研究，75万，2017.01-2020.12，项目负责人。
4. 国家自然科学基金面上项目**：滋养细胞通过分泌TSLP介导蜕膜γδT细胞免疫调节功能，55万，2012.01-2015.12，项目负责人。
5. 科技部863项目子课题2014AA020706：避孕抗生育疫苗的研发，145万，2014.01-2016.12，子课题项目负责人。
6. 上海市优秀学术带头人计划15XD**：mir-184转基因小鼠流产模型的建立及研究，40万，2015.07-2018.06，项目负责人 。
7. 上海市卫生系统优秀学科带头人培养计划: 绒毛mir-184高表达在反复自然流产中的作用及机制研究，90万，2013.11-2016.10，项目负责人。
8. 上海领军人才：mir-184转基因小鼠流产模型的建立及研究，75万，2015.05-2018.04，项目负责人。
9. 上海市教育委员会重点项目SOF157001：绒毛mir-184高表达在反复自然流产中的作用及机制研究,16万，2014.01－2016.12，项目负责人。
10. 上海市科委医学引导项目：环孢素A防治反复自然流产的临床研究，20万，2013.07-2016.06，项目负责人。
11. 上海市自然科学基金项目102R**：蜕膜γδT细胞在母-胎免疫耐受中的调节性作用，10万，2010.04-2012.03，项目负责人。
12. 教育部新教师基金9：孕期扩增的Th17细胞在母-胎免疫调节中的作用，3.6万，2009.01-2010.12，项目负责人。
13. 国家重点基础研究计划（973计划）项目2015CB943300：母-胎界面交互对话异常致妊娠相关重大疾病的分子机制，100万，2015.01-2019.12，骨干成员。

申请专利
1. 金莉萍 李明清 汪清 常凯凯 周文洁商文庆 复旦大学附属妇产科医院。 白细胞介素（IL-22）抗体在制备子宫腺肌症药物中的应用。 专利申请号：1.1 申请日期：2015-7-29
2. 李明清 常凯凯 李大金 金莉萍 邵珺 刘立兵 复旦大学附属妇产科医院。 白细胞介素抗体在制备子宫内膜异位症药物组合物中的用途。专利申请号：0.4 申请日期：2016-02-04
3. 李明清 李大金 孟玉菡 周文洁 金莉萍 杜美蓉 复旦大学附属妇产科医院。 RANK+巨噬细胞用于制备治疗自然流产保胎药物中的用途。 专利申请号：9.8申请日期：2016-07-31
4. 周文洁 李明清 金莉萍 伍科 常凯凯 谢锋 贺银燕 同济大学附属第一妇婴保健院。 雷帕霉素在治疗白细胞介素（IL）-27低表达子宫子宫内膜癌中的应用。专利申请号：6.8 申请日期：2017-11-08
5. 金莉萍 张媛 周济 张进平 李明清 周文洁 同济大学附属第一妇婴保健院。 miR-184在自然流产预警中的作用。专利申请号：20**，申请日期：2018-1-24

参编学术专著
1. 金莉萍：HLA分型，免疫球蛋白替代疗法，免疫性疾病的基因治疗。《临床免疫学》，李大金主编，复旦大学出版社，2005。
2. 金莉萍：MHC在母胎界面中的免疫调节作用；过继性细胞免疫治疗。《生殖免疫学》，李大金主编，复旦大学出版社，2008。

发表论文目录(#第一/共同第一作者，*通讯作者)
1. Yuan Zhang^#, Ji Zhou^#,Ming-qing Li, Jie Xu, Jin-ping Zhang*, Li-ping Jin*. MicroRNA-184promotes apoptosis of trophoblast cells via targeting WIG1 and induces earlyspontaneous abortion. Cell Death & Disease. Revised.
2. Bing Zhang^#,Wen-Jie Zhou^#,Chun-Jie Gu, Ke Wu, Hui-Li Yang, Jie Mei, Jia-Jun Yu, Xiao-Fan Hou, Jian-SongSun, Feng-Yuan Xu, Da-Jin Li, Li-Ping Jin*, Ming-Qing Li*. Theginsenoside PPD exerts anti-endometriosis effects by suppressing estrogenreceptor-mediated inhibition of endometrial stromal cell autophagy and NK cellcytotoxicity. Cell Death & Disease 2018 May 1;9(5):574. doi:10.1038/s41419-018-0581-2.
3. Yuan Zhang^#, Ying Wang^#,Ming-Qing Li, Jie Duan, Deng-Xuan Fan*, Li-Ping Jin*. IL-25 promotes Th2 bias by upregulating IL-4 and IL-10expression of decidual γδT cells in early pregnancy. Exp Ther Med 2018;15(2):1855-1862.
4. Yuan Zhang^#, Ying Wang^#,Xiao-Hui Wang, Wen-Jie Zhou, Li-Ping-Jin*, Ming-Qing-Li*. Crosstalkbetween human endometrial stromal cells and decidual NK cells promotes thedecidualization in vitro by upregulating IL-25. Mol Med Rep 2018;17(2):2869-2878.
5. Dong Li Cai^# and Li-PingJin*. Immune CellPopulation in Ovarian Tumor Microenvironment. Journal of Cancer.2017;8(15):2915-2923.
