方兰 研究员
硕士招生类型：学术型
硕士招生专业：肿瘤学
博士招生类型：学术型
博士招生专业：肿瘤学
所在院系：医学院
联系方式：wangong?_shediao@126.com
课题组链接：
研究方向
主要任职
科研业绩

蛋白质修饰调控与肿瘤微环境
Regulationof Post-translational Modification and Tumor Microenvironment

入选中国科协青年人才托举工程，上海市青年科技启明星计划和上海市卫计委新优青等人才计划。
Yong Scientist Sponsorship Program byCAST （2018）
Shanghai science and Technology YouthScience and Technology Star program（2019
Excellent Young Teachers Program of ShanghaiMunicipal Commission of Health and Family Planning （2017）


主要研究非组蛋白甲基化修饰调控肿瘤发生和干细胞功能的作用机制，学术成绩包括：1）发现甲基转移酶SET1A催化YAP甲基化修饰调节YAP细胞核转运促进肿瘤发生的关键分子机制，揭示YAP甲基化修饰作为肿瘤标志物的应用基础，并提示SET1A是肿瘤治疗新靶标（专利1项）（CancerCell，2018，第一作者）；2）发现甲基化修饰调控SOX2蛋白质稳定性在干细胞命运决定中的新机制，为肿瘤干细胞中SOX2功能研究提供了新的分子基础（Molecular Cell，2014，第一作者）。主持国家自然科学基金面上和青年项目。
代表性论文：
1. Lan Fang#, HongqiTeng#, Yilin Wang#, Guanghong Liao#, Linjun Weng, Yaxu Li, Xinbo Wang, JialiJin, Chenchen Jiao, Lei Chen, Xiaoping Peng, Jiayu Chen, Yongzhi Yang, HouqinFang, Dongyan Han, Cheng Li, Xueling Jin, Shihao Zhang, Zhongchen Liu, Min Liu,Qing Wei, Lujian Liao, Xin Ge, Bin Zhao, Dawang Zhou, Huan-Long Qin, Jun Zhou,Ping Wang*，SET1A-MediatedMono-Methylation at K342 Regulates YAP Activation by Blocking Its NuclearExport and Promotes Tumorigenesis. Cancer Cell, 2018 Jul 9;34(1):103-118.
2. Lan Fang#, JunZhang#, Hui Zhang#, Xiaoqin Yang, Xueling Jin, Ling Zhang, David G. Skalnik,Ying Jin, Jiwen Li, Yong Zhang, Xingxu Huang and Jiemin Wong*. H3K4Methyltransferase Set1a Is A Key Oct4 Coactivactor Essential for Generation ofOct4 Positive Inner Cell Mass. Stem Cells, 2016 Mar;34(3):565-80.
3. Yuanhui Jia#, Pishun Li#, Lan Fang#,Haijun Zhu, Liangliang Xu, Hao Cheng, Junying Zhang, Fei Li, Yan Feng, Yan Li,Jialun Li, Ruiping Wang, James X. Du, Jiwen Li, Taiping Chen, Hongbin Ji,Jackie Han, Wenqiang Yu, Qihan Wu, and Jiemin Wong*. Negative Regulation ofDNMT3A De Novo DNA Methylation by UHRF Family Proteins as a Mechanism forWidespread DNA Hypomethylation in Cancer. Cell Discovery, 2016 Apr 12;2:16007.
4. Lan Fang#, LingZhang, Wei Wei, Xueling Jin, Ping Wang, Yufeng Tong, Jiwen Li, James X. Du andJiemin Wong*. A Methylation-Phosphorylation Switch Determines Sox2 Stabilityand Function in ES cell Maintenance or Differentiation. Molecular Cell, 2014Aug 21;55(4):537-51.