徐韶华 主任医师，副教授
硕士招生类型：学术型；专业型
硕士招生专业：妇产科学
博士招生类型：学术型；专业型
博士招生专业：妇产科学
所在院系：附属第一妇婴保健院
联系方式：xushaohua@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩


科研方向：卵巢癌化疗耐药及免疫逃逸分子机制、干细胞治疗卵巢早衰宫腔粘连的临床研究及转化应用。
临床专业领域：卵巢囊肿、子宫肌瘤、子宫内膜异位症、不孕不育等妇科良恶性疾病的宫腹腔镜微创治疗、单孔腹腔镜手术治疗；干细胞治疗卵巢早衰宫腔粘连的临床研究及转化应用；各种疑难妇科内分泌疾病的诊疗。




上海医学会妇科肿瘤学分会卵巢癌学组副组长
中国医药教育协会生殖内分泌外科培训中心常务委员
中国成人教育协会医学继续教育专业委员会腔镜国际培训中心委员
中国抗癌协会肿瘤支持治疗专业委员会委员





主持或参加多项国家自然科学基金，在Nature communication等国际期刊发表SCI论文十余篇，累计影响因五十多分，谷歌学术总引用达200次。
主要论著：
1. Tao Z*, Xu S*, Ruan H, Wang T, Song W, Qian L, Chen K,MiR-195/-16 Family Enhances Radiotherapy via T Cell Activation in the TumorMicroenvironment by Blocking the PD-L1 Immune Checkpoint, Cell Physiol Biochem.2018;48(2):801-814
2. ShaohuaXu,ZhenTao, Bo Hai, Huagen Liang, Ying Shi, Tao Wang, Wen Song, Yong Chen, Jun OuYang,Jinhong Chen, Fanfei Kong, Yishan Dong, ShiWen Jiang, Weiyong Li, Ping Wang,Zhiyong Yuan, Xiaoping Wan, Chenguang Wang, Wencheng Li, Xiaoping Zhang, KeChen, miR-424(322) reverses chemoresistance via T-cell immune responseactivation by blocking the PD-L1 immune checkpoint, Nat Commun, 2016,5;7:11406.
3. ShaohuaXu,Guang-Bo Fu, Zhen Tao, Jun OuYang, Fanfei Kong, Bing-Hua Jiang, Xiaoping Wan,and Ke Chen, MiR-497 decreases cisplatin resistance in ovarian cancer cells bytargeting mTOR/P70S6K1, Oncotarget, 2015; 28:26457-71.
4. ShaohuaXu,Tao Wang, Wen Song, Tao Jiang, Feng Zhang, YuYin, Shi-Wen Jiang, Kongming Wu,ZuorenYu, Chenguang Wang, and Ke Chen, The inhibitory effects of AR/miR-190a/YB-1 negative feedback loop on prostate cancer and underlying mechanism,Sci Rep, 2015;5:13528.
5. ShaohuaXu,Peizhen Xu, Wei Wu, Yangjun Ou, Juan Xu, Guanghua Zhang, Jinping Li, andGuofeng Xu, The biphasic expression pattern of miR-200a and E-cadherin inepithelial ovarian cancer and its correlation with clinicopathologicalfeatures, Curr Pharm Des, 2014;20:1888–1895.
6. ShaohuaXu,Juan Ren, Hai Bin Chen, Yanglin Wang, Qingyou Liu, Run Zhang, Shiwen Jiang, andJinping Li, Cytostaticand Apoptotic Effects of DNMT and HDAC Inhibitors in Endometrial Cancer Cells, Curr Pharm Des,2014;20(11):1881-7.
7. ShaohuaXu,WeiWu, Hong Sun, Jing Lu, Beilei Yuan, Yankai Xia, Bart De Moor, KathleenMarcha, Xinru Wang, Peizhen Xu, and Wenjun Cheng, Association of the VascularEndothelial Growth Factor Gene Polymorphisms (–460C/T, +405G/C and +936T/C) withEndometriosis: A Meta-Analysis, Ann Hum Genet, 2012; 76:464-71.
8. JunHe, Min Wang, Yue Jiang, Qiudan Chen, Shaohua Xu, Qing Xu, Bing-HuaJiang, and Ling-Zhi Liu, Chronic Arsenic Exposure and Angiogenesis in HumanBronchial Epithelial Cells via the ROS/miR-199a-5p/HIF-1α/COX-2 Pathway,Environ Health Perspect, 2014;122(3):255-61.