6. Xiao-Hui Wang#, WeiLiu#, Deng-Xuan Fan, Li-Ping Jin*. IL-33 restricts invasion and adhesionof trophoblast cell line JEG3 by down-regulation of integrinα4β1 and CD62L. MolMed Rep. 2017 Oct;16(4):3887-3893
7. Anfei Huang, Si Chen,Yi Yang, Fei Xia, Di Sun, Fulu Dong, Deyu Fang, Sidong Xiong, Liping Jin*,Jinping Zhang*. miR-34a promotes DCs development and inhibits their function onT cell activation by targeting WNT1. Oncotarget.2017 8(10):17191-17201
8. Yuan Zhang^#, Li-Ping Jin*.Effects of TSLP on Obstetrical and Gynecological Diseases. Am J Reprod Immunol.2017; 77: e12612.
9. Han Lu^#, Da-Jin Li, Li-Ping Jin*.γδT cells and related diseases. Am J Reprod Immunol. 2016; 75(6):609-18.
10. Si Chen^#, An-Fei Huang^#,Huo Chen, Yi Yang, Fei Xia, Li-Ping Jin*, Jin-Ping Zhang*. miR-34ainhibits the apoptosis of MDSCs by suppressing the expression of N-myc. ImmunolCell Biol. 2016; 94(6):563-72
11. Liu, Li-Bing^# ，Xie, Feng^# ，Chang, Kai-Kai，Shang, Wen-Qing，Meng, Yu-Han，Yu, Jia-Jun，Li, Hui，Sun, Qian，Yuan, Min-Min，Jin, Li-Ping*，Li, Da-Jin，Li, Ming-Qing*，Chemokine CCL17 induced byhypoxia promotes the proliferation of cervical cancer cell.，American Journal of CancerResearch，2015;5(10)1:3072-3084
12. Ying Wang^#, Xiao-Hui Wang^#,Deng-Xuan Fan, Yuan Zhang, Ming-Qing Li, Hai-Xia Wu*, Li-Ping Jin*. PCSK6 regulated by LH inhibits the apoptosis of humangranulosa cells via activin A and TGF-β2. J Endocrinol 2014; 222(1):151-160
13. Fulu Dong^#, Yuan Zhang^#,Fei Xia, Yi Yang, Si-Dong Xiong, Li-Ping Jin*, Jin-Ping Zhang*. Genome-wide miRNA profiling of villus and decidua of recurrentspontaneous abortion patients. Reproduction 2014;148:33-41
14. Ying Wang^#, Yuan Zhang^#,Ming-Qing Li, Deng-Xuan Fan, Xiao-Hui Wang, Da-Jin Li, Li-Ping Jin*.Interleukin-25 induced by human chorionic gonadotrophin promotes theproliferation of decidual stromal cells by activation of JNK and AKT signal pathways.Fertil Steril. 2014; 102(1): 257-263
15. Ming-Qing Li^#, Li-Ping Jin*. Ovarian stimulation for in vitro fertilization alters the proteinprofile expression in endometrial secretion. Int J Clin Exp Pathol. 2013;6:1964-1971
16. Jie Duan^#, Xiao-Ping Jiang^#,Ming-Qing Li, Deng-Xuan Fan, Ying Wang , Da-Jin Li*, Li-Ping Jin*.Thymic stromal lymphopoietin suppresses the apoptosis of decidual gamma-delta Tcells via regulation of the signal transduction and activation of transcription3/caspase-3 signaling pathway. Am J Reprod Immunol. 2013 70(6):464-471
17. Ying Wang^#, Bing Xu^#,Ming-Qing Li, Da-Jin Li*, Li-Ping Jin*. IL-22secreted by decidual stromal cells and NK cells promotes the survival of humantrophoblasts. Int J Clin Exp Pathol. 2013; 15;6(9):1781-1790.
18. Jie Mei^#, Li-Ping Jin^#,Ding Ding, Ming-Qing Li, Da-Jin Li, Xiao-Yong Zhu*. Inhibition of IDO1suppresses cyclooxygenase-2 and matrix metalloproteinase-9 expression anddecreases proliferation, adhesion and invasion of endometrial stromal cells.Mol Hum Reprod. 2012;18(10):467-476.
19. Ying Wang^#, Deng-Xuan Fan^#,Jie Duan, Ming-Qing Li, Xiao-Yong Zhu*, Li-Ping Jin*. Thymic stromallymphopoietin downregulates NME1 expression and promotes invasion in humantrophoblasts via the activation of STAT3 signaling pathway. Clin. Immunol.2012; 143 (1):88-95.
20. Hua-Hua Pu^#, Jie Duan, Ying Wang,Deng-Xuan Fana, Da-Jin Li*, Li-Ping Jin*. Thymic stromal lymphopoietinpromotes the proliferation of human trophoblasts via phosphorylatedSTAT3-mediated c-Myc upregulation. Placenta 2012; 33(5): 387-391.
21. Deng-Xuan Fan^#, Jie Duan, Ming-QingLi, Bin Xu, Da-Jin Li*, Li-Ping Jin*. The decidual gamma-delta T cellsup-regulate the biological functions of trophoblasts via IL-10 secretion inearly human pregnancy. Clin Immunol. 2011；141: 284-292.
22. Li-Ping Jin^#, Deng-Xuan Fan^#, Tai Zhang,Pei-Fen Guo, Da-Jin Li*. The costimulatory signal upregulation is associatedwith Th1 bias at the maternal–fetal interface in human miscarriage. Am J Reprod Immunol. 2011; 66: 270–278.
