王凯 研究员-高研院
硕士招生类型：学术型
硕士招生专业：妇产科学
博士招生类型：学术型
博士招生专业：妇产科学
所在院系：附属第一妇婴保健院
联系方式：kaiwangcn@yahoo.com
课题组链接：
研究方向
主要任职
科研业绩

妇科肿瘤 （Gynecologic Oncology）
内分泌生殖生理 （Endocrinology and Reproductive Physiology）
美国生殖学会委员 (Society for the Study of Reproduction)
国际胎盘联合学会委员（International Federation of Placenta Associations）
主持科研项目
1. 重点研发计划（编号：2017YFA**）“人类上皮组织再生机制研究”，2017.07-2021.12 RMB 2668万 （项目骨干）
2. 中央高校基本科研业务费专项资金(同济大学) “芳香烃受体在早期妊娠失败中的作用机制。”项目负责人，2015.07-2017.06, RMB 200,000
3. 国家自然科学基金面上项目 (编号：**) “长期低氧对胎盘血管生成的影响及分子机制” 项目负责人，2013.01-2016.12, RMB 700,000
4. 国家自然科学基金青年项目 (编号：**) “芳香烃受体介导的二噁英类环境污染物TCDD对胎盘血管发育的影响及其分子机制.” 项目负责人，2012.01-2014.12, RMB 220,000
5. 上海市自然科学基金 (编号：11ZR**) “芳香烃受体(AhR)在胎盘血管生成中的作用”。项目负责人，2011.03-2014.04, RMB 100,000
6. 中央高校基本科研业务费专项资金(同济大学) “芳香烃受体在人滋养层细胞侵袭中的作用。”项目负责人，2012.01-2013.12, RMB 200,000
7. 2012年上海市浦江人才计划资助项目（12PJ**） “长期低氧对胎盘血管生成的影响及分子机制”项目负责人，2013.01-2015.12, RMB 200,000
发表论文（第一及通讯作者）
1. Chang X, Bian Y, He Q, Yao J, Zhu J, Wu J, Wang K*, Duan T*. Suppression of STAT3 Signaling by Δ9-Tetrahydrocannabinol (THC) Induces Trophoblast Dysfunction. Cell Physiol Biochem. 2017 ;42:537-550.
2. Wu JT, Yao JL, Wang K*, Duan T*. expression of lysyl oxidase (LOX) in human placental amnion in preterm labor. Int J Clin Exp Pathol 2016;9:9231-9236.
3. Zhou J, Ni XT, Huang XJ, Yao JL, He QZ, Wang K*, Duan T*. Potential role of hyperglycemia in fetoplacental endothelial dysfunction in gestational diabetes mellitus. Cell Physiol Biochem. 2016;39(4):1317-28.
4. Bian Y, Chang X, Liao Y, Wang J, Li Y, Wang K*, Wan XP*. Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer. Oncol Rep. 2016;36:803-10.
5. Chang X, Bian Y, Wu Y, Huang Y, Wang K*, Duan T*. Endocan of the maternal placenta tissue is increased in pre-eclampsia. Int J Clin Exp Pathol. 2015;8:14733-40.
6. Wu Y, Chen X, Chang X, Huang YJ, Bao S, He Q, Li Y, Zheng J, Duan T*, Wang K*. Potential Involvement of Placental AhR in Unexplained Recurrent Spontaneous Abortion. Reprod Toxicol. 2016;59:45-52.
7. Huang YJ, Wu YM, Chang XW, Li Y, Wang K*, Duan T*. Effects of Human Umbilical Cord Mesenchymal Stem Cells on Human Trophoblast Cell Functions In Vitro. Stem Cells Int.2016:**.
8. Li Y, Jia Y, Che Q, Zhou Q, Wang K*, Wan XP*. AMF/PGI-mediated tumorigenesis through MAPK-ERK signaling in endometrial carcinoma. Oncotarget. 2015;6:26373-87.
9. Li Y, Che Q, Bian Y, Zhou Q, Jiang F, Tong H, Ke J, Wang K*, Wan XP*. Autocrine motility factor promotes epithelial-mesenchymal transition in endometrial cancer via MAPK signaling pathway. Int J Oncol. 2015;47:1017-24.
10. Li Y, Wang K*, Zou QY, Zhou C, Magness RR, Zheng J. A possible role of aryl hydrocarbon receptor in spontaneous preterm birth. Med Hypotheses. 2015;84:494-7.
11. Shen ZJ, Wu YM, Chen X, Chang XW, Zhou Q, Zhou J, Ying H, Zheng J, Duan T*, Wang K*. Decreased Maternal Serum 2-Methoxyestradiol Levels are Associated with the Development of Preeclampsia. Cell Physiol Biochem 2014;34:2189-2199.
12. Li Y, Wang K*, Jiang YZ, Chang XW, Dai CF, Zheng J. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) inhibits human ovarian cancer cell proliferation. Cell Oncol. 2014;37:429–437.
13. Wu Y, Chen X, Zhou Q, He Q, Kang J, Zheng J, Wang K*, Duan T*. ITE and TCDD Differentially Regulate the Vascular Remodeling of Rat Placenta via the Activation of AhR. PLoS One. 2014;9(1):e86549.
14. Wang K*, Li Y*, Jiang YZ, Dai CF, Patankar MS, Song JS, Zheng J. An Endogenous Aryl Hydrocarbon Receptor Ligand Inhibits Proliferation and Migration of Human Ovarian Cancer Cells. Cancer Lett. 2013;340:63-71.
15. Hao K, Zhou Q, Chen W, Jia W, Zheng J, Kang J, Wang K*, Duan T*. Possible role of the 'IDO-AhR axis' in maternal-foetal tolerance. Cell Biol Int. 2013;37:105-8.
16. Wang K, Zheng J. Signaling regulation of fetoplacental angiogenesis. J Endocrinol. 2012;212:243-55.
17. Wang K, Zhou Q, He QZ, Tong GQ, Zhao Z, Duan T. The possible role of AhR in the protective effects of cigarette smoke on preeclampsia. Med Hypotheses. 2011;77:872-4.
18. Jiang YZ*, Wang K*, Fang R, Zheng J. Expression of Aryl Hydrocarbon Receptor in Human Placentas and Fetal Tissues. J Histochem Cytochem. 2010;58:679-85.
19. Wang SY*, Wang K*, Xin Y, Lv DC. Maggot excretions/secretions induces human microvascular endothelial cell migration through AKT1. Mol Biol Rep. 2010; 37: 2719-2725.
20. Song Y*, Wang K*, Chen DB, Magness RR, Zheng J. Suppression of protein phosphatase 2 differentially modulates VEGF- and FGF2-induced signaling in ovine fetoplacental artery endothelial cells. Placenta. 2009; 30: 907-913.
21. Wang K, Jiang YZ, Chen DB, Zheng J. Hypoxia Enhances FGF2- and VEGF-Stimulated Human Placental Artery Endothelial Cell Proliferation: Roles of MEK1/2/ERK1/2 and PI3K/AKT1 Pathways. Placenta. 2009; 30: 1045–1051.
22.Wang K, Song Y, Chen DB, Zheng J. Protein phosphatase 3 differentially modulates vascular endothelial growth factor- and fibroblast growth factor 2-stimulated cell proliferation and signaling in ovine fetoplacental artery endothelial cells. Biol Reprod. 2008; 79(4):704-10.