9. TaoWang, Zhuo Liu, Shuiming Guo, Licheng Wu, Mingchao Li, Jun Yang, Ruibao Chen,Hua Xu, Shaoxin Cai, Hui Chen, Weiyong Li, Liang Wang, Zhiquan Hu, QianyuanZhuang, Shaohua Xu, Liping Wang, Jihong Liu, Zhangqun Ye, Jun-Yuan Ji,Chenguang Wang, and Ke Chen, The tumor suppressive role of CAMK2N1 incastration-resistant prostate cancer, Oncotarget, 2014;5(11):3611-3621.
10. Tao Wang, ShuimingGuo, Zhuo Liu, Licheng Wu, Mingchao Li, Jun Yang, Ruibao Chen, Xiaming Liu, HuaXu, Shaoxin Cai, Hui Chen, Weiyong Li, Shaohua Xu, Liang Wang, ZhiquanHu, Qianyuan Zhuang, Liping Wang, Kongming Wu, Jihong Liu, Zhangqun Ye,Jun-Yuan Ji, Chenguang Wang, CAMK2N1 inhibits prostate cancer progressionthrough androgen receptor-dependent signaling, Oncotarget,2014;5(2):10293-10306.
11. Xin Sun, Shiwen Jiang,Jian Liu, Huangzhen Wang, Yiwen Zhang, Shou-Ching Tang, Jichang Wang, Ning Du,Chongwen Xu, Chenguang Wang, Sida Qin, Jia Zhang, Dapeng Liu, Yunfeng Zhang,Xiaojun Li, Jiansheng Wang, Jun Dong, Xin Wang, Shaohua Xu, Zhen Tao,Fei Xu, Jie Zhou, Tao Wang, Hong Ren, MiR-208a stimulates the cocktail of SOX2and β-cateninto inhibit the let-7 induction of self-renewal repression of breast cancer stemcells and formed miR208a/let-7 feedback loop via LIN28 and DICER1, Oncotarget,2015;6(32):32944-54.
12. Chongwen Xu, Xin Sun,Sida Qin,Huangzhen Wang, Zhiwei Zheng,Shaohua Xu, Gang Luo, Peng Liu, Jian Liu, Ning Du,Yunfeng Zhang,Dapeng Liu, Hong Ren,Let-7a regulates mammosphere formation capacity through Ras/NF-κB andRas/MAPK/ERK pathway in breast cancer stem cell, Cell cycle,2015;14(11):1686-97.
13. Ke Chen, Kongming Wu,Xuanmao Jiao, Liping Wang, Xiaoming Ju, Min Wang, Gabriele Di Sante, ShaohuaXu, Qiong Wang, Kevin Li, Xin Sun, Congwen Xu, Zhiping Li, Mathew C.Casimiro, Adam Ertel, Sankar Addya, Peter A. McCue, Michael P. Lisanti,Chenguang Wang, Richard J. Davis, Graeme Mardon, Richard G. Pestell, TheEndogenous Cell-Fate Factor Dachshund Restrains Prostate Epithelial CellMigration via Repression of Cytokine Secretion via a CXCL Signaling Module,Cancer Research, 2015;75(10):1992-2004.
14. SunX, Xu C, Tang S C, Wang J, Wang H, Wang P, Du N, Qin S, Li G, Xu S, TaoZ, Liu D, Ren H. Let-7c blocks estrogen-activated Wnt signaling in induction ofself-renewal of breast cancer stem cells. Cancer Gene Ther, 2016, 23(4): 83-9.
15. Zhu LY, Zhang WM, YangXM, Cui L, Li J, Zhang YL, Wang YH, Ao JP, Ma MZ, Lu H, Ren Y, Xu SH,Yang GD, Song WW, Wang JH, Zhang XD, Zhang R, Zhang ZG. Silencing of MICAL-L2suppresses malignancy of ovarian cancer by inducing mesenchymal-epithelialtransition. Cancer Lett. 2015;363:71-82.