23. Li-Ping Jin^#, Deng-Xuan Fan, Da-Jin Li*. Regulation ofcostimulatory signal pathway in maternal-fetal immune tolerance. Am J ReprodImmunol. 2011; 66: 76-83.
24. Li-Ping Jin^#, Qiao-Ying Chen, Tai Zhang, Pei-Feng Guo, Da-Jin Li*. TheCD4+CD25bright regulatory T cells and CTLA-4 expression in peripheral anddecidual lymphocytes are down-regulated in human miscarriage. Clin. Immunol.2009; 133(3):402-410.
25. Li-Ping Jin^#, Yue-Hua Zhou, Ming-Yan Wang, Xiao-Yong Zhu, Da-Jin Li*. Adoptivetransfer of paternal antigen-hyporesponsive T cells facilitates a Th2 bia s inperipheral lymphocytes and at materno-fetal interface in abortion-prone mating.Am J Reprod Immunol. 2006; 56(4):258-266.
26. Li-Ping Jin^#, Yue-Hua Zhou, Ming-Yan Wang, Xiao-Yong Zhu, Da-Jin Li*. Blockadeof CD80 and CD86 at the time of implantation inhibits maternal rejection of theallogeneic fetus inabortion-prone matings. J Reprod Immunol. 2005;65(2):133-146.
27. Li-Ping Jin^#, Da-Jin Li*, Jin-Ping Zhang, Ming-Yan Wang, Xiao-Yong Zhu, YingZhu, Yi Meng & Min-Min Yuan. Adoptive transfer of paternalantigen-hyporesponsive T cells induces maternal tolerance to the allogeneicfetus in abortion-prone matings. J Immunol. 2004; 173(6):3612-3619.
28. Li-Ping Jin^#, Da-jin Li, Jing-yu Shao. Effect ofmifepristone on transforming growth factor –beta and its receptor transcriptionin decidua，villiand serum tumor necrosis factor –alpha level of early human gestation.Reproduction ＆Contraception. 2004; 15 (1):33-38.
29. Hui Li^#, Yu-Han Meng, Wen-Qing Shang,Li-Bing Liu, Xuan Chen, Min-Min Yuan, Li-Ping Jin, Ming-Qing Li*, Da-JinLi*. Chemokine CCL24 promotes the growth and invasiveness of trophoblaststhrough ERK1/2 and PI3K signaling pathways in human early pregnancy.Reproduction. 2015; 150(5):417-427.
30. Jie Mei^#, Xiao-Yong Zhu^#, Li-PingJin, Zhong-Liang Duan, Da-Jin Li*, Ming-Qing Li*. Estrogen promotes thesurvival of human secretory phase endometrial stromal cells via CXCL12/CXCR4up-regulation-mediated autophagy inhibition. Hum Reprod. 2015; 30(7):1677-1689.
31. Min-Min Yuan^#, Mei-Rong Du, Ming-YanWang, Zhong-Liang Duan, Yi Meng, Li-Ping Jin, Ming-Qing Li*, Da-Jin Li*.Combination analysis of CD4+CD25+CD127- regulatory T cells with MLC-BE andBE-Ab2: an efficient evaluation of the therapy of paternal lymphocyte inducedimmunization in unexplained recurrent spontaneous abortion patients. Int J ClinExp Pathol. 2015; 8(4):4022-4032.
32. Wen-Ting Hu^#, Li-Li Huang^#,Ming-Qing Li, Li-Ping Jin, Da-Jin Li, Xiao-Yong Zhu*. Decidual stromalcells-derived IL-33 contributes to Th2 bias and inhibits decidual NK cellcytotoxicity through NF-κB signaling in human early pregnancy. J ReprodImmunol. 2015; 109:52-65.
33. Ming-Qing Li^#, Yun Wang^#,Kai-Kai Chang^#, Yu-Han Meng, Li-Bing Liu, Jie Mei, Ying Wang,Xiao-Qiu Wang, Li-Ping Jin, Da-Jin Li*. CD4+Foxp3+ regulatory T celldifferentiation mediated by endometrial stromal cell-derived TECK promotes thegrowth and invasion of endometriotic lesion. Cell Death Dis. 2014;5:e1436
34. Qing Wang^#, Li Wang, Jun Shao, YanWang, Li-Ping Jin, Da-Jin Li, Ming-Qing Li*. L-22 enhances theinvasiveness of endometrial stromal cells of adenomyosis in an autocrinemanner. Int J Clin Exp Pathol. 2014; 7(9): 5762-5771.
35. Jie Mei^#, Xue-Xin Xie^#,Ming-Qing Li, Chun-Yan Wei, Li-Ping Jin, Da-Jin Li, Xiao-Yong Zhu*.Indoleamine 2,3-dioxygenase-1 (IDO1) in human endometrial stromal cells inducesmacrophage tolerance through interleukin-33 in the progress of endometriosis.Int J Clin Exp Pathol. 2014; 7(6): 2743-2757.
36. Chuan-Ling Tang^#, Jing Liang,Jin-Feng Qian, Li-Ping Jin, Mei-Rong Du, Ming-Qing Li, Da-Jin Li*.Opposing role of JNK-p38 kinase and ERK1/2 in hydrogenperoxide-inducedoxidative damage of human trophoblast-like JEG-3 cells. Int JClin Exp Pathol. 2014; 7(3):959-968.
37. Wen-Ting Hu^#, Ming-Qing Li, Wei Liu, Li-PingJin, Da-Jin Li, Xiao-Yong Zhu*. IL-33 enhances proliferation andinvasiveness of decidual stromal cells by up-regulation of CCL2/CCR2 via NF-κBand ERK1/2 signaling. Mol Hum Reprod. 2014; 20(4):358-372.
