万小平 主任医师，教授
硕士招生类型：学术型、专业型
硕士招生专业：妇产科学
博士招生类型：学术型、专业型
博士招生专业：妇产科学
所在院系：附属第一妇婴保健院
联系方式：wanxiaoping61@126.com
课题组链接：
研究方向
主要任职
科研业绩

妇科肿瘤学、妇科整形手术学。



上海市第一妇婴保健院院长。国务院特殊津贴专家、上海市领军人才和上海市优秀学科带头人、中华医学会妇科肿瘤学分会常委、中华医学会妇产科分会委员、上海市医师协会妇产科医师分会会长、上海市医学会妇科肿瘤分会侯任主委、上海医学会妇产科学分会副主任委员、《中华妇产科杂志》等6个专业杂志编委。





发表研究论文150余篇（SCI收录62篇），主编专业著作两部，主译专业著作两部。主持上海市医学重大课题“妇科肿瘤诊疗新技术及规范化诊治方案研究”，获2012年上海市科技进步一等奖。先后主持包括8项国家自然科学基金、上海市重中之重临床医学中心和重点学科建设、上海市卫生发展重大项目基金和上海市优秀学科带头人(领军)计划项目在内的各类科研项目20余项，科研经费500余万元。探索妇科重要手术8项，其中两项手术的成果或经验发表于SCI期刊并获奖。
在研课题：
l GPER1与AMF正向反馈调控：Ⅱ型子宫内膜癌发病假想及其机制. 国家自然基金面上课题. 2017年-2020年.项目编号：**
l Activin A靶向芳香化酶介导的原位雌激素合成：子宫内膜癌发病假想与机制. 国家自然基金面上课题. 2015年-2018年.项目编号：**
l 预测子宫内膜癌后腹膜淋巴结转移的关键技术研究. 上海申康医院发展中心临床科技创新项目. 2016.1-2018.12.项目编号：SHDC**

部分代表性论著：
1. Tong H, Ke JQ, Jiang FZ, Wang XJ, Wang FY, Li YR, Lu W, Wan XP.Tumor-associated macrophage-derived CXCL8 could induce ERα suppression viaHOXB13 in endometrial cancer. CancerLett.2016;376(1):127-36.
2. Zhang Y, Bao W, Wang K, LuW, Wang H, Tong H, Wan X. SOX17 is a tumor suppressor in endometrial cancer. Oncotarget.2016;7(46):76036-76046.
3. Yang T, Zhang H, Qiu H, LiB, Wang J, Du G, Ren C, Wan X. EFEMP1 is repressed by estrogen and inhibits theepithelial-mesenchymal transition via Wnt/β-catenin signaling in endometrialcarcinoma. Oncotarget. 2016;7(18):25712-25.
4. Jiang FZ, He YY, Wang HH, Zhang HL, Zhang J, Yan XF, Wang XJ, Che Q, Ke JQ, Chen Z, Tong H, Zhang YL, Wang FY, Li YR, Wan XP*.Oncotarget. Mutant p53 induces EZH2 expression and promotesepithelial-mesenchymal transition by disrupting p68-Drosha complex assembly andattenuating miR-26a processing. Oncotarget.2015;29;6(42):44660-74
5. Chen Z, Che Q, He X, Wang F, Wang H, Zhu M, Sun J, Wan X*. Stem cell protein Piwil1 endowed endometrial cancer cells withstem-like properties via inducing epithelial-mesenchymal transition.BMC Cancer. 2015;15:811.
6. Li Y, Jia Y, Che Q, Zhou Q, Wang K, Wan XP*. AMF/PGI-mediated tumorigenesis throughMAPK-ERK signaling in endometrial carcinoma.Oncotarget. 2015; 6(28):26373-87.
7. Li Y, Che Q, Bian Y, Zhou Q, Jiang F, Tong H, Ke J, Wang K, Wan XP*. Autocrine motility factor promotesepithelial-mesenchymal transition in endometrial cancer via MAPK signalingpathway. Int J Oncol. 2015;47(3):1017-24.
8. Shaohua Xu, , Guang-Bo Fu,, Zhen Tao, Jun OuYang, Fanfei Kong, Bing-Hua Jiang, Xiaoping Wan*, KeChen. MiR-497 decreases cisplatin resistance in ovarian cancer cells bytargeting
9. Wang H, Bao W, Jiang F,Che Q, Chen Z, Wang F, Tong H, Dai C, He X, Liao Y, Liu B, Sun J, Wan X*.Mutant p53 (p53-R248Q) functions as an oncogene in promoting endometrial cancerby up-regulating REGγ.Cancer Lett. 2015;360(2):269-79.
10. Che Q, Liu BY, Liao Y,Zhang HJ, Yang TT, He YY, Xia YH, Lu W, He XY, Chen Z, Wang FY, Wan XP*.Activation of a positive feedback loop involving IL-6 and aromatase promotesintratumoral 17β-estradiol biosynthesis in endometrialcarcinoma microenvironment. Int J Cancer. 2014;135(2):282-294.
11. Liao Y, He X, Qiu H, CheQ, Wang F, Lu W, Chen Z, Qiu M, Wang J, Wang H, Wan X*. Suppression ofthe epithelial-mesenchymal transition by SHARP1 is linked to the NOTCH1signaling pathway in metastasis of endometrial cancer.BMC Cancer. 2014;14(487):1471-1481.
12. Liu B, Che Q, Qiu H, BaoW, Chen X, Lu W, Li B, Wan X*. Elevated MiR-222-3p promotesproliferation and invasion of endometrial carcinoma via targeting ERα. PLoSOne. 2014;9(1):e87563.
13. Qiu M, Bao W, Wang J, YangT, He X, Liao Y, Wan X*. FOXA1 promotes tumor cell proliferation throughAR involving the Notch pathway in endometrial cancer.BMC Cancer. 2014;14(78):2407-2417.
14. Bao W, Wang HH, Tian FJ, He XY, Qiu MT, Wang JY, Zhang HJ, Wang LH, Wan XP*. A TrkB-STAT3-miR-204-5p regulatorycircuitry controls proliferation and invasion of endometrial carcinoma cells.Mol Cancer. 2013;12(1):155.
15. Zhang J, Li S, Yan Q, ChenX, Yang Y, Liu X, Wan X.*. Interferon-β inducedmicroRNA-129-5p down-regulates HPV-18 E6 and E7 viral gene expression bytargeting SP1 in cervical cancer cells. PLoS One. 2013;8(12):e81366.
16. Bao W, Qiu H, Yang T, LuoX, Zhang H, Wan X*.Upregulation of TrkB promotes epithelial-mesenchymaltransition and anoikis resistance in endometrial carcinoma. PLoS One. 2013;8(7): e70616.
17. Yang T, Qiu H, Bao W, LiB, Lu C, Du G, Luo X, Wang L, Wan X*. Epigenetic inactivation of EFEMP1is associated with tumor suppressive function in endometrial carcinoma. PLoSOne. 2013;8(6): e67458.