梁淑静 讲师，主治医师
硕士招生类型：专业型
硕士招生专业：肿瘤学
博士招生类型：
博士招生专业：
所在院系：附属东方医院
联系方式：liangshujing02@126.com
课题组链接：
研究方向
主要任职
科研业绩

乳腺癌等免疫治疗及纳米材料在其治疗中的应用
Theapplication of nanomaterials and immunotherapy in breast cancer and other typesof tumors

同济大学附属东方医院主治医师，同济大学硕士生及本科生导师
Attending doctor of Breast CancerCenter in Shanghai East Hospital, affiliated to Tongji University School ofMedicine;
master and undergraduate students tutorof Tongji University


目前已参与多项生物纳米及肿瘤免疫相关领域相关研究工作，掌握乳腺癌及其它肿瘤免疫治疗及纳米材料应用领域的最新研究进展，熟悉免疫细胞的分离培养，掌握小鼠乳腺原位荷瘤鼠模型的建立，及分子生物学实验等技术。本课题申请者承担国家自然科学基金、浦东新区卫计委卫生科研青年项目及优秀青年人才培养行动计划等多项科研课题，已在纳米生物医学相关领域SCI及核心期刊杂志发表文献数篇。协助培养多名硕士生及博士生。具备临床及科研工作的能力及基础。
At present, she has participated in multipleresearch work in the fields of bio-nano and tumor immunization,mastered the latest research progress of the immunotherapy and nanomaterialapplication in breast cancer, and been familiar with the isolation and cultureof immune cells, establishment of tumor-bearing mouse model and molecularbiology experiments technologies. She has also undertaken a number of scientificresearch projects such as the National Nature Science Foundation of China, theProject of Excellent Youth Training of Tongji University, and the Youth Projectof Health and Family Planning Committee of Pudong New Area and so on. Several articleshave been published in SCI and core journals related to nanobiomedicine. She hasassisted in the postgraduate training of the department of Breast CancerCenter, and possessed the clinical and scientific research ability.
代表性论文（Representative paper）：
1. Shujing Liang,Chao Li, Chunlei Zhang, etc.CD44v6 Monoclonal Antibody-Conjugated GoldNanostars for Targeted Photoacoustic Imaging and Plasmonic Photothermal Therapyof Gastric Cancer Stem-like Cells [J]. Theranostic,2015, 5(9): 970-984.(IF:8.854)
2. YonglinLu, Yain Ma, Chan Feng, Donglei Zhu, Jie Liu, Lv Chen, Shujing Liang^*,Chunyan Dong^*. Co-delivery ofCyclopamine and Doxorubicin Mediated by Bovine Serum Albumin NanoparticlesReverses Doxorubicin Resistance in Breast Cancer by Down-regulatingP-glycoprotein Expression [J].J Cancer, 2019,10(10):2357-2368. (IF:3.182)
3. ChaoLi, Shujing Liang, Chunlei Zhang, Yanlei Liu, Meng Yang, Jingpu Zhang,Xiao Zhi, Fei Pan, Daxiang Cui. Allogenic dendritic cell and tumor cell fusedvaccine for targeted imaging and enhanced immunotherapeutic efficacy of gastriccancer [J]. Biomaterial, 2015,54, 177-187.(IF: 8.557)
4. Chao Li, Ji Yang, CanWang, Shujing Liang, Fei Pan, Chunlei Zhang, Feng Chen, Hualin Fu, KanWang and Daxiang Cui. BRCAA1 antibody-and Her2 antibody-conjugated amphiphilicpolymer engineered CdSe/ZnS quantum dots for targeted imaging of gastric cancer[J].Nanoscale Res Lett, 2014, 9, 1-13. (IF:2.779)
5. Zhang C, Li C, Liu Y,Jingpu Zhang, Chenchen Bao, Shujing Liang, Qing Wang, Yao Yang, HualinFu, Kan Wang, and Daxiang Cui. Gold Nanoclusters‐Based Nanoprobes forSimultaneous Fluorescence Imaging and Targeted Photodynamic Therapy withSuperior Penetration and Retention Behavior in Tumors[J]. Advanced FunctionalMaterials, 2015, 25, 1314–1325 (IF:11.805)
6. Liang Xu, Xiaobo Wu, ChunHu, Zhiying Zhang, Le Zhang, Shujing Liang, Yingchun Xu, Fengchun Zhang.A meta-analysis of combination therapy versus single-agent therapy inanthracycline- and taxane-pretreated metastatic breast cancer: results fromnine randomized Phase III trials. Onco Targets Ther. 2016, Jul4;9:4061-74(IF:2.272).
7. Liang Xu, Le Zhang, ChunHu, Shujing Liang, Xiaochun Fei, Ningning Yan, Yanyun Zhang, FengchunZhang. WNT pathway inhibitor pyrvinium pamoate inhibits the self-renewal andmetastasis of breast cancer stem cells. Int J Oncol. 2016 Mar;48(3):1175-86(IF:2.371).
8. Chun Hu, Liang Xu, ShujingLiang, Zhiying Zhang, Yanyun Zhang, Fengchun Zhang. Lentivirus-mediatedshRNA targeting Nanog inhibits cell proliferation and attenuates cancer stemcell activities in breast cancer. J Drug Target. 2016;24(5):422-32(IF:2.821).
9. 梁淑静，徐丽敏等.疣状表皮发育不良的共聚焦激光扫描显微镜下表现[J]. 中国皮肤性病学杂志，2011,25(3):231-233.2
9. 梁淑静，徐丽敏等. 扁平苔藓的共聚焦激光扫描显微镜特征表现[J].临床皮肤科杂志，2011,40（3）：139-141.