38. Kai-Kai Chang^#, Li-Bing Liu^#,Li-Ping Jin, Yu-Han Meng, Jun Shao, Ying Wang, Jie Mei, Ming-Qing Li*,Da-Jin Li*. NME1 suppression of endometrial stromalcells promotes angiogenesis in the endometriotic milieu via stimulating thesecretion of IL-8 and VEGF. Int J Clin Exp Pathol. 2013; 6(10):2030-2038.
39. Hui Li^#, Yuan-Hua Huang^#,Ming-Qing Li, Yu-Han Meng, Xuan Chen, Jun Shao, Chuan-Ling Tang, Mei-Rong Du, Li-PingJin, Da-Jin Li*. Trophoblasts-derived chemokine CCL24 promotes theproliferation, growth and apoptosis of decidual stromal cells in human earlypregnancy. Int J Clin Exp Pathol. 2013; 6(6): 1028–1037.
40. Jie Mei^#, Ming-Qing Li^#,Ding Ding, Da-Jin Li, Li-Ping Jin, Wei-Guo Hu*, Xiao-Yong Zhu*,Indoleamine 2,3-dioxygenase-1 (IDO1) enhances survival and invasiveness ofendometrial stromal cells via the activation of JNK signaling pathway. Int JClin Exp Pathol. 2013; 6(3): 431–444.
41. Song-Cun Wang^#, Min Yu^#,Yan-Hong Li, Hai-Lan Piao, Chuan-Lin Tang, Chan Sun, Rui Zhu, Ming Qing Li, Li-PingJin, Da-Jin Li*, Mei-Rong Du*. Cyclosporin A promotes proliferating cellnuclear antigen expression and migration of human cytotrophoblast cells via themitgen-activated protein kinase-3/1-mediated nuclear factor-κB signalingpathways. Int J Clin Exp Pathol. 2013; 6(10): 1999–2010.
42. Yu-Han Meng^#, Hui Li, Xuan Chen,Li-Bing Liu, Jun Shao, Kai-Kai Chang, Mei-Rong Du, Li-Ping Jin, Ming-QingLi*, Da-Jin Li*. RANKL promotes the growth of decidual stromal cells inan autocrine manner via CCL2/CCR2 interaction in human early pregnancy.Placenta. 2013; 34(8):663-671.
43. Ming-Qing Li^#, Xue-Zhen Luo^#,Yu-Han Meng, Jie Mei, Xiao-Yong Zhu, Li-Ping Jin, Da-Jin Li*. CXCL8enhances proliferation and growth and reduces apoptosis in endometrial stromalcells in an autocrine manner via a CXCR1-triggered PTEN/AKT signal pathway. HumReprod. 2012; 27:2107-2116.
44. Pei-Feng Guo^#, Mei-Rong Du^#,Hai-Xia Wu^#, Yi Lin, Li-Ping Jin, Da-Jin Li*: Thymic stromallymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2bias in the decidua during early gestation in humans. Blood.2010;116:2061-2069.
45. Hai-Xia Wu^#, Pei-Feng Guo^#,Li-Ping Jin, Shan-shan Liang, Da-Jin Li*. Functional regulation ofthymic stromal lymphopoietin on proliferation and invasion of trophoblasts inhuman first-trimester pregnancy. Hum Reprod. 2010;25:1146-1152.
46. Xia Wu^#, Li-Ping Jin, Min-minYuan, Ying Zhu, Yi Meng, Ming-yan Wang, Da-Jin Li*. Human first-trimestertrophoblast cells recruit CD56brightCD16- NK cells into decidua by way ofexpressing and secreting of CXCL12/SDF-1. J Immunol. 2005; 175(1):61-68.
47. Xiao-Yong Zhu^#, Yue-Hua Zhou,Ming-Yan Wang, Li-Ping Jin, Min-Min Yuan, Da-Jin Li*. Blockade of CD86signaling facilitates a Th2 Bias at the materno-fetal interface and expandsperipheral CD4+CD25+ regulatory T cells to rescue the abortion-prone fetuses.Biol Reprod. 2005;72(2):338-45.

Awards andhonors
2015 Shanghai leading talent
2015 Outstanding academic leaders of Shanghai
2013 Outstanding academic leaders of health system in Shanghai
2013 Shanghai excellent master's thesis, guidance tutor
2013 Excellentmaster's degree thesis of Fudan University, guidance tutor
2012 SecondPrize of graduate teaching achievements of Fudan University (ClinicalImmunology)
2012 Obstetrics and Gynecology Hospital Of Fudan University, awards of excellentscientific research personnel
2014 Chinese medical science and technology prize, second prize (the thirdinvestigator)
2014 Shanghai Medical Science and Technology prize, second prize (the thirdinvestigator)
2007 Second Class Award of Educational Ministry Science and Technology Improvement (thethird investigator)
2006 Chinese medical science and technology prize, (the third investigator)
2006 Second Class Award of Shanghai Science and Technology Improvement (the thirdinvestigator)
2005 Shanghai Medical Science andTechnology prize, second prize (the third investigator)
2004 ShanghaiMedical Science and Technology prize, third prize (the third investigator)

Research Projects (within the past five years)
1、National Natural ScienceFoundation, Key project, **, Endocrine - immunomodulatory disorder induces decidua disorder andStudy on the mechanism of pregnancy failure caused by maternal fetal immunedisorder, 2860,000 RMB, 2018.01-2022.12, Project Leader.
2、The NationalKey Research and Development Program of China 2017YFC**Human embryo implantation regulation and related major pregnancy diseasesMechanism of occurrence，3450,000 RMB 2017.07-2020.12 Project Leader.
3、National Natural ScienceFoundation, Surface Project, ** Function andmechanism of succinic acid regulating the invasion of trophoblastic cells throughIL-1 beta pathway, 750,000 RMB 2017.01-2020.12 Project Leader.
4 NationalNatural Science Foundation, Surface Project, **, Trophoblast cellsmediate immune regulatory function of γδT cells through the secretion of TSLP,550,000 RMB, 2012.01-2015.12, Project Leader.
5 “863” Projectof Ministry Science and Technology, Sub Project, 2014AA020706, Research anddevelopment of contraception anti fertility vaccine, 1450,000 RMB,2014.01-2016.12, Sub Project Leader.
6 Program of ExcellentAcademic Leaders in Shanghai, 15XD**, The establishment and research ofthe abortion model of mir-184 transgenic mice, 400,000 RMB , 2015.07-2018.06, ProjectLeader.
7 Outstanding AcademicLeader Training Program of Shanghai Health Dystem, The role and mechanism of highlyexpressed mir-184 in recurrent spontaneous abortion, 900,000 RMB,2013.11-2016.10, Project Leader.
8 Shanghai LeadingTalent Project, the establishment and study of abortion model of mir-184transgenic mice, 750,000 RMB, 2015.05-2018.04, Project Leader.
9. Key Projectsof Shanghai Municipal Education Committee, SOF157001, The effect and mechanismof highly-expressed mir-184 in chorionic villus of patients with recurrentspontaneous abortion (RSA), 160,000 RMB, 2014.01-2016.12, Project Leader.
10. Medical GuideProject of Shanghai Municipal Science and Technology Commission, Cyclosporin Atherapy in preventing recurrent spontaneous abortion clinical study, 200,000RMB, 2013.07-2016.06, Project Leader.
11 ShanghaiNatural Science Foundation Project, 102R**, The regulatory role of γδTcells in the maternal fetal immune tolerance, 100,000 RMB, 2010.04-2012.03, ProjectLeader.
12 New Teacher Fundof the Ministry of Education, The role of amplificated Th17 cells duringpregnancy in the maternal fetal immune regulation, 36,000 RMB, 2009.01-2010.12,Project Leader.
13 National Key BasicResearch Program (973 Program) Project, 2015CB943300, Molecular mechanisms ofabnormal pregnancy associated disease induced by the abnormal crosstalk ofmaternal-fetal interface, 1000,000 RMB , 2015.01-2019.12, Backbone Members.

Applicationfor Patent
1 Jin Li-ping,Li Ming-qing, Zhou Wen-jie, Shang Wen-qing. Application of interleukin (IL-22)antibody in the development of medicine for Adenomyosis. Patent applicationnumber: 1.1.
2 Li Ming-qing,Chang Kai-kai, Li Da-jin, Jin Li-ping, Shao Jun, Liu Li-bing. Use ofinterleukin antibodies in the development of pharmaceutical compositions forendometriosis. Patent application number: 0.4.
3. Li Ming-qing,Li Da-jin,Meng Yu-han, Zhou Wen-jie, Jin Li-ping,Du Mei-rong Use ofRANK+ macrophages in the preparation of drugs for the treatment of spontaneousabortion Patent application number: 9.8.
4. Zhou Wen-jie, Li Ming-qing,Jin Li-ping,Wu Ke,Chang Kai-kai Xie Feng,He Yin-yan, Application of rapamycin in the treatmentof endometrial carcinoma with low expression of interleukin (IL) -27 Patentapplication number:6.8.
5. Jin Li-ping,Zhang Yuan,Zhou Ji,Zhang Jin-ping, Li Ming-qing,Zhou Wen-jie, The role of miR-184 in early warning ofspontaneous abortion Patent application number: 20**.
Published AcademicMonograph
1 Jin Li-ping:HLA genotyping, substitution therapy with immunoglobulin, gene therapy forimmune disorders. Clinical immunology, Li Da-jin as the chief editor, FudanUniversity press, 2005.
2 Jin Li-ping:the immunoregulatory effects of MHC in maternal-fetal interface: cellularimmunotherapy of adoptive transferring. Clinical immunology, Li Da-jin as thechief editor, Fudan University press, 2008.

The Catalogof Published Papers (the first # / co-first author,* corresponding author)
1. Yuan Zhang^#, Ji Zhou^#,Ming-qing Li, Jie Xu, Jin-ping Zhang*, Li-ping Jin*. MicroRNA-184promotes apoptosis of trophoblast cells via targeting WIG1 and induces earlyspontaneous abortion. Cell Death & Disease. Revised.
2. Bing Zhang^#,Wen-Jie Zhou^#,Chun-Jie Gu, Ke Wu, Hui-Li Yang, Jie Mei, Jia-Jun Yu, Xiao-Fan Hou, Jian-SongSun, Feng-Yuan Xu, Da-Jin Li, Li-Ping Jin*, Ming-Qing Li*. Theginsenoside PPD exerts anti-endometriosis effects by suppressing estrogenreceptor-mediated inhibition of endometrial stromal cell autophagy and NK cellcytotoxicity. Cell Death & Disease 2018 May 1;9(5):574. doi:10.1038/s41419-018-0581-2.
3. Yuan Zhang^#, Ying Wang^#,Ming-Qing Li, Jie Duan, Deng-Xuan Fan*, Li-Ping Jin*. IL-25 promotes Th2bias by upregulating IL-4 and IL-10 expression of decidual γδT cells in earlypregnancy. Exp Ther Med 2018;15(2): 1855-1862.
4. Yuan Zhang^#, Ying Wang^#,Xiao-Hui Wang, Wen-Jie Zhou, Li-Ping-Jin*, Ming-Qing-Li*. Crosstalkbetween human endometrial stromal cells and decidual NK cells promotes thedecidualization in vitro by upregulating IL-25. Mol Med Rep 2018;17(2):2869-2878.
5. Dong Li Cai^# and Li-PingJin*. Immune CellPopulation in Ovarian Tumor Microenvironment. Journal of Cancer.2017;8(15):2915-2923.
6. Xiao-Hui Wang#, WeiLiu#, Deng-Xuan Fan, Li-Ping Jin*. IL-33 restricts invasion and adhesionof trophoblast cell line JEG3 by down-regulation of integrinα4β1 and CD62L. MolMed Rep. 2017 Oct;16(4):3887-3893
7. Anfei Huang, Si Chen,Yi Yang, Fei Xia, Di Sun, Fulu Dong, Deyu Fang, Sidong Xiong, Liping Jin*,Jinping Zhang*. miR-34a promotes DCs development and inhibits their function onT cell activation by targeting WNT1. Oncotarget.2017 8(10):17191-17201
8. Yuan Zhang^#, Li-Ping Jin*.Effects of TSLP on Obstetrical and Gynecological Diseases. Am J Reprod Immunol.2017; 77: e12612.
9. Han Lu^#, Da-Jin Li, Li-Ping Jin*.γδT cells and related diseases. Am J Reprod Immunol. 2016; 75(6):609-18.
10. Si Chen^#, An-Fei Huang^#,Huo Chen, Yi Yang, Fei Xia, Li-Ping Jin*, Jin-Ping Zhang*. miR-34ainhibits the apoptosis of MDSCs by suppressing the expression of N-myc. ImmunolCell Biol. 2016; 94(6):563-72
11. Liu, Li-Bing^# ，Xie, Feng^# ，Chang, Kai-Kai，Shang, Wen-Qing，Meng, Yu-Han，Yu, Jia-Jun，Li, Hui，Sun, Qian，Yuan, Min-Min，Jin, Li-Ping*，Li, Da-Jin，Li, Ming-Qing*，Chemokine CCL17 induced byhypoxia promotes the proliferation of cervical cancer cell.，American Journal of CancerResearch，2015;5(10)1:3072-3084
12. Ying Wang^#, Xiao-Hui Wang^#,Deng-Xuan Fan, Yuan Zhang, Ming-Qing Li, Hai-Xia Wu*, Li-Ping Jin*.PCSK6 regulated by LH inhibits the apoptosis of human granulosa cells viaactivin A and TGF-β2. J Endocrinol 2014; 222(1):151-160
13. Fulu Dong^#, Yuan Zhang^#,Fei Xia, Yi Yang, Si-Dong Xiong, Li-Ping Jin*, Jin-Ping Zhang*.Genome-wide miRNA profiling of villus and decidua of recurrent spontaneousabortion patients. Reproduction 2014;148:33-41
14. Ying Wang^#, Yuan Zhang^#,Ming-Qing Li, Deng-Xuan Fan, Xiao-Hui Wang, Da-Jin Li, Li-Ping Jin*.Interleukin-25 induced by human chorionic gonadotrophin promotes theproliferation of decidual stromal cells by activation of JNK and AKT signalpathways. Fertil Steril. 2014; 102(1): 257-263
15. Ming-Qing Li^#, Li-Ping Jin*. Ovarian stimulation for in vitro fertilization alters the proteinprofile expression in endometrial secretion. Int J Clin Exp Pathol. 2013;6:1964-1971
16. Jie Duan^#, Xiao-Ping Jiang^#,Ming-Qing Li, Deng-Xuan Fan, Ying Wang , Da-Jin Li*, Li-Ping Jin*.Thymic stromal lymphopoietin suppresses the apoptosis of decidual gamma-delta Tcells via regulation of the signal transduction and activation of transcription3/caspase-3 signaling pathway. Am J Reprod Immunol. 2013 70(6):464-471
17. Ying Wang^#, Bing Xu^#,Ming-Qing Li, Da-Jin Li*, Li-Ping Jin*. IL-22secreted by decidual stromal cells and NK cells promotes the survival of humantrophoblasts. Int J Clin Exp Pathol. 2013; 15;6(9):1781-1790.
18. Jie Mei^#, Li-Ping Jin^#,Ding Ding, Ming-Qing Li, Da-Jin Li, Xiao-Yong Zhu*. Inhibition of IDO1suppresses cyclooxygenase-2 and matrix metalloproteinase-9 expression anddecreases proliferation, adhesion and invasion of endometrial stromal cells.Mol Hum Reprod. 2012;18(10):467-476.
19. Ying Wang^#, Deng-Xuan Fan^#,Jie Duan, Ming-Qing Li, Xiao-Yong Zhu*, Li-Ping Jin*. Thymic stromallymphopoietin downregulates NME1 expression and promotes invasion in humantrophoblasts via the activation of STAT3 signaling pathway. Clin. Immunol.2012; 143 (1):88-95.
20. Hua-Hua Pu^#, Jie Duan, Ying Wang,Deng-Xuan Fana, Da-Jin Li*, Li-Ping Jin*. Thymic stromal lymphopoietinpromotes the proliferation of human trophoblasts via phosphorylatedSTAT3-mediated c-Myc upregulation. Placenta 2012; 33(5): 387-391.
21. Deng-Xuan Fan^#, Jie Duan, Ming-QingLi, Bin Xu, Da-Jin Li*, Li-Ping Jin*. The decidual gamma-delta T cellsup-regulate the biological functions of trophoblasts via IL-10 secretion inearly human pregnancy. Clin Immunol. 2011；141: 284-292.
22. Li-Ping Jin^#, Deng-Xuan Fan^#, Tai Zhang,Pei-Fen Guo, Da-Jin Li*. The costimulatory signal upregulation is associatedwith Th1 bias at the maternal–fetal interface in human miscarriage. Am J Reprod Immunol. 2011; 66: 270–278.
23. Li-Ping Jin^#, Deng-Xuan Fan, Da-Jin Li*. Regulation ofcostimulatory signal pathway in maternal-fetal immune tolerance. Am J ReprodImmunol. 2011; 66: 76-83.
24. Li-Ping Jin^#, Qiao-Ying Chen, Tai Zhang, Pei-Feng Guo, Da-Jin Li*. TheCD4+CD25bright regulatory T cells and CTLA-4 expression in peripheral anddecidual lymphocytes are down-regulated in human miscarriage. Clin. Immunol.2009; 133(3):402-410.
25. Li-Ping Jin^#, Yue-Hua Zhou, Ming-Yan Wang, Xiao-Yong Zhu, Da-Jin Li*. Adoptivetransfer of paternal antigen-hyporesponsive T cells facilitates a Th2 bia s inperipheral lymphocytes and at materno-fetal interface in abortion-prone mating.Am J Reprod Immunol. 2006; 56(4):258-266.
26. Li-Ping Jin^#, Yue-Hua Zhou, Ming-Yan Wang, Xiao-Yong Zhu, Da-Jin Li*. Blockadeof CD80 and CD86 at the time of implantation inhibits maternal rejection of theallogeneic fetus inabortion-prone matings. J Reprod Immunol. 2005; 65(2):133-146.
27. Li-Ping Jin^#, Da-Jin Li*, Jin-Ping Zhang, Ming-Yan Wang, Xiao-Yong Zhu, YingZhu, Yi Meng & Min-Min Yuan. Adoptive transfer of paternalantigen-hyporesponsive T cells induces maternal tolerance to the allogeneicfetus in abortion-prone matings. J Immunol. 2004; 173(6):3612-3619.
28. Li-Ping Jin^#, Da-jin Li, Jing-yu Shao. Effect ofmifepristone on transforming growth factor –beta and its receptor transcriptionin decidua，villiand serum tumor necrosis factor –alpha level of early human gestation. Reproduction＆ Contraception.2004; 15 (1):33-38.
29. Hui Li^#, Yu-Han Meng, Wen-Qing Shang,Li-Bing Liu, Xuan Chen, Min-Min Yuan, Li-Ping Jin, Ming-Qing Li*, Da-JinLi*. Chemokine CCL24 promotes the growth and invasiveness of trophoblaststhrough ERK1/2 and PI3K signaling pathways in human early pregnancy.Reproduction. 2015; 150(5):417-427.
30. Jie Mei^#, Xiao-Yong Zhu^#, Li-PingJin, Zhong-Liang Duan, Da-Jin Li*, Ming-Qing Li*. Estrogen promotes thesurvival of human secretory phase endometrial stromal cells via CXCL12/CXCR4up-regulation-mediated autophagy inhibition. Hum Reprod. 2015; 30(7):1677-1689.
31. Min-Min Yuan^#, Mei-Rong Du, Ming-YanWang, Zhong-Liang Duan, Yi Meng, Li-Ping Jin, Ming-Qing Li*, Da-Jin Li*.Combination analysis of CD4+CD25+CD127- regulatory T cells with MLC-BE andBE-Ab2: an efficient evaluation of the therapy of paternal lymphocyte inducedimmunization in unexplained recurrent spontaneous abortion patients. Int J ClinExp Pathol. 2015; 8(4):4022-4032.
32. Wen-Ting Hu^#, Li-Li Huang^#,Ming-Qing Li, Li-Ping Jin, Da-Jin Li, Xiao-Yong Zhu*. Decidual stromalcells-derived IL-33 contributes to Th2 bias and inhibits decidual NK cellcytotoxicity through NF-κB signaling in human early pregnancy. J ReprodImmunol. 2015; 109:52-65.
33. Ming-Qing Li^#, Yun Wang^#,Kai-Kai Chang^#, Yu-Han Meng, Li-Bing Liu, Jie Mei, Ying Wang,Xiao-Qiu Wang, Li-Ping Jin, Da-Jin Li*. CD4+Foxp3+ regulatory T celldifferentiation mediated by endometrial stromal cell-derived TECK promotes thegrowth and invasion of endometriotic lesion. Cell Death Dis. 2014;5:e1436
34. Qing Wang^#, Li Wang, Jun Shao, YanWang, Li-Ping Jin, Da-Jin Li, Ming-Qing Li*. L-22 enhances theinvasiveness of endometrial stromal cells of adenomyosis in an autocrinemanner. Int J Clin Exp Pathol. 2014; 7(9): 5762-5771.
35. Jie Mei^#, Xue-Xin Xie^#,Ming-Qing Li, Chun-Yan Wei, Li-Ping Jin, Da-Jin Li, Xiao-Yong Zhu*.Indoleamine 2,3-dioxygenase-1 (IDO1) in human endometrial stromal cells inducesmacrophage tolerance through interleukin-33 in the progress of endometriosis.Int J Clin Exp Pathol. 2014; 7(6): 2743-2757.
36. Chuan-Ling Tang^#, Jing Liang,Jin-Feng Qian, Li-Ping Jin, Mei-Rong Du, Ming-Qing Li, Da-Jin Li*.Opposing role of JNK-p38 kinase and ERK1/2 in hydrogenperoxide-inducedoxidative damage of human trophoblast-like JEG-3 cells. Int JClin Exp Pathol. 2014; 7(3):959-968.
37. Wen-Ting Hu^#, Ming-Qing Li, Wei Liu, Li-PingJin, Da-Jin Li, Xiao-Yong Zhu*. IL-33 enhances proliferation andinvasiveness of decidual stromal cells by up-regulation of CCL2/CCR2 via NF-κBand ERK1/2 signaling. Mol Hum Reprod. 2014; 20(4):358-372.
38. Kai-Kai Chang^#, Li-Bing Liu^#,Li-Ping Jin, Yu-Han Meng, Jun Shao, Ying Wang, Jie Mei, Ming-Qing Li*,Da-Jin Li*. NME1 suppression of endometrial stromalcells promotes angiogenesis in the endometriotic milieu via stimulating thesecretion of IL-8 and VEGF. Int J Clin Exp Pathol. 2013; 6(10):2030-2038.
39. Hui Li^#, Yuan-Hua Huang^#,Ming-Qing Li, Yu-Han Meng, Xuan Chen, Jun Shao, Chuan-Ling Tang, Mei-Rong Du, Li-PingJin, Da-Jin Li*. Trophoblasts-derived chemokine CCL24 promotes theproliferation, growth and apoptosis of decidual stromal cells in human earlypregnancy. Int J Clin Exp Pathol. 2013; 6(6): 1028–1037.
40. Jie Mei^#, Ming-Qing Li^#,Ding Ding, Da-Jin Li, Li-Ping Jin, Wei-Guo Hu*, Xiao-Yong Zhu*,Indoleamine 2,3-dioxygenase-1 (IDO1) enhances survival and invasiveness ofendometrial stromal cells via the activation of JNK signaling pathway. Int JClin Exp Pathol. 2013; 6(3): 431–444.
41. Song-Cun Wang^#, Min Yu^#,Yan-Hong Li, Hai-Lan Piao, Chuan-Lin Tang, Chan Sun, Rui Zhu, Ming Qing Li, Li-PingJin, Da-Jin Li*, Mei-Rong Du*. Cyclosporin A promotes proliferating cellnuclear antigen expression and migration of human cytotrophoblast cells via themitgen-activated protein kinase-3/1-mediated nuclear factor-κB signalingpathways. Int J Clin Exp Pathol. 2013; 6(10): 1999–2010.
42. Yu-Han Meng^#, Hui Li, Xuan Chen,Li-Bing Liu, Jun Shao, Kai-Kai Chang, Mei-Rong Du, Li-Ping Jin,Ming-Qing Li*, Da-Jin Li*. RANKL promotes the growth of decidual stromalcells in an autocrine manner via CCL2/CCR2 interaction in human earlypregnancy. Placenta. 2013; 34(8):663-671.
43. Ming-Qing Li^#, Xue-Zhen Luo^#,Yu-Han Meng, Jie Mei, Xiao-Yong Zhu, Li-Ping Jin, Da-Jin Li*. CXCL8enhances proliferation and growth and reduces apoptosis in endometrial stromalcells in an autocrine manner via a CXCR1-triggered PTEN/AKT signal pathway. HumReprod. 2012; 27:2107-2116.
44. Pei-Feng Guo^#, Mei-Rong Du^#,Hai-Xia Wu^#, Yi Lin, Li-Ping Jin, Da-Jin Li*: Thymic stromallymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2bias in the decidua during early gestation in humans. Blood.2010;116:2061-2069.
45. Hai-Xia Wu^#, Pei-Feng Guo^#,Li-Ping Jin, Shan-shan Liang, Da-Jin Li*. Functional regulation ofthymic stromal lymphopoietin on proliferation and invasion of trophoblasts inhuman first-trimester pregnancy. Hum Reprod. 2010;25:1146-1152.
46. Xia Wu^#, Li-Ping Jin, Min-minYuan, Ying Zhu, Yi Meng, Ming-yan Wang, Da-Jin Li*. Human first-trimestertrophoblast cells recruit CD56brightCD16- NK cells into decidua by way ofexpressing and secreting of CXCL12/SDF-1. J Immunol. 2005; 175(1):61-68.
47. Xiao-Yong Zhu^#, Yue-Hua Zhou,Ming-Yan Wang, Li-Ping Jin, Min-Min Yuan, Da-Jin Li*. Blockade of CD86signaling facilitates a Th2 Bias at the materno-fetal interface and expandsperipheral CD4+CD25+ regulatory T cells to rescue the abortion-prone fetuses.Biol Reprod. 2005;72(2):338-45.